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| 1 | Expression,purification and characterization of Mycobacterium tuberculosis RpfE protein显示文摘Resuscitation promoting factor E(RpfE)is one of the five Rpf-like proteins in Mycobacterium tuberculosis(M.tuberculosis).These Rpf-like proteins are secretory,which make them candidates for recognition by the host immune system.In this study,the RpfE gene was amplified from M.tuberculosis,cloned into the expression vectors pDE22 and pPRO EXHT,and were expressed in Mycobacterium vaccae(M.vaccae)and Escherichia coli DH5α,respectively.Both recombinant RpfE proteins were purified by Ni-Sepharose affinity chromatography,and were given to C57BL/6 mice.The RpfE proteins elicited T cell proliferation,and stimulated the production of gamma interferon(IFN-γ),interleukin-10(IL-10)and IL-12.Our results indicated that the RpfE protein expressed in M.vaccae could more efficiently stimulate cellular immune response,making it a promising candidate as a subunit vaccine. | Ying Xue Yinlan Bai Xue Gao Hong Jiang Limei Wang Hui Gao Zhikai Xu | 2012 | The Journal of Biomedical Research2012，26，1： | 2 |
| 2 | Validation of different personalized risk models of chemotherapy-induced nausea and vomiting:results of a randomized,double-blind,phase III trial of fosaprepitant for cancer patients treated with high-dose cisplatin显示文摘Background:Highly emetogenic chemotherapy induces emesis in cancer patients without prophylaxis.The purpose of this study was to evaluate the efficacy and safety of a fosaprepitant-based triple antiemetic regimen for the prevention of chemotherapy-induced nausea and vomiting(CINV)in patients with solid malignant tumors,determine risk factors and externally validate different personalized risk models for CINV.Methods:This phase III trial was designed to test the non-inferiority of fosaprepitant toward aprepitant in cancer patients who were to receive the first cycle of single-day cisplatin chemotherapy.The primary endpoint was complete response(CR)during the overall phase(OP)with a non-inferiority margin of 10.0%.Logistic regression modelswere used to assess the risk factors ofCRand no nausea.To validate the personalized risk models,the accuracy of the risk scoring systems was determined by measuring the specificity,sensitivity and area under the receiver operating characteristic(ROC)curve(AUC),while the predictive accuracy of the nomogram was measured using concordance index(C-index).Results:A total of 720 patients were randomly assigned.CR during the OP in the fosaprepitant group was not inferior to that in the aprepitant group(78.1%vs.77.7%,P=0.765)with a between-group difference of 0.4%(95%CI,-5.7%to 6.6%).Female sex,higher cisplatin dose(≥70 mg/m2),no history of drinking and larger body surface area(BSA)were significantly associated with nausea.The AUC for the acute and delayed CINV risk indexes was 0.68(95%CI:0.66-0.71)and 0.66(95%CI:0.61-0.70),respectively,and the C-index for nomogram CINV prediction was 0.59(95%CI,0.54-0.64).Using appropriate cutoff points,the three models could stratify patients with high-or low-risk CINV.No nausea and CR rate were significantly higher in the low-risk group than in the high-risk group(P<0.001).Conclusions:Fosaprepitant-based triple prophylaxis demonstrated non-inferior control for preventing CINV in patients treated with cisplatin-base chemotherapy.Female cancer patients without a history of alcohol consumption,with larger BSA and received high-dose cisplatin might be more vulnerable to CINV.Three personalized prediction models were well-validated and could be used to optimize antiemetic therapy for individual patients. | Yuanyuan Zhao Bing Zhao Gang Chen Yinlan Chen Zijun Liao Haiming Zhang Weineng Feng Yinyin Li Heng Weng Weidong Li Yuefen Zhou Biyong Ren Yanda Lu Jianhua Chen Zhenteng Liu Zhenzhong Su Wenliang Wang Li Zhang | 2023 | Cancer Communications2023，43，2： | 2 |
| 3 | Wavelength dispersion of Verdet constant in chalcogenide glasses for magneto-optical waveguide devices显示文摘 | Yinlan Ruan Ruth A Jarvis Andrei V Rode | 2005 | Opt Commun2005，252，13： | 1 |
