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| 1 | 骨密度测量技术诊断骨质疏松的评价显示文摘骨矿密度(BMD)是诊断骨量减少(低骨量,骨质疏松),评价骨丢失率和疗效的重要客观指标。被世界卫生组织(WHO)用来定义骨质疏松(OP)的诊断标准。目前非创伤性骨密度测量方法主要有以下几种:X线光密度法(RA),单光子吸收法(SPA),双光子吸收法(DPA),双能x线吸收测定(DEXA),定量CT(QCT)。不同的测量方法的优、缺点和临床意义不同,在此简要综述几种BMD测量方法和特点。 | 张曼华 王保岚 YING N ZHANG FOUTZ | 2007 | 中国骨质疏松杂志2007，13，11： | 17 |
| 2 | Micronuclei in Nasal Mucosa, Oral Mucosa and Lymphocytes in Students Exposed to Formaldehyde Vapor in Anatomy Class显示文摘The frequency of micronuclei (MN) in cells of the nasal mucosa, oral mucosa and in lym-phocytes was evaluated for 25 students in anatomy classes exposed to formaldehyde (FA) overan 8-week period. Each student served as his or her own control. The time-weighted averageconcentration (TWA) of fOrmaldehyde in anatomical laboratories and in students’ dormitorieswas 0. 508 ± 0. 299 mg/m3 and 0. 012 ± 0. 0025mg/m3, respectively. A higher frequency ofmicronuclei was observed in nasal and oral exfoliative cells after formaldehyde exposure (3. 85± 1. 48 vs 1 .20± 0. 676 and 0. 857 ± 0. 558 vs 0. 568 ± 0. 317, paired-t test: P< 0. 001and P < 0. 01, respectively). No significant increase in the frequency of lymphocyte micronu-clei was found after formaldehyde exposure (P >0. 05 ). The present study shows that nasalmucosa cel1s exposed through respiration are the chief target of FA-induced genotoxic | YING CHEN -JlANG YAN WEN-SHENG ZHAO MEI-YING YE XIAO-LEI XIE HONG YIN SHU-YI ZHU XIAN-SHU(Department of Environmental Health, n Dgurtment of Anatomy,Tongji the ical University, Wuhan, China)(Department of Public Health, Wengzhou theical Chllege, Ch | 1997 | Biomedical and Environmental Sciences1997，10，4： | 7 |
| 3 | Gene expression profiling and endothelin in acute experimental pancreatitis显示文摘AIM:To analyze gene expression profiles in an experimental pancreatitis and provide functional reversal of hypersensitivity with candidate gene endothelin-1 antagonists.METHODS:Dibutyltin dichloride(DBTC) is a chemical used as a polyvinyl carbonate stabilizer/catalyzer,biocide in agriculture,antifouling agent in paint and fabric.DBTC induces an acute pancreatitis flare through generation of reactive oxygen species.Lewis-inbred rats received a single i.v.injection with either DBTC or vehicle.Spinal cord and dorsal root ganglia(DRG) were taken at the peak of inflammation and processed for transcriptional profiling with a cDNA microarray biased for rat brain-specific genes.In a second study,groups of animals with DBTC-induced pancreatitis were treated with endothelin(ET) receptor antagonists [ET-A(BQ123) and ET-B BQ788)].Spontaneous pain related mechanical and thermal hypersensitivity were measured.Immunohistochemical analysis was performed using anti-ET-A and ET-B antibodies on sections from pancreatic tissues and DRG of the T10-12 spinal segments.RESULTS:Animals developed acute pancreatic inflammation persisting 7-10 d as confirmed by pathological studies(edema in parenchyma,loss of pancreatic architecture and islets,infiltration of inflammatory cells,neutrophil and mononuclear cells,degeneration,vacuolization and necrosis of acinar cells) and the painrelated behaviors(cutaneous secondary mechanical and thermal hypersensitivity).Gene expression profile was different in the spinal cord from animals with pancreatitis compared to the vehicle control group.Over 260 up-regulated and 60 down-regulated unique genes could be classified into 8 functional gene families:circulatory/acute phase/immunomodulatory;extracellular matrix;structural;channel/receptor/transporter;signaling transduction;transcription/translation-related;antioxidants/chaperones/heat