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| 1 | Fast-track program vs traditional care in surgery for gastric cancer显示文摘AIM:To systematically review the evidence for the effectiveness of fast-track program vs traditional care in laparoscopic or open surgery for gastric cancer.METHODS:PubMed,Embase and the Cochrane library databases were electronically searched for published studies between January 1995 and April 2013,and only randomized trials were included.The references of relevant studies were manually searched for further studies that may have been missed.Search terms included'gastric cancer','fast track'and'enhanced recovery'.Five outcome variables were considered most suitable for analysis:postoperative hospital stay,medical cost,duration to first flatus,C-reactive protein(CRP)level and complications.Postoperative hospital stay was calculated from the date of operation to the date of discharge.Fixed effects model was used for meta-analysis.RESULTS:Compared with traditional care,fasttrack program could significantly decrease the postoperative hospital stay[weighted mean difference(WMD)=-1.19,95%CI:-1.79--0.60,P=0.0001,fixed model],duration to first flatus(WMD=-6.82,95%CI:-11.51--2.13,P=0.004),medical costs(WMD=-2590,95%CI:-4054--1126,P=0.001),and the level of CRP(WMD=-17.78,95%CI:-32.22--3.35,P=0.0001)in laparoscopic surgery for gastric cancer.In open surgery for gastric cancer,fast-track program could also significantly decrease the postoperative hospital stay(WMD=-1.99,95%CI:-2.09--1.89,P=0.0001),duration to first flatus(WMD=-12.0,95%CI:-18.89--5.11,P=0.001),medical cost(WMD=-3674,95%CI:-5025--2323,P=0.0001),and the level of CRP(WMD=-27.34,95%CI:-35.42--19.26,P=0.0001).Furthermore,fast-track program did not significantly increase the incidence of complication(RR=1.39,95%CI:0.77-2.51,P=0.27,for laparoscopic surgery;and RR=1.52,95%CI:0.90-2.56,P=0.12,for open surgery).CONCLUSION:Our overall results suggested that compared with traditional care,fast-track program could result in shorter postoperative hospital stay,less medical costs,and lower level of CRP,with no more complications occurring in both laparoscopic and open surgery for gastric cancer. | Zhi-Xing Chen Ae-Huey Jennifer Liu Ying Cen | 2014 | World Journal of Gastroenterology2014，20，2： | 41 |
| 2 | Genome Sequences Provide Insights into the Reticulate Origin and Unique Traits of Woody Bamboos显示文摘Polyploidization is a major driver of speciation and its importance to plant evolution has been well recognized.Bamboos comprise one diploid herbaceous and three polyploid woody lineages,and are members of the only major subfamily in grasses that diversified in forests,with the woody members having a tree-like lignified culm.In this study,we generated four draft genome assemblies of major bamboo lineages with three different ploidy levels(diploid,tetraploid,and hexaploid).We also constructed a high-density genetic linkage map for a hexaploid species of bamboo,and used a linkage-map-based strategy for genome assembly and identification of subgenomes in polyploids.Further phylogenomic analyses using a large dataset of syntenic genes with expected copies based on ploidy levels revealed that woody bamboos originated subsequent to the divergence of the herbaceous bamboo