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| 1 | Analysis of long-term variations of fog and haze in China in recent 50 years and their relations with atmospheric humidity显示文摘Our analysis of fog and haze observations from the surface weather stations in China in recent 50 years(from 1961 to 2011)shows that the number of fog days has experienced two-stage variations,with an increasing trend before 1980 and a decreasing trend after 1990.Especially,an obvious decreasing trend after 1990 can be clearly seen,which is consistent with the decreasing trend of the surface relative humidity.However,the number of haze days has demonstrated an increasing trend.As such,the role of reduction of atmospheric relative humidity in the transition process from fog into haze has been further investigated.It is estimated that the mean relative humidity of haze days is about 69%,lower than previously estimated,which implies that it is more difficult for the haze particles to transform into fog drops.This is possibly one of the major environmental factors leading to the reduction of number of fog days.The threshold of the relative humidity for transition from fog into haze is about82%,also lower than previously estimated.Thus,the reduction of the surface relative humidity in China mainly due to the increase of the surface temperature and the saturation specific humidity may exert an obvious impact on the environmental conditions for the formations of fog and haze.In addition,our investigation of the relationship between haze and visibility reveals that with the increase of haze days,the visibility has declined markedly.Since 1961,the mean visibility has dropped from 4–10to 2–4 km,about a half of the previous horizontal distance of visibility. | DING YiHui LIU YanJu | 2014 | Science China Earth Sciences2014，57，1： | 75 |
| 2 | Atmospheric Circulation and Dynamic Mechanism for Persistent Haze Events in the Beijing–Tianjin–Hebei Region显示文摘In this study, regional persistent haze events(RPHEs) in the Beijing–Tianjin–Hebei(BTH) region were identified based on the Objective Identification Technique for Regional Extreme Events for the period 1980–2013. The formation mechanisms of the severe RPHEs were investigated with focus on the atmospheric circulation and dynamic mechanisms. Results indicated that:(1) 49 RPHEs occurred during the past 34 years.(2) The severe RPHEs could be categorized into two types according to the large-scale circulation, i.e. the zonal westerly airflow(ZWA) type and the high-pressure ridge(HPR) type. When the ZWA-type RPHEs occurred, the BTH region was controlled by near zonal westerly airflow in the mid–upper troposphere.Southwesterly winds prevailed in the lower troposphere, and near-surface wind speeds were only 1–2 ms^(-1). Warm and humid air originating from the northwestern Pacific was transported into the region, where the relative humidity was 70% to 80%, creating favorable moisture conditions. When the HPR-type RPHEs appeared, northwesterly airflow in the mid–upper troposphere controlled the region. Westerly winds prevailed in the lower troposphere and the moisture conditions were relatively weak.(3) Descending motion in the mid-lower troposphere caused by the above two circulation types provided a crucial dynamic mechanism for the formation of the two types of RPHEs. The descending motion contributed to a reduction in the height of the planetary boundary layer(PBL), which generated an inversion in the lower troposphere. This inversion trapped the abundant pollution and moisture in the lower PBL, leading to high concentrations of pollutants. | Ping WU Yihui DING Yanju LIU | 2017 | Advances in Atmospheric Sciences2017，34，4： | 58 |
