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| 1 | Structure and function of aggrecan显示文摘Aggrecan is the major proteoglycan in the articular cartilage. This molecule is important in the proper functioning of articular cartilage because it provides a hydrated gel structure (via its interaction with hyaluronan and link protein) that endows the cartilage with load-bearing properties. It is also crucial in chondroskeletal morphogenesis during development. Aggrecan is a multimodular molecule expressed by chondrocytes. Its core protein is composed of three globular domains (G1, G2, and G3) and a large extended region (CS) between G2 and G3 for glycosaminoglycan chain attachment. G1 comprises the amino terminus of the core protein. This domain has the same structural motif as link protein. Functionally, the G1 domain interacts with hyaluronan acid and link protein, forming stable ternary complexes in the extracellular matrix. G2 is homologous to the tandem repeats of G1 and of link protein and is involved in product processing. G3 makes up the carboxyl terminus of the core protein. It enhances glycosaminoglycan modification and product secretion. Aggrecan plays an important role in mediating chondrocyte-chondrocyte and chondrocyte-matrix interactions through its ability to bind hyaluronan. | CHRIS KIANI, LIWEN CHEN, YAO JIONG WU, ALBERT J YEE, BURTON B YANG, Sunnybrook and Women’s College Health Sciences Centre and Department of Laboratory Medicine and Patobiology, 2 Department of Surgeny, Faculty of Medicine, University of Toronto, Canada | 2002 | Cell Research2002，12，1： | 27 |
| 2 | Epidemiology of Alzheimer’s disease and other forms of dementia in China, 1990–2010: a systematic review and analysis显示文摘 | Kit Yee Chan Wei Wang Jing Jing Wu Li Liu Evropi Theodoratou Josip Car Lefkos Middleton Tom C Russ Ian J Deary Harry Campbell Wei Wang Igor Rudan | 2013 | The Lancet . 2013 (9882)2013，，9882： | 5 |
| 3 | 强化与标准降压治疗对脑卒中亚型的影响显示文摘在收缩压干预试验(systolic blood pressure intervention trial, SPRINT)中,各治疗组的脑卒中发生比例差异无统计学意义,但脑卒中亚型的病因不同,可能对强化降压治疗的反应不同。SPRINT纳入患者(n=9 361)随机分为目标收缩压<120 mm Hg(1 mm Hg=0.133 kPa)的强化治疗与目标收缩压<140 mm Hg的标准治疗组。 | Wright CB Auchus AP Lerner A Ambrosius WT Ay H Bates JT Chen J Meschia JF Pancholi S Papademetriou V Rastogi A Sweeney M Willard JJ Yee J Oparil S 赵狄(摘译) 郑武洪(审校) | 2021 | 中华高血压杂志2021，29，3： | 2 |
| 4 | Colorectal neoplasia:performance characteristics of colonography for detection in 300 patients显示文摘 | Yee J Akerkar GA Hung RK | 2001 | Radiology2001，219，： | 2 |
| 5 | The crystal structure of the antimicrobial defensin HNP-3, an amphilic dimmer, suggests mechanisms of membrane permeabilization显示文摘 | Hill CP Yee J Selsted ME | 1991 | Science1991，251，： | 2 |
| 6 | Comparison of supine and prone scanning separately and in combination at CT colonoraphy显示文摘 | Yee J Kumar NN Hung RK | 2003 | Radiology2003，226，3： | 1 |
| 7 | 显示文摘 | Yee A Morrison S J Idriss H | 2000 | Catal Today2000，63，： | 1 |
| 8 | Business Process Management: Survey and Methodology显示文摘 | Elzinga D J Horak T Chung - Yee L Bruner C | 1995 | IEEE Transactions on Engineering Management1995，24，2： | 1 |
| 9 | Buckytubes and derivatives:their growth and implications for buckyball formation显示文摘 | DRAVID V P LIN X WANG X K YEE A KETTERSON J B CHANG R P H | 1993 | Science1993，259，： | 1 |
| 10 | A numerical example of a two dimensional scattering problem using a subgrid显示文摘 | Kasher J C Yee K S | 1987 | Applied Computational Electromagnetic Society Journal and Newsletter1987，2，2： | 1 |
| 11 | CD3- and CD28-dependent induction of PDE7 required for T cell activation显示文摘 | Li L Yee C Beavo J A | 1999 | Science1999，283，5403： | 1 |
| 12 | The Effects of Risk - reducing Strate-gies on Consumer Perceived Risk and on Purchase Likelihood: A Modeling Approach 显示文摘 | Yeung R Yee W Morris J | 2010 | British Food Journal2010，112，3： | 1 |
| 13 | A chemical equilibrium model for metal adsorption onto bacterial surfaces 显示文摘 | Fein JB Daughney C J Yee N | 1997 | Geochimicaet Cosmochimica Acta1997，61，： | 1 |
| 14 | A study of ethanol reactions over Pt/CeO2 by temperature-trogrammed desorption and in situ FT-IR spectroscopy:Evidence of benzene formation显示文摘 | YEE A MORRISON S J IDRISS H | 2000 | Journal of Catalysis2000，191，1： | 1 |
| 15 | Persistent hallucinosis in borderline personality disorder显示文摘 | Yee L Korner A J McSwiggan S | 2005 | Compr Psychiatry2005，46，2： | 1 |
| 16 | Effects microcarrier pore characteristics on methanogenic fluidized bed performance显示文摘 | Yee C J Hsu Y Shieh W K | 1992 | Water Res1992，26，8： | 1 |
| 17 | Quantifying metal adsorption onto bacteria mixtures: A test and application of the surface complexation model 显示文摘 | Yee N Fein J | 2003 | Geomicrobiology Journal2003，20，： | 1 |
| 18 | 显示文摘 | Yee A Morrison S J Idriss H | 1999 | J Catal1999，186，： | 1 |
| 19 | Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection:roles of MxA,OAS-1 and PKR显示文摘 | Knapp S Yee L J Frodsham A J | 2003 | Genes Immun2003，4，： | 1 |
| 20 | Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation显示文摘 | Groh V Wu J Yee C | 2002 | Nature2002，419，6908： | 1 |
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