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| 1 | Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis显示文摘Uric acid is the end product of purine catabolism and its plasma levels are maintained below its maximum solubility in water(6–7 mg/dl).The plasma levels are tightly regulated as the balance between the rate of production and the rate of excretion,the latter occurring in urine(kidney),bile(liver)and feces(intestinal tract).Reabsorption in kidney is also an important component of this process.Both excretion and reabsorption are mediated by specific transporters.Disruption of the balance between production and excretion leads to hyperuricemia,which increases the risk of uric acid crystallization as monosodium urate with subsequent deposition of the crystals in joints causing gouty arthritis.Loss-of-function mutations in the transporters that mediate uric acid excretion are associated with gout.The ATP-Binding Cassette exporter ABCG2 is important in uric acid excretion at all three sites:kidney(urine),liver(bile),and intestine(feces).Mutations in this transporter cause gout and these mutations occur at significant prevalence in general population.However,mutations that are most prevalent result only in partial loss of transport function.Therefore,if the expression of these partially defective transporters could be induced,the increased number of the transporter molecules would compensate for the mutation-associated decrease in transport function and hence increase uric acid excretion.As such,pharmacologic agents with ability to induce the expression of ABCG2 represent potentially a novel class of drugs for treatment of gouty arthritis. | Bojana Ristic Mohd Omar Faruk Sikder Yangzom D.Bhutia Vadivel Ganapathy | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 13 |
| 2 | The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy显示文摘Tumor cells have an increased demand for glucose and amino acids to support their rapid growth,and also exhibit alterations in biochemical pathways that metabolize these nutrients.Transport across the plasma membrane is essential to feed glucose and amino acids into these tumor cell-selective metabolic pathways.Transfer of amino acids across biological membranes occurs via a multitude of transporters;tumor cells must upregulate one or more of these transporters to satisfy their increased demand for amino acids.Among the amino acid transporters,SLC6A14 stands out with specific functional features uniquely suited for the biological needs of the tumor cells.This transporter is indeed upregulated in tumors of epithelial origin,including colon cancer,cervical cancer,breast cancer,and pancreatic cancer.Since normal cells express this transporter only at low levels,blockade of this transporter should lead to amino acid starvation selectively in tumor cells,thus having little effect on normal cells.This offers a novel,yet logical,strategy for the treatment of cancers that are associated with upregulation of SLC6A14.In addition,a variety of amino acid-based prodrugs are recognized as substrates by SLC6A14,thus raising the possibility that anticancer drugs can be delivered into tumor cells selectively via this transporter in the form of amino acid prodrugs.This strategy allows exposure of SLC6A14-positive tumor cells to chemotherapy with minimal off-target effects.In conclusion,the amino acid transporter SLC6A14 holds great potential not only as a direct drug target for cancer therapy but also for tumor cell-selective delivery of anticancer drugs. | Yangzom D.Bhutia Ellappan Babu Puttur D.Prasad Vadivel Ganapathy | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，6： | 8 |
| 3 | Genome-wide DNA methylation profiles in Tibetan and Yorkshire pigs under highaltitude hypoxia显示文摘Background: Tibetan pigs, which inhabit the Tibetan Plateau, exhibit distinct phenotypic and physiological characteristics from those of lowland pigs and have adapted well to the extreme conditions at high altitude.However, the genetic and epigenetic mechanisms of hypoxic adaptation in animals remain unclear.Methods: Whole-genome DNA methylation data were generated for heart tissues of Tibetan pigs grown in the highland(TH, n = 4) and lowland(TL, n = 4), as well as Yorkshire pigs grown in the highland(YH, n = 4) and lowland(YL, n = 4), using methylated DNA immunoprecipitation