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| 1 | miRNA-711-SP1-collagen-I pathway is involved in the anti-fibrotic effect of pioglitazone in myocardial infarction显示文摘Although microRNAs(miRNAs) have been intensively studied in cardiac fibrosis,their roles in drug-mediated anti-fibrotic therapy are still unknown.Previously,Pioglitazone attenuated cardiac fibrosis and increased miR-711 experimentally.We aimed to explore the role and mechanism of miR-711 in pioglitazone-treated myocardial infarction in rats.Our results showed that pioglitazone significantly reduced collagen-I levels and increased miR-711 expression in myocardial infarction heart.Pioglitazone increased the expression of miR-711 in cardiac fibroblasts,and overexpression of miR-711 suppressed collagen-I levels in angiotensin II(Ang II)-treated or untreated cells.Transfection with antagomir-711 correspondingly abolished the pioglitazone-induced reduction in collagen-I levels.Bioinformatics analysis identified SP1,which directly promotes collagen-I synthesis,as the putative target of miR-711.This was confirmed by luciferase assay and western blot analysis.Additionally,increased SP1 expression was attenuated by pioglitazone in myocardial infarction heart.Furthermore,transfection of antagomir-711 attenuated pioglitazone-reduced SP1 expression in cardiac fibroblasts with or without Ang II stimulation.We conclude that pioglitazone up-regulated miR-711 to reduce collagen-I levels in rats with myocardial infarction.The miR-711-SP1-collagen-I pathway may be involved in the anti-fibrotic effects of pioglitazone.Our findings may provide new strategies for miRNA-based anti-fibrotic drug research. | ZHAO Na YU HaiYi YU HaiTao SUN Min ZHANG YouYi XU Ming GAO Wei | 2013 | Science China(Life Sciences)2013，56，5： | 9 |
| 2 | Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes显示文摘 | Kangmin He Xiaohua Yan Nan Li Song Dang Li Xu Bing Zhao Zijian Li Zhizhen Lv Xiaohong Fang Youyi Zhang Ye-Guang Chen | 2015 | Cell Research2015，25，6： | 7 |
| 3 | Galectin-3-centered paracrine network mediates cardiac inflammation and fibrosis upon β-adrenergic insult显示文摘Rapid over-activation of β-adrenergic receptors (β-AR) following acute stress initiates cardiac inflammation and injury by activating interleukin-18 (IL-18),however,the process of inflammation cascades has not been fully illustrated.The present study aimed to determine the mechanisms of cardiac inflammatory amplification following acute sympathetic activation.With bioinformatics analysis,galectin-3 was identified as a potential key downstream effector of β-AR and IL-18 activation.The serum level of galectin-3 was positively correlated with norepinephrine or IL-18 in patients with chest pain.In the heart of mice treated with β-AR agonist isoproterenol (ISO,5 mg kg^(-1)),galectin-3 expression was upregulated markedly later than IL-18 activation,and Nlrp3^(-/-)and Il18^(-/-)mice did not show ISO-induced galectin-3 upregulation.It was further revealed that cardiomyocyte-derived IL-18 induced galectin-3 expression in macrophages following ISO treatment.Moreover,galectin-3deficiency suppressed ISO-induced cardiac inflammation and fibrosis without blocking ISO-induced IL-18 increase.Treatment with a galectin-3 inhibitor,but not a β-blocker,one day after ISO treatment effectively attenuated cardiac inflammation and injury.In conclusion,galectin-3 is upregulated to exaggerate cardiac inflammation and injury following acute β-AR activation,a galectin-3 inhibitor effectively blocks cardiac injury one day after β-AR insult. | Guomin Hu Jimin Wu Huijun Gu Xiangning Deng Wenli Xu Shan Feng Shuaixing Wang Yao Song Zhengda Pang Xiuling Deng Aleksandr E.Vendrov Nageswara R.Madamanchi Marschall S.Runge Xinyu Wang Youyi Zhang Han Xiao Erdan Dong | 2023 | Science China(Life Sciences)2023，66，5： | 3 |
| 4 | Pathological matrix stiffness promotes cardiac fibroblast differentiation through the POU2F1 signaling pathway显示文摘Cardiac fibroblast(CF)differentiation into myofibroblasts is a crucial cause of cardiac fibrosis,which increases in the extracellular matrix(ECM)stiffness.The increased stiffness further promotes CF differentiation and fibrosis.However,the molecular mechanism is still unclear.We used bioinformatics analysis to find new candidates that regulate the genes involved in stiffnessinduced CF differentiation,and found that there were binding sites for the POU-domain transcription factor,POU2F1(also known as Oct-1),in the promoters of 50 differentially expressed genes(DEGs)in CFs on the stiffer substrate.Immunofluorescent staining and Western blotting revealed that pathological stiffness upregulated POU2F1 expression and increased CF differentiation on polyacrylamide hydrogel substrates and in mouse myocardial