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| 1 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 2 | Vitamin C promotes the proliferation and effector functions of human γδ T cells显示文摘γδT cells are of interest as effector cells for cellular immunotherapy due to their HLA-non-restricted lysis of many different tumor cell types.Potential applications include the adoptive transfer of in vitro-expandedγδT cells.Therefore,it is important to optimize the culture conditions to enable maximal proliferative and functional activity.Vitamin C(L-ascorbic acid)is an essential vitamin with multiple effects on immune cells.It is a cofactor for several enzymes,has antioxidant activity,and is an epigenetic modifier.Here,we investigated the effects of vitamin C(VC)and its more stable derivative,L-ascorbic acid 2-phosphate(pVC),on the proliferation and effector function of humanγδT cells stimulated with zoledronate(ZOL)or synthetic phosphoantigens(pAgs).VC and pVC did not increaseγδT-cell expansion within ZOL-or pAg-stimulated PBMCs,but increased the proliferation of purifiedγδT cells and 14-day-expandedγδT-cell lines in response toγδT-cell-specific pAgs.VC reduced the apoptosis ofγδT cells during primary stimulation.While pVC did not prevent activation-induced death of pAg-restimulatedγδT cells,it enhanced the cell cycle progression and cellular expansion.Furthermore,VC and pVC enhanced cytokine production during primary activation,as well as upon pAg restimulation of 14-day-expandedγδT cells.VC and pVC also increased the oxidative respiration and glycolysis ofγδT cells,but stimulus-dependent differences were observed.The modulatory activity of VC and pVC might help to increase the efficacy ofγδT-cell expansion for adoptive immunotherapy. | Léonce Kouakanou Yan Xu Christian Peters Junyi He Yangzhe Wu Zhinan Yin Dieter Kabelitz | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 3 | Pinocembrin protects rat brain against oxidation and apoptosis induced by ischemia- reperfusion both in vivo and in vitro显示文摘 | Liu R GaoM YangZH | 2008 | Brain Research2008，1216，26： | 1 |
| 4 | The analysis of morphological distor- tion during AFM study of cells 显示文摘 | Wu yangzhe Hu yi | 2008 | Scanning2008，30，5： | 1 |
| 5 | Nanoscale organization of CD4 molecules of human T helper cell mapped by NSOM and quantum dots显示文摘 | CHEN Jianan WU Yangzhe WANG Chenxi Cai Jiye | 2008 | Scanning2008，30，6： | 1 |
| 6 | 显示文摘 | 肖勇(XiaoY) 吴松(WuS) 杨朝晖(YangZH) 郑越(ZhengY) 赵峰(ZhaoF) | 2013 | 化学进展2013，，： | 1 |
| 7 | PolynomialBezoutianmatrixwithrespecttoageneralbasis显示文摘 | YANGZH | 2001 | Algebraanditsapplications2001，331，： | 1 |
| 8 | Analyti gal cualityspe- gifiGationsinlaboratorymediGine显示文摘 | ChenWX ShenZY YangZH | 2009 | Chinese Journal of Laboratory Medi Gine2009，29，4： | 1 |
| 9 | Theory and Design of Microwave-Tube Simulator Suite显示文摘 | LIB YANGZH LIJ Q etal | 2009 | IEEE Trans Electron Devices2009，56，5： | 1 |
| 10 | 显示文摘 | 梁斌(LiangB) 杨治华(YangZH) 贾德昌(JiaDC) 段小明(DuanXM) 周玉(ZhouY) | 2015 | 科学通报2015，60，： | 1 |
| 11 | Spoligotyping and polymorphic GC-rich repetitive sequence fingerprinting of Mycobacterium tuberculosis strains having few copies of IS6110显示文摘 | Ijaz K Bates JH | 2000 | J Clin Microbiol2000，38，10： | 1 |
| 12 | Alteration of transcriptional profile in human bronchial epithelial cells induced by cigarette smoke condensate显示文摘 | Hu YC YangZH Zhong KJ | | 0，，01： | 1 |
| 13 | SeedpropagationofRhododendron显示文摘 | ZhangCQ(张长芹) FengBJ(冯宝钧) ZhaoGY(赵革英) LuZW(吕正伟) YangZH(杨增宏) | | 云南植物研究0，，： | 1 |
| 14 | 显示文摘 | GanShenglong(甘盛龙) LuZhenping(路振平) YangZhe(杨哲) LiuJie(刘杰) | 2014 | 高分子学报2014，，2： | 1 |
| 15 | StructuralpropertiesofcompositecathodematerialLiFePO4-Li3V2(PO4)3 显示文摘 | ZhangB ZhengJC YangZH etal | 2011 | Ionics2011，17，： | 1 |
| 16 | Syn- thesis and properties of polyimides derived from cis- and trans- 1,2,3,4-cyclohexanetetracarboxylie dianhydrides显示文摘 | FangXZ YangZH ZhangSB GaoLX DingMX | 2004 | Polymer2004，45，18： | 1 |
| 17 | γδT cells:origin and fate,subsets,diseases and immunotherapy显示文摘The intricacy of diseases,shaped by intrinsic processes like immune system exhaustion and hyperactivation,highlights the potential of immune renormalization as a promising strategy in disease treatment.In recent years,our primary focus has centered onγδT cell-based immunotherapy,particularly pioneering the use of allogeneic Vδ2+γδT cells for treating late-stage solid tumors and tuberculosis patients.However,we recognize untapped potential and optimization opportunities to fully harnessγδT cell effector functions in immunotherapy.This review aims to thoroughly examineγδT cell immunology and its role in diseases.Initially,we elucidate functional differences betweenγδT cells and theirαβT cell counterparts.We also provide an overview of major milestones inγδT cell research since their discovery in 1984.Furthermore,we delve into the intricate biological processes governing their origin,development,fate decisions,and T cell receptor(TCR)rearrangement within the thymus.By examining the mechanisms underlying the anti-tumor functions of distinctγδT cell subtypes based onγδTCR structure or cytokine release,we emphasize the importance of accurate subtyping in understandingγδT cell function.We also explore the microenvironment-dependent functions ofγδT cell subsets,particularly in infectious diseases,autoimmune conditions,hematological malignancies,and solid tumors.Finally,we propose future strategies for utilizing allogeneicγδT cells in tumor immunotherapy.Through this comprehensive review,we aim to provide readers with a holistic understanding of the molecular fundamentals and translational research frontiers ofγδT cells,ultimately contributing to further advancements in harnessing the therapeutic potential ofγδT cells. | Yi Hu Qinglin Hu Yongsheng Li Ligong Lu Zheng Xiang Zhinan Yin Dieter Kabelitz Yangzhe Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 18 | Strategy on Development of Gasoline and Diesel Standards in China with Reference to Overseas Practice for Upgrading Gasoline and Diesel Quality显示文摘This article analyzes the standards for car exhaust emissions and gasoline and diesel quality in Europe and the US. As revealed by the evolution of gasoline and diesel standards in China, the gasoline and diesel compositions of China and the exhaust gas emissions standard are closely related with the specifics of the petroleum refining industry and automotive industry in China. After studying the current situations of gasoline and diesel quality in China while taking into account the commonly accepted practice in the overseas this article raises some suggestions on development of gasoline and diesel standards in compliance with the actual conditions of China. | YangZhe YangGuoxun | 2004 | China Petroleum Processing & Petrochemical Technology2004，6，2： | 0 |
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