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| 1 | Towards a global One Health index: a potential assessment tool for One Health performance显示文摘Background:A One Health approach has been increasingly mainstreamed by the international community, as it provides for holistic thinking in recognizing the close links and inter-dependence of the health of humans, animals and the environment. However, the dearth of real-world evidence has hampered application of a One Health approach in shaping policies and practice. This study proposes the development of a potential evaluation tool for One Health performance, in order to contribute to the scientific measurement of One Health approach and the identification of gaps where One Health capacity building is most urgently needed.Methods:We describe five steps towards a global One Health index (GOHI), including (i) framework formulation;(ii) indicator selection;(iii) database building;(iv) weight determination;and (v) GOHI scores calculation. A cell-like framework for GOHI is proposed, which comprises an external drivers index (EDI), an intrinsic drivers index (IDI) and a core drivers index (CDI). We construct the indicator scheme for GOHI based on this framework after multiple rounds of panel discussions with our expert advisory committee. A fuzzy analytical hierarchy process is adopted to determine the weights for each of the indicators.Results:The weighted indicator scheme of GOHI comprises three first-level indicators, 13 second-level indicators, and 57 third-level indicators. According to the pilot analysis based on the data from more than 200 countries/territories the GOHI scores overall are far from ideal (the highest score of 65.0 out of a maximum score of 100), and we found considerable variations among different countries/territories (31.8–65.0). The results from the pilot analysis are consistent with the results from a literature review, which suggests that a GOHI as a potential tool for the assessment of One Health performance might be feasible.Conclusions:GOHI—subject to rigorous validation—would represent the world’s first evaluation tool that constructs the conceptual framework from a holistic perspective of One Health. Future application of GOHI might promote a common understanding of a strong One Health approach and provide reference for promoting effective measures to strengthen One Health capacity building. With further adaptations under various scenarios, GOHI, along with its technical protocols and databases, will be updated regularly to address current technical limitations, and capture new knowledge. | Xiao-Xi Zhang Jing-Shu Liu Le-Fei Han Shang Xia Shi-Zhu Li Odel YLi Kokouvi Kassegne Min Li Kun Yin Qin-Qin Hu Le-Shan Xiu Yong-Zhang Zhu Liang-Yu Huang Xiang-Cheng Wang Yi Zhang Han-Qing Zhao Jing-Xian Yin Tian-Ge Jiang Qin Li Si-Wei Fei Si-Yu Gu Fu-Min Chen Nan Zhou Zi-Le Cheng Yi Xie Hui-Min Li Jin Chen Zhao-Yu Guo Jia-Xin Feng Lin Ai Jing-Bo Xue Qian Ye Liz Grant Jun-Xia Song Geoff Simm Jürg Utzinger Xiao-Kui Guo Xiao-Nong Zhou | 2022 | Infectious Diseases of Poverty2022，11，3： | 3 |
| 2 | Increansed serum and urine levels of soloble interleukin-2 receptor in active lupus nephrotis显示文摘 | Ling SH Ye RG | 1993 | J Am Soc Nephrol1993，4，3： | 1 |
| 3 | Plasma levels of growth hormone correlate with the severity of pathologic changes in the renal structure of aging rats显示文摘 | Goya RG Castelletto L Sosa YE | 1991 | Lab Invest1991，64，1： | 1 |
| 4 | Effect of anti-CD134L mAb and CTLA4Ig on ConA-induced proliferation, Th cytokine secretion, and anti-dsDNA antibody production in spleen cells from lupus-prone BXSB mice 显示文摘 | ZHOU YB YE RG LI YJ | 2008 | Autoimmunity2008，41，5： | 1 |