lineage,and experienced complex reticulate evolution through three independent allopolyploid events involving four extinct diploid ancestors.A shared but distinct subgenome was identified in all polyploid forms,and the progenitor of this subgenome could have been critical in ancient polyploidizations and the origin of woody bamboos.Important genetic clues to the unique flowering behavior and woody trait in bamboos were also found.Taken together,our study provides significant insights into ancient reticulate evolution at the subgenome level in the absence of extant donor species,and offers a potential model scenario for broad-scale study of angiosperm origination by allopolyploidization. | Zhen-Hua Guo Peng-Fei Ma Guo-Qian Yang Jin-Yong Hu Yun-Long Liu En-Hua Xia Mi-Cai Zhong Lei Zhao Gui-Ling Sun Yu-Xing Xu You-Jie Zhao Yi-Chi Zhang Yu-Xiao Zhang Xue-Mei Zhang Meng-Yuan Zhou Ying Guo Cen Guo Jing-Xia Liu Xia-Ying Ye Yun-Mei Chen Yang Yang Bin Han Choun-Sea Lin Ying Lu De-Zhu Li | 2019 | Molecular Plant2019，12，10： | 13 |
| 3 | Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism显示文摘Amycolatopsis mediterranei 被用于 rifamycin 的工业规模生产,它在 antimycobacterial 治疗起一个重要作用。作为类 Amycolatopsis 的首先定序的染色体, 236 715 底配对的包括 10 的紧张 U32 的染色体,最大的原核生物的染色体之一到目前为止曾经被定序。不同于在 streptomycetes 发现的线性拓扑学,这个染色体是圆形的,特别地类似于 Saccharopolyspora erythraea 和奴卡氏菌属 farcinica,在发展史和分类代表他们的靠近的关系。尽管在 A 预言了 9 228 编码蛋白质的基因。mediterranei 染色体 S 与那些分享了 orthologs 的最大的数字。erythraea,它被 Streptomyces coelicolor 而非 N 出人意料地跟随。farcinica,显示不同新陈代谢的特征经由改编演变到多样的生态的壁龛。除类似于那的一个核心区域以外在 streptomycetes 普通,有典型核心特征的一个新奇“伪核心”在非核心区域以内被定义,在 21 从 26 基因为第二等的代谢物生产聚类的总数被定位的地方。位于核心的 rifamycin 生合成基因簇为 rifamycin SV 的变换编码细胞色素 P450 酶必需品到 B,由比作 rifamycin 生产 B 紧张 S699 的高度相应的簇揭示了并且进一步由基因互补证实了。A 的 genomic 信息。mediterranei 表明在看起来复杂的规章的机制的控制下面不仅为各种各样的碳来源和无机的氮混合物的广泛的利用而且为新陈代谢的中介的有效 funneling 安排进第二等的抗菌素合成进程的一个新陈代谢的网络。 | Wei Zhao Yi Zhong Hua Yuan Jin Wang Huajun Zheng Ying Wang Xufeng Cen Feng Xu Jie Bai Xiaobiao Han Gang Lu Yongqiang Zhu Zhihui Shao Han Yan Chen Li Nanqiu Peng Zilong Zhang Yunyi Zhang Wei Lin Yun Fan Zhongjun Qin Yongfei Hu Baoli Zhu Shengyue Wang Xiaoming Ding Guo-Ping Zbao | 2010 | Cell Research2010，20，10： | 10 |
| 4 | Safety and Efficiency of Trabectome-mediated Trabecular Meshwork Ablation for Chinese Glaucoma Patients: A Two-year, Retrospective, Multicentre Study显示文摘 | Ya-Long Dang Yu-Jie Cen Ying Hong Ping Huang Ning-Li Wang Chao Wang Chun Zhang | 2018 | Chinese Medical Journal2018，，4： | 5 |
| 5 | BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A-YAP axis显示文摘Sulfur mustard(SM)is a highly toxic chemical warfare agent that causes acute lung injury(ALI)and/or acute respiratory distress syndrome(ARDS).There are no effective therapeutic treatments or antidotes available currently to counteract its toxic effects.Our previous study shows that bone marrow-derived mesenchymal stromal cells(BMSCs)could exert therapeutic effects against SM-induced lung injury.In this study,we explored the therapeutic potential of BMSC-derived exosomes(BMSC-Exs)against ALI and the underlying mechanisms.ALI was induced in mice by injection of SM(30 mg/kg,sc)at their medial and dorsal surfaces.BMSC-Exs(20μg/kg in 200μL PBS,iv)were injected for a 5-day period after SM exposure.We showed that BMSC-Exs administration caused a protective