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| 1 | Reversibility of minimal hepatic encephalopathy following liver transplantation in Egyptian cirrhotic patients显示文摘AIM To evaluate the reversibility of minimal hepatic encephalopathy(MHE) following liver transplantation(LT) in Egyptian cirrhotic patients. METHODS This prospective study included twenty patients with biopsy-proven liver cirrhosis listed for LT and twenty ageand sex-matched healthy control subjects. All underwent neuro-psychiatric examination, laboratory investigations, radiological studies and psychometric tests including trail making test A(TMT A), TMT B, digit symbol test and serial dotting test. The psychometric hepatic encephalopathy score(PHES) was calculated for patients to diagnose MHE. Psychometric tests were repeated six months following LT in the cirrhotic patient group. RESULTS Before LT, psychometric tests showed highly significant deficits in cirrhotic patients in comparison to controls(P < 0.001). There was a statistically significant improvement in test values in the patient group after LT; however, their values were still significantly worse than those of the controls(P < 0.001). The PHES detected MHE in 16 patients(80%) before LT with a median value of -7 ± 3.5. The median PHES value was significantly improved following LT, reaching-4.5 ± 5(P < 0.001), and the number of patients with MHE decreased to 11(55%). The pre-transplant model for end-stage liver disease(MELD) score ≥ 15 was significantly related to the presence of post-transplant MHE(P = 0.005). More patients in whom reversal of MHE was observed had a pre-transplant MELD score < 15.CONCLUSION Reversal of MHE in cirrhotic patients could be achieved by LT, especially in those with a MELD score < 15. | Mahmoud A Osman Moataz M Sayed Khaled A Mansour Shereen A Saleh Wesam A Ibrahim Sara M Abdelhakam Mohamed Bahaa Wael A Yousry Hosam S Elbaz Reginia N Mikhail Azza M Hassan Ehab H Elsayed Dalia A Mahmoud | 2016 | World Journal of Hepatology2016，8，30： | 11 |
| 2 | Decreased apoptosis in advanced-stage/high-grade hepatocellular carcinoma complicating chronic hepatitis C is mediated through the downregulation of p21 ras显示文摘Objective and background: Although p21 ras has been reported to be upregulated in hepatocellular carcinoma complicating chronic hepatitis C type I, p21 ras has a different role in advanced stages, as it has been found to be downregulated. The goal of this study was to investigate the status of p21 ras in early-stage/low-grade and late-stage/high-grade hepatocellular carcinoma and its possible link to apoptosis. Material and methods: Thirty-five cases each of chronic HCV hepatitis type 4 (group I) and cirrhosis with hepatocellular carcinoma (HCC) complicating chronic HCV hepatitis (groups II and III) were immunohistochemically evaluated using a p21 ras polyclonal antibody. The apoptotic index was determined in histologic sections using the terminal deoxynucleotidyl transferase-mediated d-UTP biotin nick end labeling (TUNEL) assay. Results: Significant differences (P=0.001) were detected in p21 ras protein expression between the three groups. A near 2-fold increase in p21 ras staining was observed in the cirrhotic cases compared to the hepatitis cases, and p21 ras expression was decreased in the HCC group. p21 ras expression correlated with stage (r=0.64, P=0.001) and grade (r=-0.65, P=0.001) in the HCC group and grade in the HCV group (r=0.44, P=0.008). Both p21 ras expression and TUNEL-LI were significantly lower in large HCCs compared to small HCCs (P=0.01 each). The TUNEL values were negatively correlated with stage in the HCC group (r=-0.85, P=0.001). The TUNEL values were also negatively correlated with grade in both the HCV and HCC groups (r=0.89, P=0.001 and r=-0.53, P=0.001, respectively). The p21 ras scores were significantly correlated with the TUNEL-LI values in the HCC group (r=0.63, P=0.001) and HCV group (r=0.88, P=0.001). Conclusions: p21 ras acts as an initiator in HCC complicating type 4 chronic HCV and is downregulated with HCC progression, which most likely promotes tumor cell survival because it facilitates the downregulation of apoptosis with tumor progression. | Nahed Baddour Ebtehal Farrag Ahmed Zeid Essam Bedewy Yousry Taher | 2013 | Chinese Journal of Cancer Research2013，25，3： | 6 |