| 3 | The impact of meteorological changes from 2013 to 2017 on PM2.5 mass reduction in key regions in China显示文摘In 2013,China issued the'Action Plan for the Prevention and Control of Air Pollution'('Ten Statements of Atmosphere')and implemented a series of pollution reduction measures from 2013 to 2017.In key regions of China,the mass concentrations of particulate matter with aerodynamic equivalent diameters less than 2.5μm(PM2.5)have dropped significantly.However,the contributions of meteorological changes to PM2.5 reduction are largely uncertain,which has attracted particular concern from the government and the public.Here,we investigated the impact of large-scale and boundary layer(BL)meteorological conditions on aerosol pollution and estimated the contributions of meteorological changes to PM2.5 reduction based on in-depth analysis and diagnosis of various observed meteorological elements and an integrated pollution-linked meteorological index(PLAM,which is approximately and linearly related to PM mass concentration).In this study,we found that the meteorological conditions worsened in 2014 and 2015 and improved in 2016 and 2017 relative to those in 2013 in key regions in China.In 2017 relative to 2013,only^5%(approximately 13%of the total PM2.5 decline)of the 39.6%reduction in PM2.5 mass concentrations can be attributed to meteorological changes in the Beijing-Tianjin-Hebei(BTH)region,and only^7%(approximately 20%of the total PM2.5 decline)of the 34.3%reduction can be attributable to meteorological changes in the Yangtze River Delta(YRD)region.Overall,the PM2.5 reduction due to meteorological improvement is much lower than the observed PM2.5 reduction in these areas,which indicates that emission reduction during the five-year implementation of the'Ten Statements of Atmosphere'is the dominant factor in the improvement in air quality.The changes in meteorology and climate are conducive to PM2.5 reduction but do not dominate the substantial improvement in air quality.Similar to the above regions,in the Pearl River Delta(PRD)region,the impact of meteorological changes on the annual averaged PM2.5 concentration from 2013 to2017 was relatively weak,and the PM2.5 reduction was mainly due to emission reductions.During winter 2017(January,February,and December of this year),the meteorological conditions improved-20%in the BTH region(observed total PM2.5reduction:40.2%)and-30%in the YRD region(observed total PM2.5 reduction:38.2%)relative to those in 2013,showing the meteorological factors played more important role in the decrease of PM2.5 in winter of these years in the two regions,respectively.The meteorological conditions in winter 2016 were 14%better than those in winter 2017,but the PM2.5 reduction in winter 2016 was still less than that in winter 2017,reinforcing the significant contributions of the increasing efforts to reduce PM2.5 emissions in 2017.The substantial progress of strict emission measures was also confirmed by a comparison of several persistent heavy aerosol pollution episodes(HPEs)with similar meteorological conditions.It is found that the decrease of PM2.5mass caused by emission reduction increases year by year,especially the decrease of PM2.5 concentration in 2016 and 2017.In China,HPEs mainly occur in winter,when meteorological conditions are approximately 40-100%worse than in other seasons.This worsening is partly due to the harbor effect of high topography,including downdrafts and the weak wind zone,and partly due to the increasingly stable regional BL structure caused by climate warming.For the formation of HPEs,it occurred under regional stagnant and stable conditions associated with upper-level circulation patterns,including the zonal westerly winds type and high-pressure ridges.After pollution formation,PM2.5 with mass accumulated to a certain degree can further worsen the BL meteorological conditions.The feedback effect associated with worsening conditions dominates PM2.5 mass explosive growth.In the context of high air pollutant emissions in China,unfavorable meteorological conditions are the necessary external conditions for the formation and accumulation of HPEs.Therefore,reducing aerosol pollution significantly during the earlier transport stage is critical in reducing persistent HPEs.Currently,even under favorable meteorological conditions,allowing emissions without restriction is also not advisable because aerosol pollution allowed to accumulate to a certain extent will significantly worsen the BL meteorological conditions and close the'meteorological channels'available for pollution dispersion. | Xiaoye ZHANG Xiangde XU Yihui DING Yanju LIU Hengde ZHANG Yaqiang WANG Junting ZHONG | 2019 | Science China Earth Sciences2019，62，12： | 42 |
