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| 1 | Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunotherapy显示文摘Genomic instability remains an enabling feature of cancer and promotes malignant transformation.Alterations of DNA damage response(DDR)pathways allow genomic instability,generate neoantigens,upregulate the expression of programmed death ligand 1(PD-L1)and interact with signaling such as cyclic GMPe AMP synthase-stimulator of interferon genes(cGASe STING)signaling.Here,we review the basic knowledge of DDR pathways,mechanisms of genomic instability induced by DDR alterations,impacts of DDR alterations on immune system,and the potential applications of DDR alterations as biomarkers and therapeutic targets in cancer immunotherapy. | Minlin Jiang Keyi Jia Lei Wang Wei Li Bin Chen Yu Liu Hao Wang Sha Zhao Yayi He Caicun Zhou | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 12 |
| 2 | Effect of anaerobic reaction time on denitrifying phosphorus removal and N 2 O production显示文摘 | Yayi Wang Junjun Geng Zhongjia Ren Weitao He Meiyan Xing Min Wu Shaowei Chen | 2011 | Bioresource Technology2011，，10： | 1 |
| 3 | The Thr241Met polymorphism in the XRCC3 gene is associated with increased risk of cancer in Chinese mainland populations显示文摘 | Liang Du Tianyuan Xiong Qing He Yayi Wang Jiani Shen Yuanling Peng Qingyi Jia Jiqiao Yang Yonggang Zhang Jin Huang | | Tumor Biology0，，2： | 1 |
| 4 | Advanced Process and Electron Device Technology显示文摘This article reviews advanced process and electron device technology of integrated circuits,including recent featuring progress and potential solutions for future development.In 5 years,for pushing the performance of fin field-effect transistors(FinFET)to its limitations,several processes and device boosters are provided.Then,the three-dimensional(3 D)integration schemes with alternative materials and device architectures will pave paths for future technology evolution.Finally,it could be concluded that Moore’s law will undoubtedly continue in the next 15 years. | Dan Zhang Xiaojing Su Hao Chang Hao Xu Xiaolei Wang Xiaobin He Junjie Li Fei Zhao Qide Yao Yanna Luo Xueli Ma Hong Yang Yongliang Li Zhenhua Wu Yajuan Su Tao Yang Yayi Wei Anyan Du Huilong Zhu Junfeng Li Huaxiang Yin Jun Luo Tianchun Ye Wenwu Wang | 2022 | Tsinghua Science and Technology2022，27，3： | 1 |
| 5 | Cryptosporidiosis threat under climate change in China:prediction and validation of habitat suitability and outbreak risk for human-derived Cryptosporidium based on ecological niche models显示文摘Background Cryptosporidiosis is a zoonotic intestinal infectious disease caused by Cryptosporidium spp.,and its transmission is highly influenced by climate factors.In the present study,the potential spatial distribution of Cryptosporidium in China was predicted based on ecological niche models for cryptosporidiosis epidemic risk warning and prevention and control.Methods The applicability of existing Cryptosporidium presence points in ENM analysis was investigated based on data from monitoring sites in 2011–2019.Cryptosporidium occurrence data for China and neighboring countries were extracted and used to construct the ENMs,namely Maxent,Bioclim,Domain,and Garp.Models were evaluated based on Receiver Operating Characteristic curve,Kappa,and True Skill Statistic coefficients.The best model was constructed using Cryptosporidium data and climate variables during 1986‒2010,and used to analyze the effects of climate factors on Cryptosporidium distribution.The climate variables for the period 2011‒2100 were projected to the simulation results to predict the ecological adaptability and potential distribution of Cryptosporidium in future in China.Results The Maxent model(AUC=0.95,maximum Kappa=0.91,maximum TSS=1.00)fit better than the other three models and was thus considered the best ENM for predicting Cryptosporidium habitat suitability.The major suitable habitats for human-derived Cryptosporidium in China were located in some high-population density areas,especially in the middle and lower reaches of the Yangtze River,the lower reaches of the Yellow River,and the Huai and the Pearl River Basins(cloglog value of habitat suitability>0.9).Under future climate change,non-suitable habitats for Cryptosporidium will shrink,while highly suitable habitats will expand significantly(χ^(2)=76.641,P<0.01;χ^(2)=86.836,P<0.01),and the main changes will likely be concentrated in the northeastern,southwestern,and northwestern regions.Conclusions The Maxent