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| 1 | Role of CD56-expressing immature biliary epithelial cells in biliary atresia显示文摘AIM: To analyze the clinical and pathological parameters and expression of the neural cell adhesion molecule(CD56) in patients with biliary atresia(BA).METHODS: Established clinical laboratory markers of hepatic function, including enzyme activity, protein synthesis, and bilirubin metabolism, were evaluated in patients with BA and compared with those in patients with choledochal cysts and neonatal hepatitis. Pathological changes in tissue morphology and fibrosis were examined by histological and tissue collagen staining. Immunohistochemical staining for the biliary epithelial cell markers CD56 and CK19 together with the Notch signaling related molecules Notch1 and Notch2 was performed in the context of alterations in the structure of intrahepatic biliary ducts.RESULTS: Differences in some clinical laboratoryparameters among the three diseases examined were observed, but they did not correlate with the pathological classification of fibrosis in BA. Immunohistochemical staining showed the presence of CD56-positive immature bile ducts in most patients(74.5%) with BA but not in patients with choledochal cysts or neonatal hepatitis. The number of CD56-expressing cells correlated with disease severity, with more positive cells present in the later stages of liver damage(81.8% vs 18.2%). Furthermore, bile plugs were mainly found in CD56-positive immature biliary ducts. Notch signaling was a key regulatory pathway in biliary duct formation and played a role in tissue fibrosis. Notch1 was co-expressed in CD56-positive cells, whereas Notch2 was found exclusively in blood vessels in the portal area of patients with BA. CONCLUSION: The maturation of biliary epithelial cells and the expression of Notch may play a role in the pathogenesis of BA. | Rui-Zhong Zhang Jia-Kang Yu Jiao Peng Feng-Hua Wang Hai-Ying Liu Vincent CH Lui John M Nicholls Paul KH Tam Jonathan R Lamb Yan Chen Hui-Min Xia | 2016 | World Journal of Gastroenterology2016，22，8： | 8 |
| 2 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 3 | A scalable dual-clock FIFO for data transfers between arbitrary and haltable clock domains显示文摘 | APPERSON R W YU Z MEEUWSEN M J | 2007 | IEEE Transactions on Very Large Scale Integration (VLS1) Systems2007，15，10： | 1 |
| 4 | Uniform Metal Nanotube Arrays by Multistep Template Replication and Electrodeposition显示文摘 | Yu Y X Wang R M | 2004 | Adv Mater2004，16，17： | 1 |
| 5 | Nonrandom distribution and frequencies of genomie and EST - derived mierosatellite markers in flee, wheat, and barley 显示文摘 | ROTA L M KANTETY R V YU J K | 2005 | BMC Genomics2005，6，： | 1 |
| 6 | Isolation of a superfamily of candidate disease resistance genes in soybean based on a con- served nucleotide-binding site 显示文摘 | Yu Y G Buss G R Maroof M A | | Proceedlings of the Na- tional Academic of Science in USA0，93，11： | 1 |
| 7 | Construction of sorghum RFLP linkage map using sorghum and maize DNA probes显示文摘 | Ragab R A Dronavalli S Saghai Maroof M A and Yu Y G | 1994 | Genome1994，37，： | 1 |
| 8 | Chem显示文摘 | Yu M F Yakobson B I and Ruoff R S Phys J | 2000 | B2000，104，： | 1 |
| 9 | Dicopper(II) Complexes of the Antitumor Analogues Acylbis(salicylaldehyde hydrazones and Crystal Structures of Monomeric·(ClO4)23H2O and Polymeric·(ClO4)2m m(C2H5OH)显示文摘 | John D R Jagadese J V Yu M W | 1998 | Inorg Chem1998，37，： | 1 |
| 10 | Photocatalytic Properties of Titania Powders Prepared by Hydrothermal Method显示文摘 | Kolenko Yu V Churagulov B R Kunst M | 2004 | Applied Catalysis B:Environmental2004，54，： | 1 |
| 11 | Effects of ketamine on pulmonary inflammatory responses and survival in rats exposed to polymicrobial sepsis显示文摘 | Yu M Shao D Yang R | 2007 | J Pharm Sci2007，10，4： | 1 |
| 12 | Replication ofavian and seasonal influenza viruses in human bronchus andlung显示文摘 | Chan R W Y Yuen K M Yu W C L | 2011 | Influenza Other Resp Viruses2011，5，： | 1 |
| 13 | Overexpression of lactate dehydrogenase-a in human intrahepatic cholangiocarcinoma:its implication for treatment显示文摘 | Yu Y Liao M Liu R | 2014 | World J Surg Oncol2014，12，1： | 1 |
| 14 | High catalytic activity of Pd2+-exchanged mesoporous sodalite and NaA zeolite for bulky aryls coupling:reusability under aerobic condition显示文摘 | Choi M Lee D H Na K Yu B W Ryoo R | | 0，，20： | 1 |
| 15 | Responses of a coastal phytoplankton community to increased nutrient input from the Changjiang (Yangtze) River显示文摘 | Zhou M Shen Z Yu R | 2008 | Con- tinental Shelf Research2008，28，12： | 1 |
| 16 | Ki- netic studies on the interactions of heparin and complement proteins using surface plasmon reso- nance显示文摘 | YU H MUNOZ E M EDENS R E | 2005 | Biochim Biophys Acta2005，1726，2： | 1 |
| 17 | Expression pattern genomic struc- ture, and promoter analysis of the gene encoding stilbene synthase from Chinese wild Vitis pseudoreticulata显示文摘 | XU W R YU Y H ZHOU Q DING J H DAI L M XIE X Q XU Y ZHANG C H WANG Y J | 2011 | Journal of Experimen- tal Botany2011，62，8： | 1 |
| 18 | Water-triggered, counteranion-controlled, and silver-phosphines complex-catalyzed stereoselective cascade alkynyiation/cyelization of terminal alkynes with salicylaldehydes 显示文摘 | Yu M Skouta R Zhou L | 2009 | The Journal of Organic Chemistry2009，74，： | 1 |
| 19 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 20 | Influence of gene polymorphisms of the rennin-angiotensin system on clinical outcome in heart failure among the chinese显示文摘 | SANDERSONJ E YU C M YOUNG R P | 1999 | American Heart J1999，137，： | 1 |
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