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| 1 | Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action显示文摘In the present paper, we overview the discovery of new biological activities induced by ginsenoside Rg 1 and Rb 1 and discuss possible mechanisms of action. Both compounds could increase neural plasticity in efficacy and structure; especially Rg 1, as one small molecular drug, can increase proliferation and differentiation of neural progenitor cells in dentate gyrus of hippocampus of normal adult mice and global ischemia model in gerbils. This finding has great value for treatment of Alzheimer's disease and other neurodegenerative disorders which is characterized by neurons loss. Increase of expression of brain derived neurotrophic factor, Bcl-2 and antioxidant enzyme, enhanced new synapse formation, inhibition of apoptosis and calcium overload are also important neuron protective factors. Rgl and Rbl have common effects, but there are some differences in pharmacology and mechanism. These differences may attribute to their different chemical structure. Rg 1 is panaxtriol with two sugars, while Rb 1 is panaxtriol with four | YongCHENG Li-hongSHEN Jun-tianZHANG | 2005 | Acta Pharmacologica Sinica2005，26，2： | 86 |
| 2 | Age of Anzishan granulites in the Mianxian-Lueyang suture zone of Qingling orogen:With a discussion of the timing of final assembly of Yangtze and North China craton blocks显示文摘Many granulite blocks have been recently dis-covered in the Anzishan area, Mianxian County, ShaanxiProvince, in the central segment of the Manxian-Lueyangsuturc zone. Sm-Nd isochron and 40 Ar39 Ar ages of mineralsamples of granulites from this area are reported in the note.The granulite mineral samples give a Sm-Nd isochron age oft=(206 ± 55) Ma (2σ), with INd = 0.51302±7(2σ) and MSWD =1.6, and a biotite 40Ar/39 Ar plateau age of (199.7±l.7) Ma(2σ). The formation and uplift of the granulites were relatedto subduction of the Yangtze block beneath the SouthQinling microcontinent and their collision and the finalamalgamation of the Yangtze and Sino-Korean craton blocksin the Indosinian, and their age is consistent with or close tothose of the Dabie ultrahigh-pressure and high-pressuremetamorphic rocks, so have great tectonic significance. | ZHANG Zongqing ZHANG Guowei TANG SuohaiV XU Jifeng YANG Yongcheng WANG Jinhui | 2002 | Chinese Science Bulletin2002，47，22： | 19 |
| 3 | Mechanical properties of hot-pressed high-entropy diboride-based ceramics显示文摘High-entropy ceramics attract more and more attention in recent years.However,mechanical properties especially strength and fracture toughness for high-entropy ceramics and their composites have not been comprehensively reported.In this work,high-entropy(Ti0.2Zr0.2Hf0.2Nb0.2Ta 0.2)B2(HEB)monolithic and its composite containing 20 vol%SiC(HEB–20SiC)are prepared by hot pressing.The addition of SiC not only accelerates the densification process but also refines the microstructure of HEB,resulting in improved mechanical properties.The obtained dense HEB and HEB–20SiC ceramics hot pressed at 1800℃exhibit four-point flexural strength of 339±17 MPa and 447±45 MPa,and fracture toughness of 3.81±0.40 MPa·m1/2 and 4.85±0.33 MPa·m1/2 measured by single-edge notched beam(SENB)technique.Crack deflection and branching by SiC particles is considered to be the main toughening mechanisms for the HEB–20SiC composite.The hardness Hv0.2 of the sintered HEB and HEB–20SiC ceramics is 23.7±0.7 GPa and 24.8±1.2 GPa,respectively.With the increase of indentation load,the hardness of the sintered ceramics decreases rapidly until the load reaches about 49 N,due to the indentation size effect.Based on the current experimental investigation it can be seen that the room temperature bending strength and fracture toughness of the high-entropy diboride ceramics are within ranges commonly observed in structure ceramics. | Ji-Xuan Liu Xiao-Qin Shen Yue Wu Fei Li Yongcheng Liang Guo-Jun Zhang | 2020 | Journal of Advanced Ceramics2020，9，4： | 16 |
| 4 | Branched Co3O4/Fe2O3 nanowires as high capacity lithium-ion battery anodes显示文摘 | Hao Wu Ming Xu Yongcheng Wang Gengfeng Zheng | 2013 | Nano Research2013，6，3： | 13 |
| 5 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 6 | Marinamide, a novel alkaloid and its methyl ester produced by the application of mixed fermentation technique to two mangrove endophytic fungi from the South China Sea显示文摘A novel 1-isoquinolone analog desig- nated as marinamide (A) and its methyl ester (B), were produced by the application of mixed fermenta- tion technique to two mangrove endophytic fungi (strains Nos. 1924 and 3893) from the South China Sea. Their structures were elucidated by compre- hensive spectra methods (mainly by 2D NMR) as 4- (2-pyrrolyl)-1-isoquinolone-3-carboxylic acid (A) and methyl 4-(2-pyrrolyl)-1-isoquinolone-3-carboxylate (B), respectively. Compounds A and B were not obtained when either strain was cultured individually under the same conditions. The results showed that the appli- cation of mixed fermentation technique maybe rep- resents a potentially important approach to discover novel metabolites. | ZHU Feng LIN Yongcheng | 2006 | Chinese Science Bulletin2006，51，12： | 8 |
