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| 1 | Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice显示文摘In clinic,perioperative neurocognitive disorder is becoming a common complication of surgery in old patients.Neuroinflammation and blood-brain barrier(BBB)disruption are important contributors for cognitive impairment.Atorvastatin,as a strong HMG-CoA reductase inhibitor,has been widely used in clinic.However,it remains unclear whether atorvastatin could prevent anesthesia and surgery-induced BBB disruption and cognitive injury by its anti-inflammatory property.In this study,aged C57BL/6J mice were used to address this question.Initially,the mice were subject to atorvastatin treatment for 7 days(10 mg/kg).After a simple laparotomy under 1.5%isoflurane anesthesia,Morris water maze was performed to assess spatial learning and memory.Western blot analysis,immunohistochemistry,and enzyme-linked immunosorbent assay were used to examine the inflammatory response,BBB integrity,and cell apoptosis.Terminal-deoxynucleotidyl transferase mediated nick end labeling assay was used to assess cell apoptosis.The fluorescein sodium and transmission electron microscopy were used to detect the permeability and structure of BBB.The results showed that anesthesia and surgery significantly injured hippocampal-dependent learning and memory,which was ameliorated by atorvastatin.Atorvastatin could also reverse the surgery-induced increase of systemic and hippocampal cytokines,including IL-1β,TNF-α,and IL-6,accompanied by inhibiting the nuclear factor kappa-B(NF-κB)pathway and Nucleotide-Binding Oligomerization Domain,or Leucine Rich Repeat and Pyrin Domain Containing 3(NLRP3)inflammasome activation,as well as hippocampal neuronal apoptosis.In addition,surgery triggered an increase of BBB permeability,paralleled by a decrease of the ZO-1,occludin,and Claudin 5 proteins in the hippocampus.However,atorvastatin treatment could protect the BBB integrity from the impact of surgery,by up-regulating the expressions of ZO-1,occludin,and Claudin 5.These findings suggest that atorvastatin exhibits neuroprotective effects on cognition in aged mice undergoing surgery. | Pengfei Liu Quansheng Gao Lei Guan Yanting Hu Jingwen Jiang Teng Gao Weixuan Sheng Xinying Xue Hui Qiao Tianzuo Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 6 |
| 2 | Research progress in protein post-translational modification显示文摘Protein post-translational modification plays an important role in organism. It makes the protein obtain more complicated structures, perfect functions, more accurate regulations and more spe-cific operations. The most common protein post- translational modifications include ubiquitylation, phosphorylation, glycosylation, lipodation, methyla-tion, and acetylation and so on. Ubiquitylation plays an essential role in cellular functions such as cellular differentiation, apoptosis, DNA repair, antigen proc-essing, and stress response. Phosphorylation is re-lated to physiological and pathological processes including cellular signal conduction, nervous activity, muscle contraction and proliferation, development and differentiation of cells. Protein glycosylation is of great importance for many cell processes like im-munoprotection, virus replication, cell growth, and occurrence of inflammation and so on. Lipodation is vital to signal conduction. Histone methylation and acetylation are responsible for transcription regula-tion. In vivo, different post-translational modifications do not occur isolatedly, but influence each other’s function and cooperate with each other. Under-standing what influences the post-translational modi-fications will help to uncover cellular processes and protein network in molecular level and finally direct more precise drug design targeting molecules. Post-translational modification mimics are set to dominate the next wave of protein therapeutics and become powerful medicinal tools in the 21st century. | HU Jia GUO Yanting LI Yanme | 2006 | Chinese Science Bulletin2006，51，6： | 4 |
