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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | Comparison of methods to detect biosurfactant production by diverse microorganisms 显示文摘 | Youssef N H Duncan K E Nagle D P | 2004 | Journal of Microbiological Methods2004，56，3： | 1 |
| 3 | Influence of r-irradiation on the bioconversion of rice straw by Tricho-derma vi ride显示文摘 | Youssef Bothaina M Aziz N H | 1999 | Into Single Cell Protein1999，97，386： | 1 |
| 4 | Synthesis and coordinating properties of new chromone thiosemicarbazones towards some transition metal i- ons显示文摘 | Youssef N S Hegab K H Eid A E | 2003 | Synthesis and reactivity in inorganic and metal -organic chemistry2003，33，9： | 1 |
| 5 | Phase transitions in some epidemic models defined on small-world networks显示文摘 | Agiza H N Elgazzar A S Youssef S A | 2003 | Int J Mod Phys C2003，14，6： | 1 |
| 6 | Modified treatment of ultrasonic plus-echo technique显示文摘 | YOUSSEF M H Gorban N K | 2002 | Ultrasonic2002，，39： | 1 |
| 7 | Antioxidant defense system in leaves of Indian mustard ( Brassica juncea) and rape ( Brassica napus ) under cadmium stress 显示文摘 | Nouairi I Ben Ammar W Ben Youssef N Ben Miled D D Ghorbal M H Zarrouk M | 2009 | Acta Physiological Plantarum2009，31，2： | 1 |
| 8 | Antibiotic-free nanotherapeutics: hypericin nanoparticles thereof forimproved in vitro and in vivo antimicrobial photodynamictherapy and wound healing 显示文摘 | Nafee N Youssef A El-Gowelli H | 2013 | Int J Pharm2013，454，1： | 1 |
| 9 | Development of criteria to evaluate uniaxial creep data and asphalt concrete permanent deform- ation potential 显示文摘 | Little D N Button J W Youssef H | 1993 | Transportation Research Record1993，1471，： | 1 |
| 10 | Synthesis and antitumor activity of some 2,3-disub- stituted quinazolin-4 (3H) -ones and 4,6-disubstituted- 1,2,3,4-tetrahydro-quinazolin-2H-ones 显示文摘 | Abdel Gawad N M Georgey H H Youssef R M | 2010 | Eur J Med Chem2010，45，12： | 1 |
| 11 | Comparison of Methods to Detect Biosurfactant Production by Diverse Microorganisms 显示文摘 | YOUSSEF N H DUNCAN K E NAGLE D P | 2004 | J Microbiological Methods2004，56，3： | 1 |
| 12 | State space approach to generalized thermoelastic problem with ther-mo-mechanical shock显示文摘 | El-Maghraby N M Youssef H M | 2004 | Journal of Applied Mathematics and Computation2004，156，2： | 1 |
| 13 | Occurrence of Aflatoxins and Aflatoxinproducing molds in fresh and processed meat in Egypt显示文摘 | AZIZ N H YOUSSEF Y A | 1991 | Food Additives and Contaminants1991，8，3： | 1 |
| 14 | Comparison of Method to Detect Biosurfactant Production by Diverse Microor ganisms 显示文摘 | Youssef N H Duncan k E Nagel D P | 2004 | Microbiological Methods2004，56，3： | 1 |
| 15 | Isolation and characterization of a linear plasmid from the entomopathogenic fungus Ascosphaera apis显示文摘 | Qin H Welker D L Youssef N N | 1993 | Plasmid1993，29，1： | 1 |
| 16 | Soil deformation and slip relative to grouser shape and spacing 显示文摘 | Yong R N Youssef A F E1-Mamlouk H | 1978 | Journal of Ter- ramechanics1978，15，3： | 1 |
| 17 | Influence of y-irradiation on the bioconversion of rice straw by Trichoderma viride 显示文摘 | YOUSSEF BOTHAINA M AZIZ N H | 1999 | Into Single Cell Protein1999，97，386： | 1 |
| 18 | Compari- son of methods to detect biosurfactant production by di- verse microorganisms 显示文摘 | Youssef N H Duncan K E Nagle D P | 2004 | J Microbiol Methods2004，56，： | 1 |
| 19 | The clinical utility of miR-21 as a diagnostic and prognostic marker for renal cell carcinoma显示文摘 | Faragalla H Youssef Y M Scorilas A Khalil B White N M Mejia-Guerrero S | | 0，，： | 1 |
| 20 | Developmentof Criteria to Evaluate Uniaxial Creep Data and AsphaltConcrete Permanent Deformation Potential 显示文摘 | LITTLE D N BUTTON JW YOUSSEF H | 1993 | Transportation Research Record1993，1417，： | 1 |
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