effect against pulmonary edema.Using a lung epithelial cell barrier model,BMSC-Exs(10,20,40μg)dose-dependently inhibited SM-induced cell apoptosis and promoted the recovery of epithelial barrier function by facilitating the expression and relocalization of junction proteins(E-cadherin,claudin-1,occludin,and ZO-1).We further demonstrated that BMSC-Exs protected against apoptosis and promoted the restoration of barrier function against SM through upregulating G protein-coupled receptor family C group 5 type A(GPRC5A),a retinoic acid target gene predominately expressed in the epithelial cells of the lung.Knockdown of GPRC5A reduced the antiapoptotic and barrier regeneration abilities of BMSC-Exs and diminished their therapeutic effects in vitro and in vivo.BMSC-Exs-caused upregulation of GPRC5A promoted the expression of Bcl-2 and junction proteins via regulating the YAP pathway.In summary,BMSC-Exs treatment exerts protective effects against SM-induced ALI by promoting alveolar epithelial barrier repair and may be an alternative approach to stem cell-based therapy. | Guan-chao Mao Chu-chu Gong Zhen Wang Ming-xue Sun Zhi-peng Pei Wen-qi Meng Jin-feng Cen Xiao-wen He Ying Lu Qing-qiang Xu Kai Xiao | 2021 | Acta Pharmacologica Sinica2021，42，12： | 4 |
| 6 | 危重型新型冠状病毒肺炎患者床边内镜诊疗后内镜再处理流程改良分析显示文摘目的:在疫情期间,需要通过保证内镜处理质量,避免过程环节操作中的接触污染,防止气溶胶的散发,从而保护从业人员,杜绝院内感染。创新点:内镜诊疗对改善重症患者预后及降低患者死亡率有重要作用。该研究依据实际临床工作特质,对内镜再处理过程中的部分方法及化学清洗消毒剂的选择进行了改良与替换。方法:从12例重症患者行23次内镜诊治后的内镜处理操作中提取经验,结合相关指南规范,提出了新型冠状病毒肺炎患者床边内镜诊疗后内镜再处理改良流程。结论:内镜诊疗在重症及危重症患者治疗中不可或缺。临床工作中床旁预处理操作及专线转运流程对于预防院内感染具有重要意义。替换后的化学清洗消毒剂(0.23%过氧乙酸)对新冠病毒可达到高水平消毒。改良后的床边内镜诊疗后内镜再处理操作流程顺畅,感染控制严谨,值得临床进一步推广。 | Qing GU Hua-fen WANG Ying FANG Ye LU Zhe SHEN Yan WANG Xin WU Li CEN Yi-shu CHEN | 2020 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2020，21，5： | 3 |
| 7 | A Modified Surgical Technique Using Levator Aponeurosis-MiJller Muscle Complex to Correct Mild-to-Moderate Blepharoptosis显示文摘 | Yi Pu Zheng-Yong Li Li-Dan Zhang Ying Cen | 2018 | Chinese Medical Journal2018，，17： | 3 |
| 8 | Clinical improvement in the therapy of aural keloids显示文摘因为翼的特殊形状,背景蟹状肿为听觉的区域有偏爱。它完全对将切除蟹状肿困难并且维持令人满意的 pinnal 形状。在有放射疗法的联合的外科的切除被认为是为严重蟹状肿可得到的最有效的治疗。这研究被进行与 intralesional 切除和立即的手术后的辅助放射疗法评估听觉的蟹状肿的治疗。有 74 aureloids 的一个联合总数的 46 个病人被 intralesional 切除和立即的手术后的辅助放射疗法对待的方法。所有病人在 10 连续的天内收到了 20 Gy 的全部的剂量。在蟹状肿切除和第一放射疗法部分的交货之间的时间间隔是在所有情况中的 24 个小时。中部的后续是 2.2 years.Results 有 48 蟹状肿(64.9%) 的 29 个病人高度对他们的结果满意,并且被外科医生作为好评估。有 12 蟹状肿(16.2%) 的六个病人显示出一般满足,但是想要美学精炼,和这些病人被外科医生作为公平评估。有四蟹状肿(5.4%) 的三个病人没在外科以后显示出复发的证据,但是因为疤表面的褪色和不规则,不喜欢结果。这些病人被外科医生作为穷人评估。部分复发与 10 蟹状肿(13.5%) 发生在 8 个病人。没有主要复杂并发症是 observed.Conclusion Intralesional 切除和立即的手术后的辅助放射疗法很好被容忍并且在阻止听觉的区域蟹状肿的复发很有效。 | ZHANG Yan-ge CEN Ying LIU Xiao-xue YU Rong XU Xue-wen | 2009 | Chinese Medical Journal2009，，23： | 3 |
| 9 | Influence of Hydrothermal Dewatering on the Gasification Characteristics of Typical Chinese Lignites显示文摘 | GE Lichao ZHANG Yanwei YING Zhi WANG Zhihua ZHOU Junhu CEN Kefa | 2013 | 中国电机工程学报2013，33，32： | 2 |