sequencing.Results: We obtained 480 million reads and detected 280679, 287224, 259066, and 332078 methylation enrichment peaks in TH, YH, TL, and YL, respectively. Pairwise TH vs. YH, TL vs. YL, TH vs. TL, and YH vs. YL comparisons revealed6829, 11997, 2828, and 1286 differentially methylated regions(DMRs), respectively. These DMRs contained 384, 619,192, and 92 differentially methylated genes(DMGs), respectively. DMGs that were enriched in the hypoxia-inducible factor 1 signaling pathway and pathways involved in cancer and hypoxia-related processes were considered to be important candidate genes for high-altitude adaptation in Tibetan pigs.Conclusions: This study elucidates the molecular and epigenetic mechanisms involved in hypoxic adaptation in pigs and may help further understand human hypoxia-related diseases. | Bo Zhang Dongmei Ban Xiao Gou Yawen Zhang Lin Yang Yangzom Chamba Hao Zhang | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 6 |
| 4 | Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice显示文摘A polyphenolic alkaloid-enriched extract(PAE)was prepared from the fruiting bodies of a wild edible mushroom Sarcodon leucopus.Oral administration of PAE reduced hyperglycemia,hyperlipidemia,hepatic steatosis,and LPS-related infl ammation in high fat diet-induced obese(DIO)mice.Furthermore,we show that PAE produces taxonomic and predicted functional changes in the gut microbiome of DIO mice.A signifi cant decrease in the family of Ruminococcaceae,especially the secondary bile acid-producing bacteria of Intestinimonas and Anaerotruncus,is detected in the gut microbiome of PAE-treate mice.Accordingly,reductions of deoxycholic acid and lithocholic acid are found in the feces of PAE-treated DIO mice,which benefi ts for the intestinal integrity and the reduction of infl ammation.A gut microbiota related mechanism for the anti-metabolic syndrome effects of the PAE is proposed.We suppose the polyphenolic alkaloid extract from S.leucopus be a new and benefi cial prebiotic regulating glucose and lipid metabolisms. | Li Sun Li Bao Dorji Phurbu Shanshan Qiao Shanshan Sun Yangzom Perma Hongwei Liu | 2021 | Food Science and Human Wellness2021，10，4： | 5 |
| 5 | Epidemiology of H elicobacter pylori in B hutan: The Role of Environment and Geographic Location显示文摘 | Dorji Dorji Tashi Dendup Hoda M. Malaty Kinley Wangchuk Deki Yangzom James M. Richter | 2014 | Helicobacter2014，，1： | 1 |
| 6 | Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer显示文摘Based on the evidence that hemochromatosis, an iron-overload disease, drives hepatocellular carcinoma, we hypothesized that chronic exposure to excess iron, either due to genetic or environmental causes, predisposes an individual to cancer. Using pancreatic cancer as our primary focus, we employed cell culture studies to interrogate the connection between excess iron and cancer, and combined in vitro and in vivo studies to explore the connection further. Ferric ammonium citrate was used as an exogenous iron source. Chronic exposure to excess iron induced epithelial-mesenchymal transition(EMT) in normal and cancer cell lines, loss of p53, and suppression of p53 transcriptional activity evidenced from decreased expression of p53 target genes(p21, cyclin D1, Bax, SLC7A11). To further extrapolate our cell culture data, we generated EL-KrasG12D( EL-Kras) mouse(pancreatic neoplastic mouse model) expressing Hfe+/+ and Hfe-/- genetic background. p53 target gene expression decreased in EL-Kras/Hfe-/- mouse pancreas compared to EL-Kras/Hfe+/+ mouse pancreas. Interestingly, the incidence of acinar-to-ductal metaplasia and cystic pancreatic neoplasms(CPN) decreased in EL-Kras/Hfe-/- mice, but the CPNs that did develop were larger in these mice than in EL-Kras/Hfe+/+ mice. In conclusion, these in vitro and in vivo studies support a potential role for chronic exposure to excess iron as a promoter of more aggressive disease via p53 loss and SLC7A11 upregulation within pancreatic epithelial cells. | Yangzom D.Bhutia Jiro Ogura Paul J.Grippo Carolina Torres Toshihiro Sato Mitchell Wachtel Sabarish Ramachandran Ellappan Babu Sathish Sivaprakasam Devaraja Rajasekaran Bradley Schniers Nhu On Logan Smoot Muthusamy Thangaraju Jaya P.Gnana-Prakasam Vadivel Ganapathy | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 1 |
