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| 1 | Abiotic-Biological Hybrid Systems for CO2 Conversion to Value-Added Chemicals and Fuels显示文摘Abiotic-biological hybrid systems that combine the advantages of abiotic catalysis and biotransformation for the conversion of carbon dioxide(CO2)to value-added chemicals and fuels have emerged as an appealing way to address the global energy and environmental crisis caused by increased CO2 emission.We illustrate the recent progress in this field.Here,we first review the natural CO2 fixation pathways for an in-depth understanding of the biological CO2 transformation strategy and why a sustainable feed of reducing power is important.Second,we review the recent progress in the construction of abiotic-biological hybrid systems for CO2 transformation from two aspects:(i)microbial electrosynthesis systems that utilize electricity to support whole-cell biological CO2 conversion to products of interest and(ii)photosynthetic semiconductor biohybrid systems that integrate semiconductor nanomaterials with CO2-fixing microorganisms to harness solar energy for biological CO2 transformation.Lastly,we discuss potential approaches for further improvement of abiotic-biological hybrid systems. | Jiansheng Li Yao Tian Yinuo Zhou Yongchao Zong Nan Yang Mai Zhang Zhiqi Guo Hao Song | 2020 | Transactions of Tianjin University2020，26，4： | 4 |
| 2 | Structure-based design,synthesis,and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors显示文摘The pathological processes of Alzheimer's disease and type 2 diabetes mellitus have been demonstrated to be linked together. Both PDE9 inhibitors and PPARγ agonists such as rosiglitazone exhibited remarkable preclinical and clinical treatment effects for these two diseases. In this study, a series of PDE9 inhibitors combining the pharmacophore of rosiglitazone were discovered. All the compounds possessed remarkable affinities towards PDE9 and four of them have the IC_(50) values 5n mol/L. In addition, these four compounds showed low cell toxicity in human SH-SY5Y neuroblastoma cells.Compound 11a, the most effective one, gave the IC_(50) of 1.1 nmol/L towards PDE9, which is significantly better than the reference compounds PF-04447943 and BAY 73-6691. The analysis of putative binding patterns and binding free energy of the designed compounds with PDE9 may explain the structure–activity relationships and provide evidence for further structural modifications. | Xu-Nian Wu Ya-Dan Huang Jin-Xuan Li Yan-Fa Yu Qian Zhou Chen Zhang Yinuo Wu Hai-Bin Luo | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 4 |
| 3 | Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia显示文摘Our previous study demonstrated that phosphodiesterase 8(PDE8)could work as a potential target for vascular dementia(Va D)using a chemical probe 3a.However,compound 3a is a chiral compound which was obtained by chiral resolution on HPLC,restricting its usage in clinic.Herein,a series of non-chiral 9-benzyl-2-chloro-adenine derivatives were discovered as novel PDE8 inhibitors.Lead 15 exhibited potent inhibitory activity against PDE8A(IC_(50)=11 nmol/L),high selectivity over other PDEs,and remarkable drug-like properties(worthy to mention is that its bioavailability was up to 100%).Oral administration of 15 significantly improved the c AMP level of the right brain and exhibited dosedependent effects on cognitive improvement in a Va D mouse model.Notably,the X-ray crystal structure of the PDE8A—15 complex showed that the potent affinity and high selectivity of 15 might come from the distinctive interactions with H-pocket including T-shapedπ—πinteractions with Phe785 as well as a unique H-bond network,which have never been observed in other PDE-inhibitor complex before,providing new strategies for the further rational design of novel selective inhibitors against PDE8. | Xu-Nian Wu Qian Zhou Ya-Dan Huang Xi Xie Zhe Li Yinuo Wu Hai-Bin Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，7： | 2 |