| 4 | Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis显示文摘 | Guohua Gong Yuan Qin Wen Huang Shu Zhou Xiaohua Wu Xiaohua Yang Yinlan Zhao Dan Li | 2010 | Chemico-Biological Interactions2010，，3： | 1 |
| 5 | Effect of site-directed PEGylation of trichosanthin on its biological activity, immunogenicity, and pharmacokinetics显示文摘 | Qunxing An Yingfeng Lei Ning Jia Xianqing Zhang Yinlan Bai Jing Yi Rui Chen Aijun Xia Jing Yang Sanhua Wei Xiaodong Cheng Ailing Fan Shijie Mu Zhikai Xu | 2007 | Biomolecular Engineering2007，，6： | 1 |
| 6 | Immunogenicity and protective efficacy of a DNA vaccine encoding the fusion protein of mycobacterium heat shock protein 65 with interleukin-2 against Mycobacterium tuberculosis in BALB/c mice 显示文摘 | Limei Wang Yinlan Bai Changhong Shi | 2008 | APMIS2008，116，： | 1 |
| 7 | Study of pyridinium-type functional polymers Ⅱ: Antibacterial activity of soluble pyridinium-type plymers显示文摘 | Guangji Li Jiarui Shen Yinlan Zhu | 1998 | J Appl Polym Sci1998，67，： | 1 |
| 8 | Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents显示文摘 | Yuan Qin Xiaohua Wu Wen Huang Guohua Gong Dan Li Yang He Yinlan Zhao | 2009 | Journal of Ethnopharmacology2009，，3： | 1 |
| 9 | On Nonsingularity and Group Inverse of Linear Combinations of Generalized and Hypergeneralized Projectors显示文摘In this paper, some conditions for the nonsingularity and group inverses of linear combinations of generalized and hypergeneralized projectors are established. Moreover, some formulae for the inverses and group inverses of them are derived. The work of this paper extends some previous results. | CHEN Yinlan ZUO Kezheng XIE Tao | 2014 | Wuhan University Journal of Natural Sciences2014，19，6： | 0 |
| 10 | Freestanding metal nanohole array for high-performance applications显示文摘Plasmonic devices using periodic metallic nanostructures have recently gained tremendous interest for color filters,sensing,surface enhanced spectroscopy,and enhanced photoluminescence,etc.However,the performance of such plasmonic devices is severely hampered by the solid substrates supporting the metallic nanostructures.Here,a strategy for freestanding metallic nanomembranes is introduced by taking advantages of hollow substrate structures.Large-area and highly uniform gold nanomembranes with nanohole array are fabricated via a flexible and simple replication-releasing method.The hollow structures include a hollow core fiber with 30μm core diameter and two ferrules with their hole diameter as 125 and 500μm,respectively.As a proof-of-concept demonstration,2 times higher sensitivity of the bulk refractive index is obtained with this platform compared to that of a counterpart on a solid silica substrate.Such a portable and compact configuration provides unique opportunities to explore the intrinsic properties of the metal nanomembranes and paves a new way to fabricate high-performance plasmonic devices for biomolecule sensing and color filter. | Bobo Du Yinlan Ruan Dexing Yang Peipei Jia Shoufei Gao Yingying Wang Pu Wang Heike Ebendorff-Heidepriem | 2020 | Photonics Research2020，8，11： | 0 |
| 11 | Puerarin inhibits NHE1 activity by interfering with the p38 pathway and attenuates mitochondrial damage induced by myocardial calcium overload in heart failure rats显示文摘Previous studies have shown that puerarin plays a key role in protecting humans and animals from cardiovascular diseases.The exact mechanism of the therapeutic effect of puerarin on various cardiovascular diseases(protective effect on cardiomyocytes)is still unclear.In the present study,we identify the role of puerarin in an animal model of experimental heart failure(HF)and explore its underlying mechanisms.The HF rat model is induced by in-traperitoneal injection of adriamycin(ADR),and puerarin is administered intragastrically at low,medium,and high concentrations.We demonstrate that puerarin significantly improves myocardial fibrosis and inflammatory