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| 1 | Characteristics of high arsenic groundwater in Hetao Basin,Inner Mongolia,northern China显示文摘It is well known that the Hetao Basin is one of the most seriously arsenic-affected groundwater areas in China. In order to understand the characteristics of high arsenic(As) groundwater in the Basin, a brief overview of arsenic in groundwater follows. High arsenic in the Basin commonly occurs in shallow groundwater and the total arsenic concentrations range from 0.58 to 572 μg/L(average 99.73 μg/L), exceeding the maximum mandated value of 10 μg/L for drinking water in China; As(Ш) is the predominant species. The regional distribution pattern of arsenic in the groundwater increases from south/southeast to north/northwest. Hangjinhouqi and Wuyuan counties are considered as the most seriously affected areas, with high incidences of endemic arsenicosic diseases in the Hetao Basin. High groundwater arsenic correlates with the increase of well depth. Previous studies proposed that groundwater arsenic in the Basin is mainly originated from desorption of some natural solid materials in the sediments, under reducing condition. Generally, reducing condition is believed to be the primary factor for arsenic releasing from the sediment to groundwater in the region. Under inorganic or bacterial processes, Fe2O3 changes to Fe S and arsenic adsorbed to Fe(OH)3 dissolves into groundwater, and As(V) is reduced to As(Ш). Besides, reducing environments, groundwater hydraulic gradients, organic matter, p H, evapotranspiration, and soil texture are presumed to be the predominant factors that control arsenic mobilization. | YangChun Zhu XueYong Zhao Min Chen YongQing Luo Xin Zhou | 2015 | Research in Cold and Arid Regions2015，7，1： | 2 |
| 2 | Comparison of diagnostic accuracy between ^(18)F-FDG PET and PET/CT for pulmonary neoplasm显示文摘Aimed at comparing diagnostic accuracy of 18F-FDG PET with PET/CT for pulmonary neoplasm, a study based on multi-center clinical trial of the diagnoses, in randomized and semi-blind ways, was executed from January 2006 to June 2007. It included 55 patients, i.e. 16 with histopathologically proved lung tumors, 16 with tuberculosis and 23 with benign lesions (inflammation, pseudotumor, granuloma, fibrosis and others). The histopathologic and clinic results were served as reference standard. Statistical significances in pulmonary nodule diagnosis between 18F-FDG PET and PET/CT were determined with 95% confidence interval obtained by ROC analysis. The 18F-FDG PET detected lung neoplasm with a sensitivity of 87.5% (14/16), a specificity of 59.0% (23/39), an accuracy of 67.3% (37/55) and a positive-likelihood ratio of 2.13. The 18F-FDG PET/CT detected lung neoplasm with a sensitivity of 93.8% (15/16), a specificity of 61.5% (24/39), an accuracy of 70.9% (39/55) and a positive-likelihood ratio of 2.43. The area under curves (AUC) of 18F-FDG PET and PET/CT were 0.803±0.068 and 0.799±0.063, respectively. It can be concluded that the diagnostic accuracy for malignant pulmonary nodules between 18F-FDG PET and PET/CT was not statistically different. | CHEN Yangchun CHEN Ping TIAN Jiahe CAI Xin YE Guangchun DENG Huaifu YANG Xiaofeng | 2009 | Nuclear Science and Techniques2009，20，1： | 2 |
| 3 | Synthesis and evaluation of ^(64)Cu-radiolabeled NOTA-cetuximab(^(64)Cu-NOTA-C225) for immuno-PET imaging of EGFR expression显示文摘Objective: Epidermal growth factor receptor(EGFR) is overexpressed in a wide variety of solid tumors, serving as a well-characterized target for cancer imaging or therapy. In this study, we aimed to design and synthesize a radiotracer, ^(64) Cu-NOTA-C225, targeting EGFR for tumor positron emission tomography(PET) imaging.Methods: Cetuximab(C225) was conjugated to a bifunctional chelator, p-isothiocyanatobenzyl-1,4,7-triazacyclononane-1,4,7-triacetic acid(NOTA), and further radiolabeled with copper-^(64) for PET imaging. ^(64) CuNOTA-IgG and Cy5.5-C225 were also synthesized as control probes. A431 and A549 mouse models were established for micro-PET and/or near-infrared fluorescence(NIRF) imaging.Results: ^(64) Cu-NOTA-C225 exhibited stability in vivo and in vitro up to 24 h and 50 h post-injection,respectively. A431 tumors with average standard uptake values(SUVs) of 5.61±0.69, 6.68±1.14, 7.80±1.51 at 6, 18 and 36 h post-injection, respectively, which were significantly higher than that of moderate EGFR expressing tumors(A549), with SUVs of 0.89±0.16, 4.70±0.81, 2.01±0.50 at 6, 18 and 36 h post-injection, respectively. The expression levels of A431 and A549 were confirmed by western blotting. Additionally, the tracer uptake in A431 tumors can be blocked by unlabeled cetuximab, suggesting that tracer uptake by tumors was receptor-mediated.Furthermore, NIRF imaging using Cy5.5-C225 showed that the fluorescence intensity in tumors increased with time, with a maximal intensity of 8.17 E+10(p/s/cm^2/sr)/(μW/cm^2) at 48 h post-injection, which is consistent with the paradigm from micro-PET imaging in A431 tumor-bearing mice.Conclusions: The ^(64) Cu-NOTA-C225 PET imaging may be able to specifically and sensitively differentiate tumor models with different EGFR expression levels. It offers potentials as a PET radiotracer for imaging of tracer EGFR-positive tumors. | Xiaoxia Xu Teli Liu Fei Liu Xiaoyi Guo Lei Xia Qing Xie Nan Li Haifeng Huang Xianteng Yang Yangchun Xin Hua Zhu Zhi Yang | 2019 | Chinese Journal of Cancer Research2019，31，2： | 1 |
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