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| 1 | Advanced characterization of pores and fractures in coals by nuclear magnetic resonance and X-ray computed tomography显示文摘This paper demonstrates capabilities of low-field nuclear magnetic resonance (NMR) and microfocus X-ray computed tomography (μCT) in advanced, nondestructive, and quantitative characterization of pore types, producible porosity, pore structure, and spatial disposition of pore-fractures in coals. Results show that the NMR transverse relaxation time (T2) at 0.5–2.5, 20–50, and >100 ms correspond to pores of <0.1 μm, >0.1 μm, and fractures, respectively. A much higher T2 spectrum peak reflects a much better development of pores (or fractures) corresponding to the T2, and vice versa. Three basic components in coals, i.e., the pores (or fractures), coal matrix, and minerals have their distinctive range of CT numbers. Among these, the CT number of pores is commonly less than 600 HU. The producible porosity, which is a determination of permeability, can be calculated by T2 cutoff value (T2C) of coal NMR. The coal pore structure can be efficiently estimated by the newly proposed 'T2C based model'. Finally, μCT scan was proven capable of modeling and spatial visualization of pores and fractures. | YAO YanBin, LIU DaMeng, CAI YiDong & LI JunQian School of Energy Resources, China University of Geosciences, Beijing 100083, China | 2010 | Science China Earth Sciences2010，53，6： | 61 |
| 2 | Precise orbit determination of Beidou Satellites with precise positioning显示文摘Chinese Beidou satellite navigation system constellation currently consists of eight Beidou satellites and can provide preliminary service of navigation and positioning in the Asia-Pacific Region.Based on the self-developed software Position And Navigation Data Analysis(PANDA) and Beidou Experimental Tracking Stations (BETS),which are built by Wuhan University,the study of Beidou precise orbit determination,static precise point positioning (PPP),and high precision relative positioning,and differential positioning are carried out comprehensively.Results show that the radial precision of the Beidou satellite orbit determination is better than 10 centimeters.The RMS of static PPP can reach several centimeters to even millimeters for baseline relative positioning.The precision of kinematic pseudo-range differential positioning and RTK mode positioning are 2-4 m and 5-10 cm respectively,which are close to the level of GPS precise positioning.Research in this paper verifies that,with support of ground reference station network,Beidou satellite navigation system can provide precise positioning from several decimeters to meters in the wide area and several centimeters in the regional area.These promising results would be helpful for the implementation and applications of Beidou satellite navigation system. | SHI Chuang ZHAO QiLe LI Min TANG WeiMing HU ZhiGang LOU YiDong ZHANG HongPing NIU XiaoJi LIU JingNan | 2012 | Science China Earth Sciences2012，55，7： | 61 |
| 3 | Experimental long-distance quantum secure direct communication显示文摘Quantum secure direct communication(QSDC) is an important quantum communication branch, which realizes the secure information transmission directly without encryption and decryption processes.Recently, two table-top experiments have demonstrated the principle of QSDC. Here, we report the first long-distance QSDC experiment, including the security test, information encoding, fiber transmission and decoding. After the fiber transmission of 0.5 km, quantum state fidelities of the two polarization entangled Bell states are 91% and 88%, respectively, which are used for information coding. We theoretically analyze the performance of the QSDC system based on current optical communication technologies,showing that QSDC over fiber links of several tens kilometers could be expected. It demonstrates the potential of long-distance QSDC and supports its future applications on quantum communication networks. | Feng Zhu Wei Zhang Yubo Sheng Yidong Huang | 2017 | Science Bulletin2017，62，22： | 25 |
| 4 | 母系遗传药物性聋与非综合征性聋大家系与基因突变的研究显示文摘目的对一个氨基糖甙类药物性聋和非综合征聋的母系遗传性中国大家系进行遗传学分析,并发现全新的线粒体DNAC1494T突变。方法征集该家系中成员进行听力学检查,并收集提取DNA进行线粒体DNAPCR扩增分析,对其主要成员建立传代细胞系进行氨基糖甙类抗生素敏感试验和细胞氧消耗率检测。结果在没有接受氨基糖甙类抗生素时,一些母系遗传的成员表现为迟发/进行性听力下降,其程度不等,平均发病年龄自55岁(第2代)逐渐提前到10岁(第5代)。氨基糖甙类抗生素可导致母系成员听力下降,而且接受药物的年龄似乎与听力下降程度有关。对该家系成员进行线粒体DNA测序发现高度保守的12SrRNA中1494位点C突变为T(C1494T),可以形成新的U1494-1555A碱基对,与耳聋有关的A1555G突变所造成的C1494-1555G碱基对结构相类似。当培养液中含有氨基糖甙类抗生素时,携带C1494T突变的4名听力遗传者和2名听力正常成员所建立的传代淋巴细胞系的细胞倍增时间显著延长,并且其细胞氧消耗总量显著降低。结论线粒体12SrRNA的A点是氨基糖甙类药物性聋的主要作用位点,而细胞核背景在氨基糖甙类药物性聋的发病中有重要作用,对C1494T突变的相关的耳聋发病中也有重要作用。 | 赵辉 李荣华 王秋菊 严庆丰 Jian-Hong Deng 韩东一 Yidong Bai 杨伟炎 管敏鑫 | 2005 | 中华耳科学杂志2005，3，1： | 23 |