shock;pancreatic and other enzymes.ET-1 was among the 52 candidate genes upregulated greater than 2-fold in animals with pancreatic inflammation and visceral pain-related behavior.Treatments with the ET-A(BQ123) and ET-B(BQ-788) antagonists revealed significant protection against inflammatory pain related mechanical and thermal hypersensitivity behaviors in animals with pancreatitis(P < 0.05).Open field spontaneous behavioral activity(at baseline,day 6 and 30 min after drug treatments(BQ123,BQ788) showed overall stable activity levels indicating that the drugs produced no undesirable effects on normal exploratory behaviors,except for a trend toward reduction of the active time and increase in resting time at the highest dose(300 μmol/L).Immunocytochemical localization revealed that expression of ET-A and ET-B receptors increased in DRG from animals with pancreatitis.Endothelin receptor localization was combined in dual staining with neuronal marker NeuN,and glia marker,glial fibrillary acidic protein.ET-A was expressed in the cell bodies and occasional nuclei of DRG neurons in na ve animals.However,phenotypic expression of ET-A receptor was greatly increased in neurons of all sizes in animals with pancreatitis.Similarly,ET-B receptor was localized in neurons and in the satellite glia,as well as in the Schwann cell glial myelin sheaths surrounding the axons passing through the DRG.CONCLUSION:Endothelin-receptor antagonists protect against inflammatory pain responses without interfering with normal exploratory behaviors.Candidate genes can serve as future biomarkers for diagnosis and/or targeted gene therapy. | Helieh S Oz Ying Lu Louis P Vera-Portocarrero Pei Ge Ada Silos-Santiago Karin N Westlund | 2012 | World Journal of Gastroenterology2012，18，32： | 6 |
| 4 | Discovering the roles of subsurface microorganisms: Progress and future of deep biosphere investigation显示文摘The discovery of the marine 'deep biosphere'-microorganisms living deep below the seafloor-is one of the most significant and exciting discoveries since the ocean drilling program began more than 40 years ago. Study of the deep biosphere has become a research frontier and a hot spot both for geological and biological sciences. Here, we introduce the history of the discovery of the deep biosphere, and then we describe the types of environments for life below the seafloor, the energy sources for the living creatures, the diversity of organisms within the deep biosphere, and the new tools and technologies used in this research field. We will highlight several recently completed Integrated Ocean Drilling Program Expeditions, which targeted the subseafloor deep biosphere within the crust and sediments. Finally, future research directions and challenges of deep biosphere investigation towards uncovering the roles of subsurface microorganisms will be briefly addressed. | WANG FengPing LU ShuLin ORCUTT Beth N XIE Wei CHEN Ying XIAO Xiang EDWARDS Katrina J | 2013 | Chinese Science Bulletin2013，58，4： | 6 |
| 5 | PDX1.1-dependent biosynthesis of vitamin B6 protects roots from ammonium-induced oxidative stress显示文摘Despite serving as a major inorganic nitrogen source for plants,ammonium causes toxicity at elevated con-centrations,inhibiting root elongation early on.While previous studies have shown that ammonium-inhibited root development relates to ammonium uptake and formation of reactive oxygen species(ROS)in roots,it remains unclear about the mechanisms underlying the repression of root growth and how plants cope with this inhibitory effect of ammonium.In