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| 1 | Meningeal lymphatic vessels regulate brain tumor drainage and immunity显示文摘Recent studies have shown that meningeal lymphatic vessels(MLVs),which are located both dorsally and basally beneath the skull,provide a route for draining macromolecules and trafficking immune cells from the central nervous system(CNS)into cervical lymph nodes(CLNs),and thus represent a potential therapeutic target for treating neurodegenerative and neuroinflammatory diseases.However,the roles of MLVs in brain tumor drainage and immunity remain unexplored.Here we show that dorsal MLVs undergo extensive remodeling in mice with intracranial gliomas or metastatic melanomas.RNA-seq analysis of MLV endothelial cells revealed changes in the gene sets involved in lymphatic remodeling,fluid drainage,as well as inflammatory and immunological responses.Disruption of dorsal MLVs alone impaired intratumor fluid drainage and the dissemination of brain tumor cells to deep CLNs(dCLNs).Notably,the dendritic cell(DC)trafficking from intracranial tumor tissues to dCLNs decreased in mice with defective dorsal MLVs,and increased in mice with enhanced dorsal meningeal lymphangiogenesis.Strikingly,disruption of dorsal MLVs alone,without affecting basal MLVs or nasal LVs,significantly reduced the efficacy of combined anti-PD-1/CTLA-4 checkpoint therapy in striatal tumor models.Furthermore,mice bearing tumors overexpressing VEGF-C displayed a better response to anti-PD-1/CTLA-4 combination therapy,and this was abolished by CCL21/CCR7 blockade,suggesting that VEGF-C potentiates checkpoint therapy via the CCL21/CCR7 pathway.Together,the results of our study not only demonstrate the functional aspects of MLVs as classic lymphatic vasculature,but also highlight that they are essential in generating an efficient immune response against brain tumors. | Xueting Hu Qiuping Deng Lu Ma Qingqing Li Yidong Chen Yuhan Liao Fan Zhou Chen Zhang Linlin Shao Jun Feng Tubao He Weihai Ning Yan Kong Yingqing Huo Aibin He Bing Liu Jingjing Zhang Ralf Adams Yulong He Fuchou Tang Xiuwu Bian Jincai Luo | 2020 | Cell Research2020，30，3： | 11 |
| 2 | An overview on the designs of distributed observers in LTI multi-agent systems显示文摘With the rapid development of information technologies and cloud computing, sensor networks play an increasingly important role in our society. Over the past few decades, distributed observer theory has attracted unprecedented attention due to its wide potential applications in different areas. Meanwhile, various approaches and algorithms have been proposed and investigated. The design of distributed observers is one of the frontier topics of system and control research, which has the significant theoretical values and broad application prospects. This paper attempts to review the representative models and the corresponding approaches for distributed observer design in linear time-invariant(LTI) systems. Firstly, the research backgrounds and main advances of distributed observer designs are briefly reviewed. Then, recent results of distributed observer designs for discrete-time and continuous-time LTI multi-agent systems(MASs) are introduced in detail, respectively. Finally, the prospects and the future work directions of the design of distributed observers are put forward. The main purpose of this paper is to promote the emerging topic on the designs of distributed observers, with focuses on the interdisciplinary interest from technological sciences. | PEI YingQing GU HaiBo LIU KeXin LU JinHu | 2021 | Science China(Technological Sciences)2021，64，11： | 3 |
| 3 | Similar gene structure of two Sox9a genes and their expres-sion patterns during gonadal differentiation in a tele-ost fish,rice field eel(Monopterus albus)显示文摘 | Zhou Rongjia Liu Li Guo Yingqing | 2003 | Mol Reprod Dev2003，66，3： | 1 |
| 4 | Real-time Texture Synthesis by Patch-based Sampling显示文摘 | Liang Lin Liu Ce Xu Yingqing | 2001 | ACM Transactions on Graphics2001，20，3： | 1 |
| 5 | Real-time texture synthesis by patch-based sampling 显示文摘 | Liang Lin Liu Ce Xu Yingqing | 2001 | ACM Transactions on Graphics2001，20，3： | 1 |
| 6 | NumericaI Computation of Flow over a Train in Cross-Winds显示文摘NumericaIComputationofFlowoveraTraininCross-WindsZhangXiaogang;LiuYingqing(WindEngineering,ResearchCenter,SouthwestJiaotongUn... | Zhang Xiaogang Liu Yingqing(Wind Engineering,Research Center,Southwest Jiaotong Universily,)Chengdu 610031 ,China | 1995 | Journal of Modern Transportation1995，12，2： | 1 |
| 7 | Birthplace of Fashion Designers: Beijing Institute of Clothing Technology显示文摘CLOTHING, as the old Chinese saying goes, is regarded as the most basic human need. In 1988 in Beijing, the first institute of higher learning to focus on the design and manufacture of clothing was established. The Beijing Institute of Clothing Technology (BICT) offers a combined curriculum of art and fashion that has fostered the talent of many outstanding young designers. The college is located near the ruins of the city wall from the Yuan Dynasty (1271-1368) and has an enrollment of 2,500 undergraduate and graduate students. Before 1988 the building housed a college of chemical fibre engineering that had many lecturers and professors who where considered accomplished at both theory and application. The school was expanded with the addition of nine subjects and three new departments—Garment, | HU YINGQING XIAOHONG LIU | 1995 | Women of China1995，，2： | 1 |