| 5 | Occurrence and Fate of Antibiotics in the Aqueous Environment and Their Removal by Constructed Wetlands in China: A review显示文摘Overuse of antibiotics has become a serious ecological problem worldwide.There is growing concern that antibiotics are losing their effectiveness due to an increased antibiotic resistance in bacteria.During the last twenty years,consumption of antibiotics has increased rapidly in China,which has been cited as one of the world's worst abusers of antibiotics.This review summarizes the current state of antibiotic contamination in China's three major rivers(the Yangtze River,Yellow River,and Pearl River) and illustrates the occurrence and fate of antibiotics in conventional municipal wastewater treatment plants(WWTPs).The analytical data indicate that traditional WWTPs cannot completely remove these concerned pharmaceuticals,as seen in the large difference between the distribution coefficient(K_d) and the uneven removal efficiency of various types of antibiotics.Although constructed wetlands(CWs)offer a potential way to remove these antibiotics from water supplies,knowledge of their mechanisms is limited.There are four main factors affecting the performance of CWs used for the treatment of antibiotics in water supplies,the types and configurations of CWs,hydraulic load rates,substrates,and plants and microorganisms.Further researches focusing on these factors are needed to improve the removal efficiency of antibiotics in CWs. | GUAN Yidong WANG Bo GAO Yongxia LIU Wen ZHAO Xiaoli HUANG Xiaofeng YU Jianghuai | 2017 | Pedosphere2017，27，1： | 22 |
| 6 | Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis显示文摘在源于 mitochondrial 机能障碍的氧化 phosphorylation 的改变长被假设了涉及 tumorigenesis。线粒体最近被显示了在调整规划房间死亡和房间增长起一个重要作用。而且, mitochondrial DNA (mtDNA ) 变化在各种各样的癌症房间被发现了。然而,在 tumorigenesis 的这些 mtDNA 变化的角色仍然保持大部分未知。这评论集中于基本 mitochondrial 遗传, mtDNA 变化和与癌症联系的结果的 mitochondrial 机能障碍。潜在的分子的机制,调停从 mtDNA 变化的致病和到 tumorigenesis 的 mitochondrial 机能障碍也被讨论。 | Jianxin Lu Lokendra Kumar Sharma Yidong Bai | 2009 | Cell Research2009，19，7： | 18 |
| 7 | The Possibility and Molecular Mechanisms of Cell Pyroptosis After Cerebral Ischemia显示文摘Introduction Stroke is an important disease that is prevalent worldwide [1-3].Ischemic stroke accounts for 80%of stroke cases. Currently,evidence-based effective treatments for ischemic stroke are limited,and only intravenous throm- bolysis with Alteplase (a commercially available throm- bolytic agent)within 4.5 h of stroke onset and thrombectomy and arterial thrombolysis within 6-24h of onset are effective [4,5].However,because these two treatments have strict indications and certain risks (reper- fusion injury and bleeding)[5-8],there is an urgent need to develop new treatment methods.Thus,comprehensive elucidation of the molecular mechanisms underlying ischemic brain damage and the search for key signaling pathways and protein molecules are important for guiding the clinical treatment of ischemic stroke. | Zhaofei Dong Kuang Pan Jingrui Pan Qingxia Peng Yidong Wang | 2018 | Neuroscience Bulletin2018，34，6： | 17 |
| 8 | Current and future editing reagent delivery systems for plant genome editing显示文摘Many genome editing tools have been developed and new ones are anticipated; some have been extensively applied in plant genetics, biotechnology and breeding, especially the CRISPR/Cas9 system. These technologies have opened up a new era for crop improvement due to their precise editing of user-specified sequences related to agronomic traits. In this review, we will focus on an update of recent developments in the methodologies of editing reagent delivery, and consider the pros and cons of current delivery systems. Finally, we will reflect on possible future directions. | Yidong Ran Zhen Liang Caixia Gao | 2017 | Science China(Life Sciences)2017，60，5： | 16 |