| 3 | A complex structure of arrestin-2 bound to a G protein-coupled receptor显示文摘Arrestins comprise a family of signal regulators of G-protein-coupled receptors(GPCRs),which include arrestins 1 to 4.While arrestins 1 and 4 are visual arrestins dedicated to rhodopsin,arrestins 2 and 3(Arr2 and Arr3)areβ-arrestins known to regulate many nonvisual GPCRs.The dynamic and promiscuous coupling of Arr2 to nonvisual GPCRs has posed technical challenges to tackle the basis of arrestin binding to GPCRs.Here we report the structure of Arr2 in complex with neurotensin receptor 1(NTSR1),which reveals an overall assembly that is strikingly different from the visual arrestin–rhodopsin complex by a 90°rotation of Arr2 relative to the receptor.In this new configuration,intracellular loop 3(ICL3)and transmembrane helix 6(TM6)of the receptor are oriented toward the N-terminal domain of the arrestin,making it possible for GPCRs that lack the C-terminal tail to couple Arr2 through their ICL3.Molecular dynamics simulation and crosslinking data further support the assembly of the Arr2‒NTSR1 complex.Sequence analysis and homology modeling suggest that the Arr2‒NTSR1 complex structure may provide an alternative template for modeling arrestin–GPCR interactions. | Wanchao Yin Zhihai Li Mingliang Jin Yu-Ling Yin Parker Wde Waal Kuntal Pal Yanting Yin Xiang Gao Yuanzheng He Jing Gao Xiaoxi Wang Yan Zhang Hu Zhou Karsten Melcher Yi Jiang Yao Cong X.Edward Zhou Xuekui Yu H.Eric Xu | 2019 | Cell Research2019，29，12： | 4 |
| 4 | MXR7 facilitates liver cancer metastasis via epithelial-mesenchymal transition显示文摘MXR7 is a cell-surface protein and highly expressed in hepatocellular carcinoma(HCC). The aim of this study is to determine the expression profile of MXR7 in HCC and investigate the influence of MXR7 on invasion and metastasis of HCC cells. For this purpose, immunohistochemical assay was used to identify the differential expression of MXR7 in 94 HCC specimens. Expression of MXR7 in 4 pairs of HCC and portal vein tumor thrombus(PVTT) was also tested. The motility of HCC cells were characterized by transwell migration and matrigel invasion assays. In vivo metastasis potential was determined via tail vein injection assay.Moreover, compared with noninvasive HCC tumors or human HCC cell lines with low metastatic potential, invasive HCC samples and HCC cell lines with high metastatic potential exhibited higher MXR7 expression. Furthermore, forced expression of MXR7 in SMMC-7721 promoted cell proliferation, migration and invasion in vitro and accelerated tumor growth and metastasis in vivo. Conversely, knockdown of MXR7 expression in HuH7 cells inhibited proliferation and motility of cells. Mechanically,overexpression of MXR7 promoted epithelial-mesenchymal transition(EMT) progress, and MXR7 depletion repressed the EMT phenotype. In conclusion, MXR7 is a mediator of EMT and metastasis in HCC and may serve as a novel therapeutic target. | guishuai lv yexiong tan hongwei lv tian fang changzheng wang ting li yanting yu congli hu wen wen hongyang wang wen yang | 2017 | Science China(Life Sciences)2017，60，11： | 2 |
| 5 | Soil aggregates and organic carbon affected by the land use change from rice paddy to vegetable field显示文摘 | Hao Wang Dongsheng Guan Renduo Zhang Yujuan Chen Yanting Hu Ling Xiao | 2014 | Ecological Engineering2014，，： | 2 |