| 4 | Decadal northward shift of the Meiyu belt and the possible cause显示文摘The feature of the decadal movement of the Meiyu belt and their association with East Asia atmospheric circulation for the period of 1979―2007 is examined in this study. It is shown that the Meiyu belt of China has a decadal shift in the late 1990s. There is a remarkable difference between the periods before and after 1999, with the Meiyu belt mainly located to the south of the Yangtze River valley before 1999, but afterward mainly located in the Huaihe River valley. At the same time, a distinctive tropospheric warming and stratospheric cooling trend is found in the mid-latitudes of East Asia, which causes the upper tropospheric pressure surfaces upward bulging and the tropoause elevated in the subtropics and associated widening of the subtropical area over East Asia. Accompanying the subtropics widening, the subtropical westerly jet over East Asia shifts northward and the East Asia tropical Hadley circulation expands poleward, which results in the northward shift of the Meiyu belt. | SI Dong DING YiHui LIU YanJu | 2009 | Chinese Science Bulletin2009，54，24： | 25 |
| 5 | Sinomenine ester derivative inhibits glioblastoma by inducing mitochondria-dependent apoptosis and autophagy by PI3K/AKT/mTOR and AMPK/mTOR pathway显示文摘Glioblastoma multiforme(GBM)in the central nervous system is the most lethal advanced glioma and currently there is no effective treatment for it.Studies of sinomenine,an alkaloid from the Chinese medicinal plant,Sinomenium acutum,showed that it had inhibitory effects on several kinds of cancer.Here,we synthesized a sinomenine derivative,sino-wcj-33(SW33),tested it for antitumor activity on GBM and explored the underlying mechanism.SW33 significantly inhibited proliferation and colony formation of GBM and reduced migration and invasion of U87 and U251 cells.It also arrested the cell cycle at G2/M phase and induced mitochondria-dependent apoptosis.Differential gene enrichment analysis and pathway validation showed that SW33 exerted anti-GBM effects by regulating PI3 K/AKT and AMPK signaling pathways and significantly suppressed tumorigenicity with no obvious adverse effects on the body.SW33 also induced autophagy through the PI3 K/AKT/mTOR and AMPK/mTOR pathways.Thus,SW33 appears to be a promising drug for treating GBM effectively and safely. | Xiangjin Zheng Wan Li Huanli Xu Jinyi Liu Liwen Ren Yihui Yang Sha Li Jinhua Wang Tengfei Ji Guanhua Du | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 6 | From MONEX to the Global Monsoon:A Review of Monsoon System Research显示文摘Substantial progress has been made over the past three decades since the Monsoon Experiments(MONEX) of 1978–79. Here, we review these achievements by highlighting four breakthroughs in monsoon research:(1) The identification of the coupled ocean–land–atmosphere nature of the monsoon in the process of the annual cycle of solar heating;(2) new understanding of the changes in the driving forces of monsoon systems, with anthropogenic factors(climate effects of increased greenhouse gas and aerosol emissions) playing an important role in the regulation of monsoons;(3) detection of the interdecadal- and centennial-scale variability of monsoon systems, and its attribution to the combined impact of global warming and natural(especially oceanic) effects; and(4) the emerging concept of the global monsoon and its long-term variation under the impact of global climate change. All the observational and model-derived evidence demonstrates that the monsoon system, as an important component of the global climate system, has already changed and will continue to change in the future. This picture of an evolving monsoon system poses great challenges for near-term prediction and long-term projection. | DING Yihui LIU Yanju SONG Yafang ZHANG Jin | 2015 | Advances in Atmospheric Sciences2015，32，1： | 14 |
| 7 | Anti-fibrotic role and mechanism of Periplaneta americana extracts in CCl4-induced hepatic fibrosis in rats显示文摘 | Dingchun Li Wu Li Yihui Chen Lihui Liu Dehong Ma Hongtu Wang Lu Zhang Shenjun Zhao Qin Peng | 2018 | Acta Biochimica et Biophysica Sinica2018，50，5： | 14 |