| 4 | Unique strength-ductility balance of AlCoCrFeNi_(2.1)eutectic high entropy alloy with ultra-fine duplex microstructure prepared by selective laser melting显示文摘As a typical dual-phase eutectic high entropy alloy(EHEA),AlCoCrFeNi_(2.1)can achieve the fair matching of strength and ductility,which has attracted wide attention.However,the engineering applications of as-cast AlCoCrFeNi_(2.1)EHEAs still face challenges,such as coarse grain and low yield strength resulting from low solidification rate and temperature gradient.In this study,selective laser melting(SLM)was introduced into the preparation of AlCoCrFeNi_(2.1)EHEA to realize unique strength-ductility balance,with emphasis on investigating the effects of processing parameters on its eutectic microstructure and properties.The results show that the SLM-ed samples exhibit a completely eutectic structure consisting of ultra-fine face-centered cubic(FCC)and ordered body-centered cubic(B2)phases,and the duplex microstructure undergoes a morphological evolution from lamellar structure to cellular structure as laser energy input reducing.The SLM-ed AlCoCrFeNi_(2.1)EHEA presents an excellent match of high tensile strength(1271 MPa),yield strength(966 MPa),and good ductility(22.5%)at room temperature,which are significantly enhanced by the ultra-fine grains and heterogeneous structure due to rapid solidification rate and high temperature gradient during SLM.Especially,the yield strength increment of~50%is realized with no loss in ductility as compared with the as-cast samples with the same composition.On this basis,the precise complex component with excellent mechanical properties is well achieved.This work paves the way for the performance improvement and complex parts preparation of EHEA by microstructural design using laser additive manufacturing. | Yinuo Guo Haijun Su Haotian Zhou Zhonglin Shen Yuan Liu Jun Zhang Lin Liu Hengzhi Fu | 2022 | Journal of Materials Science & Technology2022，，16： | 2 |
| 5 | Thiophene-Conjugated Porous C_(3)N_(4) Nanosheets for Boosted Photocatalytic Nicotinamide Cofactor Regeneration to Facilitate Solar-to-Chemical Enzymatic Reactions显示文摘The low catalytic efficiency of redox-active cofactor photoregeneration severely limits the performance of photoenzymatic hybrid systems. Herein, we synthesized thiophene-conjugated porous C3N4 nanosheets(CN-ATCN) exhibiting boosted photoregeneration activity of nicotinamide cofactors(NADH and NADPH), which are the most common redox cofactors of oxidoreductases, with regeneration rates of 59.00 μM/min for NADH and 40.99 μM/min for NADPH, ~ 84.3 and 24.7 times higher than those of bulk g-C3N4, respectively. The thin nanosheet structure of CN-ATCN facilitates the exposure of active sites to reactants and favors the diff usion of reactants and products. Upon conjugation of a thiophene moiety into the carbon nitride framework, the optical and photoelectric properties of CN-ATCN were considerably enhanced by an extended π-conjugation system in the frameworks and molecular type II heterojunctions formed between the incorporated and nonincorporated portions of CN-ATCN. Upon coupling NAD(P)H photoregeneration reaction by CN-ATCN with NAD(P)H-dependent enzymatic systems, sustainable synthesis of L-tert-leucine and styrene oxide was achieved with rates of 964 and 14.9 μM/h, respectively. | Yao Tian Yongchao Zong Yinuo Zhou Jiansheng Li Nan Yang Mai Zhang Zhiqi Guo Hao Song | 2021 | Transactions of Tianjin University2021，27，1： | 1 |
| 6 | Asymmetric transfer hydrogenation of ketones with a polyethylene glycol bound Ru catalyst in water显示文摘 | Liu Juntao Zhou Yougui Wu Yinuo | 2008 | Tetrahedron: Asymmetry2008，19，7： | 1 |
| 7 | Synergy of in-situ heterogeneous interphases tailored lithium deposition显示文摘The implementation of a robust artificial solid electrolyte interphase(ASEI)to replace the unstable natural SEI can regulate lithium deposition behaviors and avoid the safety hazards caused by dendrites permeation in lithium metal batteries.Despite of devoted efforts in tailoring components of ASEI,the intrinsic mechanism of interfacial synergy within the heterogeneous interphases has not been well elucidated yet.Herein,we show that the lithium plating/striping behaviors can be substantially enhanced(over 900 h with an overpotential of less than 20 mV at 1 mA·cm^(−2)in Li|Li symmetric cells and 146 cycles in anode-free cells)by regulating the heterogeneous interphases.This favorable ASEI composed of LiF and Li_(3)N components can be in-situ generated during cycling by large-scale fabricated fluorinated boron nitride coatings.Further,the synergy of each heterogeneous component within ASEI was explored theoretically and experimentally.Li_(3)N has high adsorption energy and low ion diffusion barrier,which facilitates the transport of lithium ions and avoids its local accumulation to evolve into dendrites.Both the substrate and LiF are interfacially stable with high electron tunneling barriers,preventing the electrolyte decomposition and parasitic reactions.Finally,the high stiffness of the boron nitride also ensures lithium dendrites are suppressed once they grow,providing a stable environment for long-term cycling of lithium metal batteries. | Yinuo Li Anjun Hu Xingdong Gan Miao He Jun Zhu Wei Chen Yin Hu Tianyu Lei Fei Li Yaoyao Li Yuxin Fan Fan Wang Mingjie Zhou An Wen Baihai Li | 2023 | Nano Research2023，16，6： | 0 |
