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| 1 | The prevalence of dementia in urban and rural areas of China显示文摘 | Jianping Jia Fen Wang Cuibai Wei Aihong Zhou Xiangfei Jia Fang Li Muni Tang Lan Chu Youlong Zhou Chunkui Zhou Yong Cui Qi Wang Weishan Wang Peng Yin Nan Hu Xiumei Zuo Haiqing Song Wei Qin Liyong Wu Dan Li Longfei Jia Juexian Song Ying Han Yi Xing Peijie Y | 2013 | Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association2013，，： | 2 |
| 2 | Age-related changes in cerebral angiogenesis and fetal liver kinase-1 expression after cerebral ischemia/reperfusion显示文摘Cerebral angiogenesis in the early stages after cerebral ischemia injury is essential for the recovery of nerve function, in which fetal liver kinase-1 (Flk-1), as a major regulator of vasculogenesis and angiogenesis, plays a very important role. Microvessel density (MVD) was greater in an aged model group compared with the young sham operated group (P < 0.01). MVD and the sum of the lumen area were decreased in the aged group at 1, 3, 6 and 12 days following ischemia/reperfusion (I/R) injury compared with the young model group (P < 0.05 and P < 0.01, respectively). Flk-1 protein and mRNA expression was greater in the aged model group when compared with the young sham operated group (P < 0.01). Flk-1 protein and mRNA expression was lower in the aged group at 1, 3, 6 and 12 days after I/R compared with the young model group (P < 0.01). Flk-1 expression in aged rats attenuated rapidly, but was still maintained at relatively higher levels at 12 days following I/R in younger rats. The results suggest that angiogenesis was weakened after cerebral I/R in aged rats, and the mechanism of which might be correlated with attenuated expression of Flk-1 protein and mRNA. | Jiansheng Li Ke Liu Xinke Yang Jianfeng Gao Youlong Zhou Yuewu Zhao Zhengguo Liu Jingxia Liu | 2010 | Neural Regeneration Research2010，5，17： | 0 |
| 3 | ERF5.1 modulates carotenoid accumulation by interacting with CCD4.1 in Lycium显示文摘Carotenoids are important natural pigments and have medical and health functions for humans.Carotenoid cleavage dioxygenase 4(CCD4)and ethylene responsive factor(ERF)participate in carotenoid metabolism,but their roles in Lycium have not been discovered.Here,we annotated LbCCDs from the Lycium reference genome and found that LbCCD4.1 expression was significantly correlated with the carotenoid metabolites during Lycium five fruit developmental stages.Over-expression of LbCCD4.1 in NQ’s leaves resulted in a series of significantly lower contents of carotenoid metabolites,includingβ-carotene andβ-cryptoxanthin.Moreover,LbERF5.1,a transcription factor belonging to the ERF family that was located in the nucleus,was isolated.Significant reductions in the carotenoids,especially lutein,violaxanthin and their derivatives,were observed in over-expressing ERF5.1 transgenic NQ’s leaves.Over-expression or virus-induced gene silencing of LbERF5.1 in NQ’s leaves induced a consistent up-or down-expression,respectively,of LbCCD4.1.Furthermore,yeast one-hybrid and dual-luciferase reporter assays showed that ERF5.1 interacted with the promoter of CCD4.1 to increase its expression,and LbERF5.1 could bind to any one of the three predicted binding sites in the promoter of LbCCD4.1.A transcriptome analysis of LbERF5.1 and LbCCD4.1 over-expressed lines showed similar global transcript expression,and geranylgeranyl diphosphate synthase,phytoene synthase,lycopeneδ-cyclase cytochrome,cytochrome P450-type monooxygenase 97A,cytochrome P450-type monooxygenase 97C,and zeaxanthin epoxidase in the carotenoid biosynthesis pathway were differentially expressed.In summary,we uncovered a novel molecular mechanism of carotenoid accumulation that involved an interaction between ERF5.1 and CCD4.1,which may be used to enhance carotenoid in Lycium. | Jianhua Zhao Yuhui Xu Haoxia Li Xinlei Zhu Yue Yin Xiyan Zhang Xiaoya Qin Jun Zhou Linyuan Duan Xiaojie Liang Ting Huang Bo Zhang Ru Wan Zhigang Shi Youlong Cao Wei An | 2023 | Horticulture Research2023，10，12： | 0 |
| 4 | 2-O-β-D-Glucopyranosyl-L-ascorbic acid,an ascorbic acid derivative isolated from the fruits of Lycium barbarum L.,ameliorates high fructose-induced neuroinflammation in mice:involvement of gut microbiota and leaky gut显示文摘Western diet(rich in highly refined sugar and fat)can induce a range of metabolic dysfunctions in animals and humans,including neuroinflammation and cognitive function decline.Neuroinflammation and cognitive impairment,two critical pathological characteristics of Alzheimer’s disease,have been closely associated with microbial alteration via the gut-brain axis.Thus,the present study aimed to investigate the influence of 2-O-β-D-glucopyranosyl-L-ascorbic acid(AA-2βG)isolated from the fruits of Lycium barbarum on preventing the high-fructose diet(HFrD)induced neuroinflammation in mice.It was found that AA-2βG prevented HFr D-induced cognitive deficits.AA-2βG also predominantly enhanced the gut barrier integrity,decreased lipopolysaccharide entry into the circulation,which subsequently countered the activation of glial cells and neuroinflammatory response.These beneficial effects were transmissible by horizontal fecal microbiome transplantation,transferring from AA-2βG fed mice to HFr D fed mice.Additionally,AA-2βG exerted neuroprotective effects involving the enrichment of Lactobacillus and Akkermansia,potentially beneficial intestinal bacteria.The present study provided the evidence that AA-2βG could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky gut.As a potential functional food ingredient,AA-2βG may be applied to attenuate neuroinflammation associated with Western-style diets. | Wei Dong Yujia Peng Guijie Chen Zhiyong Xie Weiqi Xu Wangting Zhou Jia Mi Lu Lu Yi Sun Xiaoxiong Zeng Youlong Cao Yamei Yan | 2024 | Food Science and Human Wellness2024，13，1： | 0 |
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