| 8 | Environmental and Dynamic Conditions for the Occurrence ofPersistent Haze Events in North China显示文摘This paper presents a concise summary of recent studies on the long-term variations of haze in NorthChina and on the environmental and dynamic conditions for severe persistent haze events. Resultsindicate that haze days have an obviously rising trend over the past 50 years in North China. Theoccurrence frequency of persistent haze events has a similar rising trend due to the continuous riseof winter temperatures, decrease of surface wind speeds, and aggravation of atmospheric stability. InNorth China, when severe persistent haze events occur, anomalous southwesterly winds prevail in thelower troposphere, providing sufficient moisture for the formation of haze. Moreover, North China ismainly controlled by a deep downdraft in the mid-lower troposphere, which contributes to reducing thethickness of the planetary boundary layer, obviously reducing the atmospheric capacity for pollutants.This atmospheric circulation and sinking motion provide favorable conditions for the formation andmaintenance of haze in North China. | Yihui Ding Ping Wu Yanju Liu Yafang Song | 2017 | Engineering2017，3，2： | 13 |
| 9 | Arbuscular Mycorrhizal Fungi in Wetland Habitats and Their Application in Constructed Wetland: A Review显示文摘Over the last three decades, the presence and functional roles of arbuscular mycorrhizal(AM) fungi in wetland habitats have received increasing attention. This review summarized the mycorrhizal status in wetlands and the effect of flooding on AM fungal colonization. Plants of 99 families living in 31 different habitats have been found to be associated with AM fungi, even including submerged aquatic plants and several plant species that were thought to be nonmycorrhizal(Cyperaceae, Chenopodiaceae, and Plumbaginaceae). The functions of AM fungi in wetland ecological systems could be concluded as their influences on the composition,succession, and diversity of the wetland plant community, and the growth and nutrition of wetland plants. Affecting the composition,succession, and diversity of the wetland plant community, AM fungi have positive, negative, or neutral effects on the performance of different wetland species under different conditions. The factors that affect the application effect of AM fungi in constructed wetland(CW) include flooding, phosphorus, plant species, aerenchyma, salinity, CW types, operation modes of CW, and wastewater quality.The generalist AM fungi strains can be established spontaneously, rapidly, and extensively in wastewater bioremediation technical installations; therefore, AM fungi can be considered ideal inhabitants of technical installations for the plant-based bioremediation of groundwater contaminated by organic pollutants or other contaminants. In the future, roles of AM fungi and factors that affect the purifying capacity of AM-CW system must be understood to optimize CW ecosystem. | XU Zhouying BAN Yihui JIANG Yinghe ZHANG Xiangling LIU Xiaoying | 2016 | Pedosphere2016，26，5： | 12 |
| 10 | Combined treatment with erythropoietin and granulocyte colony-stimulating factor enhances neovascularization and improves cardiac function after myocardial infarction显示文摘 | Xue Jingyi Du Guoqing Shi Jing Li Yue Masahiro Yasutake Liu Lei Li Jianqiang Kong Yihui Wang Shuxian Yun Fengxiang Li Weimin | 2014 | Chinese Medical Journal2014，，9： | 12 |
| 11 | The Record-breaking Mei-yu in 2020 and Associated Atmospheric Circulation and Tropical SST Anomalies显示文摘The record-breaking mei-yu in the Yangtze-Huaihe River valley(YHRV)in 2020 was characterized by an early onset,a delayed retreat,a long duration,a wide meridional rainbelt,abundant precipitation,and frequent heavy rainstorm processes.It is noted that the East Asian monsoon circulation system presented a significant quasi-biweekly oscillation(QBWO)during the mei-yu season of 2020 that was associated with the onset and retreat of mei-yu,a northward shift and stagnation of the rainbelt,and the occurrence and persistence of heavy rainstorm processes.Correspondingly,during the mei-yu season,the monsoon circulation subsystems,including the western Pacific subtropical high(WPSH),the upper-level East Asian westerly jet,and the low-level southwesterly jet,experienced periodic oscillations linked with the QBWO.Most notably,the repeated establishment of a large southerly center,with relatively stable latitude,led