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| 1 | Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is a leading cause of morbidity and mortality in the adult as well as in the neonate,with limited options for treatment and significant dysfunctionality.AIM To investigate the safety and preliminary efficacy of allogeneic mesenchymal stem cells(MSCs)in HIE patients.METHODS Patients who had HIE for at least 6 mo along with significant dysfunction and disability were included.All patients were given Wharton’s jelly-derived MSCs at 1×106/kg intrathecally,intravenously,and intramuscularly twice a month for two months.The therapeutic effects and prognostic implications of MSCs were evaluated by multiple follow-ups.Functional independence measure(FIM),modified Ashworth,and Karnofsky scales were used to assess any side effects,neurological and cognitive functions,and overall outcomes.RESULTS The 8 subjects included in the study had a mean age of 33.25±10.18 years.Mean HIE exposure and mean post-HIE durations were 45.63±10.18 and 19.67±29.04 mo,respectively.Mean FIM score was 18.38±1.06,mean modified Ashworth score was 43.5±4.63,and mean Karnofsky score was 20.For the first 24 h,5 of the patients experienced a subfebrile state,accompanied by mild headaches due to intrathecally administration and muscle pain because of intramuscularly administration.Neurological and functional examinations,laboratory tests,electroencephalography,and magnetic resonance imaging were performed to assess safety of treatment.Mean FIM score increased by 20.88±3.31 in the first month(P=0.027)and by 31.38±14.69 in 12 mo(P=0.012).The rate of patients with an FIM score of 126 increased from 14.58%to 16.57%in the first month and 24.90%in 12 mo.CONCLUSION Multiple triple-route Wharton’s jelly-derived MSC administrations were found to be safe for HIE patients,indicating neurological and functional improvement.Based on the findings obtained here,further randomized and placebo research could be performed. | Serdar Kabataş ErdinçCivelek Necati Kaplan Eyüp Can Savrunlu Gülseli Berivan Sezen Mourat Chasan Halil Can Ali Genç Yener Akyuva Osman Boyalı Furkan Diren Erdal Karaoz | 2021 | World Journal of Experimental Medicine2021，11，2： | 2 |
| 2 | The effect of sintering temperature on some properties of Cu-SiC composite 显示文摘 | Celebi Ere G Yener T Altinsoy I | 2011 | Journal of Alloys and Compounds2011，，509： | 1 |
| 3 | Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for application of ascorbyl palmitate 显示文摘 | UNER M WISSING S A YENER G | 2005 | Pharmazie2005，60，8： | 1 |
| 4 | Reduced retinal nerve fiber layer thickness and macular volume in pediatric multiple sclerosis显示文摘 | Yilmaz U Gücüyener K Erin DM | | 0，，12： | 1 |
| 5 | Response surfaces of apricot kernel oil yield in supercritical carbon dioxide显示文摘 | Ozkal S G Yener M E Bayindirli L | 2005 | LWT-Food Science and Technology2005，，38： | 1 |
| 6 | Supercritical carbon dioxide extraction of hazelnut oil显示文摘 | Ozkal S G Salgm U Yener M E | 2005 | Journal of Food Engineering2005，69，2： | 1 |
| 7 | Supercritieal carbon dioxide extraction of hazelnut oil显示文摘 | Ozkal S G Salgn U Yener M E | 2005 | Journal of Food Engineering2005，，69： | 1 |
| 8 | 用低能γ闪烁能谱法直接测量地质样品的^(238)U含量和不平衡状态显示文摘提出了一种用低能γ闪烁能谱法测定地质样品的铀含量和不平衡状态的厅法。制备了不同含量的放射性平衡的矿石标准,并与同含量的化学铀标准比较了低能谱.用X射线荧光能谱仪和高分辨γ能谱仪仔细地分析了这些标准的铀含量。将矿石谱中63keV光电峰和93keV光电峰形成的复合峰的计数,与化学油标准谱的相应道的计数进行了比较。发现,对于平衡的标准,复合峰下(26±2)%计数来自于^(234)Th;^(234)Th(63keV+93keV)计数与^(210)Pb(47keV)计数之间存在着常数关系。这种技术曾应用于以前在同一实验室用高能γ能谱法测定过当量铀含量的地质样品。 | Günseli Yaprak Güngr Yener 张瑞增 | 1992 | 国外铀金地质1992，，3： | 1 |
| 9 | Matrix metalloproteinase-7 and matrix metalloproteinase-9 in pediatric multiple sclerosis显示文摘 | Yulmaz ü Gücüyener K Atak A | 2012 | Pediatr Neurol2012，47，3： | 1 |
| 10 | Influence of surfactants on the physical stability of solid lipid nanoparticle (SLN) formulations显示文摘 | UNER M WISSING SA YENER G | 2004 | Pharmazie2004，59，4： | 1 |
| 11 | Response surfaces of apricot kernel oil yield in supercritical carbon dioxide 显示文摘 | OZKAL S G YENER M E BAYINDIRLI L | 2005 | Food Science and Technology2005，38，6： | 1 |
| 12 | Antimicrobial activity of lactoperoxidase system into crosslinked alginate films显示文摘 | Yener F Y G Korel F Yemenicioglu A | 2009 | Journal of Food Science2009，74，2： | 1 |
| 13 | Response surfaces of apricot kernel oil yield in supercritical carbon dioxide显示文摘 | OZKAL S G YENER M E BAYINDIRLI L | 2005 | Food Science and Technology2005，38，6： | 1 |
| 14 | Influence of surfactants on the physical stability of solid lipid nanoparticles (SLN)formulations显示文摘 | uner M Wissing SA Yener G | 2004 | Pharrnazie2004，59，4： | 1 |
| 15 | The effect of sintering temperature on some properties of Cu-SiC composite 显示文摘 | CELEBIEFE G YENER T ALTINSOY I | 2011 | Journal of Alloys and Compounds2011，509，20： | 1 |
| 16 | Dynamic analysis of sorption of Methylene Blue dye on granular and powdered activated carbon显示文摘 | YENER J KOPAC T DOGU G | 2008 | Chemical Engineering Journal2008，144，3： | 1 |
| 17 | Importance of solid lipid nanoparticles(SLN) invarious administrati on routes and future perspectivesc显示文摘 | Uner M Yener G | 2007 | IntJ Nanomed2007，2，3： | 1 |
| 18 | Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of celecoxib through human skin 显示文摘 | Yener G Gonullu U Uner M | 2003 | Pharmazie2003，58，5： | 1 |
| 19 | Solid lipidnanoparticles(SLN)and nanostructured lipid carriers(NLC)for application of ascorbyl palmitate显示文摘 | üNER M WISSING S A YENER G | 2005 | Pharmazie2005，60，8： | 1 |
| 20 | Influence of surfactants on the physical stability of solid lipid nanoparticle ( SLN ) for mulations 显示文摘 | ONER M WISSING S A YENER G | 2004 | Pharmazie2004，59，4： | 1 |
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