| 7 | The effect of diphenhydramine on sleep in pediatric burnpatients: a secondary analysis显示文摘 | Yangzom N Gottschlich MM Ossege J Wangmo T KaganRJ | 2015 | J Burn Care Res2015，36，2： | 1 |
| 8 | Nutritional and health status of Tibetan children living at high altitudes显示文摘 | Harris NS Crawford PB Yangzom Y | | 0，，5： | 1 |
| 9 | Nutritional and health status of Tibetan children living at high altitudes显示文摘 | Harris NS Crawford PB Yangzom Y | 2001 | N Engl J Med2001，344，5： | 1 |
| 10 | Nutritional and health status of Tibetan children living at high altitudes显示文摘 | Harris NS Crawford PB Yangzom Y | | 0，，05： | 1 |
| 11 | Malaria control in Bhutan: case study of a country embarking on elimination 显示文摘 | Yangzom T Smith Gueye C Namgay R et ol | 2012 | Malar J2012，11，： | 1 |
| 12 | Outcome of hospital deliveries of women living at high altitude:a study from Lhasa in Tibet显示文摘 | Yangzom Y Qian L Shan M | 2008 | Acta Paediatr2008，97，3： | 1 |
| 13 | 感受藏北非遗文化盛宴显示文摘On May 7,2022,an action-packed intangible cultural heritage show drew massive crowds to Palgon County in the heart of the grassland.Despite the early morning flurries of snow,the small amphitheater was soon packed.Many herders came from the remote Nyima and Shekyer Townships.Ngodrup,his wife,and their two children drove all the way from Mantang Township in the early morning,but they could only find seats in the outer area.'We just want to see the xieqin show,'Ngodrup shrugged. | Zhang Yu Yeshi Gyatso Sonam Tsomo Sonam Yangzom Li Xiaosu | 2022 | China's Tibet2022，33，5： | 0 |
| 14 | THE MOST BEAUTIFUL MOVABLE SCENERY AT THE FOOT OF MT.GANG RINPOCHE显示文摘Editor’s note:Every winter,when Ngari is snowbound,telephone becomes the only way for people here to connect with the outside world.A signal tower built beside Mt.Gang Rinpoche is their only hope to enjoy undisrupted communication.The tower is known by the local Tibetans as'life signals'.In January of 2013,a ceremony honoring'online personalities touching China in 2013' | Droma Yangzom Chimed Dorje | 2014 | China's Tibet2014，25，6： | 0 |
| 15 | Mining Unknown Porcine Protein Isoforms by Tissue-based Map of Proteome Enhances Pig Genome Annotation显示文摘A lack of the complete pig proteome has left a gap in our knowledge of the pig genome and has restricted the feasibility of using pigs as a biomedical model.In this study,we developed a tissue-based proteome map using 34 major normal pig tissues.A total of 5841 unknown protein isoforms were identified and systematically characterized,including 2225 novel protein isoforms,669 protein isoforms from 460 genes symbolized beginning with LOC,and 2947 protein isoforms without clear NCBI annotation in the current pig reference genome.These newly identified protein isoforms were functionally annotated through profiling the pig transcriptome with high-throughput RNA sequencing of the same pig tissues,further improving the genome annotation of the corresponding protein-coding genes.Combining the well-annotated genes that have parallel expression pattern and subcellular witness,we predicted the tissue-related subcellular locations and potential functions for these unknown proteins.Finally,we mined 3081 orthologous genes for 52.7% of unknown protein isoforms across multiple species,referring to 68 KEGG pathways as well as 23 disease signaling pathways.These findings provide valuable insights and a rich resource for enhancing studies of pig genomics and biology,as well as biomedical model application to human medicine. | Pengju Zhao Xianrui Zheng Ying Yu Zhuocheng Hou Chenguang Diao Haifei Wang Huimin Kang Chao Ning Junhui Li Wen Feng Wen Wang George ELiu Bugao Li Jacqueline Smith Yangzom Chamba Jian-Feng Liu | 2021 | Genomics, Proteomics & Bioinformatics2021，19，5： | 0 |
| 16 | Tsering Yangzom,a Singer from Yamdrok Yumco显示文摘I have known the singer Tsering Yangzom for quite a few years.She tends to stay out of the limelight as much as possible.At first,she tried to shun all media attention.Then she reluctantly took interviews but stumbled through them.Now she speaks with confidence and composure.Tsering Yangzom has changed a lot.'It’s not that I suddenly became mature and wise,but with constant learning,now I have something to say,and I can speak with fluency and confidence,'she said. | Liu Zheng Tsering Yangzom | 2018 | China's Tibet2018，29，5： | 0 |
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