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| 1 | Expression of calreticulin is associated with infiltration of T-cells in stage ⅢB colon cancer显示文摘AIM: To investigate the correlation between expression of calreticulin and infiltration of lymphocytes in stage ⅢB colon cancer. METHODS: Sixty-eight pathologically-confirmed speci-mens were obtained from stage ⅢB (T3N1M0) colon cancer patients who underwent radical resection between January 1999 and May 2002 at the Cancer Center of Sun Yat-Sen University, Guangzhou, China. Immuno-histochemical analysis was performed to show infiltration of lymphocytes and expression of calreticulin in colon cancer. Association between calreticulin expression, infiltration of lymphocytes, and 5-year survival rate of patients was assessed. RESULTS: The expression level of calreticulin was lower in cancer nest than in its adjacent normal epithelium since 61.8% (42/68) of the samples were stained with calreticulin in colon cancer. The expression of calreticulin in colon cancer was associated with the infi ltration of CD45RO+ cells rather than with that of CD3+ cells. In addition, the stronger expression of calreticulin and the higher infiltration of CD3+ and CD45RO+ cells in colon cancer were associated with the higher 5-year survival rate of patients. CONCLUSION: Expression of calreticulin is associated with infiltration of T-cells, which implies that a low expression level of molecular marker may represent a new mechanism underlying immune escape in colon cancer. | Rui-Qing Peng, Ya Ding, Xing Zhang, Yi-Xin Zeng, Xiao- Shi Zhang, State Key Laboratory of Oncology in South China, Biotherapy Center, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Ying-Bo Chen, Zhi-Wei Zhou, State Key Laboratory of Oncology in South China, Department of Gastric and Pancreatic Oncology, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Rong Zhang, State Key Laboratory of Oncology in South China, Department of Endoscopy, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China Xing-Juan Yu, Yi-Xin Zeng, State Key Laboratory of Oncology in South China, Department of Experimental Research, Cancer Center, Sun Yat-Sen University, 651 Dongfeng R E, Guangzhou 510060, Guangdong Province, China | 2010 | World Journal of Gastroenterology2010，16，19： | 16 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 4 | The gap -junctional protein connexin40 is elevated in patients susceptible to postoperative atrial fibrillation显示文摘 | Dupont E Yu Shien K Stephen R | 2001 | Circulation2001，103，6： | 1 |
| 5 | Vascular COX-2 modulates blood pressure and thrombosis in mice显示文摘 | Yu Y Ricciotti E Scalia R | 2012 | Sci Transl Med2012，4，13： | 1 |
| 6 | Ki- netic studies on the interactions of heparin and complement proteins using surface plasmon reso- nance显示文摘 | YU H MUNOZ E M EDENS R E | 2005 | Biochim Biophys Acta2005，1726，2： | 1 |
| 7 | Case studies using panel data models 显示文摘 | Frees E W Young V R Luo Yu | 2001 | North American Actuarial Journal2001，，4： | 1 |
| 8 | Developmental, cytological and transcriptional analysis of autotetraploid Arabidopsis 显示文摘 | Li X D Yu E R Fan C C | 2012 | Planta2012，236，2： | 1 |
| 9 | Influence of gene polymorphisms of the rennin-angiotensin system on clinical outcome in heart failure among the chinese显示文摘 | SANDERSONJ E YU C M YOUNG R P | 1999 | American Heart J1999，137，： | 1 |
| 10 | Water-soluble quanhum dots for biomedical applicofions显示文摘 | Yu Ww Chang E Drezek R | 2006 | Biochem Biophys Bes Commun2006，348，3： | 1 |
| 11 | Deformation behaviour of ultra-fine-grained copper显示文摘 | Valiev R Z Kozlov E V Ivanov Yu F Lian J Nazarov A A Baudelet B | 1994 | Acta Metallurgica et Materialia1994，42，7： | 1 |
| 12 | Graphite nanoplatelet-epoxy composite thermal interface materials显示文摘 | Yu A P Ramesh P hkis M E Bekyarova E Haddon R C | | 0，，： | 1 |
| 13 | Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces frac- tional absorption of dietary cholesterol显示文摘 | Yu L Li-Hawkins J Hammer R E | 2002 | J Clin Invest2002，110，5： | 1 |
| 14 | Graphite nanoplatelet-epoxy composite thermal interface materials显示文摘 | Aiping Yu Palanisamy R Mikhail E I | 2007 | The Journal of Physical Chemistry C2007，111，： | 1 |
| 15 | Cloning, sequen- eing, and mapping of the human chromosome 14 heat shock protein gene(HSPA2) 显示文摘 | Bonnycastle L L Yu C E Hunt C R | 1994 | Genomics1994，23，1： | 1 |
| 16 | Water-soluble quantum dots for biomedical applications显示文摘 | Yu WW Chang E Drezek R | 2006 | Biochem Biophys Res Commun2006，348，3： | 1 |
| 17 | Antioxidant activity of differently regioselective chilosan sulfates in vitro 显示文摘 | Xing R E Yu H H Liu S | 2005 | Bioorg Med Chem2005，13，4： | 1 |
| 18 | Water-soluble quantum dots for biomedical applications 显示文摘 | Yu WW Chang E Drezek R | 2006 | Biochem Biophls Res Commun2006，348，3： | 1 |
| 19 | Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secre- tion显示文摘 | Yu L Hammer R E Li-Hawkins J | 2002 | Proc Natl Acad Sci U S A2002，99，16： | 1 |
| 20 | The gap junctional protein connexin 40 is elevated in patients susceptible to postoperative atrial fibrillation显示文摘 | Dupont E Yu Shien K Stephen R | 2001 | Circulation2001，103，6： | 1 |
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