| 7 | Acupotomy versus sodium hyaluronate for treatment of knee osteoarthritis in rabbits显示文摘OBJECTIVE: To investigate the possible advantages of acupotomy over sodium hyaluronate injection for the treatment of knee osteoarthritis(KOA).METHODS: Twenty rabbits were divided randomly into four groups(n = 5 in each): a control group,model group, acupotomy group, and sodium hyaluronate injection group. The model, acupotomy,and sodium hyaluronate groups underwent anterior cruciate ligament transection plus partial medial meniscectomy. Sodium hyaluronate injection and acupotomy were administered to the respective groups from weeks 5 to 8, and samples of the tibial plateau and medial condyle of the femur were collected in week 9. Vascular endothelial growth factor(VEGF) expression was assessed in cartilage and subchondral bone by immunohistochemical staining.RESULTS: Articular cartilage degeneration was less pronounced in the acupotomy compared with the model and sodium hyaluronate groups. VEGF expression levels in cartilage and subchondral bone were increased in the model group compared with the control group(P < 0.01), and acupotomy had a more pronounced therapeutic effect than sodium hyaluronate injection(P < 0.01).CONCLUSION: Acupotomy and sodium hyaluronate injection may both reduce degeneration in the cartilage and subchondral bone in KOA based on the results from a rabbit model, but acupotomy improved the histopathology and reduced the VEGF content more effectively than sodium hyaluronate injection, probably by reducing venous stasis and intraosseous pressure. Acupotomy may improve KOA by lowering VEGF. | Ding Yu Yuan Xueling Wang Yongcheng Wang Aiyuan Shi Xian Wang Lu Daniela Litscher Ingrid Gaischek Irmgard Th.Lippe Gerhard Litscher | 2017 | Journal of Traditional Chinese Medicine2017，37，3： | 8 |
| 8 | Single-trial decoding of imagined grip force parameters involving the right or left hand based on movement-related cortical potentials显示文摘Time–domain feature representation for imagined grip force movement-related cortical potentials(MRCP)of the right or left hand and the decoding of imagined grip force parameters based on electroencephalogram(EEG)activity recorded during a single trial were here investigated.EEG signals were acquired from eleven healthy subjects during four different imagined tasks performed with the right or left hand.Subjects were instructed to execute imagined grip movement at two different levels of force.Each task was executed 60 times in random order.The imagined grip force MRCP of the right or left hand was analyzed by superposition and averaging technology,a single-trial extraction method,analysis of variance(ANOVA),and multiple comparisons.Significantly different features were observed among different imagined grip force tasks.These differences were used to decode imagined grip force parameters using Fisher linear discrimination analysis based on kernel function(k-FLDA)and support vector machine(SVM).Under the proposed experimental paradigm,the study showed that MRCP may characterize the dynamic processing that takes place in the brain during the planning,execution,and precision of a given imagined grip force task.This means that features related to MRCP can be used to decode imagined grip force parameters based on EEG.ANOVA and multiple comparisons of time–domain features for MRCP showed that movement-monitoring potentials(MMP)and specific interval(0–150 ms)average potentials to be significantly different among 4 different imagined grip force tasks.The minimum peak negativity differed significantly between high and low amplitude grip force.Identification of the 4different imagined grip force tasks based on MMP was performed using k-FLDA and SVM,and the average misclassification rates of 27%±5%and 24%±4%across 11 subjects were achieved respectively.The minimum misclassification rate was 15%,and the average minimum misclassification rate across 11 subjects was24%±4.5%.This investigation indicates that imagined grip force MRCP may encode imagined grip force parameters.Single-trial decoding of imagined grip force parameters based on MRCP may be feasible.The study may provide some additional and fine control instructions for brain–computer interfaces. | Yunfa Fu Baolei Xu Yongcheng Li Yuechao Wang Zhengtao Yu Hongyi Li | 2014 | Chinese Science Bulletin2014，59，16： | 8 |