| 3 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 4 | The Use of Hydrogen as a Fuel for Inland Waterway Units显示文摘关于常规石块的普遍使用的有害效果增强担心一般来说在海洋的领域里并且在内燃机造成,导致了努力并且向研究指导大大写的投资的广阔数量,持续其他的精力的开发采购原料。最答应之一并且这些来源丰富是氢。第一,当前的石块燃料的使用被讨论集中于排出物和经济方面作为一种合适的可能的选择与氢的特别参考为新、更干净、可更新的燃料强调需要。氢性质,生产和存储方法然后从节俭的观点与它的适用性一起被考察。最后,为在内燃机的氢的使用的费用分析被执行为柴油机作为代替说明它的使用的好处。这的结果花费了 98% 大写的开销被设备消费的分析表演,并且设备的 68.3% 全部的费用在太阳的光电的房间上被花。因为它是大约 10 亿的高起始的费用,氢植物作为一个大投资工程被分类 US$ ;但是因为氢以一个完全绿的方法被生产,这被认为正当。当氢被用作燃料时,没有有害排出物被获得。 | M. Morsy El Gohary Yousri M. A. Welaya AmrAbdelwahabSaad | 2014 | Journal of Marine Science and Application2014，13，2： | 3 |
| 5 | Haplotype-resolved genome assembly and allele- specific gene expression in cultivated ginger显示文摘Ginger(Zingiber officinale)is one of the most valued spice plants worldwide;it is prized for its culinary and folk medicinal applications and is therefore of high economic and cultural importance.Here,we present a haplotype-resolved,chromosome-scale assembly for diploid ginger anchored to 11 pseudochromosome pairs with a total length of 3.1 Gb.Remarkable structural variation was identified between haplotypes,and two inversions larger than 15Mb on chromosome 4 may be associated with ginger infertility.We performed a comprehensive,spatiotemporal,genome-wide analysis of allelic expression patterns,revealing that most alleles are coordinately expressed.The alleles that exhibited the largest differences in expression showed closer proximity to transposable elements,greater coding sequence divergence,more relaxed selection pressure,and more transcription factor binding site differences.We also predicted the transcription factors potentially regulating 6-gingerol biosynthesis.Our allele-aware assembly provides a powerful platform for future functional genomics,molecular breeding,and genome editing in ginger. | Shi-Ping Cheng Kai-Hua Jia Hui Liu Ren-Gang Zhang Zhi-Chao Li Shan-Shan Zhou Tian-Le Shi Ai-Chu Ma Cong-Wen Yu Chan Gao Guang-Lei Cao Wei Zhao Shuai Nie Jing-Fang Guo Si-Qian Jiao Xue-Chan Tian Xue-Mei Yan Yu-Tao Bao Quan-Zheng Yun Xin-Zhu Wang Ilga Porth Yousry AEl-Kassaby Xiao-Ru Wang Zhen Li Yves Van de Peer Jian-Feng Mao | 2021 | Horticulture Research2021，8，1： | 3 |
| 6 | Gapless genome assembly of azalea and multi-omics investigation into divergence between two species with distinct f lower color显示文摘The genus Rhododendron(Ericaceae),with more than 1000 species highly diverse in f lower color,is providing distinct ornamental values and a model system for f lower color studies.Here,we investigated the divergence between two parental species with different f lower color widely used for azalea breeding.Gapless genome assembly was generated for the yellow-f lowered azalea,Rhododendron molle.Comparative genomics found recent proliferation of long terminal repeat retrotransposons(LTR-RTs),especially Gypsy,has resulted in a 125 Mb(19%)genome size increase in species-specific regions,and a significant amount of dispersed gene duplicates(13402)and pseudogenes(17437).Metabolomic assessment revealed that yellow f lower coloration is attributed to the dynamic changes of carotenoids/f lavonols biosynthesis and chlorophyll degradation.Time-ordered gene co-expression networks(TO-GCNs)and the comparison confirmed the metabolome and uncovered the specific gene regulatory changes underpinning the distinct f lower pigmentation.B3 and ERF TFs were found dominating the gene regulation of carotenoids/f lavonols characterized pigmentation in R.molle,while WRKY,ERF,WD40,C2H2,and NAC TFs collectively regulated the anthocyanins characterized pigmentation in the red-f lowered R simsii.This study employed a multi-omics strategy in disentangling the complex divergence between two important azaleas and provided references for further functional genetics and molecular breeding. | Shuai Nie Shi-Wei Zhao Tian-Le Shi Wei Zhao Ren-Gang Zhang Xue-Chan Tian Jing-Fang Guo Xue-Mei Yan Yu-Tao Bao Zhi-Chao Li Lei Kong Hai-Yao Ma Zhao-Yang Chen Hui Liu Yousry AEl-Kassaby Ilga Porth Fu-Sheng Yang Jian-Feng Mao | 2023 | Horticulture Research2023，10，1： | 2 |
| 7 | Topography of the cortical motor hand area: prospective study with functional MR imaging and direct motor mapping at surgery 显示文摘 | Yousry TA Schmid UD Jassoy AG | 1995 | Radiology1995，195，1： | 2 |
| 8 | Detailed anatomy of the intracranial segment of the hypoglossal nerve: neurovascular relatinnships and landmarks on magnetic resonance imaging sequences 显示文摘 | Yousry I Moriggl B Schmid UD | 2002 | J Neurosurg2002，96，： | 1 |
| 9 | Radical resection of meningiomas and arteriovenous fistulas involving critical dural sinus segments: experience with intraoperative sinus pressure monitoring and elective sinus reconstruction in 10 patients 显示文摘 | Steiger HJ Yousry T | 1997 | Neurosurgery1997，41，5： | 1 |
