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| 1 | Salvage therapy with lenalidomide containing regimen for relapsed/refractory Castleman disease: a report of three cases显示文摘Castleman 疾病(CD ) 是有未知病原学的不平常的非同种细胞的 lymphoproliferative 混乱。没有标准治疗为 relapsed/refractory CD 病人被推荐,因此要求新奇试验性的途径的开发。我们有 multicentric CD (MCD ) 的三个成年病人的队被对待与对传统的化疗包含 lenalidomide 政体倔强(1025 mg lenalidomide perorally 在天管理了 121 在 28 天的周期) 作为第二 -- 到第四线的治疗。部分宽恕在第一个血浆房间 CD 病人被完成, relapsed 在自体同源的造血的干细胞移植以后的七个月然后没能对化疗的四个周期作出回应。organomegaly,部分宽恕与 CD 和 polyneuropathy 在第二个病人被获得 endocrinopathy, monoclonal gammopathy,和皮肤变化症候群。第三个案例与血小板计数的肋膜的流出和腹水和正规化的完全的消失显示出完全的宽恕。得出结论,令人鼓舞的临床的回答与基于 lenalidomide 的政体在三个病人的队被完成,不过,长期的功效尚待被遵守。我们在对待 MCD 建议这药的治疗学的潜力的进一步的调查。 | Xinping Zhou Juying Wei Yinjun Lou Gaixiang Xu Min Yang Hui Liu Liping Mao Hongyan Tong Jie Jin | 2017 | Frontiers of Medicine2017，11，2： | 6 |
| 2 | Structures of convection and turbulent kinetic energy in boundary layer over the southeastern edge of the Tibetan Plateau显示文摘Based on a comprehensive analysis on Sonic Anemometer and gradient data, wind profile radar(WPR) and GPS sounding data of March–August 2008 from the boundary layer(BL) tower observation system at Dali on the southeastern edge of Tibetan Plateau(TP), it is found that the strengths of turbulent kinetic energy(TKE), buoyancy term and shear term depend on vegetation cover in association with local stability and thermodynamic condition. Strong kinetic turbulence appears when near surface layer in neutral condition with the large contribution from shear term. In an unstable condition within near surface layer, the atmospheric turbulent motion is mainly thermal turbulence, as buoyancy term is obviously larger than shear term. Under a stable condition the intermittent turbulence is accompanied by weak shear and buoyancy term, and TKE is significantly less than neutral or instable condition. The study also presents that the buoyancy term contribution at Nyingchi station in the southern slopes of the TP large topography in spring is significantly larger than that at Dali over the southeastern TP edge, reflecting that the thermal turbulence makes an important contribution to convection activity in the southern slopes of TP. Dali station is located in complex terrain with mountain and valley leading to larger kinetic turbulence. From the perspective of interaction of turbulence-convection in different scales, the study revealed that the height of convective boundary layer(CBL) could reach up to 1500–2000 m. TKE, shear term, and buoyancy term in near surface layer have the notable correlations with BL height and local vertical motion. The daytime thermodynamic turbulence effect of heat flux and buoyancy term has an obvious impact on the height of CBL, whereas mechanical turbulence only exerts a less impact. Mechanical turbulence in near surface layer has a significant impact on vertical motion especially in the forenoon with impacting height of 2500–3000 m. The peaks in diurnal variations of shear term and buoyancy term correspond to the high instable periods, especially in summer forenoon. Our observation analysis characterized the convection activity triggered by TKE source and their interaction in the southeastern TP edge. | WANG YinJun XU XiangDe ZHAO TianLiang SUN JiHua YAO WenQing ZHOU MingYu | 2015 | Science China Earth Sciences2015，58，7： | 4 |