this study,we demonstrate that ammonium-induced apo-plastic acidification co-localizes with Fe precipitation and hydrogen peroxide(H_(2)O_(2))accumulation along the stele of the elongation and differentiation zone in root tips,indicating Fe-dependent ROS formation.By screening ammonium sensitivity in T-DNA insertion lines of ammonium-responsive genes,we identified PDX1.1,which is upregulated by ammonium in the root stele and whose product catalyzes de novo biosyn-thesis of vitamin B6.Root growth of pdx1.1 mutants is hypersensitive to ammonium,while chemical complementation or overexpression of PDX1.1 restores root elongation.This salvage strategy requires non-phosphorylated forms of vitamin B6 that are able to quench ROS and rescue root growth from ammo-nium inhibition.Collectively,these results suggest that PDX1.1-mediated synthesis of non-phosphorylated B6 vitamers acts as a primary strategy to protect roots from ammonium-dependent ROS formation. | Ying Liu Rodolfo A.Maniero Ricardo F.H.Giehl Michael Melzer Priscille Steensma Gabriel Krouk Teresa B.Fitzpatrick Nicolaus von Wirén | 2022 | Molecular Plant2022，15，5： | 3 |
| 6 | DNA and RNA-based vaccines: principles, progress and prospects显示文摘 | Leitner W W Ying H Restifo N P | 2000 | Vaccines2000，18，910： | 1 |
| 7 | Isolation and partial character- ization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid显示文摘 | LING N YING S Y UENO N | 1985 | PNAS1985，82，21： | 1 |
| 8 | Brain plasticity and cellular mechanisms of epileptogenesis in human and experimental cortical dysplasia显示文摘 | Babb TL Ying Z Mikuni N | 2000 | Epilepsia2000，41，6： | 1 |
| 9 | Isolation and partial characterization of a Mr 32,000 protein with inhibin activity from porcine follicular fluid显示文摘 | Ling N Ying S Y Ueno N | 1985 | Proc Natl Acall Sci USA1985，82，： | 1 |
| 10 | A homodimer of the β-subunit of inhibin A stimulates the secretion of pituitary follicle stimulating hormone显示文摘 | Ling N Ying SY Ueno N | 1986 | Biochem Biophys Res Commum1986，138，： | 1 |
| 11 | Identification of an emerging recombinant cluster in porcine circovirus type 2显示文摘 | Lin C Jian Q N Ying J X | 2012 | Virus Res2012，165，： | 1 |
| 12 | Influence of cerium on passvity behavior of wrought AZ91 alloy 显示文摘 | Wang H N Ying L Wang F H | 2008 | Electrochimica Acta2008，54，2： | 1 |
| 13 | 查看详情显示文摘 | Ying X T Luo J L Wang P N Cui M Q Zhao Y D Li G Zhu P P | | 0，，： | 1 |
| 14 | Ultra-thin freestanding diamond window for soft X-ray optics显示文摘 | Ying X T Luo J L Wang P N | 2003 | Diamond Related Mater2003，12，37： | 1 |
| 15 | Does educational attainment contribute to risk for delirium? A potential role for cognitive reserve显示文摘 | Richard N Jones Frances M Yang Zhang Ying | 2006 | J Gerontol A Biol Sci Med Sci2006，61，12： | 1 |
| 16 | Study on polyepoxysuccinic acid reverse osmosis scale inhibitor显示文摘 | Yonghong S U N Xiang W Ying W | 2009 | Journal of Environmental Sciences2009，21，： | 1 |
| 17 | Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase 显示文摘 | Ying G Elena N Wilfredo M | 2003 | J Neurosci2003，23，11： | 1 |
| 18 | DNA and RNA-based vac cines:principles,progress and prospects显示文摘 | Ying H Restifo N P | 1999 | Vaccine1999，18，910： | 1 |
| 19 | Alpha-crystallin protected axons from optic nerve degeneration after crushing in rats 显示文摘 | Ying X Zhang J Wang Y Wu N Wang Y Yew DT | 2008 | J Mol Neurosci2008，35，3： | 1 |
| 20 | Differentiation of scutellariae radix from astragali radix by capillary electrophoresis with electrochemical detection显示文摘 | Chen G Ying X Y Ye J N | 2000 | Analyst2000，125，5： | 1 |
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