| 6 | Hydrologic balance, net primary productivity and water use efficiency of the introduced exotic Eucalyptus grandis × Eucalyptus urophylla plantation in south-western China显示文摘Aims Land cover changes can disrupt water balance and alter the partitioning of precipitation into surface runoff,evapotranspiration and groundwater recharge.The widely planted Eucalyptus trees in south-western China have the potential to bring about hydrologic impacts.Our research aims to elucidate the hydrologic balance characteristics of the introduced exotic Eucalyptus grandis×Eucalyptus urophylla plantation and to assess whether its high productivity results from high water use efficiency(WUE)or large water consumption.Methods A 400-m^(2) experimental plot was established in an E.grandis×E.urophylla plantation in south-western China.Water balance components,including stand transpiration(T_(r)),evapotranspiration(E_(t))and runoff(R)were obtained as follows:T_(r) was estimated based on sap flow measurements,E_(t) was estimated as the average of surface transpiration and evaporation weighted by the fractional green vegetation cover using a modeling approach,and R was collected using the installed metal frame.Net primary productivity(NPP)was obtained from allometric equation and annual diameter at breast height(DBH)increment determination.Important Findings Annual E_(t) and T_(r) were 430±31 and 239±17 mm,respectively.Annual T_(r) accounts for 56±8%of total evapotranspiration on average.WUE(NPP/T_(r))of the E.grandis×E.urophylla was estimated to be 3.3–3.9 mmol·mol^(−1).Based on the comparative analysis of T_(r) and WUE,E.grandis×E.urophylla had a high productivity due to its high WUE without exhibiting prodigal water use.Meteorological factors including vapor pressure deficit and global solar radiation(R_(s))were key factors regulating E_(t) and T_(r) in our research site.Annual surface runoff,E_(t) and canopy interception occupied 7%,27–30%and 16%of total precipitation,while the remaining 46–50%of precipitation was used for sustaining groundwater recharge and altering soil water storage.The higher runoff coefficient(7.1%)indicated the weaker capability of E.grandis×E.urophylla to reserve water resource than natural forests and less disturbed plantations.The planting and protection of understory vegetation may decrease the surface runoff and exert beneficial effects on water conservation capacity of Eucalyptus plantation. | Yanting Hu Ping Zhao Yuqing Huang Liwei Zhu Guangyan Ni Xiuhua Zhao Zhihong Huang | 2019 | Journal of Plant Ecology2019，12，6： | 2 |
| 7 | A multiframe image super-resolution method显示文摘 | Li Xuelong Hu Yanting Gao Xinbo | 2010 | Signal Processing2010，90，2： | 1 |
| 8 | A multi-frame image super-resolution method显示文摘 | Xuelong Li Yanting Hu Xinbo Gao | | 0，，90： | 1 |
| 9 | Association analysis between endothelial function related factors and coronary artery stenosis degree in coronary heart disease patients with type 2 diabetes mellitus显示文摘 | Quanmin Li Zhifang Zhang Ruiqin Du Xiaoqiang Hu Yan Yan Qing Gao Yanting Fan | 2012 | 2012 (7-8)2012，，7： | 1 |
| 10 | Effect of nanocomposite-based packaging on postharvest quality of ethylene-treated kiwifruit ( Actinidia deliciosa ) during cold storage显示文摘 | Qiuhui Hu Yong Fang Yanting Yang Ning Ma Liyan Zhao | 2011 | Food Research International2011，，6： | 1 |
| 11 | Efficient bright γ-ray vortex emission from a laser-illuminated light-fan-in-channel target显示文摘X/γ-rays have many potential applications in laboratory astrophysics and particle physics.Although several methods have been proposed for generating electron,positron,and X/γ-photon beams with angular momentum(AM),the generation of ultra-intense brilliant γ-rays is still challenging.Here,we present an all-optical scheme to generate a high-energy γ-photon beam with large beam angular momentum(BAM),small divergence,and high brilliance.In the first stage,a circularly polarized laser pulse with intensity of 10^(22) W/cm^(2) irradiates a micro-channel target,drags out electrons from the channel wall,and accelerates them to high energies via the longitudinal electric fields.During the process,the laser transfers its spin angular momentum(SAM)to the electrons’orbital angular momentum(OAM).In the second stage,the drive pulse is reflected by the attached fan-foil and a vortex laser pulse is thus formed.In the third stage,the energetic electrons collide head-on with the reflected vortex pulse and transfer their AM to the γ-photons via nonlinear Compton scattering.Three-dimensional particle-in-cell simulations show that the peak brilliance of the γ-ray beam is∼10^(22) photons·s^(-1)·mm^(-2)·mrad^(-2) per 0.1% bandwidth at 1 MeV with a peak instantaneous power of 25 TW and averaged BAM of 10^(6)h/photon.The AM conversion efficiency from laser to the γ-photons is unprecedentedly 0.67%. | Hao Zhang Jie Zhao Yanting Hu Qianni Li Yu Lu Yue Cao Debin Zou Zhengming Sheng Francesco Pegoraro Paul McKenna Fuqiu Shao Tongpu Yu | 2021 | High Power Laser Science and Engineering2021，9，3： | 1 |
