| 1 | Internal States Influence the Representation and Modulation of Food Intake by Subthalamic Neurons显示文摘Deep brain stimulation of the subthalamic nucleus(STN)is an effective therapy for motor deficits in Parkinson’s disease(PD),but commonly causes weight gain in late-phase PD patients probably by increasing feeding motivation.It is unclear how STN neurons represent and modulate feeding behavior in different internal states.In the present study,we found that feeding caused a robust activation of STN neurons in mice(GCaMP6 signal increased by 48.4%±7.2%,n=9,P=0.0003),and the extent varied with the size,valence,and palatability of food,but not with the repetition of feeding.Interestingly,energy deprivation increased the spontaneous firing rate(8.5±1.5 Hz,n=17,versus 4.7±0.7 Hz,n=18,P=0.03)and the depolarization-induced spikes in STN neurons,as well as enhanced the STN responses to feeding.Optogenetic experiments revealed that stimulation and inhibition of STN neurons respectively reduced(by 11%±6%,n=6,P=0.02)and enhanced(by 36%±15%,n=7,P=0.03)food intake only in the dark phase.In conclusion,our results support the hypothesis that STN neurons are activated by feeding behavior,depending on energy homeostatic status and the palatability of food,and modulation of these neurons is sufficient to regulate food intake. | Haichuan Wu Xiang Yan Dongliang Tang Weixin Gi Yiwen Luan Haijiang Cai Chunyi Zhou Cheng Xiao | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 2 | Preparation and Arc Erosion Resistance of C_f/Cu Composite by Vacuum Melting Infiltration显示文摘Cf/Cu composite was prepared by vacuum melting infiltration. Tiand Cr were doped to the Cu alloy to improve the wettability between Cu and carbon. The microstructure was investigated by XRD, SEM and EDS. The arc erosion rate of Cf/Cu composite was investigated in vacuum. The results showed that the Tiand Cr could improve the wettability between Cu and C/C preform and the infiltration ability of Cu into C/C preform greatly. A TiC interface formed between the fibers and matrix. The good bonding between the fiber and matrix guaranteed that part of the Cu matrix can still be bonded on the fibers even when the material was exposed to the plasma. Consequently, the carbon fibers were protected from the erosion. In comparison, Cu was completely consumed by the arc erosion. Hence, the graphite was eroded and presented a caulifl ower-like morphology. Therefore, the prepared Cf/Cu had better ability to resist the arc erosion, compared with common Cu-C material. | 张华煜 LIU Yiwen ZHAO Xianling LUAN Xingang | 2014 | Journal of Wuhan University of Technology(Materials Science)2014，29，5： | 3 |
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