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| 1 | gamma/delta T cellsubsets in human aging using the classical alpha/beta T cell model显示文摘 | Vasudev A Ying CT Ayyadhury S | 2014 | J Leukoc Biol2014，96，4： | 1 |
| 2 | Multisection CT angiography compared with catheter angiography in diagnosing vertebral artery dissection显示文摘 | Ying CT Tsong HL | 2004 | AJNR Am J of Neuroradiology2004，25，： | 1 |
| 3 | Dynamic high pressure microfluidization- assisted extraction and antioxidant activities of lentinan 显示文摘 | Xiaoqin Huang Zongcai Tu Ying Jiang ct al | 2012 | International Journal of Biological Macromolecules2012，515，： | 1 |
| 4 | Oncologic outcomes of laparoseopy- assisted gastrectomy for advanced gastric cancer: a large-scale multicenter retrospective cohort study from China显示文摘 | Hu Y Ying M Huang C ct al | 2014 | Surg Endosc2014，28，7： | 1 |
| 5 | Identification of amino acids in HA and PB2 critical for the transmission ofH5N1 avian influenza viruses in a mammalian host 显示文摘 | Gao Yu-wei Zhang Ying Kyoko S ct al | 2009 | PLoS Pathog2009，5，00： | 1 |
| 6 | Multisection CT angiography compared with catheter angiography in diagnosing vertebral artery dissection显示文摘 | Chi JC Ying CT Tsong HL | 2004 | AJNR Am J of Neuroradiology2004，25，3： | 1 |
| 7 | Simultaneous determination of three polyphenols in rat plasma after orally administering hawthorn leaves extract by the HPLC method显示文摘 | Xixiang Ying Xiansheng Meng Siyuan Wang ct al | 2012 | Nat Prod Res2012，26，6： | 1 |
| 8 | NO functions as signal in UV-B-induced growth inhibition in pea sterns elongation显示文摘 | QU YING FENG HY WANG Yb ct al | 2006 | Plant Science2006，，170： | 1 |
| 9 | Genome sequencing reveals the role of rare genomic variants in Chinese patients with symptomatic intracranial atherosclerotic disease显示文摘Objectives The predisposition of intracranial atherosclerotic disease(ICAD)to East Asians over Caucasians infers a genetic basis which,however,remains largely unknown.Higher prevalence of vascular risk factors(VRFs)in Chinese over Caucasian patients who had a stroke,and shared risk factors of ICAD with other stroke subtypes indicate genes related to VRFs and/or other stroke subtypes may also contribute to ICAD.Methods Unrelated symptomatic patients with ICAD were recruited for genome sequencing(GS,60-fold).Rare and potentially deleterious single-nucleotide variants(SNVs)and small insertions/deletions(InDels)were detected in genome-wide and correlated to genes related to VRFs and/or other stroke subtypes.Rare aneuploidies,copy number variants(CNVs)and chromosomal structural rearrangements were also investigated.Lastly,candidate genes were used for pathway and gene ontology enrichment analysis.Results Among 92 patients(mean age at stroke onset 61.0±9.3 years),GS identified likely ICAD-associated rare genomic variants in 54.3%(50/92)of patients.Forty-eight patients(52.2%,48/92)had 59 rare SNVs/InDels reported or predicted to be deleterious in genes related to VRFs and/or other stroke subtypes.None of the 59 rare variants were identified in local subjects without ICAD(n=126).31 SNVs/InDels were related to conventional VRFs,and 28 were discovered in genes related to other stroke subtypes.Our study also showed that rare CNVs(n=7)and structural rearrangement(a balanced translocation)were potentially related to ICAD in 8.7%(8/92)of patients.Lastly,candidate genes were significantly enriched in pathways related to lipoprotein metabolism and cellular lipid catabolic process.Conclusions Our GS study suggests a role of rare genomic variants with various variant types contributing to the development of ICAD in Chinese patients. | Mengmeng Shi Xinyi Leng Ying Li Zihan Chen Ye Cao Tiffany Chung Bonaventure YM Ip Vincent HL Ip Yannie OY Soo Florence SY Fan Sze Ho Ma Karen Ma Anne Y Y Chan Lisa WC Au Howan Leung Alexander Y Lau Vincent CT Mok Kwong Wai Choy Zirui Dong Thomas W Leung | 2022 | Stroke & Vascular Neurology2022，7，3： | 0 |
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