3篇
您的检索式：作者名="Yiyang Hong"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeting BMI-1-mediated epitheliale-mesenchymal transition to inhibit colorectal cancer liver metastasis显示文摘Liver is the most common metastatic site for colorectal cancer(CRC),there is no satisfied approach to treat CRC liver metastasis(CRCLM).Here,we investigated the role of a polycomb protein BMI-1 in CRCLM.Immunohistochemical analysis showed that BMI-1 expression in liver metastases was upregulated and associated with T4 stage,invasion depth and right-sided primary tumor.Knockdown BMI-1 in high metastatic HCT116 and LOVO cells repressed the migratory/invasive phenotype and reversed epithelialemesenchymal transition(EMT),while BMI-1 overexpression in low metastatic Ls174 T and DLD1 cells enhanced invasiveness and EMT.The effects of BMI-1 in CRC cells were related to upregulating snail via AKT/GSK-3βpathway.Furthermore,knockdown BMI-1 in HCT116 and LOVO cells reduced CRCLM using experimental liver metastasis mice model.Meanwhile,BMI-1 overexpression in Ls174 T and DLD1 significantly increased CRCLM.Moreover,sodium butyrate,a histone deacetylase and BMI-1 inhibitor,reduced HCT116 and LOVO liver metastasis in immunodeficient mice.Our results suggest that BMI-1 is a major regulator of CRCLM and provide a potent molecular target for CRCLM treatment. | Zhiyao Xu Zhuha Zhou Jing Zhang Feichao Xuan Mengjing Fan Difan Zhou Zhenyu Liuyang Ximei Ma Yiyang Hong Yihong Wang Sherven Sharma Qinghua Dong Guanyu Wang | 2021 | Acta Pharmaceutica Sinica B2021，11，5： | 8 |
| 2 | STUDY ON CONTROLLABILITY AND OBSERVABILITY FOR THIN PLATE SYSTEM WITH PARAMETER UNCERTAINTY显示文摘STUDYONCONTROLLABILITYANDOBSERVABILITYFORTHINPLATESYSTEMWITHPARAMETERUNCERTAINTY①LiYiyangRenLihongChenGuodongLiangTianpeiDepa... | Li Yiyang Ren Lihong Chen Guodong Liang Tianpei Department of Mechanical Engineering, The Hong Kong Polytechnic University, Hong Kong | 1998 | Chinese Journal of Mechanical Engineering1998，11，3： | 0 |
| 3 | RASGRP1 targeted by H3K27me3 regulates myoblast proliferation and differentiation in mice and pigs显示文摘Skeletal muscle is not only the largest organ in the body that is responsible for locomotion and exercise but also crucial for maintaining the body’s energy metabolism and endocrine secretion.The trimethylation of histone H3 lysine 27(H3K27me3)is one of the most important histone modifications that participates in muscle development regulation by repressing the transcription of genes.Previous studies indicate that the RASGRP1 gene is regulated by H3K27me3 in embryonic muscle development in pigs,but its function and regulatory role in myogenesis are still unclear.In this study,we verify the crucial role of H3K27me3 in RASGRP1 regulation.The gain/loss function of RASGRP1 in myogenesis regulation is performed using mouse myoblast C2C12 cells and primarily isolated porcine skeletal muscle satellite cells(PSCs).The results of qPCR,western blot analysis,EdU staining,CCK-8 assay and immunofluorescence staining show that overexpression ofRASGRP1 promotes cell proliferation and differentiation in both skeletal muscle cell models,while knockdown of RASGRP1 leads to the opposite results.These findings indicate that RASGRP1 plays an important regulatory role in myogenesis in both mice and pigs. | Liyao Xiao Jiaxin Qiao Yiyang Huang Baohua Tan Linjun Hong Zicong Li Gengyuan Cai Zhenfang Wu Enqin Zheng Shanshan Wang Ting Gu | 2024 | Acta Biochimica et Biophysica Sinica2024，56，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员