| 9 | 河南永城芒山西汉梁国王陵的调查显示文摘芒山位于河南永城县东北30余公里处,面积20余平方公里,王引河从其西部流过(图一)。芒山是芒砀山、保安山、僖山、黄土山、铁角山、夫子山等山的总称。古时亦称砀山,《说文解字》“砀,文石也”。因此山出文石(制作砚台的石料)而得名。这里地处豫、皖交界,素有“豫东门户”之称,为历史上的豫东重镇所在。 | HPAI and Yongcheng County CPAM, | 1992 | 华夏考古1992，，3： | 7 |
| 10 | Proof of the Branner-Hubbard conjecture on Cantor Julia sets显示文摘By means of a nested sequence of some critical pieces constructed by Kozlovski, Shen, and van Strien, and by using a covering lemma recently proved by Kahn and Lyubich, we prove that a component of the filled-in Julia set of any polynomial is a point if and only if its forward orbit contains no periodic critical components. It follows immediately that the Julia set of a polynomial is a Cantor set if and only if each critical component of the filled-in Julia set is aperiodic. This result was a conjecture raised by Branner and Hubbard in 1992. | QIU WeiYuan YIN YongCheng | 2009 | Science China Mathematics2009，52，1： | 7 |
| 11 | Clinical outcome of ileal pouch-anal anastomosis for chronic ulcerative colitis in China显示文摘 | Liu Gang Han Hongqiu Liu Tong Fu Qiang Lyu Yongcheng | 2014 | Chinese Medical Journal2014，，8： | 7 |
| 12 | Expression of Beclin1 in non small cell lung cancer and its clinical significance显示文摘Objective:To investigate the expression of autophagy related gene;Beclin1 in human non-small cell lung cancer(NSCLC)tissues.Methods:Protein expression of Beclin1 was determined by immunofluorescence staining and Western Blot,mRNA expression was analyzed by RT-PCR.Results:Immunofluorescence staining revealed that the level of Beclin1 expression in lung cancer was significantly lower than that in adjacent noncancerous tissues and normal tissues(expression rate 8.3%,P=0.000).The Beclin1 mRNA expression in lung cancer,adjacent noncancerous tissues and normal tissues was 1.372(±0.475)1.721(±0.521)and 1.553(±0.554)when F = 15.0,P < 0.01.Beclin1 protein expression in lung cancer,adjacent noncancerous tissues and normal tissues was 3.453(±0.852)5.423(±1.351)and 6.878(±0.997)F = 11.2,P < 0.01.Conclusion:The protein and mRNA expression of Beclin1 in lung cancer was much lower than those in and around cancer tissues and normal tissues,those differences having statistical significance.However in adjacent noncancerous tissues and normal tissues,the expression showed no difference. | Quan Liu Jianjun Wang Yongcheng Pan Lifeng Meng Xi Zhan | 2008 | Journal of Nanjing Medical University2008，22，2： | 6 |
| 13 | Residual Fatigue Life Prediction of Ball Bearings Based on Paris Law and RMS显示文摘Paris law can reflect the failure mechanism of materials and is usually used to be a method to predict fatigue life or residual fatigue life.But the variable which can represent the health of machine is hardly measured on line.To a degree,the difficulty of on-line application restricts the scope of application of Paris law.The relationship between characteristic values of vibration signals and the variable in the Paris equation which can describe the health of machine is investigated by taking ball bearings as investigative objects.Based on 6205 deep groove ball bearings as a living example,historical lives and vibration signals are analyzed.The feasibility of describing that variable in the Paris equation by the characteristic value of vibration signals is inspected.After that vibration signals decomposed by empirical mode decomposition(EMD),root mean square(RMS) of intrinsic mode function(IMF) involving fault characteristic frequency has a consistent trend with the diameter of flaws.Based on the trend,two improved Paris models are proposed and the scope of application of them is inspected.These two Paris Models are validated by fatigue residual life data from tests of rolling element bearings and vibration signals monitored in the process of operation of rolling element bearings.It shows that the first improved Paris Model is simple and plain and it can be easily applied in actual conditions.The trend of the fatigue residual life predicted by the second improved Paris model is close to the actual conditions and the result of the prediction is slightly greater than the truth.In conclusion,after the appearance of detectable faults,these improved models based on RMS can predict residual fatigue life on line and a new approach to predict residual fatigue life of ball bearings on line without disturbing the machine running is provided. | XU Dong HUANG Jin'e ZHU Qin CHEN Xun XU Yongcheng WANG Shuang | 2012 | Chinese Journal of Mechanical Engineering2012，25，2： | 6 |