model is applicable in prediction of Cryptosporidium habitat suitability and can achieve excellent simulation results.These results suggest a current high risk of transmission and significant pressure for cryptosporidiosis prevention and control in China.Against a future climate change background,Cryptosporidium may gain more suitable habitats within China.Constructing a national surveillance network could facilitate further elucidation of the epidemiological trends and transmission patterns of cryptosporidiosis,and mitigate the associated epidemic and outbreak risks. | Xu Wang Yanyan Jiang Weiping Wu Xiaozhou He Zhenghuan Wang Yayi Guan Ning Xu Qilu Chen Yujuan Shen Jianping Cao | 2023 | Infectious Diseases of Poverty2023，12，2： | 0 |
| 6 | Pyroptosis:A promising target for lung cancer therapy显示文摘Pyroptosis is a type of programed cell death that differs from apoptosis,ferroptosis,or necrosis.Numerous studies have reported that it plays a critical role in tumorigenesis and modification of the tumor microenvironment in multiple tumors.In this review,we briefly describe the canonical,non-canonical,and alternative mechanisms of pyroptotic cell death.We also summarize the potential roles of pyroptosis in oncogenesis,tumor development,and lung cancer treatment,including chemotherapy,radiotherapy,targeted therapy,and immunotherapy.Pyrop-tosis has double-edged effects on the modulation of the tumor environment and lung cancer treatment.Further exploration of pyroptosis-based drugs could provide novel therapeutic strategies for lung cancer. | Wensheng Zhou Lishu Zhao Hao Wang Xinyue Liu Yujin Liu Kandi Xu Hui Yu Kenichi Suda Yayi He | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，2： | 0 |
| 7 | Changing profile of lung cancer clinical characteristics in China:Over 8-year population-based study显示文摘Background:Although examinations and therapies for bronchial lung cancer,also called lung cancer(LC),have become more effective and precise,the morbidity and mortality of LC remain high worldwide.Describing the changing profile of LC characteristics over time is indispensable.This study aimed to understand the changes in real-world settings of LC and its characteristics in China.Methods:In this study,119,785 patients were enrolled from 2012 to 2020 in the Shanghai Pulmonary Hospital.The patients’medical records were extracted from the hospital’s database.Demographic characteristics,general clinicopathological information,and blood coagulation indices at the initial diagnoses were analyzed using the Kruskal-Wallis,Nemenyi,chi-squared,and Bonferroni tests.Changes in demographic characteristics during the 8-year study period,namely dynamic changes among different stages and different pathological types,were evaluated.Results:The percentages of female(from 38.50%[323/839]in 2012 to 48.29%[5112/10,585]in 2020)and non-smoking LC(from 69.34%[475/685]to 80.48%[8055/10,009])patients increased significantly during the study period,with a trend toward a younger age at diagnosis(from 3.58%[30/839]to 8.99%[952/10,585]).Over the study period,the proportion and absolute number of lung adenocarcinoma cases increased(from 67.97%[433/637]to 76.31%[6606/8657])while the proportion of lung squamous cell carcinoma decreased(from 21.19%[135/637]to 12.08%[1046/8657]).Comprehensive driver gene mutation examination became more common,and epidermal growth factor receptor(EGFR)mutation occurred more frequently in female vs.male(62.03%[12793/20625]vs.29.90%[8207/27,447])and non-smoking vs.smoking(53.54%[17,203/32,134]vs.23.73%[3322/13,997])patients(both P<0.001).The distribution of the common driver genes differed among different stages of LC.EGFR mutation was detected most frequently at each stage,and other driver gene alterations were more common in advanced stages(P<0.001).The combination of chemotherapy,targeted ther-apy,and immunotherapy,as a comprehensive management regimen,gradually became predominant over the study period(P<0.001).A hypercoagulable state was shown in advanced-stage LC patients and patients with the anaplastic lymphoma kinase fusion,indicated by significantly elevated levels of d-dimer,fibrinogen,and fibrinogen degradation products.Conclusions:This study comprehensively depicted the changing characteristics of Chinese LC patients over an 8-year period to provide preliminary insights into LC treatment.Trial registration:ClinicalTrials.gov,NCT05423236. | Kandi Xu Hao Wang Simin Li Lishu Zhao Xinyue Liu Yujin Liu Li Ye Xiaogang Liu Linfeng Li Yayi He | 2023 | Chinese Medical Journal Pulmonary and Critical Care Medicine2023，1，3： | 0 |