| 12 | Distribution of aromatic amines,phenols,chlorobenzenes,and naphthalenes in the surface sediment of the Dianchi Lake,China显示文摘Organic pollutants are widespread environmental pollutants with high toxicity,persistence,and bioaccumulation.Our aim was to investigate the distribution of aromatic amines,phenols,chlorobenzenes,and naphthalenes in the surface sediment of the Dianchi Lake,China.Nineteen surface sediment samples were collected from the Dianchi Lake,and 40 types of organic pollutants were analyzed via gas chromatography-mass spectrometry.The total organic pollutant concentrations in the surface sediment of the Dianchi Lake varied from 27.4 to 1.62×10^3 ng/g.The concentrations of phenols were much higher than those in other water bodies but still within a controllable range,whereas the concentrations of the other organic pollutant classes were similar or even lower.The detection ratio of 3-or 4-methylphenol was the highest(100.00%)among the pollutants.The average total organic pollutant concentrations decreased in the following order:Caohai(540 ng/g)>the middle of Waihai(488 ng/g)>the edge of Waihai(351 ng/g)>Haigeng Dam(90.4 ng/g).Pearson analysis showed a strong correlation among 1-methylnaphthalene,2-methylnaphthalene,1,3-dinitronaphthalene,and 1,4-dinitronaphthalene(P<0.01).Caohai,the north lakeshore of Waihai and the south of Waihai showed higher risk because of high concentration;meanwhile,1,4-dichlorobenzene,3-or 4-methylphenol and 1,2,4-trichlorobenzene were mor e likely to cause risks. | Xinyi Hu Ting Yang Chen Liu Jun Jin Bingli Gao Xuejun Wang Min Qi Baokai Wei Yuyu Zhan Tan Chen Hongtao Wang Yanting Liu Dongrui Bai Zhu Rao Nan Zhan | 2020 | Frontiers of Environmental Science & Engineering2020，14，4： | 1 |
| 13 | Effect of nanocomposite-based packaging on postharvest quality of ethylene-treated kiwifruit ( Actinidia deliciosa ) during cold storage显示文摘 | Qiuhui Hu Yong Fang Yanting Yang Ning Ma Liyan Zhao | 2011 | Food Research International2011，，6： | 1 |
| 14 | A multi-frame image super-resolution method 显示文摘 | Li Xuelong Hu Yanting Gao Xinbo | 2010 | Signal Processing2010，90，2： | 1 |
| 15 | A multi-frame image super-resolution method显示文摘 | Xuelong Li Yanting Hu Xinbo Gao | 2010 | Signal Processing2010，90，2： | 1 |
| 16 | Plant functional trait diversity and structural diversity co-underpin ecosystem multifunctionality in subtropical forests显示文摘Tree species diversity is assumed to be an important component in managing forest ecosystems because of effects on multiple functions or ecosystem multifunctionality.However,the importance of tree diversity in determining multifunctionality in structurally complex subtropical forests relative to other regulators(e.g.,soil microbial diversity,stand structure,and environmental conditions)remains uncertain.In this study,effects of aboveground(species richness and functional and structural diversity)and belowground(bacterial and fungal diversity)biodiversity,functional composition(community-weighted means of species traits),stand structure(diameter at breast height and stand density),and soil factors(pH and bulk density)on multifunctionality(including biomass production,carbon stock,and nutrient cycling)were examined along a tree diversity gradient in subtropical forests.The community-weighted mean of tree maximum height was the best predictor of ecosystem multifunctionality.Functional diversity explained a higher proportion of the