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| 1 | Effects of gravity on the microstructure of Zr_(41)Ti_(14)-Cu_(12.5)Ni_(10)Be_(22.5) bulk glass forming alloy显示文摘The ZrTiCuNiBe alloy is melt and solidified by Bridgman unidirectional solidification on two gravity field orientations (the gravity field orientation is parallel and opposite to solidification direction). Effects of gravity on morphology and microstructure are investigated by scanning electron microscope (SEM) and X-ray diffraction (XRD). When gravity field orientation is parallel to solidificationdirection, less needle-like primary phase is embedded in a matrix eutectic; when gravity field orientation is opposite to solidification direction, a large amount of coarser needle-like primary phases were observed. | LI Gong, ZHAN Zaiji, WANG Limin, CAO Limin, SUN Liling, DAI Daoyang, ZHANG Jun & WANG WenkuiInstitute of Physics, Center for Condensed Matter Physics, Chinese Academy of Sciences, Beijing 100080, China Department of Materials Science and Engineering, Yanshan University, Qinhuangdao 066004, China | 2001 | Chinese Science Bulletin2001，46，11： | 3 |
| 2 | Compression behavior of Zr_(41)Ti_(14)Cu_(12.5)Ni_(10)Be_(22.5) bulk metallic glass up to 24 GPa显示文摘The compression of a Zr41Ti14Cu12.5Ni10Be22.5 bulk metallic glass (BMG) is investigated at room temperature up to 24 GPa using in-situ high pressure energy dispersive X-ray diffraction with a synchrotron radiation source. The pressure-induced structural relaxation is exhibited. It is found that below about 8 GPa, the existence of excess free volume contributes to the rapid structural relaxation, which gives rise to the rapid volumetric change, and the structural relaxation results in the structural stiffness under higher pressure. | LI Gong 1, 2 , ZHAN Zaiji 2 , LIU Jing 3 , YUN Jinku 1 , SUN Liling 2 , LIU Riping 1 , ZHANG Jun 2 & WANG Wenkui 1, 2 1. Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China 2. Center for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China 3. BSRF, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100039, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，3： | 1 |
| 3 | Preparation of tanshinone Ⅱ_(A) self-soluble microneedles and its inhibition on proliferation of human skin fibroblasts显示文摘Objective:Hypertrophic scars(HS)are a variety of skin tissue fibrosis disease that occurs in human skin,the effective therapeutic method of which is still inaccessible up to now.As a bioactive constituent of a well-known medical plant,Salvia miltiorrhiza(Danshen in Chinese),tanshinone Ⅱ_(A)(TSA)is reported to inhibit cell proliferation in HS.Therefore,the aim of this study was to prepare TSA self-soluble microneedles to strengthen its dermal retention and break through the difficulty of significantly thickening epidermal connective tissue and stratum corneum at the HS site.The possible mechanism of action in suppressing HS was studied using human skin fibroblasts(HSF).Methods:Tanshinone Ⅱ_(A) self-dissolving microneedles(TSA-MN)was prepared using a negative mold casting method.The prescription process of microneedle was optimized by Box-Behnken effect surface method.Different media were selected to investigate the ability of transdermal absorption and in vitro release.Furthermore,according to Cell Counting Kit-8(CCK8)method as well as the Western blot method,the effect of TSA-MN on the biological characteristics of HSF was investigated.Results:With remarkable slow release effect and dermal retention,the release and transdermal properties of TSA-MN in vitro were better than both TSA and ordinary dosage forms.Its effect of HSF confirmed the essential decrease in cell motility during cell proliferation and cell migration in vitro,which plays a significant role in down-regulating the secretion of transforming growth factor-β1(TGF-β1)in HSF and increasing the expression level of Smad7.Conclusion:The prepared TSA self-soluble microneedles is helpful in solving the problem of hypertrophic scars,with a stable dermal retention effect after process optimization. | Yanshan Zhan Xiaoqi Xu Xi Luo Ruiping Liu Yujian Lin Ping Zhao Jun Shi | 2023 | Chinese Herbal Medicines2023，15，2： | 0 |
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