| 9 | Single-cell transcriptome analysis of the novel coronavirus (SARS-CoV-2) associated gene ACE2 expression in normal and non-obstructive azoospermia (NOA) human male testes显示文摘Being infected by SARS-CoV-2 may cause damage to multiple organs in patients, such as the lung, liver and heart. Angiotensin-converting enzyme 2(ACE2), reported as a SARS-CoV-2 receptor, is also expressed in human male testes. This suggests a potential risk in human male reproductive system. However, the characteristics of ACE2-positive cells and the expression of other SARS-CoV-2 process-related genes are still worthy of further investigation. Here, we performed singlecell RNA seq(scRNA-seq) analysis on 853 male embryo primordial germ cells(PGCs) and 2,854 normal testis cells to assess the effects of the SARS-CoV-2 virus on the male reproductive system from embryonic stage to adulthood. We also collected and constructed the scRNA-seq library on 228 Sertoli cells from three non-obstructive azoospermia(NOA) patients to assess the effects at disease state. We found that ACE2 expressing cells existed in almost all testis cell types and Sertoli cells had highest expression level and positive cells ratio. Moreover, ACE2 was also expressed in human male PGCs. In adulthood, the level of ACE2 expression decreased with the increase of age. We also found that ACE2 positive cells had high expressions of stress response and immune activation-related genes. Interestingly, some potential SARS-CoV-2 process-related genes such as TMPRSS2, BSG, CTSL and CTSB had different expression patterns in the same cell type. Furthermore, ACE2 expression level in NOA donors’ Sertoli cells was significantly decreased. Our work would help to assess the risk of SARS-CoV-2 infection in the male reproductive system. | Xixi Liu Yidong Chen Wenhao Tang Li Zhang Wei Chen Zhiqiang Yan Peng Yuan Ming Yang Siming Kong Liying Yan Jie Qiao | 2020 | Science China(Life Sciences)2020，63，7： | 14 |
| 10 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 11 | Characteristics of secondary inorganic aerosol and sulfate species in size-fractionated aerosol particles in Shanghai显示文摘Sulfate, nitrate and ammonium(SNA) are the dominant species in secondary inorganic aerosol, and are considered an important factor in regional haze formation. Size-fractionated aerosol particles for a whole year were collected to study the size distribution of SNA as well as their chemical species in Shanghai. SNA mainly accumulated in fine particles and the highest average ratio of SNA to particulate matter(PM) was observed to be 47% in the fine size fraction(0.49–0.95 μm). Higher sulfur oxidation ratio and nitrogen oxidation ratio values were observed in PM of fine size less than 0.95 μm. Ion balance calculations indicated that more secondary sulfate and nitrate would be generated in PM of fine size(0.49–0.95 μm). Sulfur K-edge X-ray absorption near-edge structure(XANES) spectra of typical samples were analyzed. Results revealed that sulfur mainly existed as sulfate with a proportion(atomic basis) more than 73% in all size of PM and even higher at 90% in fine particles. Sulfate mainly existed as(NH4)2SO4 and gypsum in PM of Shanghai. Compared to non-haze days, a dramatic increase of(NH4)2SO4 content was found in fine particles on haze days only, which suggested the promoting impact of(NH4)2SO4 on haze formation. According to the result of air mass backward trajectory analysis, more(NH4)2SO4 would be generated during the periods of air mass stagnation. Based on XANES, analysis of sulfate species in size-fractionated aerosol particles can be an effective way to evaluate the impact of sulfate aerosols on regional haze formation. | Shilei Long Jianrong Zeng Yan Li Liangman Bao Lingling Cao Ke Liu Liang Xu Jun Lin Wei Liu Guanghua Wang Jian Yao Chenyan Ma Yidong Zhao | 2014 | Journal of Environmental Sciences2014，26，5： | 10 |
| 12 | Sulfur speciation and bioaccumulation in camphor tree leaves as atmospheric sulfur indicator analyzed by synchrotron radiation XRF and XANES显示文摘Analyzing and understanding the effects of ambient pollution on plants is getting more and more attention as a topic of environmental biology.A method based on synchrotron radiation X-ray fluorescence and X-ray absorption near edge structure spectroscopy was established to analyze the sulfur concentration and speciation in mature camphor tree leaves (CTLs),which were sampled from 5 local fields in Shanghai,China.Annual SO2 concentration,SO42-concentration in atmospheric particulate,SO42-and sulfur concentration in soil were also analyzed to explore the relationship between ambient sulfur sources and the sulfur nutrient cycling in CTLs.Total sulfur concentration in mature camphor tree leaves was 766-1704 mg/kg.The mainly detected sulfur states and their corresponding compounds were +6 (sulfate,include inorganic sulfate and organic sulfate),+5.2 (sulfonate),+2.2 (suloxides),+0.6 (thiols and thiothers),+0.2 (organic sulfides).Total sulfur concentration was strongly correlated with sulfate proportion with a linear correlation coefficient up to 0.977,which suggested that sulfur accumulated in CTLs as sulfate form.Reduced sulfur compounds (organic sulfides,thiols,thioethers,sulfoxide and sulfonate) assimilation was sufficed to meet the nutrient requirement for growth at a balanced level around 526 mg/kg.The sulfate accumulation mainly caused by atmospheric sulfur pollution such as SO2 and airborne sulfate particulate instead of soil contamination.From urban to suburb place,sulfate in mature CTLs decreased as the atmospheric sulfur pollution reduced,but a dramatic increase presented near the seashore,where the marine sulfate emission and maritime activity pollution were significant.The sulfur concentration and speciation in mature CTLs effectively represented the long-term biological accumulation of atmospheric sulfur pollution in local environment. | Jianrong Zeng Guilin Zhang Liangman Bao Shilei Long Mingguang Tan Yan Li Chenyan Ma Yidong Zhao | 2013 | Journal of Environmental Sciences2013，25，3： | 9 |
| 13 | Hydrogen evolution and electromigration in the corrosion of aluminium metal sheath inside high‐voltage cables显示文摘The urgent need for power transmission is the reason for leading research on the safer operation of high‐voltage cables.These high‐voltage cables are emerging as an efficient technology for underground power transmission.However,the electrochemical corrosion of aluminium(Al)metal sheaths in these cables is a common and challenging degradation process.Herein,the corrosion mechanisms and electrochemical analysis are investigated by using scanning electron microscopy(SEM),Fourier transform infrared spectroscopy(FTIR),electrochemical impedance spectroscopy(EIS)and laboratory‐designed electro-chemical characterisation techniques.In the corrosion experiments,the authors evaluated the corrosion rate by measuring the release rate of hydrogen gas and explored the different roles of sodium polyacrylate(NaPA)during the corrosion process.It is found that the complexation reactions between NaPA and Al inhibited corrosion while increased the resistance of the buffer layer.The proposed mechanisms of corrosion in this study can improve the lifespan and sustainability of high‐voltage power transmission. | Yidong Chen Kai Zhou Jiamin Kong Shakeel Akram Xiancheng Ren Xiaoshan Zhang Yuan Li Qi Zhao | 2022 | High Voltage2022，7，2： | 7 |
| 14 | Whole-genome sequencing to detect mutations associated with resistance to insecticides and Bt proteins in Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a major pest native to the Americas that has recently invaded the Old World.Point mutations in the target-site proteins acetylcholinesterase-1(ace-1),voltage-gated sodium channel(VGSC)and ryanodine receptor(RyR)have been identified in S.frugiperda as major resistance mechanisms to organophosphate,pyrethroid and diamide insecticides respectively.Mutations in the adenosine triphosphate-binding cassette transporter C2 gene(ABCC2)have also been identified to confer resistance to Cry IF protein.In this study,we applied a whole-genome sequencing(WGS)approach to identify point mutations in the target-site genes in 150 FAW individuals collected from China,Malawi,Uganda and Brazil.This approach revealed three amino acid substitutions(A201S,G227A and F290V)of S.frugiperda ace-1,which are known to be associated with organophosphate resistance.The Brazilian population had all three ace-1 point mutations and the 227A allele(mean frequency=0.54)was the most common.Populations from China,Malawi and Uganda harbored two of the three ace-1 point mutations(A201S and F290V)with the 290V allele(0.47-0.58)as the dominant allele.Point mutations in VGSC(T929I,L932F and L1014F)and RyR(I4790M and G4946E)were not detected in any of the 150 individuals.A novel 12-bp insertion mutation in exon 15 of the ABCC2 gene was identified in some of the Brazilian individuals but absent in the invasive populations.Our results not only demonstrate robustness of the WGS-based genomic approach for detection of resistance mutations,but also provide insights for improvement of resistance management tactics in S.frugiperda. | Fang Guan Jianpeng Zhang Huiwen Shen Xingliang Wang Amanda Padovan Tom K.Walsh Wee Tek Tay Karl H.J.Gordon William James Cecilia Czepak Michael Hilary Otim Donald Kachigamba Yidong Wu | 2021 | Insect Science2021，28，3： | 6 |
