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| 1 | Control of Leaf Senescence by an MeOH- Jasmonates Cascade that Is Epigenetically Regulated by OsSRT1 in Rice显示文摘 | ChuanYing Fang Hua Zhang Jian Wan YangYang Wu Kang Li Cheng Jin Wei Chen ShouChuang Wang WenSheng Wang HaiWei Zhang Pan Zhang Fei Zhang LiangHuan Qu Xianqing Liu Dao-Xiu Zhou Jie Luo | 2016 | Molecular Plant2016，9，10： | 14 |
| 2 | Additive manufacturing of high-strength CrMnFeCoNi high-entropy alloys-based composites with WC addition显示文摘Laser melting deposition with WC addition has been developed to fabricate high-strength CrMnFeCoNibased high-entropy alloys-based composites.By this technique,a microstructure of compact refined equiaxed grains can be achieved,and the tensile strength can be remarkably improved.The sample with 5 wt%WC addition shows a promising mechanical performance with a tensile strength of 800 MPa and an elongation of 37%.The improvement in mechanical property may be attributed to the formation of Cr(23)C6 reinforcement precipitates,which could promote the heterogeneous nucleation of grains and hinder the propagation of slip bands. | Jinfeng Li Shuo Xiang Hengwei Luan Abdukadir Amar Xue Liu Siyuan Lu Yangyang Zeng Guomin Le Xiaoying Wang Fengsheng Qu Chunli Jiang Guannan Yang | 2019 | Journal of Materials Science & Technology2019，35，11： | 13 |
| 3 | Current status and perspectives of regulatory T cell-based therapy显示文摘The CD4FOXP3regulatory T(Treg)cells are essential for maintaining immune homeostasis in healthy individuals.Results from clinical trials of Treg cell-based therapies in patients with graft versus host disease(GVHD),type 1 diabetes(T1D),liver transplantation,and kidney transplantation have demonstrated that adoptive transfer of Treg cells is emerging as a promising strategy to promote immune tolerance.Here we provide an overview of recent progresses and current challenges of Treg cell-based therapies.We summarize the completed and ongoing clinical trials with human Treg cells.Notably,a few of the chimeric antigen receptor(CAR)-Treg cell therapies are currently undergoing clinical trials.Meanwhile,we describe the new strategies for engineering Treg cells used in preclinical studies.Finally,we envision that the use of novel synthetic receptors,metabolic regulators,combined therapies,and in vivo generated antigen-specific or engineered Treg cells through the delivery of modified mRNA and CRISPR-based gene editing will further promote the advances of next-generation Treg cell therapies. | Guojun Qu Jieqiong Chen Yangyang Li Yaqin Yuan Rui Liang Bin Li | 2022 | Journal of Genetics and Genomics2022，49，7： | 3 |
| 4 | Branched-chain amino acids regulate plant growth by affecting the homeostasis of mineral elements in rice显示文摘Dear Editor,Branched-chain amino acids(BCAAs)are essential amino acids that must be obtained from the diet for humans and animals.Branched-chain amino acid transaminases(BCATs)catalyze a key step in the BCAA synthesis pathway,however,little is known about their biological roles in planta.In this study,we functionally characterized two BCATs,OsBCAT4 and OsBCAT5,in rice and showed that they regulate the development of rice roots by affecting the levels of mineral elements. | Cheng Jin Yangyang Sun Yuheng Shi Yuanyuan Zhang Kai Chen Yuan Li Guige Liu Fang Yao Deng Cheng Jie Li Junjie Zhou Lianghuan Qu Xianqing Liu Jie Luo | 2019 | Science China(Life Sciences)2019，62，8： | 3 |
| 5 | Ultra-small hollow ternary alloy nanoparticles for efficient hydrogen evolution reaction显示文摘Hollow nanoparticles with large specific surface area and high atom utilization are promising catalysts for the hydrogen evolution reaction(HER). We describe herein the design and synthesis of a series of ultra-small hollow ternary alloy nanostructures using a simple one-pot strategy. The same technique was demonstrated for hollow PtNiCu nanoparticles, hollow PtCoCu nanoparticles and hollow CuNiCo nanoparticles. During synthesis, the displacement reaction and oxidative etching played important roles in the formation of hollow structures. Moreover, our hollow PtNiCu and PtCoCu nanoparticles were single crystalline, with an average diameter of 5 nm. Impressively, ultra-small hollow PtNiCu nanoparticles,containing only 10% Pt, exhibited greater electrocatalytic HER activity and stability than a commercial Pt/C catalyst. The overpotential of hollow Pt Ni Cu nanoparticles at 10 mA cm^(-2) was 28 mV versus reversible hydrogen electrode(RHE). The mass activity was 4.54 A mg Pt^(-1) at-70 mV versus RHE, which is 5.62-fold greater than that of a commercial Pt/C system(0.81 A mg Pt^(-1)). Through analyses of bonding and antibonding orbital filling, density functional theory calculations demonstrated that the bonding strength of different metals to the hydrogen intermediate(H*) was in the order of Pt > Co > Ni > Cu. The excellent HER performance of our hollow PtNiCu nanoparticles derives from moderately synergistic interactions between the three metals and H*. This work demonstrates a new strategy for the design of low-cost and high-activity HER catalysts. | Zhenxing Li Chengcheng Yu Yikun Kang Xin Zhang Yangyang Wen Zhao-Kui Wang Chang Ma Cong Wang Kaiwen Wang Xianlin Qu Miao He Ya-Wen Zhang Weiyu Song | 2021 | National Science Review2021，8，7： | 2 |
