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| 1 | Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH. | Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma | 2018 | Stroke & Vascular Neurology2018，3，1： | 10 |
| 2 | FGF-2 regulation of neurogenesis in adult hippocampus after brain injury.显示文摘 | Yoshimura S Takagi Y Harada J | | 0，，： | 2 |
| 3 | 显示文摘 | Cho W S Yoshimura M | 1997 | Eur J solid State Inorg Chem1997，34，9： | 1 |
| 4 | Micro determination of Chromium,iron,copper and cobalt in water显示文摘 | Yoshimura K Waki H Ohashi S | 1976 | Talanta1976，23，： | 1 |
| 5 | Electrical and envi-ronmental aging of silicone rubber used in outdoor insulation显示文摘 | Yoshimura N Kumagai S Nishimura S | 1999 | IEEE Transactions on Dielectrics and Electrical Insula-tion1999，6，5： | 1 |
| 6 | A new coal flash pyrolysis method utilizing effective radical transfer from solvent to coal显示文摘 | MIURA K MAE K ASAOKA S YOSHIMURA T HASHIMOTO K | 1991 | Energy Fuels1991，5，2： | 1 |
| 7 | FGF-2 regulation of neurogenesis in adult hippoeampus afier brain injury显示文摘 | Yoshimura S Takagi Y Harada J | 2001 | Proe Natl Aead Sei USA2001，98，10： | 1 |
| 8 | A multiple cross-sectional shape optimization method for automotive body frames显示文摘 | YOSHIMURA M NISHIWAKI S IZUI K | 2005 | Journal of Mechanical Design2005，127，1： | 1 |
| 9 | Combination efectsof normobaric hyperoxia and edaravone on focal cerebralischemia-induced neuronal damage in mice显示文摘 | Nonaka Shimazawa M Yoshimura S | | 0，，02： | 1 |
| 10 | 1,8-cineole inhibits both proliferation and elongation of BY-2 cultured tobacco cells显示文摘 | YOSHIMURA H SAWAI Y TAMOTSU S | 2011 | Journal of Chemical Ecology2011，37，3： | 1 |
| 11 | Prediction of neurologic deterioration in patients with lacunar infarction in the territory of the tenticulostriate artery using perfusion CT显示文摘 | Yamada M Yoshimura S Kaku Y | 2004 | AJNR Am J Neuroradiol2004，25，： | 1 |
| 12 | Staged angioplasty for carotid artery stenosis to prevent postoperative hyperperfusion显示文摘 | Yoshimura S Kitajima H Enomoto Y | 2009 | Neurosurgery2009，64，3： | 1 |
| 13 | Live at-tenuated listeria monoeytagenes effectively treats hepatic colorectal cancer metastases and is strongly enhanced by depletion of regulatory t cells 显示文摘 | YOSHIMURA K LAIRD L S CHIA C Y | 2007 | Cancer Res2007，67，10： | 1 |
| 14 | A new breed of mouse showing multiple osteochondral lesions:Twy mouse 显示文摘 | Hosoda Y Yoshimura Y Higaki S | 1981 | Ryumachi1981，，： | 1 |
| 15 | Anticachectic effects of the natural herb coptidis rhizome and berberine on mice bearing colon 26/clone 20 adenocarcinoma显示文摘 | Lizuka N Hazama S Yoshimura K | 2002 | Int J Cancer2002，99，： | 1 |
| 16 | Identification of aYAC clone carrying the Xa1 allele,a bacterial blight resistance gene in rice显示文摘 | YOSHIMURA S YAMANOUCHI U KURATA N | 1996 | Theor Appl Genet1996，93，： | 1 |
| 17 | Postoperative chemotherapy vs chemoradiotherapy for thoracic esophageal cancer: a prospective randomized clinical trial显示文摘 | Taehibana M Yoshimura H Kinugasa S | 2003 | Eur J Surg Oncol2003，29，7： | 1 |
| 18 | Cognitive behav-ioral therapy for depression changes medial prefrontal and ven-tral anterior cingulate cortex activity associated with self-ref-erential processing显示文摘 | Yoshimura S Okamoto Y Onoda K | 2013 | Soc Cogn Affect Neurosci2013，9，4： | 1 |
| 19 | Plastic iodophor drape during liver surgery operative use of the iodophor im- pregnated adhesive drape to prevent wound infection during high risk surgery显示文摘 | Yoshimura Y Kubo S Hirohashi K | 2003 | World J Surg2003，27，6： | 1 |
| 20 | Cyclophos- phamide augments antitumor immunity:studies in an au- tochthonous prostate cancer model显示文摘 | WADA S YOSHIMURA K HIPKISS EL | 2009 | Cancer Res2009，69，10： | 1 |
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