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| 1 | CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice显示文摘Several factors have been implicated in obesity-related hypertension, but the genesis of the hypertension is largely unknown. In this study, we found a significantly upregulated expression of CPI-17(C-kinasepotentiated protein phosphatase 1 inhibitor of 17 kDa) and protein kinase C(PKC) isoforms in the vascular smooth muscles of high-fat diet(HFD)-fed obese mice. The obese wild-type mice showed a significant elevation of blood pressure and enhanced calcium-sensitized contraction of vascular smooth muscles. However, the obese CPI-17-deficient mice showed a normotensive blood pressure, and the calcium-sensitized contraction was consistently reduced. In addition, the mutant muscle displayed an abolished responsive force to a PKC activator and a 30%-50% reduction in both the initial peak force and sustained force in response to various G protein-coupled receptor(GPCR) agonists. Our observations showed that CPI-17-mediated calcium sensitization is mediated through a GPCR/PKC/CPI-17/MLCP/RLC signaling pathway. We therefore propose that the upregulation of CPI-17-mediated calcium-sensitized vasocontraction by obesity contributes to the development of obesity-related hypertension. | Jie Sun Tao Tao Wei Zhao Lisha Wei Fan She Pei Wang Yeqiong Li Yanyan Zheng Xin Chen Wei Wang Yanning Qiao Xue-Na Zhang Min-Sheng Zhu | 2019 | Journal of Genetics and Genomics2019，46，3： | 4 |
| 2 | WorldFIP和FF非周期信息调度的性能比较显示文摘World FIP和FF都采用集中控制的方式来管理周期信息的通讯,但是二者对非周期信息的通讯管理有着本质的不同。World FIP利用查询方式发送非周期信息,而FF采用轮循的方式并辅以PT令牌来完成非周期信息的通讯。讨论了两类总线不同的非周期管理模式,给出了两类总线不同非周期通信模式的利用率公式,比较了在不同非周期到达率下。 | 陈积明 王智 Song Yeqiong 孙优贤 | 2005 | 仪器仪表学报2005，26，4： | 2 |
| 3 | Electronic structure and properties of LaNi_5 compound from first principles显示文摘The energy,electronic structure,and magnetic and mechanical properties of LaNi5 compound have been studied by the first-principles method based on the density functional theory.The results show that the calculated lattice parameters of LaNi5 compound are almost the same with the experimental ones,and the compound is easy to form and very stable.The bond between La and Ni1 atoms is an ionic bond,and electrostatic attraction effect exists between Ni atoms.The farther the distance between Ni atoms in the LaNi5 crystal cell is,the stronger the electrostatic attraction effect is.LaNi5 intermetallic compound is ductile and ferromagnetic.The calculated hardness value of LaNi5 compound is 7.04 GPa,and the calculated elastic properties are close to the experimental results. | WU Yeqiong YAN Mufu | 2010 | Rare Metals2010，29，4： | 2 |
| 4 | The roles of ADIPOQ genetic variations in cancer risk: evidence from published studies显示文摘 | Yeqiong Xu Bangshun He Yuqin Pan Ling Gu Zhenlin Nie Liping Chen Rui Li Tianyi Gao Shukui Wang | 2013 | Molecular Biology Reports2013，，2： | 1 |
| 5 | Graceful degradation of loss-tolerant QoS using (m, k )-firm constraints in guaranteed rate networks 显示文摘 | Koubaa Anis Song Yeqiong | 2005 | Computer Communications2005，28，12： | 1 |
| 6 | 显示文摘 | XIEYong-Rong(谢永荣) YEQiong(叶琼) | | WujiHuaxueXuebao0，，： | 1 |
| 7 | Trends in automotive communication systems显示文摘 | Navet N Song Yeqiong Simonot-Lion F | 2005 | Proceedings of the IEEE2005，93，6： | 1 |
| 8 | Distinct functions of Trio GEF domains in axon outgrowth of cerebellar granule neurons显示文摘As a critical guanine nucleotide exchange factor(GEF) regulating neurite outgrowth, Trio coordinates multiple processes of cytoskeletal dynamics through activating Rac1, Cdc42 and RhoA small GTPases by two GEF domains, but the in vivo roles of these GEF domains and corresponding downstream effectors have not been determined yet. We established multiple lines of knockout mice and assessed the respective roles of Trio GEF domains and Rac1 in axon outgrowth. Knockout of total Trio in cerebellar granule neurons(CGNs) led to an impaired F-actin rearrangement of growth cone and hence a retarded neurite outgrowth. Such a retardation was reproduced by inhibition of GEF1 domain or knockdown of Cdc42 and restored apparently by introduction of active Cdc42. As Rac1 deficiency did not affect the neurite outgrowth of CGNs, we suggested that Trio GEF1-mediated Cdc42 activation was required for neurite outgrowth. We established a GEF2-knockout line with deletion of all Trio isoforms except a cerebella-specific Trio8, a short isoform of Trio without GEF2 domain, and used this line as a GEF2-deficient animal model. The GEF2-deficient CGNs had a normal neurite outgrowth but abolished Netrin-1-promoted growth, without affecting Netrin-1 induced Rac1 activation. We thus suggested that Trio GEF1-mediated Cdc42 activation rather than Rac1 activation drives the F-actin dynamics necessary for neurite outgrowth, while GEF2 functions in Netrin-1-promoted neurite elongation. Our results delineated the distinct roles of Trio GEF domains in neurite outgrowth, which is instructive to understand the pathogenesis of clinical Trio-related neurodevelopmental disorders. | Tao Tao Jie Sun Yajing Peng Pei Wang Xin Chen Wei Zhao Yeqiong Li Lisha Wei Wei Wang Yanyan Zheng Ye Wang Xuena Zhang Min-Sheng Zhu | 2019 | Journal of Genetics and Genomics2019，46，2： | 1 |
| 9 | Trends in Automotive Communication Systems 显示文摘 | Navet N Song Yeqiong Simonot-lion F | 2005 | Proceedings of the IEEE2005，93，6： | 1 |
| 10 | Trends in automotive communication systems显示文摘 | Nicolas N Yeqiong S Francoise S | 2005 | Industrial Communication Systems2005，93，6： | 1 |