| 10 | Facile scalable one-step wet-spinning of surgical sutures with shape memory function and antibacterial activity for wound healing显示文摘Surgical suture is commonly used in clinic due to its action in accelerating the process of wound healing.However,difficultly handling in minimally invasive surgery and bacteria-induced infection usually limit its use in a wide range of applications.Here,we report a facile scalable strategy to fabricate surgical sutures with shape memory function and antibacterial activity for wound healing.Specifically,a shape memory polyurethane(SMPU)with a transition temperature(Ttrans)at 41.3℃was synthesized by adjusting the mole ratio of the hard/soft segment,and then the shape memory surgical sutures containing polyhexamethylene biguanide hydrochloride(PHMB)as a model drug for antibacterial activity were fabricated by a facile scalable one-step wet-spinning approach,in which PHMB was directly dissolved in the coagulation bath that enable its loading into the sutures through the dual diffusion during the phase separation.The prepared sutures were characterized by their morphology,mechanical properties,shape memory,antibacterial activity,as well as biocompatibility before the wound healing capability was tested in a mouse skin suture-wound model.It was demonstrated that the optimized suture is capable of both shape memory function and antibacterial activity,and promote wound healing,suggesting that the facile scalable one-step wet-spinning strategy provides a promising tool to fabricate surgical sutures for wound healing. | Xinghan Chen Pengfei Tan Ya Wen Wencheng Zhou Ying Cen Chao You Lin Tan Meng Tian | 2020 | Chinese Chemical Letters2020，31，6： | 1 |
| 11 | mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1–GluA2 interaction in the nucleus accumbens显示文摘Behavioral sensitization is a progressive increase in locomotor or stereotypic behaviours in response to drugs. It is believed to contribute to the reinforcing properties of drugs and to play an important role in relapse after cessation of drug abuse. However, the mechanism underlying this behaviour remains poorly understood. In this study, we showed that mTOR signaling was activated during the expression of behavioral sensitization to cocaine and that intraperitoneal or intra-nucleus accumbens (NAc) treatment with rapamycin, a specific mTOR inhibitor, attenuated cocaine-induced behavioural sensitization. Cocaine significantly modified brain lipid profiles in the NAc of cocaine-sensitized mice and markedly elevated the levels of phosphatidylinositol-4-monophosphates (PIPs), including PIP, PIP2, and PIP3. The behavioural effect of cocaine was attenuated by intra-NAc administration of LY294002, an AKT-specific inhibitor, suggesting that PIPs may contribute to mTOR activation in response to cocaine. An RNA-sequencing analysis of the downstream effectors of mTOR signalling revealed that cocaine significantly decreased the expression of SynDIG1, a known substrate of mTOR signalling, and decreased the surface expression of GluA2. In contrast, AAV-mediated SynDIG1 overexpression in NAc attenuated intracellular GluA2 internalization by promoting the SynDIG1–GluA2 interaction, thus maintaining GluA2 surface expression and repressing cocaine-induced behaviours. In conclusion, NAc SynDIG1 may play a negative regulatory role in cocaine-induced behavioural sensitization by regulating synaptic surface expression of GluA2. | Hong-chun Li Jia-mei Zhang Rui Xu Yong-hai Wang Wei Xu Rong Chen Xue-mei Wan Hao-luo Zhang Liang Wang Xiao-jie Wang Lin-hong Jiang Bin Liu Ying Zhao Yuan-yuan Chen Yan-ping Dai Min Li Hua-qin Zhang Zhen Yang Lin Bai Jie Zhang Hong-bo Wang Jing-wei Tian Ying-lan Zhao Xiao-bo Cen | 2022 | Acta Pharmacologica Sinica2022，43，2： | 1 |
