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| 1 | Clinicopathological significance of the gene expression ofmatrix metalloproteinases and reversion-inducing cysteine-richprotein with Kazal motifs in patients with colorectal cancer:MMP-2 gene expression is a useful predictor of liver metastasisfrom colorectal cancer 显示文摘 | Oshima T Kunisaki C? Yoshihara K | 2008 | Oncol Rep2008，19，5： | 1 |
| 2 | Clinicopathologlcal significance of the gene expression of matrix metulloproteinases and version-inducing eysteine-rieh protein with Kazal motifs in patients with coloreetul cancer:MMP-2 gene expression is a useful predictor of liver metastasis from colorectul cancer显示文摘 | Oshima T Kunisaki C Yoshihara K | 2008 | Oncol Rep2008，19，5： | 1 |
| 3 | Effect of ion implantation on the oxidation resistance of TiAI 显示文摘 | Yoshihara M Tsniguchi S Zhu Y C | 2003 | Metallurgical and Materials Transactions A2003，34，10： | 1 |
| 4 | Methanol synthesis and reverse ater-gas shift kinetics over Cu(ll0) model catalysts: Structural sensitivity 显示文摘 | Yoshihara J Campbell C T | 1996 | Journal of Catalysis1996，161，： | 1 |
| 5 | Isolation of an ct--methylene--?--butyrolactone derivative, a toxin from the plant pathogen Lasiodiplodia theobromae 显示文摘 | He G C Matsuura H Yoshihara T | 2004 | Phytochemistry2004，65，20： | 1 |
| 6 | Ciinicopathological significance of the gene expression of matrix metailoproteinases and reversion-inducing eysteine-rich protein with Kazai motifs in patients with colorectal cancer:MMP-2 gene expression is a useful predictor of liver metastasis from eolorectal cancer显示文摘 | Oshima T Kunisaki C Yoshihara K | 2008 | Oncol Rep2008，19，5： | 1 |
| 7 | Island growth kinetics during vapor deposition of Cu onto the Zn-terminated ZnO(0001)surface显示文摘 | Yoshihara J Parker S C Campbell C T | 1999 | Surf Sci1999，439，13： | 1 |
| 8 | Brillouin scattering studies of the successive phase transitions in (CH3NH3)2FeCl4 显示文摘 | A Yoshihara J C Burr S M Mudara | 1984 | J Chem Phys1984，80，： | 1 |
| 9 | Reduced expression of the claudin-7 gene correlates with venous invasion and liver metastasis in colorectal cancer显示文摘 | Oshima T Kunisaki C Yoshihara K | 2008 | Oncology Reports2008，19，4： | 1 |
| 10 | Adrenocorticotropic hormone-secreting pancreatic neuroendocrine carcinoma with multiple organ infections and widespread thrombosis:A case report显示文摘BACKGROUND Ectopic adrenocorticotropic hormone(ACTH)-secreting neuroendocrine tumors are rare diseases.Patients with ACTH-secreting pancreatic neuroendocrine carcinomas have a poor prognosis.Infections and coagulopathies have been reported as the cause of death.However,detailed clinical descriptions of the morbid complications of ACTH-secreting neuroendocrine carcinomas have not been reported.CASE SUMMARY A 78-year-old Japanese woman consulted a medical center due to systemic edema and epigastric discomfort.Laboratory analysis revealed hypercortisolemia with increased ACTH secretion without diurnal variation in serum cortisol level.An enhanced computed tomography(CT)scan revealed a 3-cm tumor in the pancreatic head.The cytological material from endoscopic ultrasound-guided fine-needle aspiration was compatible with ACTHsecreting pancreatic neuroendocrine carcinoma.The Ki-67 index was 40%.She was transferred to Mie University Hospital for surgical treatment.The patient was diagnosed with urinary tract infection,cytomegalovirus hepatitis,esophageal candidiasis,pulmonary infiltrates suspicious for Pneumocystis carinii pneumonia,peripheral deep vein thrombosis,pulmonary embolism,and disseminated intravascular coagulation.The