| 6 | Fabrication of high-aspect-ratio electrode array by combining UV-LIGA with micro electro-discharge machining 显示文摘 | Hu Yangyang Zhu Di Qu Ningsong | 2009 | Microsyst Technol2009，15，： | 1 |
| 7 | N^(6)-methyladenosine methyltransferase plays a role in hypoxic preconditioning partially through the interaction with lncRNA H19显示文摘N^(6)-methyladenosine(m6A),a m ethylation in the N6 position of adenosine especially in the mRNA,exerts diverse physiological and pathological functions.However,the precise role of m 6A methylation in hypoxic preconditioning(HPC)is still unknown.Here,we observed that HPC treatm ent protected H9c2 cells against H2O2-induced injury,upregulated the m 6A level in the total RNA and the expression of methyltransferase like 3(METTL3),methyltransferase like 14(METTL14),and long noncoding RNA(lncRNA)H19.Either knockdown of METTL3 or METTL14 notably reversed the HPC-induced enhancement of cell viability,anti-apoptosis ability,and H19 expression.M ethylated RNA im m unoprecipitation(IP)indicated that knockdown of METTL3 or METTL14 decreased m 6A level in the lncRNA H19.Gain-of-function assay dem onstrated that H19 overexpression could partially rescue the decreased protection mediated by METTL3 or METTL14 knockdown in HPCtreated H9c2 cells.RNA binding protein im m unoprecipitation(RIP)assay showed that METTL3 and METTL14 could directly bind w ith H19.Our study identified a novel pattern of posttranscriptional regulation in HPC treatm ent.Since METTL3,METTL14,and lncRNA H19 were involved in HPC protection,they could be considered as potential biomarkers and therapeutic targets in HPC-derived cardiac rehabilitation and therapeutic approaches. | Yamin Su Rongfeng X u Rui Zhang Yangyang Qu Wenjie Zuo Zhenjun Ji Haihua Geng Min Pan Genshan Ma | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 1 |
| 8 | Fabrication of high-as- pect-ratio electrode array by combining UV-LIGA with micro electro- discharge machining 显示文摘 | Hu Yangyang Zhu Di Qu Ningsong | 2009 | Microsystem Technologies2009，15，51： | 1 |
| 9 | Insertion/deletion variants within the IGF2BP2 gene identified in reported genome-wide selective sweep analysis reveal a correlation with goat litter size显示文摘Insulin-like growth factor 2 m RNA-binding protein 2(IGF2 BP2,also called IMP2)plays an essential role in the development and maturation of germ cells and embryos and is a candidate gene for goat litter size,based on a previous genomewide selective sweep analysis.In this study,the m RNA expression level of IGF2 BP2 was found to be significantly higher in a single-lamb group than in a multi-lamb group.Insertions/deletions(indels)within the goat IGF2 BP2 gene,including P4-Ins-13 bp and P5-Del-12 bp,were verified in 918 Shaanbei White Cashmere(SBWC)female goats.The minor allelic frequencies(MAFs)of P4-Ins-13 bp and P5-Del-12 bp loci were 0.349 and 0.295,respectively.Analysis using the Chi-square(χ^(2))test showed that the genotype(χ^(2)=14.479,P=0.006)distribution of P4-Ins-13 bp was significantly different between the single-lamb and multi-lamb groups.Correlation analysis demonstrated that P4-Ins-13 bp was significantly associated with goat litter size(P=0.022),and individual goats with the homozygous deletion/deletion(DD)genotype produced more litters than other goats.Therefore,considered as a potential molecular marker significantly related to lambing traits,the P4-Ins-13 bp mutation of the goat IGF2 BP2 gene can be used in goat breeding with practical molecular marker-assisted selection(MAS)to optimize female reproduction and improve economic efficiency in the goat industry. | Dongyun XIN Yangyang BAI Yi BI Libang HE Yuxin KANG Chuanying PAN Haijing ZHU Hong CHEN Lei QU Xianyong LAN | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，9： | 0 |
| 10 | Experimental study on spraying performance of biological pesticides in aerial rotary cage nozzle显示文摘Aviation spraying is one of the most important methods for the treatment of forestry pests and diseases,which has a high operation efficiency and effectiveness.The combination of aviation spray and biological pesticides to reduce the impact of pesticide spray on environment has become an important development in the direction of agricultural aviation.In order to explore the effects of aviation spray parameters on particle size distribution and activity retention of biological pesticide droplets,a system of droplets size test and an activity retention rate test system of biological pesticides were constructed.The related experiments were conducted by changing the structural parameters of the rotary cage nozzle(the diameter of nozzle)and the technical parameters of the operation(rotary speed and flow rate).The results showed that the average relative width S of the droplets of the rotary cage nozzle was close to 1,and the droplet distribution was uniform.The influence factors on the particle size distribution of biological pesticide droplets were rotary speed,nozzle diameter,medium and flow rate in descending order.The rotary speed,nozzle diameter,and medium had a significant influence on droplet size distribution.The average activity retention rate of Bacillus thuringiensis was 88.83%,and the germination rate of Beauveria bassiana was 89.80%.The rotary speed had a significant effect on the activity retention rate of bacterial and fungal biological pesticides,and it was negatively correlated.The rotary speed was between 3000-5000 r/min,and the activity retention rate was higher.The research results can provide guidance for spraying biological pesticides in aerial plant protection operations with rotary cage nozzle. | Yu Ru Yangyang Liu Rongjia Qu Manoj Kumar Patel | 2020 | International Journal of Agricultural and Biological Engineering2020，13，6： | 0 |