to moisture convergence and ascent which was observed to develop repeatedly.This was accompanied by a long-term duration of the mei-yu rainfall in the YHRV and frequent occurrences of rainstorm processes.Moreover,two blocking highs were present in the middle to high latitudes over Eurasia,and a trough along the East Asian coast was also active,which allowed cold air intrusions to move southward through the northwestern and/or northeastern paths.The cold air frequently merged with the warm and moist air from the low latitudes resulting in low-level convergence over the YHRV.The persistent warming in the tropical Indian Ocean is found to be an important external contributor to an EAP/PJ-like teleconnection pattern over East Asia along with an intensified and southerly displaced WPSH,which was observed to be favorable for excessive rainfall over YHRV. | Yihui DING Yunyun LIU Zeng-Zhen HU | 2021 | Advances in Atmospheric Sciences2021，38，12： | 11 |
| 12 | The 2016 Summer Floods in China and Associated Physical Mechanisms:A Comparison with 1998显示文摘The characteristics of droughts and floods in China during the summers(May–August)of 2016 and 1998 were compared in great detail,together with the associated atmospheric circulations and external-forcing factors.Following results are obtained.(1)The precipitation was mostly above normal in China in summer 2016,with two main rainfall belts located in the Yangtze River valley(YRV)and North China.Compared with 1998,a similar rainfall belt was located over the YRV,with precipitation 100%and more above normal.However,the seasonal processes of Meiyu were different.A typical'Secondary Meiyu'occurred in 1998,whereas dry conditions dominated the YRV in2016.(2)During May–July 2016,the Ural high was weaker than normal,but it was stronger than normal in 1998.This difference resulted from fairly different distributions of sea surface temperature anomalies(SSTAs)over the North Atlantic Ocean during the preceding winter and spring of the two years.(3)Nonetheless,tropical and subtropical circulation systems were much more similar in May–July of 2016 and 1998.The circulation systems in both years were characterized by a stronger than normal and more westward-extending western Pacific subtropical high(WPSH),a weaker than normal East Asian summer monsoon(EASM),and anomalous convergence of moisture flux in the mid and lower reaches of the YRV.These similar circulation anomalies were attributed to the similar tropical SSTA pattern in the preceding seasons,i.e.,the super El Ni?o and strong warming in the tropical Indian Ocean.(4)Significant differences in the circulation pattern were observed in August between the two years.The WPSH broke up in August 2016,with its western part being combined with the continental high and persistently dominating eastern China.The EASM suddenly became stronger,and dry conditions prevailed in the YRV.On the contrary,the EASM was weaker in August 1998 and the'Secondary Meiyu'took place in the YRV.The Madden–Julian Oscillation(MJO)was extremely active in August 2016 and stayed in western Pacific for 25 days.It triggered frequent tropical cyclone activities and further influenced the significant turning of tropical and subtropical circulations in August2016.In contrast,the MJO was active over the tropical Indian Ocean in August 1998,conducive to the maintenance of a strong WPSH.Alongside the above oceanic factors and atmospheric circulation anomalies,the thermal effect of snow cover over the Qinghai–Tibetan Plateau from the preceding winter to spring in 2016 was much weaker than that in 1998.This may explain the relatively stronger EASM and more abundant precipitation in North China in 2016than those in 1998. | Yuan YUAN Hui GAO Weijing LI Yanju LIU Lijuan CHEN Bin ZHOU Yihui DING | 2017 | Journal of Meteorological Research2017，31，2： | 11 |