variation in multifunctionality than that of species richness and fungal diversity.Stand structure-played an important role in modulating the effects of tree diversity on multifunctionality.The work highlights that species composition and maximizing forest structural complexity are effective strategies to increase forest multifunctionality while also conserving biodiversity in the management of multifunctional forests under global environmental changes. | Shuai Ouyang Mengmeng Gou Pifeng Lei Yue Liu Liang Chen Xiangwen Deng Zhonghui Zhao Yelin Zeng Yanting Hu Changhui Peng Wenhua Xiang | 2023 | Forest Ecosystems2023，10，2： | 0 |
| 17 | Laser chirp controlled relativistic few-cycle mid-infrared pulse generation显示文摘Relativistic few-cycle mid-infrared(mid-IR)pulses are unique tools for strong-field physics and ultrafast science,but are difficult to generate with traditional nonlinear optical methods.Here,we propose a scheme to generate such pulses with high efficiency via plasma-based frequency modulation with a negatively chirped laser pulse(NCLP).The NCLP is rapidly compressed longitudinally due to dispersion and plasma etching,and its central frequency is downshifted via photon deceleration due to the enhanced laser intensity and plasma density modulations.Simulation results show that few-cycle mid-IR pulses with the maximum center wavelength of 7.9µm and pulse intensity of a_(MIR)=2.9 can be generated under a proper chirp parameter.Further,the maximum energy conversion efficiency can approach 5.0%.Such a relativistic mid-IR source is promising for a wide range of applications. | Dongao Li Guobo Zhang Jie Zhao Yanting Hu Yu Lu Hao Zhang Qianni Li Dongze Zhang Rong Sha Fuqiu Shao Zhengming Sheng Tongpu Yu | 2023 | High Power Laser Science and Engineering2023，11，5： | 0 |
| 18 | Sources appointment and health risks of PM_(2.5)-bound trace elements in a coastal city of southeastern China显示文摘To gain a comprehensive understanding of sources and health risks of trace elements in an area of China with high population densities and low PM_(2.5)concentrations,15 trace elements(Al,K,Ca,Ti,V,Cr,Mn,Fe,Ni,Cu,Zn,As,Sn,Ba,Pb)in PM_(2.5)were monitored from December 2020 to November 2021 in a representative city,Xiamen.The concentrations of trace elements in Xiamen displayed an obvious seasonal variation and were dominated by K,Fe,Al,Ca and Zn.Based on Positive Matrix Factorization analysis,source appointment revealed that the major sources of trace elements in Xiamen were traffic,dust,biomass and firework combustion,industrial manufacture and shipping emission.According to health risk assessment combined with the source appointment results,it indicated that the average noncarcinogenic risk was below the threshold and cancer risk of four hazardous metals(Cr,Ni,As,Pb)exceeded the threshold(10^(-6)).Traffic-related source had almost half amount of contribution to the health risk induced by PM_(2.5)-bound trace elements.During the dust transport period or Spring Festival period,the health risks exceeded an acceptable threshold even an order of magnitude higher,suggesting that the serious health risks still existed in low PM_(2.5)environment at certain times.Health risk assessment reminded that the health risk reduction in PM_(2.5)at southeastern China should prioritize traffic-related hazardous trace elements and highlighted the importance of controlling vehicles emissions in the future. | Ziyi Lin Xiaolong Fan Gaojie Chen Youwei Hong Mengren Li Lingling Xu Baoye Hu Chen Yang Yanting Chen Zhiqian Shao Jinsheng Chen | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 19 | Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3显示文摘The TEA domain(TEAD)family proteins(TEAD1-4)are essential transcription factors that control cell differentiation and organ size in the Hippo pathway.Although the sequences and structures of TEAD family proteins are highly conserved,each TEAD isoform has unique physiological and pathological