| 11 | Meta-Analysis of Flowering-Related Traits and Mining of Candidate Genes in Maize显示文摘Maize flowering is an important agronomic character,which is controlled by quantitative trait loci(QTL).Over the years,a large number of flowering-related QTL have been found in maize and exist in public databases.However,combining these data,re-analyzing and mining candidate loci and fine mapping of flowering-related traits to reduce confidence intervals has become a hot issue in maize.In this study,the QTL of 6 important agronomic traits of maize flowering were collected from 15 published articles,including flowering period(DA),Days to tasseling(DTT),Days to silking(DS),Days to pollen shedding(DTP),anthesis-silking interval(ASI)and the photosensitive(PS).Through meta-analysis,622 QTL were integrated into 26 meta-QTLs(MQTL).Finally,the candidate genes related to maize flowering(Gene IDs:ZM00001D005791,ZM00001D019045,ZM00001D050697,ZM00001D011139)were identified by Gene Ontology(GO)enrichment and hierarchical cluster analysis of expression profile.Based on the results of this study,the genetic characteristics of maize flowering traits will be further analyzed,which is of great significance to guide the improvement of important agronomic characters and improve the efficiency of breeding. | Jianyu Lu Qingping Jiang Tongyu Liu Yangyang Zhou Mengtong Liu Jing Qu Yiyong Ma Shuyan Guan | 2022 | Phyton-International Journal of Experimental Botany2022，91，6： | 0 |
| 12 | Substation rotational object detection based on multi-scale feature fusion and refinement显示文摘In modern energy systems,substations are the core of electricity transmission and distribution.However,similar appearance and small size pose significant challenges for automatic identification of electrical devices.To address these issues,we collect and annotate the substation rotated device dataset(SRDD).Further,feature fusion and feature refinement network(F3RNet)are constructed based on the classic structure pattern of backbone-neck-head.Considering the similar appearance of electrical devices,the deconvolution fusion module(DFM)is designed to enhance the expression of feature information.The balanced feature pyramid(BFP)is embedded to aggregate the global feature.The feature refinement is constructed to adjust the original feature maps by considering the feature alignment between the anchors and devices.It can generate more accurate feature vectors.To address the problem of sample imbalance between electrical devices,the gradient harmonized mechanism(GHM)loss is utilized to adjust the weight of each sample.The ablation experiments are conducted on the SRDD dataset.F3RNet achieves the best detection performance compared with classical object detection networks.Also,it is verified that the features from global feature maps can effectively recognize the similar and small devices. | Bin Li Yalin Li Xinshan Zhu Luyao Qu Shuai Wang Yangyang Tian Dan Xu | 2023 | Energy and AI2023，14，4： | 0 |
| 13 | Optimization of Agrobacterium tumefaciens-Mediated Genetic Transformation of Maize显示文摘Immature embryos of inbred maize(Zea mays)lines(H8183,H8184,and H8185)were used for Agrobacterium infection.We used theβ-glucuronidase gene(GUS)as the target gene and the glufosinate resistance gene(bar)as the selection marker.We conducted research on several aspects,such as different genotypes,coculture conditions,screening agent concentrations,and concentrations of indole-3-butytric acid(IBA),6-benzylaminopurine(6-BA),and ascorbic acid(Vc)in the differentiation medium.We optimized the genetic transformation system,and the obtained results indicated that among the three lines studied,the induction rate of H8185 was the highest at 93.2%,followed by H8184,with H8183 having the lowest induction rate(80.1%).The best coculture method was that using the N6 coculture medium layered with a sterile filter paper.Using orthogonal analysis,we found that the optimal combination of the three factors in the differentiation medium was A_(3)(1 mg mL^(−1)IBA),B_(3)C_(1)(1.6 mg mL^(−1)6-BA),and D_(3)(1.5 mg mL^(−1)Vc).Through GUS staining analysis,Bar test-strip analysis,and polymerase chain reaction,five transgenic plants were finally obtained.This study established the optimal conditions for genetic transformation in maize. | Mengtong Liu Yangyang Zhou Tongyu Liu Jianyu Lu Jing Qu Shuyan Guan Yiyong Ma | 2022 | Phyton-International Journal of Experimental Botany2022，91，2： | 0 |
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