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4篇 您的检索式:作者名="Yolanda Alvarez"
    题名 作者 年代 出处 被引量
1Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG显示文摘Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c mice.Methods: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western blot.Results: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in vivo.Conclusions: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages.Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento Mohd-Nor Norazmi JoséLuis Pérez Armando Acosta 2017Asian Pacific Journal of Tropical Biomedicine2017,7,3:3
2Phenolic profiles, antioxidant activity and in vitro antivirat properties of apple pomace显示文摘Belen Suarez Angel L Alvarez Yolanda Dineiro Garcia 2010Food chemistry2010,120,1:1
3Vasodilator effects of peptides derived from egg white proteins显示文摘Marta Miguel Yolanda Alvarez Rosina Lopez-Fandino et cd 2007Regulatory Peptide2007,140,:1
4(9Z)-and (11 Z) -8-methylretinals for artificial visual pigment studies:Stereoselective synthesis,structure,and binding models显示文摘Alvarez Rosana Dominguez Marta Pazos Yolanda 2003Chem--A European J2003,9,23:1
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