infarction tissue.A chromatin immunoprecipitation assay showed that POU2F1 bound to the promoters of fibrosis repressors IL1R2,CD69,and TGIF2.The expression of these fibrosis repressors was inhibited on pathological substrate stiffness.Knockdown of POU2F1 upregulated these repressors and attenuated CF differentiation on pathological substrate stiffness(35 kPa).Whereas,overexpression of POU2F1 downregulated these repressors and enhanced CF differentiation.In conclusion,pathological stiffness upregulates the transcription factor POU2F1 to promote CF differentiation by inhibiting fibrosis repressors.Our work elucidated the crosstalk between CF differentiation and the ECM and provided a potential target for cardiac fibrosis treatment. | Mingzhe Li Jimin Wu Guomin Hu Yao Song Jing Shen Junzhou Xin Zijian Li Wei Liu Erdan Dong Ming Xu Youyi Zhang Han Xiao | 2021 | Science China(Life Sciences)2021，64，2： | 3 |
| 5 | Preparation and properties of gel membrane containing porous PVDF-HFP matrix and cross-linked PEG for lithium ion conduction显示文摘Lithium ion conducting membranes are the key materials for lithium batteries.The lithium ion conducting gel polymer electrolyte membrane(Li-GPEM)based on porous poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)matrix and cross-linked PEG network is pre-pared by a typical phase inversion process.By immersing theporousPVDF-HFPmembraneinliquidelectrolytecon-taining poly(ethylene glycol)diacrylate(PEGDA)and an initiator to absorb the liquid electrolyte at 25℃,and then thermally cross-linking at 60℃,the Li-GPEM is fabricated successfully.The measurements on its weight loss,mech-anical and electrochemical properties reveal that the obtained Li-GPEM has better overall performance than the liquid and blend gel systems used as conductive media in lithium batteries.The ionic conductivity of the fabricated Li-GPEM can reach as high as 2.25×10^(-3) S/cm at 25℃. | Mei ZHANG Aiqing ZHANG Zhenyu CUI Baoku ZHU Gaige HAN Youyi XU | 2008 | Frontiers of Chemical Science and Engineering2008，2，1： | 3 |
| 6 | Preparation and characterization of PES/TiO 2 composite membranes显示文摘 | Guiping Wu Shuying Gan Longzhe Cui Youyi Xu | 2008 | Applied Surface Science2008，，21： | 1 |
| 7 | A novel positively charged nanofiltration membrane prepared from N,N-dime- thylaminoethyl methacrylate by quaternization cross-linking显示文摘 | Li Xiaolin Zhu Liping Xu Youyi | 2011 | Journal of Membrane Science2011，374，12： | 1 |
| 8 | Fabrication andcharacterization of a novel TiO2 nanoparticle self-assemblymembrane with improved fouling resistance显示文摘 | LI Jianhua XU Youyi ZHU Liping | 2009 | J Membr Sci2009，326，： | 1 |
| 9 | Logarithmic Spiral and its Application to the Design of the Relieving Shaped Milling Cutter显示文摘 | XU XINGXIN ZHANG XIAOHUI ZHENG YOUYI | 2011 | Applied Mechanics and Materials2011，42，： | 1 |
| 10 | Modification of polysulfone membranes via surface-initiated atom transfer radical polymerization显示文摘 | Dong Hanbang Xu Youyi Yi Zhuan | 2009 | Applied Surface Science2009，255，21： | 1 |
| 11 | 显示文摘 | XU Ying ZHU Baoku XU Youyi | 2005 | Polymer2005，46，： | 1 |
| 12 | Amphiphilic ABA copolymers used for surface modification of polysulfone membranes, Part 1: Molecular design, synthesis and characterization 显示文摘 | Wang Jianyu Xu Youyi Zhu Liping | 2008 | Polymer2008，49，15： | 1 |
| 13 | Synthesis of ultrahigh molecular weight poly(styrene-alt-maleic anhydride) in super-critical carbon dioxide显示文摘 | QIU Guangming ZHU Baoku XU Youyi | 2006 | Macromolecules2006，39，9： | 1 |
| 14 | Pilot test of vacuum membrane distillation for seawater desalination on a ship 显示文摘 | Xu Ying Zhu Baoku Xu Youyi | 2006 | Desalination2006，189，： | 1 |
| 15 | 显示文摘 | Xi Zhenyu Xu Youyi Zhu Liping | 2009 | J Membr Sci2009，339，： | 1 |
| 16 | Characterization and di electric property of polyimide-silica composite films prepared via sol-gel and thermal imidization process 显示文摘 | Zhang Jian Zhu Baoku Xu Youyi | 2005 | J Mater Sci2005，40，： | 1 |
| 17 | Fabrication andcharacterization of a novel TiO2 nanoparticle self -assemblymembrane with improved fouling resistance显示文摘 | LI Jianhua XU Youyi ZHU Liping | 2009 | J Membr Sci2009，326，： | 1 |
| 18 | Logarithmic spiral and its ap-plication to the design of the relieving shaped milling cutter 显示文摘 | Xu Xingxin Zhang Xiaohui Zheng Youyi | 2011 | AppliedMechanics and Materials2011，42，： | 1 |
| 19 | Pilot test of vacuum membrane dis-tillation for seawater desalination on a ship 显示文摘 | Xu Ying Zhu Baoku Xu Youyi | 2006 | Desalination2006，189，： | 1 |
| 20 | Surface modification of PVDF porous membranes via poly (DOPA) coating and heparin immobilization显示文摘 | Zhu Liping Yu Jingzhen Xu Youyi | 2009 | Colloids and Surfaces B: Biointerfaces2009，69，： | 1 |
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