| 8 | A Knowledge Survey on Health Education of Echinococcosis Among Students — Ganzi Tibetan Autonomous Prefecture, Sichuan Province, China, 2020显示文摘Summary What is already known about this topic?Previous surveys have mainly focused on how well residents and primary school students have understood the core knowledge of echinococcosis control and are limited in terms of the comprehensiveness of the knowledge category and respondents.What is added by this report?There were some shortcomings in related knowledge of echinococcosis among students,which showed a tendency to know methods but not the rationale.The differences among regions indicated a lack of a unified system for training educators and allocating comprehensive educational material.What are the implications for public health practices?The results of this study provide evidence to potentially help improve health education programs in the new phase of echinococcosis prevention and control in China. | Xu Wang Meihua Fu Qian Wang Wei Li Zeli Danba Shuai Han Xiaozhou He Jianfeng Ba Chumu Luorong Quzhen Jiangyang Yixi Luorong Dali Chunyang Li Dandan Shi Yayi Guan Weiping Wu Ning Xiao | 2022 | China CDC weekly2022，4，8： | 0 |
| 9 | Prediction of Driver Gene Matching in Lung Cancer NOG/PDX Models Based on Artificial Intelligence显示文摘Patient-derived tumor xenografts(PDXs)are a powerful tool for drug discovery and screening in cancer.However,current studies have led to little understanding of genotype mismatches in PDXs,leading to massive economic losses.Here,we established PDX models from 53 lung cancer patients with a genotype matching rate of 79.2%(42/53).Furthermore,17 clinicopathological features were examined and input in stepwise logistic regression(LR)models based on the lowest Akaike information criterion(AIC),least absolute shrinkage and selection operator(LASSO)-LR,support vector machine(SVM)recursive feature elimination(SVM-RFE),extreme gradient boosting(XGBoost),gradient boosting and categorical features(Cat Boost),and the synthetic minority oversampling technique(SMOTE).Finally,the performance of all models was evaluated by the accuracy,area under the receiver operating characteristic curve(AUC),and F1 score in 100 testing groups.Two multivariable LR models revealed that age,number of driver gene mutations,epidermal growth factor receptor(EGFR)gene mutations,type of prior chemotherapy,prior tyrosine kinase inhibitor(TKI)therapy,and the source of the sample were powerful predictors.Moreover,Cat Boost(mean accuracy=0.960;mean AUC=0.939;mean F1 score=0.908)and the eight-feature SVM-RFE(mean accuracy=0.950;mean AUC=0.934;mean F1 score=0.903)showed the best performance among the algorithms.Meanwhile,application of the SMOTE improved the predictive capability of most models,except Cat Boost.Based on the SMOTE,the ensemble classifier of single models achieved the highest accuracy(mean=0.975),AUC(mean=0.949),and F1 score(mean=0.938).In conclusion,we established an optimal predictive model to screen lung cancer patients for non-obese diabetic(NOD)/Shi-scid,interleukin-2 receptor(IL-2R)γ^(null)(NOG)/PDX models and offer a general approach for building predictive models. | Yayi He Haoyue Guo Li Diao Yu Chen Junjie Zhu Hiran C.Fernando Diego Gonzalez Rivas Hui Qi Chunlei Dai Xuzhen Tang Jun Zhu Jiawei Dai Kan He Dan Chan Yang Yang | 2022 | Engineering2022，8，8： | 0 |
| 10 | Update on lymphocyte-activation gene 3 (LAG-3) in cancers: from biological properties to clinical applications显示文摘Immunotherapy that targets checkpoints, especially programmed cell death protein 1 and programmed cell death ligand 1, has revolutionized cancer therapy regimens. The overall response rate to mono-immunotherapy, however, is limited, emphasizing the need to potentiate the efficacy of these regimens. The functions of immune cells are modulated by multiple stimulatory and inhibitory molecules, including lymphocyte activation gene 3 (LAG-3). LAG-3 is co-expressed together with other inhibitory checkpoints and plays key roles in immune suppression. Increasing evidence, particularly in the last 5 years, has shown the potential of LAG-3 blockade in anti-tumor immunity. This review provides an update on the biological properties and clinical applications of LAG-3 in cancers. | Lishu Zhao Hao Wang Kandi Xu Xinyue Liu Yayi He | 2022 | Chinese Medical Journal2022，，10： | 0 |
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