| 15 | Methods for optical phase retardation measurement:A review显示文摘Optical-phase-retardation elements are widely used in many fields.Accurate measurement of their phase retardation is crucial to the practical effect of the element's processing and application.The development and present situation of the methods for optical phase retardation measurement are reviewed,with the wave plate,the most typical phase-retardation element,as an example.The latest research progress in this field is introduced;the principles and characteristics of individual measurement method are summarized and discussed.Three new methods based on laser frequency splitting or laser feedback are presented in detail,in which the laser is not only regarded as a light source but also plays a role of sensor.Moreover,no standard wave plates are needed and arbitrary phase retardation can be measured.Traceability,high precision and high repeatability are achieved as well. | ZHANG Peng TAN YiDong LIU WeiXin CHEN WenXue | 2013 | Science China(Technological Sciences)2013，56，5： | 6 |
| 16 | Ketamine induces tau hyperphosphorylation at serine 404 in the hippocampus of neonatal rats显示文摘Male Wistar 7-day-old rats were injected with 40 mg/kg ketamine intraperitoneally, followed by three additional injections of 20 mg/kg ketamine each upon restoration of the righting reflex. Neonatal rats injected with equivalent volumes of saline served as controls. Hippocampal samples were collected at 1, 7 or 14 days following administration. Electron microscopy showed that neuronal structure changed noticeably following ketamine treatment. Specifically, microtubular structure became irregular and disorganized. Quantitative real time-PCR revealed that phosphorylated tau mRNA was upregulated after ketamine. Western blot analysis demonstrated that phosphorylated tau levels at serine 396 initially decreased at 1 day after ketamine injection, and then gradually returned to control values. At 14 days after injection, levels of phosphorylated tau were higher in the ketamine group than in the control group. Tau protein phosphorylated at serine 404 significantly increased after ketamine injection, and then gradually decreased with time. However, the levels of tau protein at serine 404 were significantly greater in the ketamine group than in the control group until 14 days. The present results indicate that ketamine induces an increase of phosphorylated tau mRNA and excessive phosphorylation of tau protein at serine 404, causing disruption of microtubules in the neonatal rat hippocampus and potentially resulting in damage to hippocampal neurons. | Haiyan Jin Zhiyong Hu Mengjie Dong Yidong Wu Zhirui Zhu Lili Xu | 2013 | Neural Regeneration Research2013，8，17： | 5 |
| 17 | Pore structure of selected Chinese coals with heating and pressurization treatments显示文摘Pore structure of Chinese coals with heating and pressurization treatments was studied using small angle X-ray scattering(SAXS),N2adsorption/desorption isotherms and scanning electron microscope(SEM).SAXS was performed for some samples after heat treatment at seven elevated temperatures from 25 to 250°C at 0 MPa and for other samples with hydrostatic pressure treatment at 0,5,10,15 and 20 MPa at the room temperature.The results show that N2adsorption isotherm together with SAXS could be a comprehensive method to evaluate the pore shape and the pore size distribution:the pore shapes are generally spherical for low rank coal and they are mainly ellipsoidal for high rank coal.All these measurements were then interpreted using the fractal theory to reveal relationship between surface fractals and coal rank,and the evolution of surface fractals under heating and pressurization treatments.The results show that surface fractal dimension(Ds)changes with different treating temperature and pressure and maximum vitrinite reflectance(Ro,m).Especially in the bituminous stage,Ds shows an increasing trend with Ro,m under varied temperatures.Moreover,Ds shows an increasing trend with increasing temperature before 200°C,and a decreasing trend after 200°C.Furthermore,the results show that Ds has a more complex relationship with Ro,m under varied treating temperature than that under varied treating pressure. | CAI YiDong LIU DaMeng PAN ZheJun YAO YanBin LI JunQian QIU YongKai | 2014 | Science China Earth Sciences2014，57，7： | 5 |
