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| 1 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 2 | 显示文摘 | Linsebigler A Lu G Yates J T | 1995 | Chem Rev1995，95，： | 2 |
| 3 | Nutrient require- ment and cycling in energy crops 显示文摘 | Christian D G Riche A B Yates N E | 1997 | Sustainable Agri- culture for Food Energy and Industry1997，2，： | 1 |
| 4 | Canine distemper epizootic in lions,tigers,and leopards in North America显示文摘 | APPEL M J YATES R A FOLEY G L | 1994 | J Vet Diagn Invest1994，6，3： | 1 |
| 5 | Photocatalysis on TiO2 Surfaces: Principles, Mechanisms, and Selected Results 显示文摘 | Linsebigler A L Lu G Yates J T | 1995 | Chemical Reviews1995，95，3： | 1 |
| 6 | Photocatalysis on TiO2 surface: principles, mechanisms and selected results 显示文摘 | Linsebiger A L Lu G Q Yates J T | 1995 | Chem Rev1995，95，： | 1 |
| 7 | Photocatalysis on TiO2 surface:principles,mechanisms and selected results显示文摘 | Linsebigler A L Lu G Q Yates J T | 1995 | Chem Rev1995，95，3： | 1 |
| 8 | Photocatalysis on TiO2Surfaces:Principles,Mechanisms,and Selected Results显示文摘 | LINSEBIGLER A L LU G Q YATES J T | 1995 | Chemical Reviews1995，95，3： | 1 |
| 9 | Bistatic SAR image formation显示文摘 | Yates G Home A M Blake A P | 2006 | IET Radar Sonar and Navigation2006，153，3： | 1 |
| 10 | photo-catalysis on TiO2 surfaces: principles, mechanisms, and selected results 显示文摘 | Linsebigler A L Lu G Q Yates JT | 1995 | Chemical Review1995，25，： | 1 |
| 11 | Photocatalysis on TiO2 surfaces: Principles, mechanism, and selected results 显示文摘 | Linsebigler A L Lu G Yate J T | 1995 | Chem Rev1995，95，3： | 1 |
| 12 | Photocatalysis on TiO2 Surface:Principles,Mechanisms and Selected Results显示文摘 | Linsebigler A L Lu G Q Yates J T | 1995 | ChemRev1995，95，3： | 1 |
| 13 | Photocatalysis on TiO2 surfaces:principles,Mechanisms,and selected results显示文摘 | Linsebigler A L Lu G Yates J T | 1995 | Chemical Reviews1995，，95： | 1 |
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| 15 | Photocatalysis onTiO2 surfaces rinciples mechanisms and selected results 显示文摘 | Linsebigler A L Lu G Q Yates J T | 1995 | Chemical Reviews1995，95，3： | 1 |
| 16 | Photocatalysis on TiO2 surface: principles,mechanisms,and selected results显示文摘 | LINSEBIGLER A L LU G YATES J T | 1995 | Chem Rev1995，95，： | 1 |
| 17 | Photocatalysis on TiO2 surfaces: Principles, Mechanisms, and Selected Results 显示文摘 | Linsebigler A L Lu G Q Yates J T | 1995 | Chemical Reviews1995，95，73： | 1 |
| 18 | Bistatic SAR image formation显示文摘 | Yates G Home A M Plake A P | 2006 | IEE Proceedings of Radar Sonar Navigation2006，153，3： | 1 |
| 19 | Photocatalysis on TiO2 surfaces:principles,mechanisms,and selected results显示文摘 | Linsebigler A L Lu G Q Yates J T | 1995 | Chemical Reviews1995，95，3： | 1 |
| 20 | Growth, yield and mineral content of MiscanthusX Giganteus grown as a biofuel for 14 successive harvests显示文摘 | Christian D G Riche A B Yates N E | 2008 | Industrial Crops and Products2008，28，： | 1 |
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