| 14 | Soil heavy metal pollution from Pb/Zn smelting regions in China and the remediation potential of biomineralization显示文摘Smelting activities pose serious environmental problems due to the local and regional heavy metal pollution in soils they cause. It is therefore important to understand the pollution situation and its source in the contaminated soils. In this paper, data on heavy metal pollution in soils resulting from Pb/Zn smelting(published in the last 10 years) in China was summarized. The heavy metal pollution was analyzed from a macroscopic point of view. The results indicated that Pb, Zn, As and Cd were common contaminants that were present in soils with extremely high concentrations. Because of the extreme carcinogenicity, genotoxicity and neurotoxicity that heavy metals pose, remediation of the soils contaminated by smelting is urgently required. The primary anthropogenic activities contributing to soil pollution in smelting areas and the progressive development of accurate source identification were performed. Due to the advantages of biominerals, the potential of biomineralization for heavy metal contaminated soils was introduced. Furthermore, the prospects of geochemical fraction analysis, combined source identification methods as well as several optimization methods for biomineralization are presented, to provide a reference for pollution investigation and remediation in smelting contaminated soils in the future. | Xinghua Luo Chuan Wu Yongcheng Lin Waichin Li Min Deng Jingqiang Tan Shengguo Xue | 2023 | Journal of Environmental Sciences2023，，3： | 5 |
| 15 | Paleomagnetism of early Paleozoic volcanic rocks from the Beishan area,Gansu of northwest China:Preliminary insight into early Paleozoic kinemics of the Beishan terrane显示文摘We report rock magnetic and paleomagnetic results for Middle Silurian Gongpoquan and Middle Ordo-vician Huaniushan volcanic samples collected from the Ma-zongshan and Hongliuyuan areas of Gansu Province, northwest China. The results indicate that the main magnetic mineral of the Gongpoquan and Huaniushan volcanic rock is magnetite, and it may remain characteristic remanent magnetization acquired at the time of formation of the rocks. However, with the exception of samples from site go20, most of Middle Ordovician Huaniushan volcanic samples have a very weak nature remanent magnetization, and generally show an erratic demagnetization behavior, which does not allow isolation of characteristic remanent magnetizations from these samples. Comparison of paleomagnetic results obtained from the Beishan area of Gansu with Paleozoic apparent polar wander paths for Tarim and Siberia suggests that the Beishan tarrane, the southern part of the Beishan area of Gansu beyond the Mingshui-Shipanjin-Xiaohuang-shan zone, | Baochun Huang Yongcheng Wang Rixiang Zhu Fuqin Zhang | 2002 | Chinese Science Bulletin2002，47，18： | 4 |
| 16 | Energy conservation and emissions reduction strategies in foundry industry显示文摘Current energy conservation and emissions reduction strategies in iron and steel industry were reviewed. Since foundry industry is one of the major source of energy consumption and pollution emission (especially CO 2 ), issues concerning energy-saving and emission-reduction have been raised by governments and the industry. Specialists from around the world carried out multidimensional analyses and evaluation on the potentials in energy conservation and emissions reduction in iron and steel industry, and proposed various kinds of analyzing models. The primary measures mainly focus on the targeted policies formulation and also on clean and highefficient technologies development. The differences and similarities in energy conservation and emission reduction in foundry industry between China and other countries were discussed, while, the future development trend was also pointed out. | Li Yuanyuan Chen Weiping Huang Dan Luo Jie Liu Zhe Chen Yongcheng Liu Qiping Su Shifang | 2010 | China Foundry2010，7，4： | 4 |
| 17 | Optimizing reliability, maintainability and testability parameters of equipment based on GSPN显示文摘Reliability, maintainability and testability(RMT) are important properties of equipment, since they have important influence on operational availability and life cycle costs(LCC). Therefore, weighting and optimizing the three properties are of great significance. A new approach for optimization of RMT parameters is proposed. First of all, the model for the equipment operation process is established based on the generalized stochastic Petri nets(GSPN) theory. Then, by solving the GSPN model, the quantitative relationship between operational availability and RMT parameters is obtained. Afterwards, taking history data of similar equipment and operation process into consideration, a cost model of design,manufacture and maintenance is developed. Based on operational availability, the cost model and parameters ranges, an optimization model of RMT parameters is built. Finally, the effectiveness and practicability of this approach are validated through an example. | Tingpeng Li Yue Li Yanling Qian Yongcheng Xu | 2015 | Journal of Systems Engineering and Electronics2015，26，3： | 3 |
