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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Reproducibility of the diagnosis of dysplasia in Barrett esophagus: A reaffirmation显示文摘 | Elizabeth Montgomery Mary P Bronner John R Goldblum Joel K Greenson Marian M Haber John Hart Laura W Lamps Gregory Y Lauwers Audrey J Lazenby David N Lewin Marie E Robert Alicia Y Toledano Yu Shyr Kay Washington | 2001 | Human Pathology2001，，4： | 3 |
| 4 | An integrated approach to high --level information fusion 显示文摘 | Sycara K Glinton R Yu B | 2009 | Information Fusion2009，10，2009： | 1 |
| 5 | Nonrandom distribution and frequencies of genomie and EST - derived mierosatellite markers in flee, wheat, and barley 显示文摘 | ROTA L M KANTETY R V YU J K | 2005 | BMC Genomics2005，6，： | 1 |
| 6 | The gap -junctional protein connexin40 is elevated in patients susceptible to postoperative atrial fibrillation显示文摘 | Dupont E Yu Shien K Stephen R | 2001 | Circulation2001，103，6： | 1 |
| 7 | Replication ofavian and seasonal influenza viruses in human bronchus andlung显示文摘 | Chan R W Y Yuen K M Yu W C L | 2011 | Influenza Other Resp Viruses2011，5，： | 1 |
| 8 | Effects of nutritionallevel on pork quality and gene expression of (X -calpain andcalpastatin in muscle of finishing pigs显示文摘 | Tang R Y Yu B Zhang K Y | 2010 | Meat Science2010，85，4： | 1 |
| 9 | High catalytic activity of Pd2+-exchanged mesoporous sodalite and NaA zeolite for bulky aryls coupling:reusability under aerobic condition显示文摘 | Choi M Lee D H Na K Yu B W Ryoo R | | 0，，20： | 1 |
| 10 | An integrated approach to high-level information fusion显示文摘 | Sycera K Glinton R Yu Bin | | 0，，01： | 1 |
| 11 | Integrating Case-based and Fuzzy Reasoning to Qualitatively Predict Risk in an Environmental Impact Assessment Review显示文摘 | Liu K F R Yu C W | 2009 | En- vironmental Modelling & Software2009，24，10： | 1 |
| 12 | An adaptive Kalman filter for dynamic harmonic state estimation and harmonic injection tracking显示文摘 | Yu K K C Watson N R Arrillaga J | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 13 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 14 | Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra显示文摘 | Yu L R Zhu Z Y Chan K C | 2007 | J Proteome Res2007，6，： | 1 |
| 15 | The nanostructured origin of deformation twinning显示文摘 | YU Q QI L CHEN K MISHRA R K LI J MINOR A M | 2012 | Nano Letters2012，12，： | 1 |
| 16 | Coral communities on the remote atoll reefs in the Nansha Islands, southern South China Sea显示文摘 | ZHAO M X YU K F SHI Q CHEN T R ZHANG H L CHEN T G | 2013 | Environmental Monitoring and Assessments2013，185，： | 1 |
| 17 | Effect of rhythmic auditory stimulation on gait parameters and gait emg in patients with hemiplegia after stroke显示文摘 | Yu H Ohata K Kitatani R | 2014 | Gait&Posture2014，1，39： | 1 |
| 18 | Cryogenic toughness of commercial aluminum-lithium alloy: role of delamination toughening显示文摘 | Rao K T V Yu W K Ritchie R O | 1989 | Metal Trans A1989，20，3： | 1 |
| 19 | Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma显示文摘 | ROSS R K YUAN J M YU M C | 1992 | Lancet1992，339，： | 1 |
| 20 | Mechanism of 3,4-methylenedioxymethamphetamine(MDMA,ecstasy)-mediated mitochondrial dysfunction in rat liver显示文摘 | Moon K H Upreti V V Yu L R | 2008 | Proteomics2008，8，18： | 1 |
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