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| 1 | Design and development of an oral remdesivir derivative W116 against SARS-CoV-2显示文摘Dear Editor,Since the declaration of COVID-19 as a global pandemic on March 11,2020,this pandemic has been circulating for 17 months throughout the world,leading to more than 200 million infections and nearly 4.4 million deaths as of August 15,2021.The pathogen of COVID-19 is a novel coronavirus named SARS-CoV-2,which shares-79%genome sequence identity with SARS-CoV.1 At the early stage of the COVID-19 outbreak,5ARS-CoV-2 caused great panic in the hardest-hit areas due to its high transmissibility and pathogenicity.To fight the COVID-19 crisis,drug repurposing was immediately pursued in order to find potential therapeutics. | Yuanchao Xie Wanchao Yin Yumin Zhang Weijuan Shang Zhen Wang Xiaodong Luan Guanghui Tian Haji A.Aisa Yechun Xu Gengfu Xiao Jia Li Hualiang Jiang Shuyang Zhanq Leike Zhang H.Eric Xu Jingshan Shen | 2021 | Cell Research2021，31，11： | 12 |
| 2 | Evaluating the blank contamination and recovery of sample pretreatment procedures for analyzing organophosphorus flame retardants in waters显示文摘Organophosphate esters(OPEs), used as flame retardants and plasticizers, are widely present in environmental waters. Development of accurate determination methods for trace OPEs in water is urgent for understanding the fate and risk of this class of emerging pollutants. However, the wide use of OPEs in experimental materials results in blank interference, which influences the accuracy of analytical results. In the present work, blank contamination and recovery of pretreatment procedures for analysis of OPEs in water samples were systematically examined for the first time. Blank contaminations were observed in filtration membranes, glass bottles, solid phase extraction cartridges, and nitrogen blowing instruments. These contaminations could be as high as 6.4–64 ng/L per treatment. Different kinds of membranes were compared in terms of contamination levels left after common glassware cleaning, and a special wash procedure was proposed to eliminate the contamination from membranes. Meanwhile, adsorption of highly hydrophobic OPEs on the inside wall of glass bottles was found to be 42.4%–86.1%, which was the primary cause of low recoveries and was significantly reduced by an additional washing step with acetonitrile. This work is expected to provide guidelines for the establishment of analysis methods for OPEs in aqueous samples. | Kang Liang Yumin Niu Yongguang Yin Jingfu Liu | 2015 | Journal of Environmental Sciences2015，27，8： | 3 |
| 3 | Fabrication and microstructure investigation of ultra-high-strength porcelain insulator显示文摘 | Yong Meng Guohong Gong Zhengping Wu Zhongju Yin Yumin Xie Shirong Liu | 2012 | Journal of the European Ceramic Society2012，，12： | 1 |
| 4 | Ultrasound imaging of chitosan nerve conduits that bridge sciatic nerve defects in rats显示文摘The repair of peripheral nerve injuries with autologous nerve remains the gold standard(Wang et al.,2005;Yao et al.,2010;Deal et al.,2012;Kriebel et al.,2014;Liu et al.,2014;Tamaki et al.,2014;Yu et al.,2014;Zhu and Lou,2014).With advances in tissue engineering and biomaterials,tissue-engineered nerve conduits with various biomaterials and structures,such as collagen and chitosan nerve conduits,have already been used | Xiaoyang Chen Yifei Yin Tingting Zhang Yahong Zhao Yumin Yang Xiaomei Yu Hongkui Wang | 2014 | Neural Regeneration Research2014，9，14： | 1 |
| 5 | Fabrication and microstructure investigation of ultra-high-strength porcelain insulator显示文摘 | Yong Meng Guohong Gong Zhengping Wu Zhongju Yin Yumin Xie Shirong Liu | 2012 | Journal of the European Ceramic Society2012，，12： | 1 |
| 6 | Neuroproteetion against focal ischemic brain injury by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone 显示文摘 | Luo Yumin Yin Wei Signore AP | 2006 | J Neurochem2006，97，2： | 1 |
| 7 | Combination therapy with low molecular weight heparin and Adriamycinresults in decreased breast cancer cell metastasis in C3H mice显示文摘 | Weiwei Yin Jing Zhang Yumin Jiang Shen Juan | 2014 | Experimental and Therapeutic Medicine2014，，4： | 1 |
| 8 | Quantum dots capped with dummy the molecularly imprinted film as lumimesieent sensor for the determination of tetrabrom ofobisphenol A in water and soils 显示文摘 | Chen Yiping Wang Daning Yin Yumin | 2012 | J Agric Food Chem2012，60，10： | 1 |
| 9 | Influence of support on catalytic activity of Ni catalysts in p-nitro- phenol hydrogenation to p-aminophenol显示文摘 | Lu Huihong Yin Hengbo Liu Yumin | 2008 | Catal Com- mu2008，10，3： | 1 |
| 10 | Products of methotrexate during chlorination显示文摘Methotrexate(MTX)is a cytotoxic drug widely used in the treatment of tumors,autoimmune diseases and severe asthma. jen00883 This drug has been frequently detected in the aquatic environment with concentrations up to μg/L levels. The MTX present in environmental water might be transformed and removed during chlorination disinfection treatment. In this work,the fate of MTX during aqueous chlorination was investigated in laboratory batch experiments,and the transformation products of MTX were identified. Aqueous solutions of MTX(1 mg/L)were chlorinated by sodium hypochlorite solution at room temperature under neutral p H conditions. Chlorinated products were pre-concentrated with solid-phase extraction(SPE)cartridges and determined by liquid chromatography electrospray ionization tandem mass spectrometry(LC–ESI–MS/MS). The reaction of MTX chlorination exhibited pseudo-first-order kinetics and the half-life time of MTX degradation was calculated to be 1.65 min,when the initial chlorine concentration was 2 mg/L. Two chlorinated MTX congeners,4-amino-3-chlorinated-N10-methylpteroylglutamic(monochloro-MTX)and 4-amino-3,5-dichloro-N10-methylpteroylglutamic(dichloro-MTX)were found in the chlorinated solution. Monochloro-MTX was successfully fractionated by high performance liquid chromatography(HPLC)and its structure was further identified using ~1H nuclear magnetic resonance(NMR)analysis. The presence of the two products in real hospital wastewater was then examined and both compounds were detected. Finally,the effects of MTX and monochloro-MTX on the cell cycle progression in vitro were evaluated using zebrafish liver cell line. It was found that both compounds could inhibit the proliferation of zebrafish liver cells through S phase arrest and their effects on the cell cycle profile had no significant difference. | Jie Yin Yumin Niu Bing Shao | 2017 | Journal of Environmental Sciences2017，29，5： | 1 |
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