3篇
您的检索式：作者名="Yongshu Lin"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Dispersion state of CuO on CeO2显示文摘 | Lin Dong Yongshu Jin Yi Chen | 1997 | Science in China Series B: Chemistry1997，，1： | 1 |
| 2 | Progress in building clinically relevant patient-derived tumor xenograft models for cancer research显示文摘Patient-derived tumor xenograft(PDX)models,a method involving the surgical extraction of tumor tissues from cancer patients and subsequent transplantation into immunodeficient mice,have emerged as a pivotal approach in translational research,particularly in advancing precision medicine.As the first stage of PDX development,the patient-derived orthotopic xenograft(PDOX)models implant tumor tissue in mice in the corresponding anatomical locations of the patient.The PDOX models have several advantages,including high fidelity to the original tumor,heightened drug sensitivity,and an elevated rate of successful transplantation.However,the PDOX models present significant challenges,requiring advanced surgical techniques and resourceintensive imaging technologies,which limit its application.And then,the humanized mouse models,as well as the zebrafish models,were developed.Humanized mouse models contain a human immune environment resembling the tumor and immune system interplay.The humanized mouse models are a hot topic in PDX model research.Regarding zebrafish patient-derived tumor xenografts(zPDX)and patient-derived organoids(PDO)as promising models for studying cancer and drug discovery,zPDX models are used to transplant tumors into zebrafish as novel personalized medical animal models with the advantage of reducing patient waiting time.PDO models provide a cost-effective approach for drug testing that replicates the in vivo environment and preserves important tumor-related information for patients.The present review highlights the functional characteristics of each new phase of PDX and provides insights into the challenges and prospective developments in this rapidly evolving field. | Weijing Wang Yongshu Li Kaida Lin Xiaokang Wang Yanyang Tu Zhenjian Zhuo | 2023 | Animal Models and Experimental Medicine2023，6，5： | 1 |
| 3 | A cellphone-based colorimetric multi-channel sensor for water environmental monitoring显示文摘The development of colorimetric analysis technologies for the commercial cellphone platform has attracted great attention in environmental monitoring due to the low cost,high versatility,easy miniaturization,and widespread ownership of cellphones.This work demonstrates a cellphone-based colorimetric multi-channel sensor for quantifying multiple environmental contaminants simultaneously with high sensitivity and stability.To improve the sensitivity of the sensor,a delicate optical path system was created by using a diffraction grating to split six white beams transmitting through the multiple colored samples,which allows the cellphone CMOS camera to capture the diffracted light for image analysis.The proposed sensor is a universal colorimetric detection platform for a variety of environmental contaminants with the colorimetry assay in the range of 400–700 nm.By introducing the diffraction grating for splitting light,the sensitivity was improved by over six folds compared with a system that directly photographed transmitted light.As a successful proof-of-concept,the sensor was used to detect turbidity,orthophosphate,ammonia nitrogen and three heavy metals simultaneously with high sensitivity(turbidity:detection limit of 1.3 NTU,linear range of 5–400 NTU;ammonia nitrogen:0.014 mg/L,0.05–5 mg/L;orthophosphate:0.028 mg/L,0.1–10 mg/L;Cr(VI):0.0069 mg/L,0.01–0.5 mg/L;Fe:0.025 mg/L,0.1–2 mg/L;Zn:0.032 mg/L,0.05–2 mg/L)and reliability(relative standard deviations of six parallel measurements of 0.37%–1.60%and recoveries of 95.5%–106.0%in surface water).The miniature sensor demonstrated in-field sensing ability in environmental monitoring,which can be extended to point-of-care diagnosis and food safety control. | Yunpeng Xing Boyuan Xue Yongshu Lin Xueqi Wu Fang Fang Peishi Qi Jinsong Guo Xiaohong Zhou | 2022 | Frontiers of Environmental Science & Engineering2022，16，12： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员