| 18 | The China Space Station:a new opportunity for space science显示文摘The space station is a large-scale and comprehensive research facility capable of long-term human habitation in near-Earth space,with systematic support by space transport and widely covered tracking,telemetry,command and communication.It allows extensive and long-term research under the special conditions of space and responds to urgent scientific needs in space in a timely manner. | Yidong Gu | 2022 | National Science Review2022，9，1： | 5 |
| 19 | Study on pneumatic-fuel hybrid system based on waste heat recovery from cooling water of internal combustion engine显示文摘The paper proposes a novel pneumatic-fuel hybrid system,which combines a traditional internal combustion engine(ICE)and a pneumatic engine.One important merit of this concept is that the system can recover waste from cooling water of internal combustion engine to optimize the working process of pneumatic engine,and thus to improve the entire efficiency of the hybrid system.Meanwhile,energy-saving effect due to lower cooling fan power can be achieved on ICE by waste heat recovery of pneumatic engine.Based on thermodynamic analysis,an experimental system is designed and established for verification.The experimental results show that the performance of pneumatic engine is improved when the waste heat recovery concept of the hybrid system is applied.Then an application example on a 4-cylinder engine is analyzed and discussed using numerical simulation.The results show that the fan power of the ICE cooling system can be saved up to 50%by applying the hybrid system.Considering the appreciable improvements on the energy efficiency with only limited system modifications when the concept is applied to traditional ICE based power systems,the proposed hybrid concept has the potential to serve as an alternative technology aiming for energy saving and emission reduction. | FANG YiDong LI DaoFei FAN ZhiPeng XU HuanXiang WANG Lei YU XiaoLi | 2013 | Science China(Technological Sciences)2013，56，12： | 5 |
| 20 | Ki-67 index,progesterone receptor expression,histologic grade and tumor size in predicting breast cancer recurrence risk:A consecutive cohort study显示文摘Background:The 21-gene recurrence score(RS)assay has been recommended by major guidelines for treatment decision in hormone receptor(HR)-positive early breast cancer(EBC).However,the genomic assay is not accessible and affordable worldwide.Alternatively,an increasing number of studies have shown that traditional immunohistochemistry(IHC)can partially or even completely replace the role of the 21-gene genomic assay.Here,we developed and validated a predictive model(IHC3 model)combining the Ki-67 index,progesterone receptor(PR)expression,histologic grade,and tumor size to predict the recurrence risk of HR-positive EBC.Methods:The data from 389 patients(development set)with HR-positive,human epidermal growth factor receptor 2-negative,lymph node non-metastasized invasive breast cancer were used to construct the IHC3 model based on the Surexam®21-gene RS and the TAILORx clinical trial criteria.An additional 146 patients with the same characteristics constituted the validation set.The predictive accuracy of the IHC3 model was compared with that of Orucevic et al.’s nomogram.Invasive diseasefree survival(IDFS)was analyzed in the IHC3 predictive low-recurrence risk(pLR)group and the predictive high-recurrence risk(pHR)group.The Pearson chi-square test,Fisher exact test,and log-rank test were used for analysis.Results:The pLR and pHR group could be easily stratified using the decision tree model without network dependence.The accuracies of the IHC3 model were 86.1%in the development set and 87.7%in the validation set.The predictive accuracy of the IHC3 model and Orucevic et al.’s nomogram for the whole cohort was 86.5%and 86.9%,respectively.After a 52-month of median follow-up,a significant difference was found in IDFS between of the IHC3 pLR and the pHR groups(P=0.001)but not in the IDFS between the low-and high-recurrence risk groups according to the Surexam®21-gene RS and the TAILORx clinical trial criteria(P=0.556)or 21-gene binary RS group(P=0.511).Conclusions:The proposed IHC3 model could reliably predict low and high recurrence risks in most HR-positive EBC patients.This easy-to-use predictive model may be a reliable replacement for the 21-gene genomic assay in patients with EBC who have no access to or cannot afford the 21-gene genomic assay. | Yanna Zhang Yidong Zhou Feng Mao Ru Yao Qiang Sun | 2020 | Cancer Communications2020，40，4： | 5 |
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