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| 1 | Emergent Schr?dinger equation in an introspective machine learning architecture显示文摘Can physical concepts and laws emerge in a neural network as it learns to predict the observation data of physical systems? As a benchmark and a proof-of-principle study of this possibility, here we show an introspective learning architecture that can automatically develop the concept of the quantum wave function and discover the Schr?dinger equation from simulated experimental data of the potential-todensity mappings of a quantum particle. This introspective learning architecture contains a machine translator to perform the potential to density mapping, and a knowledge distiller auto-encoder to extract the essential information and its update law from the hidden states of the translator, which turns out to be the quantum wave function and the Schr?dinger equation. We envision that our introspective learning architecture can enable machine learning to discover new physics in the future. | Ce Wang Hui Zhai Yi-Zhuang You | 2019 | Science Bulletin2019，64，17： | 4 |
| 2 | Numerical study on dynamic mechanism of brain volume and shear deformation under blast loading显示文摘Blast-induced traumatic brain injury(b-TBI)is a kind of significant injury to soldiers in the current military conflicts.However,the mechanism of b-TBI has not been well understood,and even there are some contradictory conclusions.It is crucial to reveal the dynamic mechanism of brain volume and shear deformations under blast loading for better understanding of b-TBI.In this paper,the numerical simulation method is adopted to carry out comprehensive and in-depth researches on this issue for the first time.Based on the coupled Eulerian-Lagrangian method,the fluid-structure coupling model of the blast wave and human head is developed to simulate two situations,namely the head subjected to the frontal and lateral impacts.The simulation results are analyzed to obtain the underlying dynamic mechanisms of brain deformation.The brain volume deformation is dominated by the local bending vibration of the skull,and the corresponding frequency for the forehead skull under the frontal impact and the lateral skull faced to the lateral impact is as high as 8 kHz and 5 kHz,respectively.This leads to the high-frequency fluctuation of brain pressure and the large pressure gradient along the skull,totally different from the dynamic response of brain under head collisions.While the brain shear deformation mainly depends on the relative tangential displacement between the skull and brain and the anatomical structure of inner skull,being not related to the brain pressure and its gradient.By further comparing the medical statistics,it is inferred that diffuse axonal injury and brain contusion,the two most common types of b-TBI,are mainly attributed to brain shear deformations.And the von Mises stress can be adopted as the indicator for these two brain injuries.This study can provide theoretical guidance for the diagnosis of b-TBI and the development of protective equipment. | Zhijie Li Zhibo Du Xiaochuan You Zhanli Liu Jian Cheng Chengcheng Luo Dongyang Chu Shaowu Ning Yue Kang Ce Yang Zhuo Zhuang | 2019 | Acta Mechanica Sinica2019，35，5： | 3 |
| 3 | SRSF1 plays a critical role in invariant natural killer T cell development and function显示文摘Invariant natural killer T(iNKT)cells are highly conserved innate-like T lymphocytes that originate from CD4^(+)CD8^(+)double-positive(DP)thymocytes.Here,we report that serine/arginine splicing factor 1(SRSF1)intrinsically regulates iNKT cell development by directly targeting Myb and balancing the abundance of short and long isoforms.Conditional ablation of SRSF1 in DP cells led to a substantially diminished iNKT cell pool due to defects in proliferation,survival,and TCRαrearrangement.The transition from stage 0 to stage 1 of iNKT cells was substantially blocked,and the iNKT2 subset was notably diminished