| 11 | Trends in Automotive Communication Systems 显示文摘 | Nicolas Navet Yeqiong Song Francqise Simonot-Lion Cedric Wilwert | 2005 | Proceedings of the IEEE (S0018-9219)2005，93，6： | 1 |
| 12 | The relationship between zinc deficiency and infectious complications in patients with hepatitis B virus-related acute-on-chronic liver failure显示文摘Background The prevalence of zinc deficiency is high in patients with chronic liver disease,but few studies have hitherto explored the relationship between the serum zinc level and hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).This study aimed to assess the association between zinc deficiency and infectious complications,and model for end-stage liver disease(MELD)score in patients with HBV-related ACLF.Methods Patients with HBV-related ACLF from the Department of Infectious Diseases of the Third Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between January 2019 and December 2019 were retrospectively analysed in this study.Their demographic,clinical,and laboratory data were retrieved from the hospital information system and analysed.The Student’s t-test was used for normally distributed continuous variables between two groups and the Chi-square test was used for categorical data.Univariate and multivariate logistic regression analyses were applied to identify independent parameters.Results A total of 284 patients were included in this study,including 205 liver cirrhosis and 79 non-cirrhosis patients.The proportion of patients with zinc deficiency was the highest(84.5%),followed by subclinical zinc deficiency(14.1%)and normal zinc level(1.4%).Patients in the zinc deficiency group had a higher MELD score than the subclinical zinc deficiency or normal zinc group(P=0.021).Age,total bilirubin,and serum zinc level were independent factors for infection(P_(s)<0.05).The serum zinc level in patients without complications at admission was significantly higher than that in patients with complications(P=0.004).Moreover,the serum zinc level in patients with prothrombin time activity(PTA)of<20%was significantly lower than that in patients with 20%≤PTA<30%(P=0.007)and that in patients with 30%≤PTA<40%(P<0.001).Conclusions Zinc deficiency is common in patients with HBV-related ACLF.Zinc deficiency is closely associated with infectious complications and MELD score in patients with HBV-related ACLF. | Xinhua Li Lu Wang Na He Yeqiong Zhang Jiahui Pang Heping Wang Meng Yu Yongyu Mei Liang Peng Wenxiong Xu | 2022 | Gastroenterology Report2022，10，1： | 0 |
| 13 | LIMK2 is required for membrane cytoskeleton reorganization of contracting airway smooth muscle显示文摘Airway smooth muscle(ASM)has developed a mechanical adaption mechanism by which it transduces force and responds to environmental forces,which is essential for periodic breathing.Cytoskeletal reorganization has been implicated in this process,but the regulatory mechanism remains to be determined.We here observe that ASM abundantly expresses cytoskeleton regulators Limk1 and Limk2,and their expression levels are further upregulated in chronic obstructive pulmonary disease(COPD)animals.By establishing mouse lines with deletions of Limk1 or Limk2,we analyse the length-sensitive contraction,F/Gactin dynamics,and F-actin pool of mutant ASM cells.As LIMK1 phosphorylation does not respond to the contractile stimulation,LIMK1-deficient ASM develops normal maximal force,while LIMK2 or LIMK1/LIMK2 deficient ASMs show approximately 30%inhibition.LIMK2 deletion causes a significant decrease in cofilin phosphorylation along with a reduced F/G-actin ratio.As LIMK2 functions independently of cross-bridge movement,this observation indicates that LIMK2 is necessary for F-actin dynamics and hence force transduction.Moreover,LIMK2-deficient ASMs display abolishes stretching-induced suppression of 5-hydroxytryptamine(5-HT)but not acetylcholine-evoks force,which is due to the differential contraction mechanisms adopted by the agonists.We propose that LIMK2-mediated cofilin phosphorylation is required for membrane cytoskeleton reorganization that is necessary for ASM mechanical adaption including the 5-HT-evoked length-sensitive effect. | Yeqiong Li Yuwei Zhou Pei Wang Tao Tao Lisha Wei Ye Wang Wei Wang Yanyan Zheng Zhihui Jiang Tiantian Qiu Wei Zhao Jie Sun Xin Chen Xue-Na Zhang Min-Sheng Zhu | 2021 | Journal of Genetics and Genomics2021，48，6： | 0 |
| 14 | First principles study on effect of lanthanum on nitrogen diffusion in ε-Fe_3N phase显示文摘The effect of lanthanum(La) on nitrogen atom diffusion in ε-Fe3N phase produced during nitriding with and without rare earth addition were studied based on the density function theory of first principles and the quantum mechanics program CASTEP code of Material Studio software.Calculated results show that the presence of La in ε-Fe3N phase can lead to the shrinks of a and b axis and the elongation of c axis of ε-Fe3N crystal cell.The total energy and the stability of the crystal cell with La are lower and higher than that without La,respectively.Diffusion activation energy of nitrogen atom in ε-Fe3N phase with La is 1.01 eV smaller than that in ε-Fe3N phase without La.This is the main reason why rare earth elements diffusing into compound layer produced during nitriding can accelerate the nitriding process or shorten the nitriding duration. | WU Yeqiong,and YAN Mufu School of Materials Science and Engineering,Harbin Institute of Technology,Harbin 150001,China | 2007 | Rare Metals2007，26，S1： | 0 |
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