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| 1 | 晚期肝细胞癌患者PD-1阻断期间的疾病超进展显示文摘【据Journal of Hepatology 2020年8月报道】题:晚期肝细胞癌患者PD-1阻断期间的疾病超进展(作者Kim CG等)PD-1抑制剂治疗可导致疾病超进展(HPD),但在接受PD-1阻断治疗的肝细胞癌(HCC)患者中,HPD的发生率,结局和预测因素尚不清楚。评估了用纳武单抗治疗的晚期HCC患者中HPD的存在和预测因素。来自韩国的Kim等在延世癌症中心、本港医疗中心、三星医疗中心纳入了纳武单抗治疗的晚期HCC患者(n=189)。 | KIM CG KIM C YOON SE 张笑晨 胡玉琳 | 2020 | 临床肝胆病杂志2020，36，11： | 11 |
| 2 | Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation 显示文摘 | Yoon J C Chickering T W Rosen E D | 2000 | Mol Cell Biol2000，20，14： | 2 |
| 3 | SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct显示文摘Pendred syndrome(PS) is characterized by autosomal recessive inheritance of goiter associated with a defect of iodide organification, hearing loss, enlargement of the vestibular aqueduct(EVA), and mutations of the SLC26A4 gene. However, not all EVA patients have PSor SLC26A4 mutations. Two mutant alleles of SLC26A4 are detected in 1/4 of North American or European EVA populations, one mutant allele is detected in another 1/4 of patient populations, and no mutations are detected in the other 1/2. The presence of two mutant alleles of SLC26A4 is associated with abnormal iodide organification, increased thyroid gland volume, increased severity of hearing loss, and bilateral EVA. The presence of a single mutant allele of SLC26A4 is associated with normal iodide organification, normal thyroid gland volume, less severe hearing loss and either bilateral or unilateral EVA. When other underlying correlations are accounted for, the presence of a cochlear malformation or the size of EVA does not have an effect on hearing thresholds. This is consistent with observations of an Slc26a4 mutant mouse model of EVA in which hearing loss is independent of endolymphatic hydrops or inner ear malformations. Segregation analyses of EVA in families suggest that the patients carrying one mutant allele of SLC26A4 have a second, undetected mutant allele of SLC26A4, and the probability of a sibling having EVA is consistent with its segregation as an autosomal recessive trait. Patients without any mutations are an etiologically heterogeneous group in which siblings have a lower probability of having EVA. SLC26A4 mutation testing can provide prognostic information to guide clinical surveillance and management, as well as the probability of EVA affecting a sibling. | Taku Ito Julie Muskett Parna Chattaraj Byung Yoon Choi Kyu Yup Lee Christopher K Zalewski Kelly A King Xiangming Li Philine Wangemann Thomas Shawker Carmen C Brewer Seth L Alper Andrew J Griffith | 2013 | World Journal of Otorhinolaryngology2013，3，2： | 2 |
| 4 | Continuous HMM applied to quantization of on - line Korean character spaces显示文摘 | JUNG K C YOON S M KIM H J | 2000 | Pattern Recognition Letters2000，21，： | 2 |
| 5 | A problem reduction and decomposition approach for scheduling for a flowshop of batch processing machines 显示文摘 | Sung C S Kim Y H Yoon S H | 2000 | European Journal of Operational Research2000，121，： | 2 |
| 6 | Sequence-based screening for putative polyketide synthase gene-harboring clones from a soil metagenome library 显示文摘 | JI S C KIM D YOON J H | 2006 | J Microbiol Biotechnol2006，16，： | 1 |
| 7 | 显示文摘 | Park S H Yoon C S Kang S G | 2004 | Electrochimica Acta2004，49，4： | 1 |
| 8 | Microemulsion templated synthesis of carbon nanotube-supported Pd and Rh nanoparticles for ca- talytic applications显示文摘 | Yoon B Wai C M | 2005 | J Am Chem Soc2005，127，17： | 1 |
| 9 | Multipotential neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex显示文摘 | Snyder EY Yoon C Flax JD | 1997 | PNAS1997，94，11： | 1 |
| 10 | Heating of ions by Alfvén waves via nonresonant interactions显示文摘 | Wang C B Wu C S Yoon P H | 2006 | Physical Review Letters2006，96，12： | 1 |
| 11 | Lipase-catalyzed incorporation of conjugated linoleie acid into tricaprylin显示文摘 | KIMA I H YOON C S CHO S H | 2001 | Journal of the American Oil Chemists'' Society2001，78，5： | 1 |
| 12 | Endothelial nitric oxide synthase gene(E298D)is aasociated with vessel stenosis in Korean population 显示文摘 | YOON S SHIN C PARK HY | 2005 | Clinica Chimica Acta2005，353，12： | 1 |
| 13 | Microfluidic im- munosensor for rapid and sensitive detection of bovine vi- ral diarrhea virus 显示文摘 | Heinze B C Song J Y Yoon J Y | 2009 | Sens Actuator B-Chem2009，138，2： | 1 |
| 14 | Finite element analysis and modeling of structure with bolted joints 显示文摘 | Kim J Yoon J C Kang B S | 2007 | Applied Mathematical Modelling2007，31，5： | 1 |
| 15 | Investigation on vari- able shear modulus of magnetorheologieal elastomer based on natural rubber due to change of fabrication design显示文摘 | Yoon J H Yang I H Jeong U C | 2013 | Poly- mer Engineering and Science2013，53，5： | 1 |
| 16 | Transcatheter arterial embolization with 188Rhenium-HDD-labeled iodized oil in rabbit VX2 liver tumor显示文摘 | Yoon C J Chung JW Park JH | 2004 | J Vasc Interv Radiol2004，15，10： | 1 |
| 17 | Investigating the relationships among perceived value,satisfaction,and recommendations:The case of the Korean DMZ显示文摘 | Lee C K Yoon Y S Lee S K | | 0，，： | 1 |
| 18 | 查看详情显示文摘 | D W Yoon D E Gross V M Lynch J M Sessler B P Hay C H Lee | | 0，，： | 1 |
| 19 | Magnetic fluid grinding of ceramic balls显示文摘 | CHILDS T H C MAHMOOD S YOON H J | | 0，，06： | 1 |
| 20 | Mechanism of the decomposition of aqueous hydrogen peroxide over heterogeneous TiSBA15 and TS-1 selective oxidation catalysts: Insights from spectroscopic anddensity functional theory studies显示文摘 | YOON C W HIRSEKORN K F NEIDIG M L | 2011 | ACS Catalysis2011，1，12： | 1 |
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