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| 1 | Fructus Broussonetae extract improves cognitive function and endoplasmic reticulum stress in Alzheimer's disease models显示文摘This study investigated the effects and possible targets of Fructus Broussonetiae extract,a traditional Chinese medicinal herb,on a model of Alzheimer's disease induced by beta-amyloid peptide 25-35 and D-galactose.The results revealed that intragastric administration of Fructus Broussonetiae significantly increased the expression of immunoglobulin-binding protein,a key factor in the endoplasmic reticulum stress-signaling pathway in rat hippocampus.In contrast,the treatment significantly decreased expression levels of PKR-like endoplasmic reticulum kinase and C/EBP homologous protein,and substantially improved learning,memory and spatial recognition dysfunction in rats.This evidence indicates that Fructus Broussonetiae extract improves spatial learning and memory abilities in rats by affecting the regulation of hippocampal endoplasmic reticulum stress and activation of the apoptosis pathway. | Yinghong Li Li Hu Zhengzhi Wu Zhiling Yu Meiqun Cao Kehuan Sun Yu Jin Anmin Wu Andrew CJ Huang | 2011 | Neural Regeneration Research2011，6，30： | 7 |
| 2 | Complement activation by phospholipids: the interplay of factor H and C1q显示文摘Complement proteins in blood recognize charged particles.The anionic phospholipid(aPL)cardiolipin binds both complement proteins C1q and factor H.C1q is an activator of the complement classical pathway,while factor H is an inhibitor of the alternative pathway.To examine opposing effects of C1q and factor H on complement activation by aPL,we surveyed C1q and factor H binding,and complement activation by aPL,either coated on microtitre plates or in liposomes.Both C1q and factor H bound to all aPL tested,and competed directly with each other for binding.All the aPL activated the complement classical pathway,but negligibly the alternative pathway,consistent with accepted roles of C1q and factor H.However,in this system,factor H,by competing directly with C1q for binding to aPL,acts as a direct regulator of the complement classical pathway.This regulatory mechanism is distinct from its action on the alternative pathway.Regulation of classical pathway activation by factor H was confirmed by measuring C4 activation by aPL in human sera in which the C1q:factor H molar ratio was adjusted over a wide range.Thus factor H,which is regarded as a down-regulator only of the alternative pathway,has a distinct role in downregulating activation of the classical complement pathway by aPL.A factor H homologue,β2-glycoprotein-1,also strongly inhibits C1q binding to cardiolipin.Recombinant globular domains of C1q A,B and C chains bound aPL similarly to native C1q,confirming that C1q binds aPL via its globular heads. | Lee Aun Tan Bingbin Yu Francis CJ Sim Uday Kishore Robert B Sim | 2010 | Protein & Cell2010，1，11： | 2 |
| 3 | Resveratrol protects cardiomyocytes from hypoxia-induced apoptosis through the SIRT1-FoxO1 pathway显示文摘 | Chen CJ Yu W Fu YC | 2009 | Biochem Biophys Res Commun2009，378，3： | 1 |
| 4 | Outcome of Pulmonary Multidrug-Resistant Tuberculosis: a 6-yr Follow-up Study显示文摘 | Chiang CY Enarson DA Yu MC Bai KJ Huang RM Hsu CJ Suo J Lin TP | 2006 | Eur Respir J2006，28，5： | 1 |
| 5 | Evolution of H9N2 influenza viruses from domestic poultry in Mainland China显示文摘 | LI CJ YU KZ TIAN GB | 2005 | Virology2005，340，1： | 1 |
| 6 | Low serum level of high- density lipoprotein cholesterol is a poor prognostic factor for severe sepsis显示文摘 | Chien JY Jerng JS Yu CJ | 2005 | Crit Care Med2005，33，8： | 1 |
| 7 | Decreased tobacco-specific nitrosamines by microbial treatment with Bacillus amyloliquefaciens DA9 during the Air-Curing process of burley tobacco 显示文摘 | Wei XT Deng XW Cai DB Ji ZX Wang CJ Yu J Li JP and Chen SW | 2014 | J Agric Food Chem2014，62，12： | 1 |
| 8 | Potent induction of apoptosis by beta-lapachone in human multiple myeloma cill ines and patient cells显示文摘 | Li Y Li CJ Yu D | 2000 | Mol Med2000，，12： | 1 |
| 9 | Expression of group IIA phos pholipase A2 is an independent predictor of favorable outcome for patients with gastric eancer显示文摘 | Wang X Huang CJ Yu GZ | 2013 | Hum Pathol2013，44，10： | 1 |
| 10 | Vaccination of malignant galioma patients with peptide-pulsed dendritic cells elicits system cytotoxity and Tcell infiltration显示文摘 | Yu JS Wheeler CJ Zeltyer PM | 2001 | Cancer Res2001，61，3： | 1 |
| 11 | Effectiveness oftyrosine kinase inhibitors on 'uncommon' epidermal growth fac- tor receptor mutations of unknown clinical significance in non-small cell lung cancer显示文摘 | Wu JY Yu CJ Chang YC | 2011 | Clin Cancer Res2011，17，11： | 1 |
| 12 | Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response显示文摘 | Yu YW Chen TJ Hong CJ | 2003 | Neuropsyehopharmacology2003，28，6： | 1 |
| 13 | Proteomic analysis of osteoarthritic chondrocyte reveals the hyaluronic acid-regulated proteins involved in chondroprotective effect under oxidative stress显示文摘 | Yu CJ Ko CJ Hsieh CH | 2014 | J Proteomics2014，99，： | 1 |
| 14 | Genetic polymorphisms of cytochrome p450 and matrix metalloproteinase in chronic obstructive pulmonary disease显示文摘 | Cheng SL Yu CJ Yang PC | 2009 | Biochem Genet2009，47，78： | 1 |
| 15 | Impact of interleukin-8 genepolymorphisms and environmental factors on oral cancer susceptibilityin Taiwan显示文摘 | Liu CM Yeh CJ Yu CC | 2012 | Oral Dis2012，18，3： | 1 |
| 16 | Effect of quercetin and aspirin on platelet- neutrophil interaction 显示文摘 | Lin Y Gao CJ Yu XX | 1999 | Chinese Journal of Pharmacology and Toxicology1999，13，2： | 1 |
| 17 | Chronological changes in genetic variance and heritability of anthropometric charac- teristics among Chinese twin infants显示文摘 | Chen CJ YU MW Wang CJ | 1990 | Acta Genet Med Gemellol (Roma)1990，39，4： | 1 |
| 18 | Genetic polymorphism of epoxide hydrolase and glutathione S-transferase in COPD显示文摘 | CHENG SL YU CJ CHEN CJ | 2004 | Eur Respir2004，23，： | 1 |
| 19 | A link between mir-100 and FRAP1/m TOR in clear cell ovarian cancer显示文摘 | Nagaraja AK Creighton CJ Yu Z | 2010 | Mol Endocrinol2010，24，2： | 1 |
| 20 | Clinical featueres of pandrug-resistant Acinelobacter baumannii bacteremia at a university hospital in Taiwan显示文摘 | Kuo LC Yu CJ Lee LN | 2003 | J Formos Med Assoc2003，102，9： | 1 |
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