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| 1 | Multiple characteristic structure fragments scans coupled to high-resolution mass spectrometry strategy for discovering unknown structural analogs of mycotoxins in food显示文摘The cereals and their products,which have been easily infected by fungi and contaminated with mycotoxins,are serious threat to both human and animals alike.And yet,detection of these unknown fungal infection and mycotoxins contaminates remains a great challenge.In this work,a holistic approach based on multiple characteristic structure fragments scans and high-resolution mass spectrometry(HRMS)was proposed for discovering unknown structural analogues of mycotoxins.The structural similarity of the same class of compounds provides a direction for the discovery and identification of unknown structural analogues of mycotoxins.The following steps were carried out:the fragmentation pathways of four types of mycotoxins were elucidated through comprehensive fragment analysis.By the combination of fragmentation pathways,the multiple characteristic structure fragments were screened out,with the common fragments were obtained by Veen diagram.Finally multiple characteristic structure fragments scans were carried out to find the unknown structural analogues of mycotoxins.The approach,first proposed by us,was proved to be effective in discovering and identifying 5 structural analogues of mycotoxins in real samples.It was proved to be a simple,fast and accurate method for early detection of fungal infection and mycotoxin contaminants,even for trace amounts of chemicals in complex matrix,and is of great significance to prevent hazardous substances infection from the food supply chains worldwide. | Dongwei Cui Xiuli Xu Xiujuan Wang Feng Zhang Fengming Chen Tong Liu Han Wang Yuan Zhang Yaxuan Song Xuesong Feng | 2022 | Journal of Future Foods2022，2，2： | 0 |
| 2 | Analysis on the Observation Data of Three Profiles across the Qilian Mountain-Haiyuan Fault Zone显示文摘由分析 GPS,铺平并且从 Minle, Huazangsi 和 Shagouhe 的严肃观察数据在 2005 期间介绍 Qilian Mountain-Haiyuan 差错到对面 - 2009,这些数据的变化和在不同时间的主要差错的活动特征被获得。Changma-Erbo, Maomaoshan, Zhunglanghe 和 Haiyuan 指责的结果表演在最近的年里是活跃的。在垂直排水量和活动严肃数据之间的关系被分析,并且结果表明严肃变化主要由于集体转移。水平运动速度的方向几乎沿着差错的 GPS 观察表演的结果在 2006 罢工 - 2007 当水平速度在 2007 从差错方向背离了时 - 2008,由增加的东方排水量描绘了。在连续观察的 N 和 E 坐标值的时间系列上的线性趋势的移动之上的进一步的分析在三侧面附近中国的外壳的运动观察网络驻扎表明 Wenchuan 地震在 2007 在观察上有效果 - 2008。在 2008 比较重力的变化 - 2009 与 Bouguer 严肃异例背景,我们发现 Minle 侧面附近的区域在调整和恢复的阶段,当异例完全没在 Huazangsi 和 Shagouhe 侧面附近被恢复时。 | Hu Yaxuan Wang Xiong Cui Duxin Zhu Yiqing | 2011 | Earthquake Research in China2011，25，4： | 0 |
| 3 | 前额叶皮质中兴奋性神经元集合编码短期记忆显示文摘文章简介短期记忆(STM)对于动物在一小段时间内保存信息来说至关重要。已经知道,持续性或复发性的神经活动和神经振荡在细胞水平上编码STM。然而,微回路级的编码机制仍然是一个谜。在本文中,我们对行为小鼠进行了双光子成像以监测神经元微回路的活动。 | Yonglu Tian Chaojuan Yang Yaxuan Cui Feng Su Yongjie Wang Yangzhen Wang Peijiang Yuan Shujiang Shang Hao Li Jizong Zhao Desheng Zhu Shiming Tang Peng Cao Yunbo Liu Xunli Wang Liecheng Wang Wenbo Zeng Haifei Jiang Fei Zhao Minhua Luo Wei Xiong 仇子龙 李相尧 张晨 | 2019 | 科学新闻2019，0，2： | 0 |
| 4 | Restoration of FMRP expression in adult V1 neurons rescues visual deficits in a mouse model of fragile X syndrome显示文摘Many people affected by fragile X syndrome(FXS)and autism spectrum disorders have sensory processing deficits,such as hypersensitivity to auditory,tactile,and visual stimuli.Like FXS in humans,loss of Fmr1 in rodents also cause sensory,behavioral,and cognitive deficits.However,the neural mechanisms underlying sensory impairment,especially vision impairment,remain unclear.It remains elusive whether the visual processing deficits originate from corrupted inputs,impaired perception in the primary sensory cortex,or altered integration in the higher cortex,and there is no effective treatment.In this study,we used a genetic knockout mouse model(Fmr1^(KO)),in vivo imaging,and behavioral measurements to show that the loss of Fmr1 impaired signal processing in the primary visual cortex(V1).Specifically,Fmr1^(KO) mice showed enhanced responses to low-intensity stimuli but normal responses to high-intensity stimuli.This abnormality was accompanied by enhancements in local network connectivity in V1 microcircuits and increased dendritic complexity of V1 neurons.These effects were ameliorated by the acute application of GABAA receptor activators,which enhanced the activity of inhibitory neurons,or by reintroducing Fmr1 gene expression in knockout V1 neurons in both juvenile and young-adult mice.Overall,V1 plays an important role in the visual abnormalities of Fmr1^(KO) mice and it could be possible to rescue the sensory disturbances in developed FXS and autism patients. | Chaojuan Yang Yonglu Tian Feng Su Yangzhen Wang Mengna Liu Hongyi Wang Yaxuan Cui Peijiang Yuan Xiangning Li Anan Li Hui Gong Qingming Luo Desheng Zhu Peng Cao Yunbo Liu Xunli Wang Min-hua Luo Fuqiang Xu Wei Xiong Liecheng Wang Xiang-yao Li Chen Zhang | 2022 | Protein & Cell2022，13，3： | 0 |
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