in SRSF1-deficient mice.SRSF1 deficiency resulted in aberrant expression of a series of regulators that are tightly correlated with iNKT cell development and iNKT2 differentiation,including Myb,PLZF,Gata3,ICOS,and CD5.In particular,we found that SRSF1 directly binds and regulates pre-mRNA alternative splicing of Myb and that the expression of the short isoform of Myb is substantially reduced in SRSF1-deficient DP and iNKT cells.Strikingly,ectopic expression of the Myb short isoform partially rectified the defects caused by ablation of SRSF1.Furthermore,we confirmed that the SRSF1-deficient mice exhibited resistance to acute liver injury uponα-GalCer and Con A induction.Our findings thus uncovered a previously unknown role of SRSF1 as an essential post-transcriptional regulator in iNKT cell development and functional differentiation,providing new clinical insights into iNKT-correlated disease. | Jingjing Liu Menghao You Yingpeng Yao Ce Ji Zhao Wang Fang Wang Di Wang Zhihong Qi Guotao Yu Zhen Sun Wenhui Guo Juanjuan Liu Shumin Li Yipeng Jin Tianyan Zhao Hai-Hui Xue Yuanchao Xue Shuyang Yu | 2021 | Cellular & Molecular Immunology2021，18，11： | 3 |
| 4 | Blue and red light combination LED photo- therapy for ache vulgaris in patients with skin phototype Ⅳ 显示文摘 | Lee SY You CE Park MY | 2007 | Lasers Surg Med2007，39，2： | 1 |
| 5 | Blue and Red Light Combination LED Phototherapy for Ache Vulgaris in Patients with Skin Phototype Ⅳ显示文摘 | Lee SY You CE Park MY | 2007 | Lasers Surg Med2007，39，2： | 1 |
| 6 | Blue and red light combination LED phototherapy for acne vulgaris in patients with SKin phototype IV显示文摘 | Lee SY You CE Park MY | 2007 | Lasers Surg Med2007，39，2： | 1 |
| 7 | Blue and red light combination LED photo- therapy for acne vulgairs in patients with skin phototype Ⅳ 显示文摘 | Lee SY You CE Park MY | 2007 | Laser surg Med2007，39，2： | 1 |
| 8 | Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype Ⅳ显示文摘 | Lee SY You CE Park MY | 2007 | Lasers Surg Med2007，39，2： | 1 |
| 9 | Blue and red light combination LEDphototherapy for acne vulgaris in patients with skin phototype IV显示文摘 | Lee SY You CE Park MY | 2007 | J Lasers Surg Med2007，39，2： | 1 |
| 10 | Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype Ⅳ显示文摘 | Lee SY You CE Park MY | 2007 | Lasers Surg Med2007，39，2： | 1 |
| 11 | Blue and red light combination LED phototherapy for ache vulgaris in patients with skin phototype IV 显示文摘 | Lee SY You CE Park MY | 2007 | Lasers SurgMed2007，39，2： | 1 |
| 12 | Oscillatory fluid flow- induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling 显示文摘 | Kim CH You L Yellowley CE | 2006 | Bone2006，39，5： | 1 |
| 13 | Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV显示文摘 | Lee SY You CE Park MY | 2007 | Lasers Surg Med2007，39，： | 1 |
| 14 | Blue and red light combination LED phototherapy for acne vulgaris in patients with skin pho- totype IV 显示文摘 | Lee SY You CE Park MY | 2007 | Lasers Surg Med2007，39，2： | 1 |
| 15 | Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV显示文摘 | Lee SY You CE Park MY | 2007 | Lasers Surg Med2007，39，2： | 1 |
| 16 | Blue and red light combination LED photopherapy for ache vulgaris inpatients with skin phototype Ⅵ 显示文摘 | Lee SY You CE Park MY | 2007 | Lasers Surg Med2007，39，12： | 1 |
| 17 | Blue and red light combination LED phototherapy for acne vulgaris in patients with SKin phototype IV显示文摘 | Lee SY You CE Park MY | 2007 | Lasers Surg Med2007，39，2： | 1 |
| 18 | Increasing disparities in the age- Related incidences of colon and rectal cancers in the United States, 1975-2010显示文摘 | Bailey CE Hu CY You YN | 2015 | JAMA Surg2015，150，1： | 1 |
| 19 | Blue and red light combination LED phototherapy for acne vulgaris in patients with skin phototype IV显示文摘 | Lee SY You CE Park MY | 2007 | Lasers Surg Med2007，39，2： | 1 |
| 20 | Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling显示文摘 | Kim CH You L Yellowley CE | 2006 | Bone (NewYork)2006，39，5： | 1 |
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