| 13 | Design of sandwich-structured ZnO/ZnS/Au photoanode for enhanced efficiency of photoelectrochemical wate splitting显示文摘We developed and demonstrated a ZnO/ZnS/Au composite photoanode with significantly enhanced photoelectrochemical water-splitting performance, con- taining a ZnS interlayer and Au nanoparticles. The solar-to-hydrogen conversion efficiency of this ZnO/ZnS/Au heterostructure reached 0.21%, 3.5 times that of pristine ZnO. The comparison of the incident photon-to-current efficiency (IPCE) and the photoresponse in the white and visible light regions further verified that the enhancement resulted from contributions of both UV and visible light. The modification of the Au NPs was shown to improve the photoelectrochemical (PEC) performance to both UV and visible light, as modification encouraged effective surface passivation and surface-plasmon- resonance effects. The ZnS interlayer favored the movement of photogenerated electrons under UV light and hot electrons under visible light, causing their injection into ZnO; this simultaneously suppressed the electron-hole recombination at the photoanode-electrolyte interface. The optimized design of the interlayer within plasmonic metal/semiconductor composite systems, as reported here, provided a facile and compatible photoelectrode configuration, enhancing the utilization efficiency of incident light for photoelectrochemical applications. | Yichong Liu Yousong Gu Xiaoqin Yan Zhuo Kang Shengnan Lu Yihui Sun Yue Zhang | 2015 | Nano Research2015，8，9： | 10 |
| 14 | TNF-α suppresses sweat gland differentiation of MSCs by reducing FTO-mediated m^6 A-demethylation of Nanog mRNA显示文摘An effect of inhibition of tumor necrosis factor-α(TNF-α)on differentiation of mesenchymal stromal cells(MSCs)has been demonstrated,but the exact mechanisms that govern MSCs differentiation remain to be further elucidated.Here,we show that TNF-αinhibits the differentiation of MSCs to sweat glands in a specific sweat gland-inducing environment,accompanied with reduced expression of Nanog,a core pluripotency factor.We elucidated that fat mass and obesity-associated protein(FTO)-mediated m^6 A demethylation is involved in the regulation of MSCs differentiation potential.Exposure of MSCs to TNF-αreduced expression of FTO,which demethylated Nanog m RNA.Reduced expression of FTO increased Nanog m RNA methylation,decreased Nanog m RNA and protein expression,and significantly inhibited MSCs capacity for differentiation to sweat gland cells.Our finding is the first to elucidate the functional importance of m^6 A modification in MSCs,providing new insights that the microenvironment can regulate the multipotency of MSCs at the post-transcriptional level.Moreover,to maintain differentiation capacity of MSCs by regulating m^6 A modification suggested a novel potential therapeutic target for stem cellmediated regenerative medicine. | Yihui Wang Rui Wang Bin Yao Tian Hu Zhao Li Yufan Liu Xiaoli Cui Liuhanghang Cheng Wei Song Sha Huang Xiaobing Fu | 2020 | Science China(Life Sciences)2020，63，1： | 9 |
| 15 | Inter-decadal variations,causes and future projection of the Asian summer monsoon显示文摘The present paper presents a concise summary of our recent studies on the Asian summer monsoon,with highting decadal and inter- decadal scales. The studies on the long- term variations of the Asian summer monsoon and its impacts on the change in the summer precipitation in China are reviewed. Moreover,recent changes in the Asian summer monsoon and summer precipitation in East Asia(including Meiyu precipitation)are discussed. Finally,the future changes of the Asian summer monsoon are also pointed out in this paper. | Ding Yihui Si Dong Sun Ying Liu Yanju Song Yafang | 2014 | Engineering Sciences2014，12，2： | 8 |
| 16 | Tropospheric biennial oscillation of the western Pacific subtropical high and its relationships with the tropical SST and atmospheric circulation anomalies显示文摘There is the significant period of tropospheric biennial Oscillation(TBO)over East Asian monsoon region at the interannual timescales,which has the important influences on East China climate.Based on a set of reconstructed indices which describes the western Pacific subtropical high(WPSH)objectively,this paper focuses on the TBO component of WPSH,one of the key members of the East Asian Monsoon system,and its relationships with the tropical SST and atmospheric circulation anomalies.It is found that(1)As an important interannual component of WPSH,the time series of TBO has the obvious transition in the late1970s,and the variability of the WPSH’s TBO component is more significant after the late 1970s.