| 5 | Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long-term expression, cell cycle dependency, and effects on hormone secretion 显示文摘 | Castro MG Goya RG Sosa YE | 1997 | Endo- crinology1997，138，5： | 1 |
| 6 | Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion 显示文摘 | Castro MG Goya RG Sosa YE | 1997 | Endocrinology1997，138，5： | 1 |
| 7 | Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenovirus: long-term expression, cell cycle dependency, and effects on hormone secretion 显示文摘 | Goya RG Sosa YE | 1997 | Endocrinology1997，138，5： | 1 |
| 8 | Use of recombinant herpes simplex virus type vectors for gene transfer into tumors and normal anterior pituitary cells 显示文摘 | Goya RG Rowe J Sosa YE | 1998 | Mol Cell Endocrinol1998，139，12： | 1 |
| 9 | Targeting the CD134-CD134L interaction using anti-CD134 and/or rhCD134 fusion protein as a possible strategy to prevent lupus nephritis显示文摘 | Zhou YB Ye RG Li YJ | 2009 | Rheumatol Int2009，29，4： | 1 |
| 10 | Effect of anti-CD134L mAb and CTLA4Ig on ConA-induced proliferation,Th cytokine secretion,and anti-dsDNA antibody production in spleen cells from lupus prone BXSB mice显示文摘 | Zhou YB Ye RG Li YJ | 2008 | Autoimmunity2008，41，5： | 1 |
| 11 | Use of recombinant herpes simplex virus type vectors for gene transfer into tumors and normal anterior pituitary cells 显示文摘 | Goya RG Rowe J Sosa YE | 1998 | Mol Cell Endocrinol1998，139，12： | 1 |
| 12 | Effect of dialysate composition on the apoptosis and proliferation of human peritoneal mesothelial cells and protein ex- pression of Fas and c-Myc显示文摘 | Zheng ZH Ye RG Bergstrom J Lindholm B | 2000 | Adv Perit Dial2000，6，： | 1 |
| 13 | CD40 ligand expression on maerophages during peritonitis in continuous ambulatory peritoneal dialysis patients 显示文摘 | Yang X Ye RG Yong QY | 2000 | Adv Perit Dial2000，16，2： | 1 |
| 14 | Effect of dialysate composition on apoptosis and proliferation of HPMC and protein expression of Fas and C-myc Perit显示文摘 | Zheng ZH Ye RG Bergstrom J | 2000 | Dial Int2000，20，1： | 1 |
| 15 | Technical considerations to avoid pitfalls during transapical aortic valve implantation 显示文摘 | Wong DR Ye J Cheung A Webb JG Carere RG Lichtenstein SV | 2010 | J Thorac Cardiovasc Surg2010，140，： | 1 |
| 16 | Effect of dialysate composition on the apoptosis and proliferation of human peritoneal mesothelial cells and protein expression of Fas and c-Myc显示文摘 | Zheng ZH Ye RG Bergstrom J | | 0，，01： | 1 |
| 17 | Con- served methylation of the glucocorticoid receptor gene exon 1(7) promoter in rats subjected to a maternal methyl- supplemented diet显示文摘 | Herbeek YE Gulevich RG Amelkina OA | 2010 | Int J Dev Neurosc2010，28，1： | 1 |
| 18 | Targeting the CD134-CD134L interaction using anti-CD134 and/or rhCD134 fusion protein as a possible strategy to prevent lupus nephritis 显示文摘 | Zhou YB Ye RG Li YJ | 2009 | Rheumatol Int2009，29，4： | 1 |
| 19 | Effect of dialysate composition on the apoptosis and proliferation of human peritoneal mesothelial cells and protein expression of fas and c-myc显示文摘 | Zheng ZH Ye RG Bergstrm J Lindholm B | 2000 | Adv Perit Dial2000，16，： | 1 |
| 20 | Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy显示文摘Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of the PDAC-associated immunophenotype is scarce. | Okan Safak Shenghan Wang Carmen Mota Reyes Ibrahim Halil Gürcinar Sergey Tokalov Nedim Can Cevik Kivanc Görgülü Bengi Su Yilmaz Emre Erdogan Linhan Ye Qiaolin Li Elif Arik Sever SamedÖzer Güldal Süyen Helmut Friess Güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir | 2024 | Cancer Communications2024，44，1： | 0 |
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