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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Mapping forest post-fire canopy consumption in several overstory types using multi-temporal Landsat TM and ETM data显示文摘 | Miller J D Yool S R | 2002 | Remote Sensing of Environment2002，82，： | 1 |
| 3 | Monitoring mountain snowpack evolution using near-surface optical and thermal properties显示文摘 | Lampkin D J Yool S R | 2004 | Hydrological Process2004，18，： | 1 |
| 4 | Excess potassium induces larval metamorphosis in four marine invertebrate species显示文摘 | YOOL A J GRAU S M HADFIELD M G | 1986 | Biol Bull1986，170，： | 1 |
| 5 | Topography affected landscape fire history patterns in southern Arizona, USA 显示文摘 | Iniguez J M Swetnam T W Yool S R | 2008 | Forest Ecology and Management2008，256，3： | 1 |
| 6 | Mechanism of gating and ion conductivity of a possible tetrameric pore in Aquaporin-1 显示文摘 | Yu J Yool A J Schulten K | 2006 | Structure2006，14，9： | 1 |
| 7 | Monitoring mountain snow pack evolution using near-surface optical and thermal properties显示文摘 | Lampkin D J Yool S R | 2004 | Hydrological Process2004，18，： | 1 |
| 8 | Computational and experimental study on performance of sail of a sailing yacht显示文摘 | Yool J Kim H T | 2006 | O cean Engineering2006，，33： | 1 |
| 9 | Characterizing the spatial structure of vegetation communities in the Mojave Desert using geostatistical techniques 显示文摘 | Wallace C S A Watts J M Yool S R | 2000 | Computers and Geosciences2000，26，： | 1 |
| 10 | Excess potassium induces larval metamorphosis in four marine invertebrate species显示文摘 | Andrea J Yool Susan M | 1986 | Biol Bull1986，170，： | 1 |
| 11 | Bullying:elementary teachers's attitudes and intervention strategies显示文摘 | Yool J Kerber K | 2003 | Research in Education2003，69，1： | 1 |
| 12 | An examination of the 'continental shelf pump' in an open ocean general circulation model显示文摘 | YOOL A FASHAM M J R | 2001 | Global Biogeochemical cycles2001，15，4： | 1 |
| 13 | Functional domains of aquaporin-Ⅰ : keys to physiology, and targets for drug discovery显示文摘 | YOOL A J | 2007 | Curr Pharm Des2007，13，31： | 1 |
| 14 | Structure, function and translational relevance of aquaporin dual water and ion channels显示文摘 | Yool A J Campbell E M | 2012 | Molecular Aspects of Medicine2012，33，56： | 1 |
| 15 | Functional domains of aquaporin-l: keys to physiology, and targets for drug discovery显示文摘 | YOOL A J | 2007 | Curr Pharm Des2007，13，31： | 1 |
| 16 | Excess potassium induces larval metamorphosis in four marine invertebrate species 显示文摘 | Yool A J Grau S M Hadfield M G | 1986 | Biol Bull1986，，170： | 1 |
| 17 | Aq F026 is a pharmacologic agonist of the waterchannel aquaporin-1显示文摘 | Yool AJ Morelle J Cnops Y | 2013 | Am Soc Nephrol2013，24，7： | 1 |
| 18 | Mechanism of gating and ion conductivity of a possible tetrameric pore in aquaporin-1显示文摘 | Yu J Yool AJ Schulten K | 2006 | Structure2006，14，9： | 1 |
| 19 | Structure, function and translational relevance of aquaporin dual water and ion chan- nels 显示文摘 | YOOL A J CAMPBELL E M | 2012 | Mol Aspects Med2012，33，5： | 1 |
| 20 | Tetraethylammonium block of water flux in Aquaporin-1 channels expressed in kidney thin limbs of Henle's loop and a kidney-derived cell line显示文摘 | YOOL A J BROKL O H PANNABECKER T L | 2002 | BMC Physiol2002，2，1： | 1 |
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