| 18 | Connectivity of the Mandelbrot set for the family of renormalization transformations显示文摘We show that the Mandelbrot set for the family of renormalization transformations of 2-dimensional diamond-like hierachical Potts models in statistical mechanics is connected. We also give an upper bound for the Hausdorff dimension of Julia set when it is a quasi-circle. | WANG XiaoGuang 1,QIU WeiYuan 1 , YIN YongCheng 1 , QIAO JianYong 2 & GAO JunYang 2 1 School of Mathematical Sciences, Fudan University, Shanghai 200433, China 2 Center of Mathematics, China University of Mining and Technology, Beijing 100083, China | 2010 | Science China Mathematics2010，53，3： | 3 |
| 19 | Effect of Zn atom in Fe-N-C catalysts for electro-catalytic reactions: theoretical considerations显示文摘Due to the high specific surface area,abundant nitrogen and micropores,ZIF-8 is a commonly used precursor for preparing high performance Fe-N-C catalysts.However,the Zn element is inevitably remained in the prepared Fe-N-C catalyst.Whether the residual Zn element affects the catalytic activity and active site center of the Fe-N-C catalyst caused widespread curiosity,but has not been studied yet.Herein,we built several Fe,Zn,and N co-doped graphene models to investigate the effect of Zn atoms on the electrocatalytic performance of Fe-N-C catalysts by using density functional theory method.The calculation results show that all the calculated Fe-Zn-N_(x) structures are thermodynamically stable due to the negative formation energies and relative stabilities.The active sites around Fe and Zn atoms in the structure of Fe-Zn-N_(6)(III)show the lowest oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)overpotentials of 0.38 and 0.43 V,respectively.The bridge site of Fe-Zn in Fe-Zn-N_(5) shows the lowest η^(HER) of−0.26 V.A few structures with a better activity than that of FeN_(4) or ZnN_(4) are attributed to the synergistic effects between Fe and Zn atoms.The calculated ORR reaction pathways on Fe-Zn-N6(III)show that H_(2)O is the final product and the ORR mechanism on the catalyst would be a four-electron process,and the existence of Zn element in the Fe-N-C catalysts plays a key role in reducing the ORR activation energy barrier.The results are helpful for the deep understand of high-performance Fe-N-C catalysts. | Yongcheng Li Riming Hu Zhibin Chen Xin Wan Jia-Xiang Shang Fu-He Wang Jianglan Shui | 2021 | Nano Research2021，14，3： | 3 |
| 20 | New paleomagnetic and magnetic fabric results for Early Cretaceous rocks from the Turpan intramontane basin,east Tianshan,northwest China显示文摘In order to further constrain the tectonic configuration of the Tianshan fold belt and the blocks of its northern and southern sides prior to the Eocene India/Eurasia collision and to reveal their general kinematic characteristics after the collision,we carried out pa- leomagnetic study for Early Cretaceous rocks collected from the Turpan intramontane basin of east Tianshan,northwest China.A high-temperature component (HTC)with dual polarities can be isolated from most samples after progressive thermal demagnetization.Thermal demagnetization behavior and some rock magnetic features of the samples indicate that this HTC resides mainly in hematite.The positive fold and reversal tests suggest that the HTC may be a primary mag- netization acquired at or close to the time of formation of the rocks.Similar to previous results obtained from Cretaceous rocks in western China,paleomagnetic results from the Turpan in- tramontane basin retain also the inclination shallowing relative to stable Eurasia.However, the anisotropy of magnetic susceptibility (AMS)measurements showed weak anisotropy degrees for Early Cretaceous Shengjinkou sandstones from the Turpan Basin.These weak anisotropy degrees are independent of inclinations of the HTC,confirming that the effect of sedimentary compaction in most of these rocks can generally be neglected. Comparison of the Early Cretaceous results from Turpan with the coeval ones from Tarim, Junggar and stable Eurasia suggests that the Turpan intramontane basin displaced with no or slightly relative tectonic movement compared with Tarim but with a distinguishable latitudinal conver-gence relative to both Junggar and stable Eurasia since the India/Eurasia collision. | HUANG Baochun WANG Yongcheng ZHU Rixiang | 2004 | Science China Earth Sciences2004，47，6： | 3 |
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