| 10 | Localization of the motor hand area to a knob on the precentral gyrus,a new land- mark显示文摘 | Yousry TA Schmid UD Alkhadhi H | 1997 | Brain1997，120，1： | 1 |
| 11 | MHD pressure drop and thermal hydraulic analysis for the 1TER breeding blanket design显示文摘 | Hua Thanh Q Yousry Gohar | 1995 | Fusion Engineering and Design1995，27，： | 1 |
| 12 | MR anatomy of the proximal cisternal segment of the trochlear nerve; neurovascular relationships and landmarks显示文摘 | Yousry I Mori B Dieterich M | 2002 | Radiology2002，223，1： | 1 |
| 13 | Atypical idiopathic inflammatory demyelinating lesions: prognostic implications and relation to multiple sclerosis显示文摘 | Mirja Wallner-Blazek Alex Rovira Massimo Fillipp Mara A. Rocca David H. Miller Klaus Schmierer Jette Frederiksen Achim Gass Hugo Gama Charles P. Tilbery Antonio J. Rocha José Flores Frederik Barkhof Alexandra Seewann Jacqueline Palace Tarek Yousry Xavier | 2013 | Journal of Neurology2013，，8： | 1 |
| 14 | Reversible encephalopathy with cerebral wasospasm in a Guillain-Barre syndrome patient treated with intravenous immunoglobulin显示文摘 | Voltz R Rosen FV Yousry T | 1996 | Neurology1996，46，： | 1 |
| 15 | Trigeminal ganglion and its divisions:detailed anatomic MR imaging with contrastenhanced 3D constructive interference in the steady state sequences显示文摘 | Yousry I Moriggl B Schmid UD | 2005 | AJNR Am J Neuroradiol2005，26，5： | 1 |
| 16 | Morbidity associated with posterior intravaginal slingplasty for uterovaginal and vault prolapse显示文摘 | Hefni M Yousri N El-Toukhy T | 2007 | Arch Gynecol Obstet2007，276，5： | 1 |
| 17 | 胸腔镜内乳淋巴结清扫:一种针对乳腺癌内乳淋巴结的分期技术(英文)显示文摘Objective: The aim of our study was to investigate the feasibility and safety of thoracoscopic internal mammary lymphadenectomy as a method to refine and thereby improve nodal staging in breast cancer. Methods: During the period from June 2004 to May 2007, 50 patients with operable breast cancer underwent modified radical mastectomy (MRM) or breast conserving surgery (BCS), followed by thoracoscopic internal mammary lymphadenectomy, using 3 ports through the skin incision of the MRM or the BCS. Metal clips were used to mark precise site of lymphadenectomy. Results: of total number of 50 patients, the mean age of patients was 44 years (range, 27-60 years). 40 (80%) had medio-central tumor, 10 (20%) had lateral tumor. 35 (70%) had clinically involved axillary nodes. 16 out of 50 patients received neo-adjuvant CTH. 44 patients underwent MRM and 6 patients underwent BCS. No intra-operative complications occurred. Atelectasis was the only postoperative complication that was encountered, which occurred in 12 cases, and was treated conservatively. The average chest drainage period was 1.2 day (range, 1-2 days). The total number of IMN metastasis was 18 patients (36%). The risk of IMN metastasis was higher; in younger patients (P = 0.03), in medio-central tumors (P = 0.03), in bigger tumors (P = 0.05), with heavier metastasis of axillary LNs (P = 0.001). But a correlation with the histological pattern of the 1ry tumor didn't exist (P = 1). Knowing the IMN status helped in proper staging of patients, 7 patients showed evident stage migration after adding the IMN analysis to that of primary tumor and axillary LN. During the follow up period (the median, 22 months; range, 7 to 42 months), no patient had pleural dissemination or port-site metastasis. Conclusion: Thoracoscopic IMN lymphadenectomy is a safe procedure, which can be done serious additional complications or cosmetic compromise. And allow proper nodal staging, which allow proper treatment planning. | Waheed Yousry Garee Hesham Elsebaie Haytham Gareer Hytham Ahmed Mohamed Wafa Hussein Soliman | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，10： | 1 |
| 18 | Regional relative blood volume MR maps of meningiomas before and after partial embolization显示文摘 | Bruening R Wu RH Yousry TA | 1998 | J Comput Assist Tomogr1998，22，1： | 1 |
| 19 | Cavernous malformations of the brainstem three-dimensionalconstructive interference in steady-state magnetic resonance imaging for improvement of surgical approach and clinical results 显示文摘 | Zausinger S Yousry I Bruechmann H | 2006 | Neurosurgery2006，58，2： | 1 |
| 20 | MR anatomy of the proximal cisternal segment of the trochlear nerve: neurovascular relationships and landmarks显示文摘 | Yousry I Moriggl B Dieterich M | 2002 | Radiology2002，223，5： | 1 |
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