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| 1 | Autophagy is increased in cryptorchid testis resulting in abnormal spermatozoa显示文摘Autophagy is invoIved in spermatogenesis by regulating germ cell maturation.This catabolic process increases with hyperthermic conditions to prevent the accumulation of damaged organelles.Cryptorchidism is associated with impairment of germ cell maturation revealed by the presence of immature forms of sperm cells in ejaculates.The aim of the present study was to evaluate the status of autophagy in sperm cells from cryptorchid patients.Semen samples of cryptorchid patients and normozoospermic controls were analyzed by immuno cytochemistry and electron microscopy.Autophagy protei ns,autophagy-related protein 9(ATG9)and microtubule-associated protein,lA/lB-light chain 3(LC3)were localized by immunocytochemistry on the acrosome and on the equatorial segment of sperm cells.LC3 was also detected in the midpiece of cryptorchid sperm tail.Autophagy substrate p62 protein was present in the acrosome and in the postequatorial segment of sperm in control samples,but not in the cryptorchid ones.Transmission electron microscopy revealed double-membrane-limited autophagosomes in postequatorial part of spermatozoa head and midpiece in cryptorchid samples.Partly degraded mitochondria were frequently discerned in autophagic vacuoles.In conclusion,autophagy is increased in sperm cells from patients with cryptorchid history comparatively to control.Our work provides insights into the role of autophagy in the maturation and survival of human male gametes in pathological conditions.Thus,regulating autophagy could represent a potential way to improve sperm quality in cryptorchid men. | Marina G Yefimova Antoine Buschiazzo Agnes Burel Marie-Therese Lavault Celine Pimentel Guilhem Jouve Sylvie Jaillard Bernard Jegou Nicolas Bourmeyster Celia Ravel | 2019 | Asian Journal of Andrology2019，21，6： | 2 |
| 2 | Iron,ferritin,transferrin receptor in the adult rat retina显示文摘 | Yefimova MG Jeanny JC Guillonneau X et a1 | 2000 | IOVS2000，41，8： | 1 |
| 3 | Study of Imperfect Natural Diamonds with the Application of the X-ray Synchrotron Radiation ( the'Laue-SR' Method ) 显示文摘 | Rylov G M Yefimova E S Sobolev N V | 2001 | Nuclear Instruments & Methods in Physics Reseach A-Accelerators Spectrometers Detectors and Associated Equipment2001，470，12： | 1 |
| 4 | Iron,ferritin,transferrin,and transferrin receptor in the adult rat retina显示文摘 | Yefimova MG Jeanny JC Guillonneau X Keller N Nguyen-Legros J Sergeant C | | 0，，8： | 1 |
| 5 | Exact solutions of the Burgers-Huxley equation显示文摘 | Yefimova O Yu Kudryashov N A | 2004 | Journal of Applied Mathematics and Mechanics2004，68，： | 1 |
| 6 | Unusual upper mantle beneath Guaniamo,Guyana shield,Venezuela:Evidence from diamond inclusions 显示文摘 | Sobolev N V Yefimova E S Channer D M DeR | 1998 | Geolo-gy1998，26，11： | 1 |
| 7 | Study of Imperfect Natural Diamonds with the Application of the X-Ray Synchrotron Radiation (the 'Laue-SR' Method)显示文摘 | Rylov G M Yefimova E S Sobolev N V | 2001 | Nuclear Instruments and Methods in Physics Research A--Accelerators Spectrometers Detectors and Associated Equipment2001，470，12： | 1 |
| 8 | Study of imperfect natural diamonds with the application of the X-ray synchrotron radiation(the'Laue-SR'method)显示文摘 | Rylov G M Yefimova E S Sobolev N V | 2001 | Nuclear Instruments and Methods in Physics Research(A)2001，470，： | 1 |
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