(2)The time-lag correlations between the WPSH’s TBO and the tropical sea surface temperature(SST)anomalies in several key ocean regions are more significant and have longer correlation duration than the raw data.The response of the western boundary index to ENSO is earlier than the intensity index,and the time-lag correlations of them are up to maximum when lagging ENSO by 3–5 months and 5–6months,respectively.(3)In the course of the WPSH’s TBO cycle,the occurrence of the El Ni o-like anomaly in the tropical central-eastern Pacific in winter is always coupled with the weak East Asian winter monsoon,with the most significant enhancing phase of the WPSH’TBO.In contrast,the La Ni a-like anomaly in the central-eastern Pacific in winter is coupled with the strong East Asian winter monsoon,with the most weakening phase of the WPSH’s TBO.(4)The distribution of the tropical SST and atmospheric circulations anomalies are asymmetric in the TBO cycle.The WPSH’s TBO is more significant in the period of the developing El Ni o-like anomaly in central-eastern Pacific than in the period of the developing La Ni a-like anomaly.Therefore,during the period of developing El Ni o-like anomaly,more attention should be paid to the interannual component of TBO signal in the short-term climate prediction. | LIU YunYun DING YiHui GAO Hui LI WeiJing | 2013 | Chinese Science Bulletin2013，58，30： | 8 |
| 17 | Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma显示文摘Chemotherapy is among the limited choices approved for the treatment of hepatocellular carcinoma(HCC) at intermediate and advanced stages. Preferential and prolonged drug exposure in diseased sites is required to maximize the therapeutic index of the drug. Here, we report an injectable supramolecular peptide hydrogel as an intraperitoneal depot for localized and sustained release of triptolide for the treatment of orthotopic HCC. We chose peptide amphiphile C16-GNNQQNYKD-OH-based nanofibers as gelators and carriers for triptolide. Sustained triptolide release from the hydrogel was achieved over 14 days in vitro, with higher accumulation in and cytotoxicity against human HCC Bel-7402 in comparison with L-02 fetal hepatocytes. After intraperitoneal injection, the hydrogel showed prolonged retention over 13 days and preferential accumulation in the liver, realizing HCC growth inhibition by99.7 ± 0.1% and animal median survival extension from 19 to 43 days, without causing noticeable pathological changes in the major organs. These results demonstrate that injectable peptide hydrogel can be a potential carrier for localized chemotherapy of HCC. | Xiyue Zhao Xiaoyu Liu Pengcheng Zhang Yiran Liu Wei Ran Ying Cai Junyang Wang Yihui Zhai Guanru Wang Yaping Ding Yaping Li | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 7 |
| 18 | Methods of computed tomography screening and management of lung cancer in Tianjin: design of a population-based cohort study显示文摘Objective: European lung cancer screening studies using computed tomography(CT) have shown that a management protocol based on measuring lung nodule volume and volume doubling time(VDT) is more specific for early lung cancer detection than a diameter-based protocol. However, whether this also applies to a Chinese population is unclear. The aim of this study is to compare the diagnostic performance of a volume-based protocol with a diameter-based protocol for lung cancer detection and optimize the nodule management criteria for a Chinese population.Methods: This study has a population-based, prospective cohort design and includes 4000 participants from the Hexi district of Tianjin, China. Participants will undergo low-dose chest CT at baseline and after 1 year. Initially, detected lung nodules will be evaluated for diameter and managed according to a routine diameter-based protocol(Clinical Practice Guideline in Oncology for Lung Cancer Screening, Version 2.2018). Subsequently, lung nodules will be evaluated for volume and management will be simulated according to a volume-based protocol and VDT(a European lung nodule management protocol). Participants will be followed up for 4 years to evaluate lung cancer incidence and mortality. The primary outcome is the diagnostic performance of the European volume-based protocol compared to diameter-based management