| 12 | Occurrence of the Bunsen side reaction in the sulfur-iodine thermochemical cycle for hydrogen production显示文摘This study aimed to establish a closed-cycle operation technology with high thermal efficiency in the thermochemical sulfur-iodine cycle for large-scale hydrogen production.A series of experimental studies were performed to investigate the occurrence of side reactions in both the H2SO4 and HI x phases from the H2SO4/HI/I2/H2O quaternary system within a constant temperature range of 323-363 K.The effects of iodine content,water content and reaction temperature on the side reactions were evaluated.The results showed that an increase in the reaction temperature promoted the side reactions.However,they were prevented as the iodine or water content increased.The occurrence of side reactions was faster in kinetics and more intense in the H2SO4 phase than in the HI x phase.The sulfur or hydrogen sulfide formation reaction or the reverse Bunsen reaction was validated under certain conditions. | Qiao-qiao ZHU Yan-wei ZHANG Zhi YING Jun-hu ZHOU Zhi-hua WANG Ke-fa CEN | 2013 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2013，14，4： | 1 |
| 13 | Surface modification of polymeric films and membranes to achieve antibacterial properties显示文摘 | Cen L Neoh K G Ying L | 2004 | Surf Interf Anal2004，36，8： | 1 |
| 14 | A Novel Eleven-membered Heterocyclic Compound from Algae Sargassum Vachell显示文摘A novel eleven-membered heterocyclic compound with high nitrogen has been isolatedtyom the marine alga Sargussum vachell collected from the South China Sea. Its structure has beenestablished by verity of spectroscopic techniques such as IR. EIMS. 1D NMR. HMQC. HNBC. | Shi Hat XU Ying Zhou CEN Yao Lan LI Shao Yu XU(Department of chemistry. Jinan University. Guangzhou 510632) | 1999 | Chinese Chemical Letters1999，10，5： | 1 |
| 15 | Warming with an underbody warming system reduces intraoperative hypothermia in patients undergoing laparoscopic gastrointestinal surgery: A randomized controlled study显示文摘 | Ying Pu Gang Cen Jing Sun Jin Gong Ying Zhang Min Zhang Xia Wu Junjie Zhang Zhengjun Qiu Fang Fang | 2013 | International Journal of Nursing Studies2013，，： | 1 |
| 16 | Study of the decorporation efficacy and toxicity of tetradentate 3-hydroxy- 2-pyridinone ligands at the cellular level显示文摘Objective:A series of experiments were carried out to study the comparative decorporation efficacy and toxicity of three tetradentate hydroxypyridinone ligands(3LI-1-Cm-3,2-HOPO,5LIO-1-Cm-3,2-HOPO,and 7LIO-1-Cm-3,2-HOPO)with the variation of the linker length and the substituents.Methods:Three ligands were obtained from a 4-step synthesis via the amidation of HOPO unit and different backbones.Potentiometric titrations were carried out to evaluate the formation constants of their corresponding uranyl complexes.CCK-8 and colony formation assays were used to compare the cytotoxicity of the three ligands and uranyl using renal proximal tubular epithelial(NRK-52E)cells.In vitro uranium removal assays were performed to assess decorporation efficiencies of those ligands