| 1 | Exploring the potential to enhance drug distribution in the brain subregion via intranasal delivery of nanoemulsion in combination with borneol as a guider显示文摘The number of people with Alzheimer’s disease(AD)is increasing annually,with the nidus mainly concentrated in the cortex and hippocampus.Despite of numerous efforts,effective treatment of AD is still facing great challenges due to the blood brain barrier(BBB)and limited drug distribution in the AD nidus sites.Thus,in this study,using vinpocetine(VIN)as a model drug,the objective is to explore the feasibility of tackling the above bottleneck via intranasal drug delivery in combination with a brain guider,borneol(BOR),using nanoemulsion(NE)as the carrier.First of all,the NE were prepared and characterized.In vivo behavior of the NE after intranasal administration was investigated.Influence of BOR dose,BOR administration route on drug brain targeting behavior was evaluated,and the influence of BOR addition on drug brain subregion distribution was probed.It was demonstrated that all the NE had comparable size and similar retention behavior after intranasal delivery.Compared to intravenous injection,improved brain targeting effect was observed by intranasal route,and drug targeting index(DTI)of the VIN–NE group was 154.1%,with the nose-to-brain direct transport percentage(DTP)35.1%.Especially,remarkably enhanced brain distribution was achieved after BOR addition in the NE,with the extent depending on BOR dose.VIN brain concentration was the highest in the VIN-1-BOR-NE group at BOR dose of 1 mg/kg,with the DTI reaching 596.1%and the DTP increased to 83.1%.BOR could exert better nose to brain delivery when administrated together with the drug via intranasal route.Notably,BOR can remarkably enhance drug distribution in both hippocampus and cortex,the nidus areas of AD.In conclusion,in combination with intranasal delivery and the intrinsic brain guiding effect of BOR,drug distribution not only in the brain but also in the cortex and hippocampus can be enhanced significantly,providing the perquisite for improved therapeutic efficacy of AD. | Xin Shen Zhixiang Cui Yidan Wei Yingnan Huo Duo Yu Xin Zhang Shirui Mao | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，6： | 1 |
| 2 | Efficiently coupled glucose oxidation for high-value D-glucaric acid with ultradurable hydrogen via Mn(III)in acidic solution显示文摘The electrooxidation of the alcohol and aldehyde molecules instead of water coupled with H2 production has been proven to be effective for producing high-value fine chemicals under alkaline conditions.It is also noteworthy that under acidic conditions,the stability of non-noble metal water oxidation catalysts remains a great challenge due to the lattice oxygen mechanism.Hence,we coupled the biomass-derived glucose oxidation for high-value D-glucaric acid(GRA)with ultra-durable hydrogen in acid solution over a Yb-MnO_(2)catalyst.The Mn^(3+)regulated by Yb atoms doped in MnO_(2)can effectively optimize the adsorption and desorption processes of the alcohol and aldehyde group and improve the intrinsic activity but cannot for H2O.The catalyst exhibited extremely high activity and stability after 50 h for glucose oxidation,inhibiting the lattice oxygen process and MnO4−formation,while the activity was quickly lost within 0.5 h for water oxidation.Density functional theory(DFT)calculations further demonstrated that glucose oxidation reaction proceeds preferentially due to the oxidation of aldehyde group with lower adsorption-free energy(−0.4 eV)than water(ΔG>0 eV),avoiding the lattice oxygen mechanism.This work suggests that biomass-derived glucose oxidation not only provides a cost-effective approach for high-value chemicals,but also shows an extremely potential as an alternative to acidic oxygen evolution reaction(OER)for ultradurable H2 production. | Junhua Li Yi Jiang Xu Zhang Yidan Huo Fanglin Du Yongxiao Tuo Zhiyan Guo Dawei Chen Shenghua Chen | 2023 | Nano Research2023，16，8： | 0 |
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