regarding lung nodules detected using low-dose CT.Results: The diagnostic performance of volume-and diameter-based management for lung nodules in a Chinese population will be estimated and compared.Conclusions: Through the study, we expect to improve the management of lung nodules and early detection of lung cancer in Chinese populations. | Yihui Du Yingru Zhao Grigory Sidorenkov Geertruida H.de Bock Xiaonan Cui Yubei Huang Monique D.Dorrius Mieneke Rook Harry J.M.Groen Marjolein A.Heuvelmans Rozemarijn Vliegenthart Kexin Chen Xueqian Xie Shiyuan Liu Matthijs Oudkerk Zhaoxiang Ye | 2019 | Cancer Biology & Medicine2019，16，1： | 7 |
| 19 | Electroacupuncture at Tianshu (ST 25) for diarrhea-predominant irritable bowel syndrome using positron emission tomography Changes in visceral sensation center显示文摘Previous studies have demonstrated that electroacupuncture therapy is effective in the treatment of irritable bowel syndrome. However, the precise mechanism of this therapy is unknown. The present study served to investigate the effects of electroacupuncture therapy on treatment of patients with diarrhea-predominant irritable bowel syndrome (IBS). We compared brain activation maps based on the changes of cerebral glucose metabolism obtained by 18-fluorodeoxyglucose positron emission tomography scanning under three conditions: resting, rectal balloon distension and rectal balloon distension plus electroacupuncture. Under the resting condition, compared with healthy controls, IBS patients displayed an increasing regional cerebral metabolic rate of glucose over a wide range: bilateral superior temporal gyrus, right middle occipital gyrus, superior frontal gyrus and bilateral middle frontal gyrus. However, there was no significant activity in the visceral pain center. Compared with the resting condition, under the rectal balloon distension condition, patients with IBS had a greater regional cerebral metabolic rate of glucose in the prefrontal cortex, left anterior cingulate cortex, postcentral gyrus, precentral gyrus and temporal gyrus. Under the rectal balloon distension plus electroacupuncture condition, stimulation by electroacupuncture at Tianshu (ST 25) manifested a decreased regional cerebral metabolic rate of glucose in the left cingulate gyrus, right insula, right caudate nucleus, fusiform gyrus and hippocampal gyrus. Electroacupuncture therapy relieved abdominal pain, distension or discomfort by decreasing glucose metabolism in the brain. | Huirong Liu Li Qi Xiaolong Wang Yihui Guan Chuantao Zuo Linying Tan Lingsong Yuan Xiaopeng Ma Xiaomei Wang Enhua Zhou Huangan Wu | 2010 | Neural Regeneration Research2010，5，16： | 6 |
| 20 | Arsenic trioxide encapsulated liposomes prepared via copper acetate gradient loading method and its antitumor efficiency显示文摘In this study, arsenic trioxide(ATO) was encapsulated in liposomes via copper acetate(Cu(OAc)2) gradients and high entrapment efficiency of over 80% was obtained. The average particle size and the zeta-potential of the liposomes were detected to be 115.1 ± 29.1 nm and-21.97 ± 0.6 m V, respectively. The TEM images showed rod-like precipitates in the inner aqueous phase, which was supposed be due to the formation of insoluble ATO–Cu complex.The in vitro drug release of ATO–Cu liposomes exhibited a sustained release over 72 h, and the release rates decreased with the increase of the p H of release media. Pharmacokinetic and tissue distribution studies of ATO liposomes showed significantly reduced plasma clearance rate, increased AUC0–12h and T1/2, and improved tumor distribution of As compared to iv administration of ATO solution. The anti-tumor effect of ATO loaded liposomes to S180 tumor-bearing mice was significantly improved with a tumor inhibition rate of 61.2%,meanwhile the toxicity of encapsulated ATO was greatly decreased. In conclusion, ATO can be effectively encapsulated into liposomes by remote loading method via Cu(OAc)2 gradients;the co-administration of ATO and Cu(Ⅱ) via liposomal formulation may find wide applications in the treatment of various tumors. | Shaoning Wang Chunxiu Liu Cunyang Wang Jia Ma Hui Xu Jianbo Guo Yihui Deng | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 6 |
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