| 8 | XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer显示文摘Macrophages are among the most abundant immune cells in colorectal cancer (CRC). Re-educating tumor-associated macrophages (TAMs) to switch from protumoral to anti-tumoral activity is an attractive treatment strategy that warrants further investigation. However, little is known about the key pathway that is activated in TAMs. In this study, infitrating CD206^(+) TAMs in CRC were sorted and subjected to RNA-seq analysis. Differentially expressed genes were found to be enriched in unfolded protein response/endoplasmic reticulum stress response processes, and XBP1 splicing/activation was specifically observed in TAMs. XBP1 activation in TAMs promoted the growth and metastasis of CRC. Ablation of XBP1 inhibited the expression of the pro-tumor cytokine signature of TAMs, including IL-6, VEGFA, and IL-4. Simultaneously, XBP1 depletion could directly inhibit the expression of SIRPα and THBS1, thereby blocking “don’t eat me” recognition signals and enhancing phagocytosis. Therapeutic XBP1 gene editing using AAV2-sgXBP1 enhanced the anti-tumor activity. Together, XBP1 activation in TAMs drives CRC progression by elevating pro-tumor cytokine expression and secretion, as well as inhibiting macrophage phagocytosis. Targeting XBP1 signaling in TAMs may be a potential strategy for CRC therapy. | Yahui Zhao Weina Zhang Miaomiao Huo Peng Wang Xianghe Liu Yu Wang Yinuo Li Zhixiang Zhou Ningzhi Xu Hongxia Zhu | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 0 |
| 9 | Decoding the spatiotemporal regulation of transcription factors during human spinal cord development显示文摘The spinal cord is a crucial component of the central nervous system that facilitates sensory processing and motor performance.Despite its importance,the spatiotemporal codes underlying human spinal cord development have remained elusive.In this study,we have introduced an image-based single-cell transcription factor(TF)expression decoding spatial transcriptome method(TF-seqFISH)to investigate the spatial expression and regulation of TFs during human spinal cord development.By combining spatial transcriptomic data from TF-seqFISH and single-cell RNA-sequencing data,we uncovered the spatial distribution of neural progenitor cells characterized by combinatorial TFs along the dorsoventral axis,as well as the molecular and spatial features governing neuronal generation,migration,and differentiation along the mediolateral axis.Notably,we observed a sandwich-like organization of excitatory and inhibitory interneurons transiently appearing in the dorsal horns of the developing human spinal cord.In addition,we integrated data from 10×Visium to identify early and late waves of neurogenesis in the dorsal horn,revealing the formation of laminas in the dorsal horns.Our study also illuminated the spatial differences and molecular cues underlying motor neuron(MN)diversification,and the enrichment of Amyotrophic Lateral Sclerosis(ALS)risk genes in MNs and microglia.Interestingly,we detected disease-associated microglia(DAM)-like microglia groups in the developing human spinal cord,which are predicted to be vulnerable to ALS and engaged in the TYROBP causal network and response to unfolded proteins.These findings provide spatiotemporal transcriptomic resources on the developing human spinal cord and potential strategies for spinal cord injury repair and ALS treatment. | Yingchao Shi Luwei Huang Hao Dong Meng Yang Wenyu Ding Xiang Zhou Tian Lu Zeyuan Liu Xin Zhou Mengdi Wang Bo Zeng Yinuo Sun Suijuan Zhong Bosong Wang Wei Wang Chonghai Yin Xiaoqun Wang Qian Wu | 2024 | Cell Research2024，34，3： | 0 |