multiple organ infections and thromboses responded well to antimicrobial and anticoagulant therapy.Radioisotope studies disclosed a pancreatic tumor and a metastatic lesion in the liver,whereas somatostatin receptor scintigraphy showed negative findings,suggesting the primary and metastatic tumors were poorly differentiated.A CT scan before admission showed no metastatic liver lesion,suggesting that the pancreatic tumor was rapidly progressing.Instead of surgery,antitumor chemotherapy was indicated.The patient was transferred to another hospital to initiate chemotherapy.However,she died four months later due to the rapidly progressive tumor.CONCLUSION ACTH-secreting pancreatic neuroendocrine neoplasm is a rare disease with a very poor prognosis.The clinical course and acute complications of the tumor remain unreported.Here we report the clinical course of a rapidly progressive case of ACTH-secreting pancreatic neuroendocrine tumor that developed infectious complications due to many types of pathogens in multiple organs,widespread thromboses,pulmonary embolism,and disseminated intravascular coagulation. | Akihiro Yoshihara Kota Nishihama Chisa Inoue Yuko Okano Kazuhito Eguchi Soichiro Tanaka Kanako Maki Valeria Fridman D'Alessandro Atsuro Takeshita Taro Yasuma Mei Uemura Toshinari Suzuki Esteban C Gabazza Yutaka Yano | 2022 | World Journal of Clinical Cases2022，10，17： | 1 |
| 11 | Reduced expression of the Cln-7 gene correlates with venous invasion and liver metastasis in colorectal cancer显示文摘 | Oshima T Kunisaki C Yoshihara K | | 0，，： | 1 |
| 12 | Island Growth Kinetics During Vapor Deposition of Cu onto the Zn-Terminated ZnO(0001) Surface显示文摘 | Yoshihara J Parker S C Campbell C T | 1999 | Surface Science1999，439，： | 1 |
| 13 | Cu films on a Zn terminated ZnO (0001) surface:Structure and electronic properties显示文摘 | Yoshihara J Campbell J M Campbell C T | 1998 | Surface Science1998，406，1： | 1 |
| 14 | Clinicopathologieal significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with colorectal cancer: MMP-2 gene expression is a use- ful predictor of liver metastasis from colorectal cancer显示文摘 | Oshima T Kunisaki C Yoshihara K | 2008 | Oncol Rep2008，19，5： | 1 |
| 15 | Methanol synthesis and reverse water-gas shift kinetics over Cu(110) model catalysts: structural sensitivity显示文摘 | Yoshihara J Campbell C T | 1996 | J Catal1996，161，： | 1 |
| 16 | Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing eysteine-rieh protein with Kazal motifs in patients with elolreetal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from eoloreetal eaneer 显示文摘 | Oshima T Kunisaki C Yoshihara K | 2008 | Oneol Rep2008，19，5： | 1 |
| 17 | Reduced expression of theclaudin-7 gene correlates with venous invasion and liver metastasisin colorectal cancer显示文摘 | Oshima T Kunisaki C Yoshihara K | 2008 | Oncol Rep2008，19，4： | 1 |
| 18 | DNA/polyethylenei-mine/hyaluronic acid small complex particles and tumor sup-pression in mice显示文摘 | Ito T Yoshihara C Hamadak Koyama Y | 2010 | Biomaterials2010，31，： | 1 |
| 19 | Clinicopathological significance of the gene expression of matrix metalloproteinases and reversion-inducing cysteine-rich protein with Kazal motifs in patients with clolrectal cancer: MMP-2 gene expression is a useful predictor of liver metastasis from colorectal cancer显示文摘 | Oshima T Kunisaki C Yoshihara K | 2008 | Oncol Rep2008，19，5： | 1 |
| 20 | Surgical treatment for atlantooccipital osteoarthritis: a case report of two patients显示文摘 | Yoshihara H Kepler C Hasegawa K | 2011 | Eur Spine J2011，20，2： | 1 |
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