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| 1 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 2 | 灰鹤在天山木扎提河湿地越冬及行为观察显示文摘于2017年10月—2019年5月,采用直接计数法、瞬时扫描取样法、卫星跟踪和最小凸多边形法(MCP),对新疆阿克苏地区拜城县木扎提河流域灰鹤(Grus grus)的种群特征、活动范围、行为时间分配和行为节律进行调查和分析。结果表明,2019年越冬灰鹤种群数量超过4700只,较2016年增加1倍多,种群发展动态呈上升趋势。灰鹤主要以家庭群为主(63.90%),聚集群次之(28.62%),孤鹤最少(7.48%)。家庭群主要以2成鸟1幼鸟为主(占46.82%),聚集群以5~8只个体为主(占65.91%)。整个越冬期持续140~160 d,灰鹤越冬期活动距离为1058 km,活动区域相对固定,活动区域面积为125 km^2。日活动面积和活动距离随着气温的变化而变化,温度降低,日活动范围和活动距离降低;反之,则增加。因此,活动面积和活动距离呈凹形变化,即先增加(10—11月),再逐渐减少(12—1月),然后增加(2—3月)的变化趋势。取食和警戒是灰鹤的主要越冬行为。灰鹤的46.8%日间时间用于取食,17.8%的日间时间用于警戒,用于休息、走动、理羽和其他行为的日间时间分别占13.4%、11.4%、7.4%和3.2%。日取食高峰呈双凸型,出现在8:00—9:00和17:00—18:00,分别达到57.0%和58.5%。休息高峰出现在11:00—15:00,占24.6%,呈单峰型。研究区灰鹤种群面临着放牧、农耕、天敌、道路车辆、低温和人为驱赶等诸多威胁因素。 | 李军伟 马鸣 孟凡娟 E I Ilyashenko V Yu Ilyashenko O V Belyalov A E Gavrilov S Kh Zaripova N Batbayar 曹垒 | 2020 | 生态与农村环境学报2020，36，5： | 4 |
| 3 | Effectiveness of biofeedbacktherapy in the treatment of anterior resection syndrome afterrectal cancer surgery显示文摘 | Kim KH Yu CS Yoon YS | 2011 | Dis Colon Rectum2011，54，9： | 1 |
| 4 | Hypokalemia: an independent risk factor of enterobacteriaceae peritonitis in CAPD patients显示文摘 | Chuang YW Shu KH YU TM | 2009 | Nephrol Dial Transplant2009，24，5： | 1 |
| 5 | Adenomyoma of the jejunum - a rare cause of gastrointestinal bleeding显示文摘 | Yu HC Lo GH Lai KH | 2008 | J Chin Med Assoe2008，71，2： | 1 |
| 6 | SOCS 3 and PPAR-gamma ligands inhibit the expression of IL-6 and TGF-betal by regulating JAK2/STAT3 signaling in pancreas 显示文摘 | Yu JH Kim KH Kim H | 2008 | Int J Biochem Cell Biol2008，40，： | 1 |
| 7 | Cognitive impairment evaluated with Vascular Cognitive Impaimmnt Harmonization Standards in a muhicenter prospective stroke cohort in Korea 显示文摘 | Yu KH Cho S J Oh MS | 2013 | Stroke2013，44，3： | 1 |
| 8 | Identification of parasite DNA in common bile duct stones by PCR and DNA sequencing显示文摘 | Jang JS Kim KH Yu JR | 2007 | Ko rean J Parasitol2007，45，4： | 1 |
| 9 | Type distribution of serogroup 6 Streptococcus pneumoniae and molecular epidemiology of new- ly identified serotypes 6C and 6D in China显示文摘 | Yao KH Liu Z J Yu JG | 2011 | Diagn Microbi- ol Infect Dis2011，70，3： | 1 |
| 10 | Modification of surface layers of copper under the action of the volumetric discharge initiated by an ava- lanche electron beam in nitrogen and CO2 at atmospheric pressure显示文摘 | Shulepov M A Akhmadeev Yu Kh Tarasenko Y F | 2011 | Russian Physics Journal2011，53，12： | 1 |
| 11 | Patterns of early treatment fail- ure in non-metastatic nasopharyngeal carcinoma: a study based on CT scanning 显示文摘 | Yu KH Teo PM Lee WY | 1994 | Clin Oncol1994，6，3： | 1 |
| 12 | Gender differences in the mortality and outcome of stroke patients in Korea显示文摘 | Oh MS Yu KH Roh JK | 2009 | Cerebrovasc Dis2009，28，： | 1 |
| 13 | Role of uric acid in the link between arterial stiffness and cardiac hypertrophy:a cross-sectional study 显示文摘 | Kuo CF Yu KH Luo SF | 2010 | Rheumatology ( Oxford )2010，49，6： | 1 |
| 14 | The relationship of air pollution to the prevalence of allergic diseases in Taichung and Chu-Shan in 2002显示文摘 | Yu JH Lue KH Lu KH | 2005 | Microbiol Immunol Infect2005，38，2： | 1 |
| 15 | Anisakis simplex: analysis of expressed sequence tags(ESTs) of third-stage larva显示文摘 | Yu HS Park SK Lee KH | 2007 | Exp Parasitol2007，117，1： | 1 |
| 16 | Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands 显示文摘 | Huang MX Ma DQ Sun KH Yu GY Guo CB Gao F | 1997 | Int J Oral Maxillofac Surg1997，26，6： | 1 |
| 17 | MicroRNA miR-124 regulates neuri- out growth duringneuronal differentiation 显示文摘 | Yu JY Chung KH Deo M | 2008 | Exp Cell Res2008，314，14： | 1 |
| 18 | Double-joint PCR: a PCR- based molecular tool for gene manipulations in filamentous fungi 显示文摘 | Yu JH Hamari Z Han KH | 2004 | Fungal Genet Biol2004，41，11： | 1 |
| 19 | Genotype replacement within serotype 23F Streptococcus pneumoniae in Beijing, China: characterization of serotype 23F显示文摘 | Ma X Yao KH Yu SJ | 2013 | Epidemiol Infect2013，141，8： | 1 |
| 20 | Significance of serum uricacid levels on the risk of all -cause and cardiovascular mor-tality显示文摘 | KuoCF See LC Yu KH | 2013 | Rheumatology2013，52，1： | 1 |
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