| 3 | The Upstream "Strong Signals" of the Water Vapor Transport over the Tibetan Plateau during a Heavy Rainfall Event in the Yangtze River Basin显示文摘A heavy rainfall event that occurred over the middle and lower reaches of the Yangtze River Basin(YRB) during July11–13 2000 is explored in this study. The potential/stream function is used to analyze the upstream 'strong signals' of the water vapor transport in the Tibetan Plateau(TP). The studied time period covers from 2000 LST 5 July to 2000 LST 15 July(temporal resolution: 6 hours). By analyzing the three-dimensional structure of the water vapor flux, vorticity and divergence prior to and during the heavy rainfall event, the upstream 'strong signals' related to this heavy rainfall event are revealed. A strong correlation exists between the heavy rainfall event in the YRB and the convective clouds over the TP. The 'convergence zone' of the water vapor transport is also identified, based on correlation analysis of the water vapor flux two days and one day prior to, and on the day of, the heavy rainfall. And this 'convergence zone' coincides with the migration of the maximum rainfall over the YRB. This specific coupled structure actually plays a key role in generating heavy rainfall over the YRB. The eastward movement of the coupled system with a divergence/convergence center of the potential function at the upper/lower level resembles the spatiotemporal evolution of the heavy rainfall event over the YRB. These upstream 'strong signals' are clearly traced in this study through analyzing the three-dimensional structure of the potential/stream function of upstream water vapor transport. | Yang ZHAO Xiangde XU Bin CHEN Yinjun Wang | 2016 | Advances in Atmospheric Sciences2016，33，12： | 4 |
| 4 | Performance of WRF Large Eddy Simulations in Modeling the Convective Boundary Layer over the Taklimakan Desert, China显示文摘The maximum height of the convective boundary layer(CBL)over the Taklimakan Desert can exceed 5000 m during summer and plays a crucial role in the regional circulation and weather.We combined the Weather Research and Forecasting Large Eddy Simulation(WRF-LES)with data from Global Positioning System(GPS)radiosondes and from eddy covariance stations to evaluate the performance of the WRF-LES in simulating the characteristics of the deep CBL over the central Taklimakan Desert.The model reproduced the evolution of the CBL processes reasonably well,but the simulations generated warmer and moister conditions than the observation as a result of the over-prediction of surface fluxes and large-scale advection.Further simulations were performed with multiple configurations and sensitivity tests.The sensitivity tests for the lateral boundary conditions(LBCs)showed that the model results are sensitive to changes in the time resolution and domain size of the specified LBCs.A larger domain size varies the distance of the area of interest from the LBCs and reduces the influence of large forecast errors near the LBCs.Comparing the model results using the original parameterization of sensible heat flux with the Noah land surface scheme and those of the sensitivity experiments showed that the desert CBL is sensitive to the sensible heat flux produced by the land surface scheme during daytime in summer.A reduction in the sensible heat flux can correct overestimates of the potential temperature profile.However,increasing the sensible heat flux significantly reduces the total time needed to increase the CBL to a relatively low altitude(<3 km)in the middle and initial stages of the development of the CBL rather than producing a higher CBL in the later stages. | Hongxiong XU Minzhong WANG Yinjun WANG Wenyue CAI | 2018 | Journal of Meteorological Research2018，32，6： | 3 |
| 5 | Efficacy and prognostic factors of imatinib plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia显示文摘一个 CALLG2008 协议被中国尖锐成淋巴细胞的白血病合作的组为成年尖锐成淋巴细胞的白血病(所有) 开发。我们回顾地与费城染色体(Ph ) 分析了 153 个最新诊断的成年病人积极加在 2009 和 2015 之间的 CALLG2008 政体注册进 imatinib (400 mg/d ) 的所有。中部的年龄是 40 年(范围, 1868 年) ,与 81 (52.3%) 男性。全面 hematologic 完全的宽恕(CR ) 率在正式就职以后是 96.7% 。与 24.2 个月的中部的后续,估计的 3 年的全面幸存(OS ) 和没有事件的幸存(EFS ) 评价是 49.5%(95% 信心间隔(CI ) :38.5%59.5%) 并且 49.2%(95% CI:38.3%59.2%) 分别地。58 (36 与 haploidentical 施主) 病人们经历了 allogeneic 在第一 CR 的造血的干细胞移植(allo-HSCT ) 。在在在正式就职以后的 CR1 的病人之中, 3 年的 OS 和 EFS 比在 without allo-HSCT 组在 allo-HSCT 组显著地更好(73.2% , 95% CI:58.3%83.5% 对 22.2% , 95% CI:8.7%39.6% 并且 66.5% , 95% CI:50.7%78.2% 对 16.1% , 95% CI:5.1%32.7% ,分别地) 。Multivariate 分析显示出那 allo-HSCT,主要分子的反应的成就独立地与有利 OS 或 EFS 被联系。在 allo-HSCT 队,有趣地,施主类型(haploidentical 对匹配的施主) 没在 EFS 或 OS 上有重要影响。所有这些结果建议加 CALLG2008 的那 imatinib 是一个有效协议为 Ph 积极所有。Haploidentical 施主能也是一个合理其他的有用施主水池。 | Yinjun Lou Yafang Ma Chenyin Li Sansan Suo Hongyan Tong Wenbin Qian Wenyuan Mai Haitao Meng Wenjuan Yu Liping Mao Juyin Wei Weilei Xu Jie Jin | 2017 | Frontiers of Medicine2017，11，2： | 3 |
