| 1 | Effects of self-blood on the molding process of polymethyl methacrylate bone cement显示文摘ObjectiveTo 评估自我血是否在 polymethyl methacrylate (PMMA ) 的塑造的过程上有影响骨头水泥并且它是否为在 vitro 学习的临床的 practiceMethodsAn 是珍贵的,被执行确认在 PMMA 骨头水泥上评估自我血的延长效果。延长的效果到面团时间被评估(T D ) 和合用的时间(T O ) 。而且,坚硬测试,压榨的价值测试和山峰温度测试也被进行完成这 program.ResultsThe 自我血的评估,特别血浆,没有包括坚硬,漏水平和山峰温度影响它的基本特征,能极大地延长 PMMA 骨头水泥的处理时间。在另一方面,我们发现处于一些反常条件,例如与 hyperlipemia,自我血能也不过延长处理时间,将引起某 sideeffects.ConclusionWe 报告一个新有效方法由增加自我血的中等数量延长 PMMA 骨头水泥的处理时间。但是 “individualized medicine”因为象 hyperlipemia 一样的一些反常条件将引起不希望得到的副作用,应该被注意。 | Guo Yingjun Nie Lin Zhang Wen Mu Qing | 2014 | Chinese Journal of Traumatology2014，17，4： | 0 |
| 2 | Expressions of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in malignant peripheral nerve sheath tumor显示文摘BACKGROUND: Matrix metalloproteinase-9 (MMP-9) can degrade collagen Ⅳ (the main structural ingredient of basilar membrane), and it also plays an important role in tumor vascularization, tumor cell progression, formation of metastatic focus, etc. Tissue inhibitor of metalloproteinase-1 (TIMP-1) can bind with MMP-9 to form 1∶1 compound and inhibit its activity, and can negatively regulate the tumor progression and metastasis. OBJECTIVE: To analyze the relationship of MMP-9 and TIMP-1 expressions with the pathological grade, metastasis and prognosis of malignant peripheral nerve sheath tumor (MPNST). DESIGN: An observational comparative experiment. SETTING: Heze Medical College. PARTICIPANTS: Fifty-eight surgical pathological samples, which were clearly diagnosed to be MPNST, were collected from the pathological laboratory archives in the Department of Pathology, Heze Municipal Hospital from January 1988 to December 2003. The MPNST pathological types were common tumor in 53 cases, malignant triton tumor in 2 cases, epithelial MPNST in 2 cases and MPNST with gland differentiation in 1 case. The pathological grade was grade 1 in 11 cases, grade 2 in 24 cases and grade 3 in 23 cases. Besides, the resected tumor samples of 20 patients with benign peripheral nerve tumor (10 cases of nerve sheath tumor and 10 cases of neurofibromatosis) and the normal peripheral nerves (by-products of some surgeries) of 5 patients were also collected. The samples were used with the approval of the patients. Rat-anti-human MMP-9, TIMP-1 monoclonal antibody and S-P kit were purchased from Fuzhou Maixin Biotechnology, Co.,Ltd. METHODS: The documented paraffin blocks were again prepared to sections of 5 μm. The expressions of MMP-9 and TIMP-1 in the samples were detected with mmunohistochemical S-P method. The relationships of the MPNST severity, recurrence, metastasis and survival rate with the expressions of MMP-9 and TIMP-1 were analyzed. MAIN OUTCOME MEASURES: Relationships of MMP-9 and TIMP-1 expressions with the MPNST severity and prognosis. RESULTS: ① Expressions of MMP-9 and TIMP-1 in three tissues: MMP-9 and TIMP-1 stainings were mainly observed in cytoplasm. Among the 58 MPNST patients, the MMP-9 expression was significantly higher than those in normal peripheral nerve and benign tumor (P < 0.05), while the TIMP-1 expression in MPNST was lower than those in normal peripheral nerve and benign tumor (P < 0.05). ② Relationship of MMP-9 and TIMP-1 expressions with the severity and prognosis of MPNST: The expressions of both proteins were observed in the four subtypes. The positive expression of MMP-9 in the MPNST patients of grades 2-3 was significantly higher than that in the MPNST patients of grade 1 (P < 0.05), while the expression of MMP-9 was significantly lower than that in the MPNST patients of grade 1 (P < 0.05). The metastatic rate was positively correlated with MMP-9 expression (r =1.696, P < 0.05), but negatively correlated with TIMP-1 expression (r =-2.125, P < 0.05). CONCLUSION: MMP-9 and TIMP-1 are associated with MPNST pathological grades and metastasis, and can be used as the indicators for judging the severity and prognosis of MPNST. | Yunfei Qi Yingjun Mu Lixia Pei | 2007 | Neural Regeneration Research2007，2，8： | 0 |
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