in-filtration and,as a result,improves cardiac function in ADR-induced HF rats.Mechanistically,we find for the first time that puerarin inhibits overactivated Na+/H+exchange isoform 1(NHE1)in HF,which may improve HF by decreasing Na+and Ca2+ion concentrations and attenuating mitochondrial damage caused by calcium overload;on the other hand,puerarin inhibits the activation of the p38 pathway in HF,reduces the expressions of TGF-βand proinflammatory cytokines,and suppresses myocardial fibrosis.In conclusion,our results suggest that Puerarin is an effective drug against HF and may play a protective role in the myocardium by inhibiting the activation of p38 and its downstream NHE1. | Guopin Pan Baoyue Cui Mingming Han Laibiao Lin Yinlan Li Ling Wang Shuang Guo Yaling Yin Heqin Zhan Peng Li | 2024 | Acta Biochimica et Biophysica Sinica2024，56，2： | 0 |
| 12 | Nonlinear Integrated Optical Waveguides in Chalcogenide Glasses显示文摘This paper reports on the study and measurement of the third order optical nonlinearity in bulk sulfide-based chalcogenide glasses; The fabrication process of the ultrafast laser deposited As-S-(Se)-based chalcogenide films and optical waveguides using two techniques: wet chemistry etching and plasma etching. | Yinlan Ruan Barry Luther-Davies Weitang Li Andrei Rode Marek Samoc | 2003 | 光学学报2003，23，S1： | 0 |
| 13 | Extended Power Law Nonlinear Response and Amplitude-Dependent ac Susceptibility of High-To Superconductors显示文摘We show a nonlinear materials equation of superconductors in the form of an extended power law which can be derived from the Ginzburg-Landau (GL) functional. The critical current Jc and ac susceptibility X are analysed by using this equation, and the puzzling question of the increasing height of the out-of-phase susceptibility peak Xpeak with increasing amplitude hac is explained. | NINGZhen-Hua CHENKai-Xuan YINLan LUGuo XUXiao-Lin GUOjian-Dong WANGFu-Ren YINDao-Le | 2004 | Chinese Physics Letters2004，21，7： | 0 |
| 14 | Dynamic changes in butyrate levels regulate satellite cell homeostasis by preventing spontaneous activation during aging显示文摘The gut microbiota plays a pivotal role in systemic metabolic processes and in particular functions,such as developing and preserving the skeletal muscle system.However,the interplay between gut microbiota/metabolites and the regulation of satellite cell(SC)homeostasis,particularly during aging,remains elusive.We propose that gut microbiota and its metabolites modulate SC physiology and homeostasis throughout skeletal muscle development,regeneration,and aging process.Our investigation reveals that microbial dysbiosis manipulated by either antibiotic treatment or fecal microbiota transplantation from aged to adult mice,leads to the activation of SCs or a significant reduction in the total number.Furthermore,employing multi-omics(e.g.,RNA-seq,16S r RNA gene sequencing,and metabolomics)and bioinformatic analysis,we demonstrate that the reduced butyrate levels,alongside the gut microbial dysbiosis,could be the primary factor contributing to the reduction in the number of SCs and subsequent impairments during skeletal muscle aging.Meanwhile,butyrate supplementation can mitigate the antibiotics-induced SC activation irrespective of gut microbiota,potentially by inhibiting the proliferation and differentiation of SCs/myoblasts.The butyrate effect is likely facilitated through the monocarboxylate transporter 1(Mct1),a lactate transporter enriched on membranes of SCs and myoblasts.As a result,butyrate could serve as an alternative strategy to enhance SC homeostasis and function during skeletal muscle aging.Our findings shed light on the potential application of microbial metabolites in maintaining SC homeostasis and preventing skeletal muscle aging. | Shujie Chen Liujing Huang Bingdong Liu Huimin Duan Ze Li Yifan Liu Hu Li Xiang Fu Jingchao Lin Yinlan Xu Li Liu Dan Wan Yulong Yin Liwei Xie | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
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