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| 1 | Recent advances in hydrogel-based anti-infective coatings显示文摘Bacterial infections associated with biomedical devices and implants have posed a great challenge to global healthcare systems.These infections are mainly caused by bacterial biofilm formed on the surface of biomaterials,protecting the encapsulated bacteria from conventional antibiotic treatment and attack of the immune system.As the bacterial biofilm is difficult to eradicate,bactericidal and antifouling coatings have emerged as promising strategies to prevent biofilm fo rmation and subsequent infections.Hydrogels with three-dimensional crosslinked hydrophilic networks,tunable mechanical property and large drugloading capacity are desirable coating materials,which can kill bacteria and/or prevent bacterial adhesion on the surface,inhibiting biofilm formation.Herein,we review recent developments of hydrogels as anti-infective coatings.Particularly,we highlight two chemical approaches(graft-from and graft-to),which have been used to immobilize hydrogels on surfaces,and present advances in the development of bactericidal(contact-killing and antimicrobial-releasing),antifouling(hydrophilic polymer network)and bifunctional hydrogel coatings with both bactericidal and antifouling activities.In addition,the challe nges of hydrogel coatings for clinical applications are discussed,and future research directions of anti-infective hydrogel coatings are proposed. | Mengjing Fu Yijing Liang Xue Lv Chengnan Li Yi Yan Yang Peiyan Yuan Xin Ding | 2021 | Journal of Materials Science & Technology2021，，26： | 1 |
| 2 | Gene expression profiling reveals potential key pathways involved in pyrazinamide‐mediated hepatotoxicity in Wistar rats显示文摘 | Yun Zhang Zhenzhou Jiang Yijing Su Mi Chen Fu Li Li Liu Lixin Sun Yun Wang Shuang Zhang Luyong Zhang | 2013 | J Appl Toxicol2013，，8： | 1 |
| 3 | BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction显示文摘ribosomal 蛋白质(RP ) 的 Extraribosomal 功能在 tumorigenesis 和前进为他们的含意获得了许多注意。然而,为在 ribosomal 和 RP 的 extraribosomal 功能之间的转变的规定很少被报导。此处,我们识别了一个 ribosomal 蛋白质交往 S7 搭挡, BCCIP,它调制 S7 的功能的变换。通过 N 终端酸的领域, BCCIP 在 S7 与中央基本区域交往并且调整 S7 的 extraribosomal 分发。BCCIP 缺乏废除 ribosomal 累积,但是提高 S7 的没有核糖体的地点。这 translocation 进一步损害蛋白质合成和扳机 ribosomal 应力。因而, BCCIP 缺乏压制 ribosomal 功能并且开始 S7 的 extraribosomal 功能,导致房间增长的限制。而且,临床上相关的 S7 变化被发现阻抑和 BCCIP 的相互作用并且便于 S7 的功能的转变。在结论,作为一个 S7 调节的人, BCCIP 贡献 ribosomal 的规定, extraribosomal S7 工作并且在房间生长和肿瘤开发有含意。 | Qian Ba Xiaoguang Li Chao Huang Junyang Li Yijing Fu Peizhan Chen Juan Duan Miao Hao Yinghua Zhang Jingquan Li Chuanqi Sun Hao Ying Haiyun Song Ruiwen Zhang Zhiyuan Shen Hui Wang | 2017 | Journal of Molecular Cell Biology2017，9，3： | 0 |
| 4 | Transcriptional landscapes of de novo root regeneration from detached Arabidopsis leaves revealed by time-lapse and single-cell RNA sequencing analyses显示文摘Detached Arabidopsis thaliana leaves can regenerate adventitious roots,providing a platformfor studying de novo root regeneration(DNRR).However,the comprehensive transcriptional framework of DNRR remains elusive.Here,we provide a high-resolution landscape of transcriptome reprogramming from wound response to root organogenesis in DNRR and show key factors involved in DNRR.Time-lapse RNA sequencing(RNA-seq)of the entire leaf within 12 h of leaf detachment revealed rapid activation of jasmonate,ethylene,and reactive oxygen species(ROS)pathways in response towounding.Genetic analyses confirmed that ethylene andROSmay serve as wound signals to promoteDNRR.Next,time-lapse RNA-seq within 5 d of leaf detachment revealed the activation of genes involved in organogenesis,wound-induced regeneration,and resource allocation in the wounded region of detached leaves during adventitious rooting.Genetic studies showed that BLADE-ON-PETIOLE1/2,which control aboveground organs,PLETHORA3/5/7,which control root organogenesis,and ETHYLENE RESPONSE FACTOR115,which controlswound-induced regeneration,are involved in DNRR.Furthermore,single-cell RNA-seq data revealed gene expression patterns in thewounded region of detached leaves during adventitious rooting.Overall,our study not only provides transcriptome tools but also reveals key factors involved in DNRR from detached Arabidopsis leaves. | Wu Liu Yuyun Zhang Xing Fang Sorrel Tran Ning Zhai Zhengfei Yang Fu Guo Lyuqin Chen Jie Yu Madalene SIson Teng Zhang Lijun Sun Hongwu Bian Yijing Zhang Li Yang Lin Xu | 2022 | Plant Communications2022，3，4： | 0 |
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