| 8 | Application of The Geo-anomaly Unit Concept in Quantitative Delineation and Assessment of Gold Ore Targets In Western Shandong Uplift Terrain, Eastern China显示文摘 | Pengda Zhao Jianguo Chen Jiping Liu | 2001 | Natural Resources Research2001，10，1： | 1 |
| 9 | Compounding effects of human activities and climatic changes on coexistence of oasis-desert ecosystems:Prioritizing resilient decision-making for a riskier world显示文摘Water-salt balance is critical for the stable coexistence of salt-affected and groundwater-fed oasis-desert ecosystems. Yet, a comprehensive investigation of how soil salinization and groundwater degradation threaten the coexistence of oasis-desert ecosystems is still scarce, especially under the compounding effects of human activities and climatic changes. Here, we assessed the impacts of irrigated agriculture on hydrological regimes in oasisdesert systems, investigated the spatio-temporal variations of soil salinization in irrigated cropland, and evaluated the implications of the interplays of soil salinization and groundwater degradation on the coexistence of oasis-desert ecosystems in northwestern China, based on meaningful modelling approaches and comprehensive measurements over 1995–2020. The results showed that the irrigation return flow coefficient decreased sharply from 0.21 ± 0.09 in the traditional irrigation period to 0.09 ± 0.01 in the water-saving irrigation period. The continuous drop in groundwater tables and significant degradation of groundwater quality are occurring throughout this watershed. The eco-environmental flows are reaching to their limit with watershed closures(i.e.,the drainage from the oasis region into the desert region is being weakened or even eliminated), although these progressions were largely hidden by regional precipitation and streamflow variability. The process of salt migration and accumulation across different landscapes in oasis-desert system is being reshaped, and soil salinization in water-saving agricultural irrigated lands is accelerating with a regional average annual growth rate of18%. The vegetation in this watershed is degrading, and anthropogenic disturbance accelerates this trend. Our results highlight that environmental stress adaptation strategies must account for resilience maintenance to avoid accelerating catastrophic transitions in oasis-desert ecosystems. Determining the optimal oasis scales and formulating the best irrigation management plans are effective and resilient decision-making ways to maintain the coexistence relationship of oasis-desert ecosystem in drylands. | XinWei Yin Wei Liu Meng Zhu JuTao Zhang Qi Feng HaiYang Xi LinShan Yang Tuo Han WenJu Cheng YingQing Su BaiTing Zhang YuanYuan Xue ZeXia Chen LingGe Wang | 2023 | Research in Cold and Arid Regions2023，15，5： | 0 |
| 10 | Spectroscopic Analysis of the Interaction between Bovine Serum Protein and Lead Ion显示文摘In this paper, the spectral characteristics of the interaction between lead and bovine serum albumin (BSA) were analyzed by fluorescence spectroscopy, ultraviolet spectroscopy and infrared spectroscopy. The effects of pH, bovine serum albumin concentration, lead ion concentration and ionic strength on the spectra of lead ion-bovine serum albumin system were investigated, and the best testing condition is to determine the interaction between lead and BSA by testing the peak changes or displacement in the UV spectrum analysis. Fluorescence spectroscopy showed that lead ion could induce the fluorescence quenching of bovine serum albumin. The influence of lead ion on the secondary structure of protein was analyzed by infrared spectroscopy. It was found that β-angle increased,α-helix decreased and β-slice increased. | Xiangqian Kong Yingqing Liu Yanhua Chen | 2018 | Journal of Analytical Chromatography and Spectroscopy2018，1，1： | 0 |
| 11 | SIMULATION STUDY OF AERODYNAMIC FORCE FOR HIGH-SPEED MAGNETICALLY-LEVITATED TRAINS显示文摘基于雷纳兹一般水准 Navier-Storkes 方程粘滞不可压缩的液体和 k-epsilon 二个方程狂暴的模型, high-speedmagnetically-levitated (磁悬浮火车) 的空气动力学的力量在横向、纵的风中的火车被有限体积方法调查。在为横向的风回答的 2D 的 80 个计算案例和为 3Dlongitudinal 风的 20 个案例附近,领域被分析。空气动力学的方面力量,偏航,拖,为磁悬浮火车火车和一列车轮 / 栏杆火车的不同类型的电梯和投球的时刻在不同的风速度下面被比较。磁悬浮火车的类型为横向的风分析包括了的 2D 训练模型电磁的暂停(他们)类型火车,电力学的暂停(版本)类型火车,有在一个方面或指南方法的二个方面的躲蔽处风墙的他们类型火车和墙,它从火车身体是冷淡的高度或/并且不同距离。在旱桥上跑的磁悬浮火车火车的状况也被分析。为 3D 纵的风地分析,有在磁悬浮火车火车下面的空气清理的不同尺寸的模特儿为不同速度被检查。计算结果 hows 那:不同横向的效果在磁悬浮火车火车的不同类型被显示出的①。② Theshelter 风墙能相当减少磁悬浮火车火车上的横向的效果。③当躲蔽处墙高度是 2 m 时,火车上有最小的方面力量。当躲蔽处墙高度是 2.5m 时,火车上有最小的偏航时刻。④ 当在里面之间的距离墙出现,指南方法的中心是 4.0 m 时,火车上有最小的横向的影响,在火车身体下面的空气清理的⑤ Thesize 穿上小影响空气动力学火车拖,但是在空气动力学的电梯和火车的投球的时刻上有相当大的效果。为磁悬浮火车火车的精明的电梯和投球的时刻建模的⑥减价值。 | LI Renxian LIU Yingqing ZHAI Wanming | 2006 | Chinese Journal of Mechanical Engineering2006，19，2： | 0 |
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