| 6 | Clinical characteristics and prognostic values of 1p32.3 deletion detected through fluorescence in situ hybridization in patients with newly diagnosed multiple myeloma: a single-center study in China显示文摘This study aimed to investigate the prevalence,clinical characteristics,and prognostic impact of 1p32.3 deletion in patients with newly diagnosed multiple myeloma (MM).A retrospective analysis was conducted on 411 patients with newly diagnosed MM;among which,270 received bortezomib-based therapies,and 141 received thalidomide-based therapies.Fluorescence in situ hybridization (FISH) was performed to detect six cytogenetic abnormalities,namely,del(1p32.3),gain(1q21),del(17p13),del(13q14),t(4;14),and t(11;14).Results showed that 8.3% of patients with MM were detected with del(1p32.3) and had significantly more bone marrow plasma cells (P =0.025),higher β2-microglobulin levels (P =0.036),and higher lactate dehydrogenase levels (P =0.042) than those without del(1p32.3).Univariate analysis showed that patients with del(1p32.3) under thalidomide-based therapies were strongly associated with short progression-free survival (PFS) (median PFS 11.6 vs.31.2 months,P =0.002) and overall survival (OS) (median OS 16.8 vs.45.9 months,P < 0.001).Multivariate analysis revealed that del(1p32.3) remained a powerful independent factor with worse PFS (P =0.006) and OS (P =0.016) for patients under thalidomide-based treatments.Patients with del(1 p32.3) under bortezomib-based treatments tended to have short PFS and OS.In conclusion,del(1p32.3) is associated with short PFS and OS in patients with MM who received thalidomide-or bortezomib-based treatments. | Huanping Wang Haitao Meng Jinghan Wang Yinjun Lou Yile Zhou Peipei Lin Fenglin Li Lin Liu Huan Xu Min Yang Jie Jin | 2020 | Frontiers of Medicine2020，14，3： | 2 |
| 7 | Steroidal saponins from Disporopsis pemyi显示文摘 | Yang Qingxiang Xu Min Zhang Yinjun | 2004 | Helv Chim Acta2004，87，5： | 1 |
| 8 | Steroidal saponins from Disporopsis pernyi显示文摘 | Yang Qingxiang Xu Min Zhang Yinjun | | 0，，05： | 1 |
| 9 | NOMA-Based Spectrum Sensing for Satellite-Terrestrial Communication显示文摘With the continuous development of wireless communication technology,the number of access devices continues to soar,which poses a grate challenge to the already scarce spectrum resources.Meanwhile,6G will be an era of air-space-terrestrial-sea integration,and satellite spectrum resources are also very tight in the context of giant constellations.In this paper,we propose a Non-Orthogonal Multiple Access(NOMA)based spectrum sensing scheme for the future satellite-terrestrial communication scenarios,and design the transceiver from uplink and downlink scenarios,respectively.In order to better identify the user's transmission status,we obtain the feature values of each user through feature detection to make decision.We combine these two technologies to design the transceiver architecture and deduce the threshold value of feature detection in the satellite-terrestrial communication scenario.Simulations are performed in each scenario,and the results illustrate that the proposed scheme combining NOMA and spectrum sensing can greatly improve the throughput with a similar detection probability as Orthogonal Multiple Access(OMA). | Tianheng Xu Yinjun Xu Ting Zhou Xianfu Chen Honglin Hu | 2023 | China Communications2023，20，4： | 1 |
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