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| 1 | Structure and function of aggrecan显示文摘Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan. | CHRIS KIANI, LIWEN CHEN, YAO JIONG WU, ALBERT J YEE, BURTON B YANG, Sunnybrook and Women’s College Health Sciences Centre and Department of Laboratory Medicine and Patobiology, 2 Department of Surgeny, Faculty of Medicine, University of Toronto, Canada | 2002 | Cell Research2002，12，1： | 27 |
| 2 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 3 | 机械负荷调节猪腰椎间盘细胞表达α5β1整合素的体外研究显示文摘目的研究α5β1整合素在体外培养的猪腰椎间盘细胞中的表达和机械负荷对其的影响。方法取10只年龄5~6周、体重25~30kg的猪,处死后12h内,无菌条件下切取完整的腰椎,剔除腰椎周围的韧带和软组织,尤其是椎间盘周围的韧带。从腹侧一次性切开椎间盘取出髓核(nucleuspulpous,NP),仔细分离纤维环(anulusfibrous,AF),将两者立即置于Hanks平衡盐溶液中,制成细胞悬液。分别对腰椎间盘的AF和NP细胞施加1MPa、1Hz,3h/d,共3d的周期性液压,通过对细胞的形态学观察、Western免疫印迹和免疫组织化学染色,检测α5β1整合素在正常腰椎间盘AF细胞和NP细胞中的表达及周期性压力对其的影响。结果经周期性液压后,NP细胞的存活率大于90%,AF细胞的存活率大于85%,加压后的AF细胞和NP细胞均可见体积缩小。α5β1整合素在正常腰椎间盘AF细胞和NP细胞中的表达呈强阳性。Western免疫印迹结果显示:加压后α5β1整合素在AF细胞中的表达均明显减少,P值分别为0.000、0.003,与对照组比较差异有统计学意义;α5β1整合素在NP细胞中的表达也明显减少,P值分别为0.001、0.015,与对照组比较差异有统计学意义。结论机械负荷可引起腰椎间盘细胞中α5β1整合素的变化,提示α5β1整合素在腰椎间盘细胞中可能发挥力学传感器的作用。 | 于胜吉 邱贵兴 Yang B Roth S Whyne C Yee AJ | 2006 | 中华骨科杂志2006，26，6： | 2 |
| 4 | Buckytubes and derivatives:their growth and implications for buckyball formation显示文摘 | DRAVID V P LIN X WANG X K YEE A KETTERSON J B CHANG R P H | 1993 | Science1993，259，： | 1 |
| 5 | Forward kinematics solution of stewartplatform using neural networks 显示文摘 | YEE C S LIM K B | 1997 | Neurocomputing1997，16，3： | 1 |
| 6 | Stromal cell-derived fac-tor-lalpha and CXCR4 expression in hemangioblastoma and clear cell-~nal cell carcinoma:von Hippel-Lindau loss-of-function in- duces expression ofa ligand and its receptor 显示文摘 | Zagzag D Krishnamachary B Yee H | 2005 | Cancer Res2005，65，14： | 1 |
| 7 | An evaluation of color-spatial retrieval techniques for large image databases显示文摘 | Tan K L Ooi B C Yee C Y | | 0，，01： | 1 |
| 8 | Automated Regional Citrate Anticoagulation: Technological Barriers and Possible Solutions 显示文摘 | Szamosfalvi B Frinak S Yee J | 2010 | Blood Purif2010，，29： | 1 |
| 9 | Synthetic bile acid derivatives inhibit cell proliferation and induce apoptosis in HT-29 human colon cancer cells显示文摘 | Park S E Choi H J Yee S B | 2004 | Int J Oncol2004，25，1： | 1 |
| 10 | Treatment of obesity hypoventilation syndrome and serum leptin显示文摘 | YEE B J CHEUNG J PHIPPS P | 2006 | Respiration2006，73，： | 1 |
| 11 | Forward kinematics solution of stewart platform using neural networks显示文摘 | Yee C S Lim K B | 1997 | Neurocomuting1997，16，3： | 1 |
| 12 | Moisture diffusion and hydrothermal aging in bismaleimide matrix carbon fiber composites part I: woven and hybrid composites 显示文摘 | Li R B Yee A F | 2002 | Composites Science and Technology2002，62，1： | 1 |
| 13 | Effects of finite length in solid - rotor induction machines显示文摘 | Yee H Sc B E B | 1971 | PROC lEE1971，118，8： | 1 |
| 14 | Zinc and carbon co-limitation of marine phytoplankton显示文摘 | Morel F M M Reinfelder J R Roberts S B Chamberlain C P Lee J G Yee D | 1994 | Nature1994，369，6483： | 1 |
| 15 | Pupal mortality and adult emer-gence of western cherry fruit fly ( Diptera: Tephritidae ) exposed tothe fungus Muscodor albus ( Xylariales:Xylariaceae) 显示文摘 | Yee W L Lacey L A Bishop B J B | 2009 | Journal ofEconomic Entomology2009，102，6： | 1 |
| 16 | Paelitaxel-Induced Apoptosis and Mitotic Arrest Assessed by Serial Fine-Needle Aspiration : Implications for Early Prediction of Breast Cancer Response to Neoadjuvant Treatment 显示文摘 | SYMMANS W F VOLM M D SHAPIRO R L PERKINS A B KIM A Y DEMARIA S YEE H T MCMULLEN H ORATZ R KLEIN P FORMENTI S C MUGGIA F | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 17 | Regulation of tumor angiogene- sis by thrombospondin-1 显示文摘 | Ren B Yee KO Lawler J | 2006 | Biochim Biophys Acta2006，1765，2： | 1 |
| 18 | Type 1 insulinlike growth factor receptor as a therapeutic target in cancer显示文摘 | Miller B S Yee D | 2005 | Cancer Res2005，65，10： | 1 |
| 19 | The alphaherpesvirus US3/ORF66 protein kinases direct phosphorylation of the nuclear matrix protein matrin 3显示文摘 | Erazo A Yee M B Banfield B W | | 0，，01： | 1 |
| 20 | Phase I clinical and pharmacological studies of benzylacyclouridine, a uridine phosphorylase inhibitor显示文摘 | Pizzomo G Yee L Burtness B A | 1998 | Clin Cancer Res1998，4，5： | 1 |
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