functions.Therefore,the development and discovery of subtype selective inhibitors for TEAD protein will provide important chemical probes for the TEAD-related function studies in development and diseases.Here,we identified a novel TEAD 1/3 covalent inhibitor(DC-TEADin1072)with biochemical IC50 values of 0.61±0.02 and 0.58±0.12μmol/L against TEAD1 and TEAD3,respectively.Further chemical optimization based on DC-TEAD in 1072 yielded a selective TEAD3 inhibitor DCTEAD3 in03 with the IC_(50) value of 0.16±0.03μmol/L,which shows 100-fold selectivity over other TEAD isoforms in activity-based protein profiling(ABPP)assays.In cells,DC-TEAD3 in03 showed selective inhibitory effect on TEAD3 in GAL4-TEAD(1-4)reporter assays with the IC50 value of1.15μmol/L.When administered to zebrafish juveniles,experiments showed that DC-TEAD3 in03 reduced the growth rate of zebrafish caudal fins,indicating the importance of TEAD3 activity in controlling proportional growth of vertebrate appendages. | Tian Lu Yong Li Wenchao Lu TWGM Spitters Xueyu Fang Jun Wang Simian Cai Jing Gao Yanting Zhou Zhe Duan Huan Xiong Liping Liu Qi Li Hualiang Jiang Kaixian Chen Hu Zhou Hua Lin Huijin Feng Bing Zhou Christopher L.Antos Cheng Luo | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 0 |
| 20 | Water transport of native and exotic tree species in relation to xylem anatomical characteristics in low subtropical China显示文摘Aims Exotic fast-growing tree species have been commonly planted as pioneer species to facilitate ecological restoration in South China.Their growth and resource utilization behavior related to intrinsic physiology and structural properties have profound influences on forest ecosystem.However,the contrastive research focusing on water utilization features along with xylem anatomical properties between native and exotic species is scarce in South China.The objective of this study is to investigate the sapwood anatomical characteristics and water utilization conditions of native and exotic fast-growing species,and to elucidate the relationship between sap-flux density and conduit features.Methods We measured sap-flux density,conduit length,diameter and density of four native species(Schima superba,Michelia mac-clurei,Castanopsis hystrix and Castanopsis fissa)and four exotic species(Eucalyptus citriodora,Eucalyptus urophylla×grandis,Acacia auriculaeformis and Acacia mangium).Sap flux density was measured based on the Granier’s thermal dissipation probe method.The whole-tree water transport was quantified by mul-tiplying sap-flux density by sapwood area.The measurements of conduit characteristics were conducted by using segregation and slice method.Important Findings Sapwood area increased with the growing diameter at breast height(DBH)as a power function.Native species had a larger water-conducting tissue area than exotic species at the same DBH value when trees grew to a size with a certain value of DBH.The con-duit diameter of exotic species was significantly larger than that of native species.Conversely,native species,such as S.superba and M.macclurei,had longer conduit length and higher conduit den-sity than other tree species.Based on a physiological interpretation of the measured conduit characteristics,native tree species devel-oped a safe water transport system while exotic fast-growing tree species come into being an efficient system instead.Water trans-port increased with the growing DBH as a power function,and the exponent for native species(1.60)was higher than that for exotic species(1.22).Under the combined impact of sap-flux density and sapwood area,native species presented a larger water transport at a larger DBH value,indicating that growth advantage of exotic fast-growing species might weaken as DBH increased. | Yanting Hu Jianguo Gao Ping Zhao Weijun Shen Peiqiang Zhao Liwei Zhu Guangyan Ni Junfeng Niu Lei Ouyang | 2018 | Journal of Plant Ecology2018，11，3： | 0 |
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