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| 1 | Synthesis and Biological Activity of Novel Furan/Thiophene and Piperazine-Containing (Bis)1,2,4-triazole Mannich Bases显示文摘Mannich 基于的新奇 furan/thiophene 和包含 piperazine 1,2,4-triazole Mannich 底和二度(1,2,4-triazole ) 的系列方便地作为中介与 triazole Schiff 底,各种各样的 piperazine 衍生物,和甲醛经由 Mannich 反应被综合了在好收益。他们的结构被融化点描绘, 1 H NMR, 13 C NMR,红外和元素的分析。初步的生物鉴定证明在 vitro 并且在对几测试的 vivo 杀菌剂活动重要的展出的大多数混合物种真菌。在 32 新混合物之中,包含 trifluoromethyl 混合物比包含甲基的显示出优异活动。几混合物例如 F8, F9, F10, G5, H7, H8, I3 和 I4,在现在的学习期间与对不同真菌的一些商业杀真菌剂是可比较的,进一步的在结构上能被优化。同时,几混合物在 100 µg/mL 和 KARI 对 Brassica campestris 显示出好 herbicidal 活动在 200 µg/mL 的禁止的活动。然而,混合物在初步的研究在 200 µg/mL 对东方粟蚕展出了差的杀虫的活动。研究结果将为新农业化肥的设计和发现向有用信息提供新奇杂环的结构。 | Baolei Wang Yanxia Shi Yizhou Zhan Liyuan Zhang Yan Zhang Lizhong Wang Xiao Zhang Yonghong Li Zhengming Li Baoju Li | 2015 | Chinese Journal of Chemistry2015，33，10： | 2 |
| 2 | GROWTH OF DIAMOND-LIKE FILMS BY DC PLASMA CHEMICAL VAPOR DEPOSITION显示文摘Diamond-like films have been deposited by dc plasma chemical vapor deposition(CVD).During deposition,the characteristics of the plasma have been measured by means of the Langmuir single probe.The structure of the deposits has been studied by X-ray diffraction,Raman spectroscopy and Fourier transform infrared spectroscopy. | ZHAN Rujuan GAO Kelin ZOU Zuping WANG Yanxia LIU Jiezhou XIANG Zhilin LIU Hongtu WU Zhiqiang YE Jian ZHOU Guien WANG Changsui | 1990 | Chinese Physics Letters1990，7，10： | 1 |
| 3 | MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages显示文摘Primary immune thrombocytopenia(ITP)is an autoimmune hemorrhagic disorder in which macrophages play a critical role.Mammalian sterile-20-like kinase 4(MST4),a member of the germinal-center kinase STE20 family,has been demonstrated to be a regulator of inflammation.Whether MST4 participates in the macrophage-dependent inflammation of ITP remains elusive.The expression and function of MST4 in macrophages of ITP patients and THP-1 cells,and of a macrophage-specific Mst4−/−(Mst4ΔM/ΔM)ITP mouse model were determined.Macrophage phagocytic assays,RNA sequencing(RNA-seq)analysis,immunofluorescence analysis,coimmunoprecipitation(co-IP),mass spectrometry(MS),bioinformatics analysis,and phosphoproteomics analysis were performed to reveal the underlying mechanisms.The expression levels of the MST4 gene were elevated in the expanded M1-like macrophages of ITP patients,and this elevated expression of MST4 was restored to basal levels in patients with remission after high-dose dexamethasone treatment.The expression of the MST4 gene was significantly elevated in THP-1-derived M1 macrophages.Silencing of MST4 decreased the expression of M1 macrophage markers and cytokines,and impaired phagocytosis,which could be increased by overexpression of MST4.In a passive ITP mouse model,macrophage-specific depletion of Mst4 reduced the numbers of M1 macrophages in the spleen and peritoneal lavage fluid,attenuated the expression of M1 cytokines,and promoted the predominance of FcγRIIb in splenic macrophages,which resulted in amelioration of thrombocytopenia.Downregulation of MST4 directly inhibited STAT1 phosphorylation,which is essential for M1 polarization of macrophages.Our study elucidates a critical role for MST4 kinase in the pathology of ITP and identifies MST4 kinase as a potential therapeutic target for refractory ITP. | Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 4 | Author Correction:MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages显示文摘In this article,the details for Affiliation 1 were incorrectly given as‘Department of Hematology,Fudan University,Shanghai 200032,China’but should have been‘Department of Hematology,Zhongshan Hospital,Fudan University,Shanghai 200032,China’;the details for Affiliation 3 were incorrectly given as‘Department of Transfusion Medicine,Fudan University,Shanghai 200032,China’but should have been‘Department of Transfusion Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China’;the details for Affiliation 4 were incorrectly given as‘Department of Laboratory Medicine,Fudan University,Shanghai 200032,China’but should have been‘Department of Laboratory Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China’.The original article has been corrected. | Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 5 | New insights into the correlations between circulating tumor cells and target organ metastasis显示文摘Organ-specific metastasis is the primary cause of cancer patient death.The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their microenvironment.During an intermediate stage of metastasis,circulating tumor cells(CTCs)are released into the bloodstream from primary and metastatic tumors.CTCs harboring aggressive or metastatic features can extravasate to remote sites for continuous colonizing growth,leading to further lesions.In the past decade,numerous studies demonstrated that CTCs exhibited huge clinical value including predicting distant metastasis,assessing prognosis and monitoring treatment response et al.Furthermore,increasingly numerous experiments are dedicated to identifying the key molecules on or inside CTCs and exploring how they mediate CTC-related organ-specific metastasis.Based on the above molecules,more and more inhibitors are being developed to target CTCs and being utilized to completely clean CTCs,which should provide promising prospects to administer advanced tumor.Recently,the application of various nanomaterials and microfluidic technologies in CTCs enrichment technology has assisted to improve our deep insights into the phenotypic characteristics and biological functions of CTCs as a potential therapy target,which may pave the way for us to make practical clinical strategies.In the present review,we mainly focus on the role of CTCs being involved in targeted organ metastasis,especially the latest molecular mechanism research and clinical intervention strategies related to CTCs. | Qinru Zhan Bixia Liu Xiaohua Situ Yuting Luo Tongze Fu Yanxia Wang Zhongpeng Xie Lijuan Ren Ying Zhu Weiling He Zunfu Ke | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
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