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251篇 您的检索式：作者名="Yarbrough"

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	题名	作者	年代	出处	被引量
1	Targeted Antimicrobial Therapy Against Streptococcus mutans Establishes Protective Non-cariogenic Oral Biofilms and Reduces Subsequent Infection显示文摘Aim Dental biofilms are complex communities composed largely of harmless bacteria. Certain pathogenic species including Streptococcus mutans (S. mutans) can become predominant when host factors such as dietary sucrose intake imbalance the biofilm ecology. Current approaches to control S. mutans infection are not pathogen-specific and eliminate the entire oral community along with any protective benefits provided. Here, we tested the hypothesis that removal of S. mutans from the oral community through targeted antimicrobial therapy achieves protection against subsequent S. mutans colonization. Methodology Controlled amounts of S. mutans were mixed with S. mutans-free saliva, grown into biofilms and visualized by antibody staining and cfu quantization. Two specifically-targeted antimicrobial peptides (STAMPs) against S. mutans were tested for their ability to reduce S. mutans biofilm incorporation upon treatment of the inocula. The resulting biofilms were also evaluated for their ability to resist subsequent exogenous S. mutans colonization. Results S. mutans colonization was considerably reduced (9 ± 0.4 fold reduction, P=0.01) when the surface was preoccupied with saliva-derived biofilms. Furthermore, treatment with S. mutans-specific STAMPs yielded S. mutans-deficient biofilms with significant protection against further S. mutans colonization (5 minutes treatment: 38 ± 13 fold reduction P=0.01; 16 hours treatment: 96 ± 28 fold reduction P=0.07). Conclusion S. mutans infection is reduced by the pre- sence of existing biofilms. Thus maintaining a healthy or 'normal' biofilm through targeted antimicrobial therapy (such as the STAMPs) could represent an effective strategy for the treatment and prevention of S. mutans colonization in the oral cavity and caries progression.	Li-na Li Li-hong Guo Renate Lux Randal Eckert Daniel Yarbrough Jian He Maxwell Anderson Wen-yuan Shi	2010	International Journal of Oral Science2010，2，2：	5
2	The ARF-p16 gene locus in carcinogenesis and therapy of head and neck squamous cell carcinoma 显示文摘	Yarbrough WG	2002	Laryngoscope2002，112，12：	1
3	Test chip based approach to automated diagnosis of CMOS yield problems显示文摘	Lukaszek W Grambow K G Yarbrough W J	1990	IEEE Transactions on Semiconductor Manufac- turing1990，3，1：	1
4	Thyrotropin-releasing hormone can relieve cancer-related fatigue:hypothesis and preliminary observations显示文摘	Kamath J Yarbrough GG Prange AJ		0，，04：	1
5	ARF promotes MDM2 degradation and stabilizes p53:ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways 显示文摘	Zhang Y Xiong Y Yarbrough W G	1998	Cell1998，92，6：	1
6	Complexity, organization, and stuart kauffman' s the origins of order显示文摘	Westhoff F H Yarbrough B V Yarbrough R M	1996	Journal of Economic Behavior and Organization1996，29，1：	1
7	毫米波系统主动/被动末制导仿真技术显示文摘	Larry Keese Dong Drake Dwight Mcpherson Howard yarbrough 宋航	1986	航空兵器1986，，06：	1
8	Large animal models of congestive heart failure: a critical step in translating basic observations into clinical applications显示文摘	Yarbrough WM Spinale FG	2003	J Nucl Cardiol2003，10，1：	1
9	ARF promotes MDM2 degradation and stabilizes P53:ARF-INK-4a locus deletion impairs both the Rb and P53 tumor suppression pathways显示文摘	Zhang Y Xiong Y Yarbrough WG	1998	Cell1998，92，6：	1
10	Adding selectivity to antimicrobial peptides:rational design of a multidomain peptide against Pseudomonas spp显示文摘	Eckert R Qi F Yarbrough D K		0，，04：	1
11	Marketing's role in the development of competitive advantage:evidence from the motor carrier industry显示文摘	YARBROUGH L	1998	Journal of Market Focused Management1998，2，4：	1
12	Treatmcnt of SCID/human B cell precursor ALL with anti CD19 and anti-CD22 immunotoxins 显示文摘	HERRERA L YARBROUGH S GHETIE V	2003	Leukemia2003，17，33：	1
13	Human tumor suppressor ARF impedes S-phase progression independent of p53显示文摘	Yarbrough WG Bessho M Zanation A	2002	CancerRes2002，62，：	1
14	Hangman's fracture resulting from improper seat belt use显示文摘	Yarbrough BE Hendey GW	1990	South Med J1990，83，7：	1
15	Hangman's fracture resulting from improper seat belt use显示文摘	Yarbrough BE Hendey GW	1990	South Med J1990，83，7：	1
16	Cardiac-restricted overexpression or deletion of tissue in- hibitor of matrix metalloproteinase-4 : differential effects on left ventricular structure and function following pressure o- verload-induced hypertrophy 显示文摘	YARBROUGH W M BAICU C MUKHERJEE R	2014	Am J Physiol Heart Circ Physio12014，307，5：	1
17	Large animal models of congestive heart failure: A critical step in translating basic observations into clinical applications 显示文摘	Yarbrough WM Spinale FG	2003	J Nucl Cardiol2003，10，1：	1
18	Determination ofcarboplatin in canine plasma by high-performance liquidchromatography显示文摘	Villarino N Cox S Yarbrough J	2010	Biomed Chromatogr2010，24，8：	1
19	The treatment of compressed air illness using oxygen显示文摘	Yarbrough OD Behnke AR	1939	J Indust Hygrograph Toxicol1939，21，：	1
20	Professional values held by baccalaureate and associate degree nursing students 显示文摘	Matin P Yarbrough S Alfred D	2003	J Nurs Scholarsh2003，35，3：	1

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