by co-incubating uranium and chelators with NRK-52E cells for 48 h.Results:Among the three ligands,5LIO-1-Cm-3,2-HOPO exhibits the highest uranyl affinity(logβ110?18.6(7))in comparison to the other two ligands(logβ110?14.9(2)for 3LI-1-Cm-3,2-HOPO and logβ110?16.7(1)for 7LIO-1-Cm-3,2-HOPO).The results of CCK-8 tests and colony formation assays further elucidate that 5LIO-1-Cm-3,2-HOPO and 7LIO-1-Cm-3,2-HOPO both show a similar level of cytotoxicity compared with ZnNa3-DTPA at relatively low ligand concentrations.In contrast,in the 3LI-1-Cm-3,2-HOPO treated group,the cell viability decreased markedly with the increase of the ligand concentrations,and the colony formation capability of NRK-52E cells was inhibited.Furthermore,the comparative decorporation efficacy of the three ligands was obtained from in vitro uranium removal assays,suggesting that these ligands could significantly inhibit the cellular uptake and prompt the cellular release of uranium from NRK-52E cells by the level of 81.9%,91.8%,and 87.1%,respectively.Conclusion:Our current results demonstrate that the linker/backbone species would significantly affect the decorporation efficacy and toxicity of the tetradentate 3-hydroxy-2-pyridinone ligands,which is informative for the future design and modification of novel decorporation ligands. | Xiaomei Wang Cen Shi Manni Gao Ying Xu Yang Jiao Jianmei Wan Jianping Cao Zhifang Chai Juan Diwu | 2020 | Radiation Medicine and Protection2020，1，4： | 1 |
| 17 | Surface modification of polymeric films and membranes to achieve antibacterial properties显示文摘 | Cen L Neoh KG Ying L | 2004 | Surf Interface Anal2004，36，8： | 1 |
| 18 | Surface Modification of Polymeric Films and Membranes to Achieve Antibacterial Properties显示文摘 | Cen L Neoh KG Ying L | 2004 | Surface and Interface Analysis2004，36，8： | 1 |
| 19 | Studies on Antivirus Effects of Polysaccharides from Sargassum fusiforme in vitro显示文摘 To assay antiviral effects of the polysaccharide and its separated products from Sargassumfusiforme on HSV-1 and CVB3 and their antiviral mechanism, the antiviral effects of all samples on HSV-1 and CVB3 and their cytotoxicity on vero cells were studied by CPE and MTT method. Antiviral mechanism of two samples was briefly studied by four different ways. The cytotoxicity of samples on vero cells was not detected (CC>5000 μg/mL). All samples except PSJ had obviously HSV-1 inhibitory effect. Antiviral activities of them were increasingly strengthened with raising their purities.Antiviral activities of F1, F2 and F4 were better than that of ACV, and antiviral activities of all samples on CVB3 were better than ribavirin injection. Fi, F2 and F4 had remarkable anti-CVB3 activity. The experiment showed that polysaccharide was able to not only kill the above viruses directly but also restrain them by getting into cell or absorbing on cells.…… | CEN,Ying-Zhou KHOO,Gaik-Ming WANG,Ling-Yun ZHANG,Ying | 2004 | 有机化学2004，24，z1： | 1 |
| 20 | Characterization of a New GlnR Binding Box in the Promoter of amtB in Streptomyces coelicolor Inferred a PhoP/GlnR Competitive Binding Mechanism for Transcriptional Regulation of amtB显示文摘 | Ying Wang Xu-Feng Cen Guo-Ping Zhao Jin Wang | 2012 | Journal of Bacteriology2012，，19： | 1 |
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