| 10 | Structural basis of Semliki Forest virus entry using the very-low-density lipoprotein receptor显示文摘Alphaviruses are a group of important viruses that cause significant diseases in humans.Among them,Semliki Forest vi-rus(SFV)not only causes symptoms such as joint pain but also infects neuron cells and induces encephalitis in rodents.Recently,the very-low-density lipoprotein receptor(VLDLR)was identified as the cellular receptor for SFV entry.In this study,we present the cryo-electron microscopy structure of SFV bound to human VLDLR.VLDLR targets E1-DIII region of SFV using its membrane-distal LDLR class A(LA)repeats.Structural and functional analyses emphasize the synergistic role of multiple VLDLR repeats in the SFV entry.Remarkably,VLDLR’s binding mode to SFV closely mirrors that of minor group human rhinoviruses but differs significantly from other alphaviruses’interactions with receptors in the canyon re-gion of the E protein.We also assessed SFV binding to VLDLR or apolipoprotein E receptor 2(ApoER2)proteins in horses and mosquitoes and revealed their use of multiple but different LA repeats for binding.Our findings illuminate SFV’s cross-species infectivity,offering insights into potential antiviral strategies against alphavirus infections. | Ying Li Zhennan Zhao Sheng Liu Haichen Wang Junqing Sun Yan Chai Jingya Zhou Yinuo Wang Yi Shi Hao Song George Fu Gao | 2023 | hLife2023，1，2： | 0 |
| 11 | Formation and Evolution of Surface Morphology in Overhang Structure of IN718 Superalloy Fabricated by Laser Powder Bed Fusion显示文摘Controlling the overhang surface quality is still a formidable challenge in manufacturing the components with complex structures during laser powder bed fusion(LPBF).This study systematically uncovers the effects of the volume energy density(VED)and overhang angle on the evolution of surface morphology and corresponding surface roughness(Ra)of top and down-skin surfaces of IN718 superalloy samples.The results show that balling,Plateau-Rayleigh instability,open pore and humping caused by the material stacking are the main factors contributing to the apparent deterioration of top surface quality.When the VED is 80–100 J/mm^(3),the high down-skin surface roughness is attributed to the serious dross caused by recoil pressure and sinking of the melt pool.Using insufficient VED(15–50 J/mm^(3))can easily lead to poor metallurgical bonding and material spalling on the down-skin surface.In addition,overhang angle also significantly affects down-skin surface roughness due to the stair effect and the adhered unmelted powders.An improvement in the surface quality of down-skin surface is observed when the overhang angle increases.Based on the finding of this investigation,an optical VED(59.5 J/mm^(3))significantly improves the top and down-skin surface quality and porosity of overhang samples.This study provides an insight into synergy ascension of the top and down-skin surface quality in the overhang structure. | Haotian Zhou Haijun Su Yinuo Guo Yuan Liu Di Zhao Peixin Yang Zhonglin Shen Le Xia Min Guo | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，9： | 0 |
| 12 | Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia:Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis显示文摘Vascular dementia(VaD)is the second commonest type of dementia which lacks of efficient treatments currently.Neuroinflammation as a prominent pathological feature of VaD,is highly involved in the development of VaD.In order to verify the therapeutic potential of PDE1 inhibitors against VaD,the anti-neuroinflammation,memory and cognitive improvement were evaluated in vitro and in vivo by a potent and selective PDE1 inhibitor 4a.Also,the mechanism of 4a in ameliorating neuroinflammation and VaD was systematically explored.Furthermore,to optimize the drug-like properties of 4a,especially for metabolic stability,15 derivatives were designed and synthesized.As a result,candidate 5f,with a potent IC50 value of 4.5 nmol/L against PDE1C,high selectivity over PDEs,and remarkable metabolic stability,efficiently ameliorated neuron degeneration,cognition and memory impairment in VaD mice model by suppressing NF-κB transcription regulation and activating cAMP/CREB axis.These results further identified PDE1 inhibition could serve as a new therapeutic strategy for treatment of VaD. | Qian Zhou Meiling Le Yiyi Yang Wenjuan Wang Yuqi Huang Quan Wang Yijing Tian Meiyan Jiang Yong Rao Hai-Bin Luo Yinuo Wu | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 0 |
| 13 | ANNUAL CONFERENCE REVIEW OF THE RESEARCH INSTITUTE OF LEGAL JOURNALS OF THE CHINA LAW SOCIETY IN 2017显示文摘On October 9,2017,the Annual Conference of the Research Institute of Legal Journals of the China Law Society and the Seminar about Legal Journals Leading and Serving for the Research on the Legal Theory of Socialism with Chinese Characteristics was held in Guangzhou,which was hosted by the Research Institute of Legal Journals of the China Law Society, | Zhou Yinuo | 2017 | China Legal Science2017，5，6： | 0 |
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