| 4 | Methylmercury chloride damage to the adult rat hippocampus cannot be detected by proton magnetic resonance spectroscopy显示文摘Previous studies have found that methylmercury can damage hippocampal neurons and accordingly cause cognitive dysfunction. However, a non-invasive, safe and accurate detection method for detecting hippocampal injury has yet to be developed. This study aimed to detect methylmercury-induced damage on hippocampal tissue using proton magnetic resonance spectroscopy. Rats were given a subcutaneous injection of 4 and 2 mg/kg methylmercury into the neck for 50 consecutive days. Water maze and pathology tests confirmed that cognitive function had been impaired and that the ultrastructure of hippocampal tissue was altered after injection. The results of proton magnetic resonance spectroscopy revealed that the nitrogen-acetyl aspartate/creatine, choline complex/creatine and myoinositol/creatine ratio in rat hippocampal tissue were unchanged. Therefore, proton magnetic resonance spectroscopy can not be used to determine structural damage in the adult rat hippocampus caused by methylmercury chloride. | Zhiyan Lu Jinwei Wu Guangyuan Cheng Jianying Tian Zeqing Lu Yongyi Bi | 2014 | Neural Regeneration Research2014，9，17： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员